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Isolation of exosomes from whole blood by integrating acoustics and microfluidics
Open accessAbstract
Significance: We have developed a unique, integrated, on-chip technology that is capable of isolating exosomes or other types of extracellular vesicles, directly from undiluted whole-blood samples in an automated fashion. Automated exosome isolation enables biohazard containment, short processing time, reproducible results with little human intervention, and convenient integration with downstream exosome analysis units. Our method of integrating acoustics and microfluidics leads to the isolation of exosomes with high purity and yield. With its label-free, contact-free, and biocompatible nature, it offers the potential to preserve the structures, characteristics, and functions of isolated exosomes. This automated, point-of-care device can further help in advancing exosome-related biomedical research with potential applications in health monitoring, disease diagnostics, and therapeutics.
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Cites
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Self-citationExosomes as a new frontier of cancer liquid biopsy
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Recent advances in isolation and detection of exosomal microRNAs related to Alzheimer's disease
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Metadata
- Authors
- Wu, M., Ouyang, Y., Wang, Z., Zhang, R., Huang, P.-H., Chen, C., Li, H., Li, P., Quinn, D., Dao, M., Suresh, S., Sadovsky, Y., & Huang, T. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-09-18
- Volume
- 114
- Issue
- 40
- Pages
- 10584-10589
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2754283165
- Cited by
- 952
- References
- 3
- FWCI
- 29.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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