The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin
Open accessAbstract
Oxytocin produces uterine contractions and milk ejection, functions related to parturition and nuturing. Studies were conducted to determine if this peptide, native to the brain and the posterior pituitary gland, plays a role in the induction of maternal behavior. Intact virgin female rats were given 0.4 μg of oxytocin, 0.4 μg of [Arg 8 ]vasopressin, or saline through lateral ventricular cannulae. Forty-two percent of intact rats receiving oxytocin displayed full maternal behavior towards foster pups. None of the saline- or vasopressin-treated animals displayed full maternal behavior. Criteria in five behavioral categories had to be fulfilled by an animal within 2 hr of injection for its behavior to be considered fully maternal. When partial maternal responses were considered, oxytocin was significantly more effective than saline and marginally more effective than vasopressin. Five animals responding fully maternally after oxytocin injection were allowed to stay with pups for 10 days. All five continued to display full maternal behavior during this time. Nearly all animals that responded fully maternally to oxytocin injection were in the last day of diestrus or in proestrus or estrus. This suggested that elevated or recently elevated levels of estrogen may be necessary for the induction of full maternal behavior by oxytocin. Twenty-seven virgin female rats were ovariectomized and given either 100 μg of estradiol benzoate per kg in oil subcutaneously or oil alone immediately after operation. Forty-eight hours later, all animals received 0.4 μg of oxytocin intracerebroventricularly. Eleven of 13 estrogen-primed animals became fully maternal; none of 14 nonprimed animals became fully maternal.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Smith, M. S., Freeman, M. E., & Neill, J. D. (1975) · Endocrinology · doi:10.1210/endo-96-1-219 · Cited by 1,286
Nonhormonal basis of maternal behavior in the rat
Rosenblatt, J. S. (1967) · Science · doi:10.1126/science.156.3781.1512 · Cited by 721
Estrogen Secretion by the Rat Ovaryin VivoDuring the Estrous Cycle and Pregnancy
Yoshinaga, K., Hawkins, R. A., & Stocker, J. (1969) · Endocrinology · doi:10.1210/endo-85-1-103 · Cited by 432
Shaikh, A. A. (1971) · Biology of Reproduction · doi:10.1093/biolreprod/5.3.297 · Cited by 385
Hormonal induction of maternal behavior in the ovariectomized nulliparous rat
Moltz, H., Lubin, M. F., Leon, M., & Numan, M. (1970) · Physiology & Behavior · doi:10.1016/0031-9384(70)90122-8 · Cited by 262
Dogterom, J., Greidanus, T. B. V. W., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000122702 · Cited by 247
BOHUS, B., URBAN, I., VANWIMERSMAGREIDANUS, T., & DEWIED, D. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90107-7 · Cited by 231
Isolation and structure of hypothalamic MSH release-inhibiting hormone
Nair, R. M. G., Kastin, A. J., & Schally, A. V. (1971) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(71)80026-8 · Cited by 224
MORISHIGE, W. K., & ROTHCHILD, I. (1974) · Endocrinology · doi:10.1210/endo-95-1-260 · Cited by 205
Handbook of Psychopharmacology
Iversen, L. L., Iversen, S. D., & Snyder, S. H. (1978) · Springer eBooks · doi:10.1007/978-1-4613-4045-4 · Cited by 199
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–127 of 127
Flexibility and adaptation of the neural substrate that supports maternal behavior in mammals
Olazábal, D. E., Pereira, M., Agrati, D., Ferreira, A., Fleming, A. S., González-Mariscal, G., Lévy, F., Lucion, A. B., Morrell, J. I., Numan, M., et al. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.004 · Cited by 97
Rault, J.-L., Carter, C. S., Garner, J. P., Marchant, J. N., Richert, B. T., & Lay, D. C. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.007 · Cited by 94
Alvares, G. A., Quintana, D. S., & Whitehouse, A. J. O. (2017) · Autism Research · doi:10.1002/aur.1692 · Cited by 91
Wamboldt, M. Z., & Insel, T. R. (1987) · Behavioral Neuroscience · doi:10.1037/0735-7044.101.3.439 · Cited by 89
Intranasal oxytocin in obsessive-compulsive disorder
Epperson, C. N., McDougle, C. J., & Price, L. H. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(96)00120-5 · Cited by 88
Fleming, A. S., Steiner, M., & Anderson, V. (1987) · Journal of Reproductive and Infant Psychology · doi:10.1080/02646838708403495 · Cited by 87
Maternal behaviour in sheep and its neuroendocrine regulation
Keverne, B., & Kendrick, K. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13265.x · Cited by 82
Cocaine addiction in mothers: Potential effects on maternal care and infant development
Strathearn, L., & Mayes, L. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05142.x · Cited by 80
Editorial comment: Oxytocin, vasopressin and social behavior
Young, L. J., & Flanagan-Cato, L. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.019 · Cited by 81
Leckman, J. F., & Mayes, L. C. (1999) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(18)30172-x · Cited by 79
Ebner, N. C., Lin, T., Muradoglu, M., Weir, D. H., Plasencia, G. M., Lillard, T. S., Pournajafi-Nazarloo, H., Cohen, R. A., Sue Carter, C., & Connelly, J. J. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.01.008 · Cited by 79
Mayes, L. C., Swain, J. E., & Leckman, J. F. (2005) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2005.03.009 · Cited by 71
The neurobiology of offensive aggression: Revealing a modular view
de Boer, S. F., Olivier, B., Veening, J., & Koolhaas, J. M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.04.040 · Cited by 70
Is oxytocin a maternal-foetal signalling molecule at birth? Implications for development
Kenkel, W. M., Yee, J. R., & Carter, C. S. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12186 · Cited by 70
Homologous regulation of brain oxytocin receptors.
Insel, T. R., Winslow, J. T., & Witt, D. M. (1992) · Endocrinology · doi:10.1210/endo.130.5.1315251 · Cited by 63
Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90396-3 · Cited by 60
Jensen Peña, C., & Champagne, F. A. (2013) · Behavioral Neuroscience · doi:10.1037/a0031219 · Cited by 54
Oxytocin modulates unconditioned fear response in lactating dams: An fMRI study
Febo, M., Shields, J., Ferris, C. F., & King, J. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.043 · Cited by 47
Brain vasopressin signaling modulates aspects of maternal behavior in lactating rats
Bayerl, D. S., & Bosch, O. J. (2019) · Genes, Brain and Behavior · doi:10.1111/gbb.12517 · Cited by 46
A precision medicine approach to oxytocin trials
Andari, E., Hurlemann, R., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_29 · Cited by 40
An evolutionary perspective on the behavioral consequences of exogenous oxytocin application
Ebitz, R. B., & Platt, M. L. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00225 · Cited by 35
Oxytocin and vulnerable romantic relationships
Grebe, N. M., Kristoffersen, A. A., Grøntvedt, T. V., Emery Thompson, M., Kennair, L. E. O., & Gangestad, S. W. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.02.009 · Cited by 34
Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research
Putnam, P. T., Young, L. J., & Gothard, K. M. (2018) · American Journal of Primatology · doi:10.1002/ajp.22756 · Cited by 28
“For example,virgin female rats normallyignoreorattackpups,yetwhentheyreceiveanintra-ventricular infusionofOTintothebraintheydisplaymaternalbehaviors(Pedersen& Prange, 1979).”
Oxytocin promotes attention to social cues regardless of group membership
Pfundmair, M., Zwarg, C., Paulus, M., & Rimpel, A. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.03.006 · Cited by 23
McEwen (2004) · doi:10.1016/s1054-3589(04)50016-9 · Cited by 22
Estrous phase alters social behavior in a polygynous but not a monogamous Peromyscus species
Karelina, K., Walton, J. C., Weil, Z. M., Norman, G. J., Nelson, R. J., & DeVries, A. C. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.022 · Cited by 15
Kirsch, P., & Meyer-Lindenberg, A. (2010) · The Neurochemical Basis of Autism · doi:10.1007/978-1-4419-1272-5_10 · Cited by 6
Metadata
- Authors
- Pedersen, C. A., & Prange, A. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Pedersen, Cort A.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1979-12
- Volume
- 76
- Issue
- 12
- Pages
- 6661-6665
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC411928
- OpenAlex
- W2029315800
- Cited by
- 841
- References
- 36
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 19 · 2023: 20 · 2022: 26 · 2021: 20 · 2020: 55 · 2019: 21 · 2018: 39 · 2017: 38 · 2016: 31 · 2015: 32 · 2014: 36 · 2013: 34 · 2012: 20
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, maternal behavior, virgin female rats, intracerebroventricular administration, vasopressin, estrogen, estradiol benzoate, ovariectomy, estrous cycle, childbirth, milk ejection
- MeSH terms
- Animals, Arginine Vasopressin, Drug Synergism, Estrogens, Estrus, Female, Injections, Intraventricular, Maternal Behavior, Oxytocin, Pregnancy, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
