Cocaine addiction in mothers: Potential effects on maternal care and infant development
Open accessAbstract
Maternal cocaine addiction is a significant public health issue particularly affecting children, with high rates of reported abuse, neglect, and foster care placement. This review examines both preclinical and clinical evidence for how cocaine abuse may affect maternal care and infant development, exploring brain, behavioral, and neuroendocrine mechanisms. There is evidence that cocaine affects infant development both directly, via in utero exposure, and indirectly via alterations in maternal care. Two neural systems known to play an important role in both maternal care and cocaine addiction are the oxytocin and dopamine systems, mediating social and reward-related behaviors and stress reactivity. These same neural mechanisms may also be involved in the infant's development of vulnerability to addiction. Understanding the neuroendocrine pathways involved in maternal behavior and addiction may help facilitate earlier, more effective interventions to help substance-abusing mothers provide adequate care for their infant and perhaps prevent the intergenerational transmission of risk.
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Addiction problems in mothers are associated with a range of major parenting difficulties, often resulting in child abuse and neglect.
“Addiction problems in mothers are associated with a range of major parenting difficulties, often resulting in child abuse and neglect (Mayes et al., 1997; Strathearn and Mayes, 2010).”
From The maternal brain and its plasticity in humans (2016) · cites this paper as Strathearn and Mayes, 2010
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- Authors
- Strathearn, L., & Mayes, L. C.
- Affiliations
- Baylor College of Medicine (US)
- Yale University (US)
- Corresponding author
- Strathearn, Lane
- ORCID
- Strathearn, Lane
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-02
- Volume
- 1187
- Issue
- 1
- Pages
- 172-183
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC3016156
- OpenAlex
- W2055581663
- Cited by
- 80
- References
- 105
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 12 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 7 · 2014: 4 · 2013: 7 · 2012: 6
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R01DA006025, K05DA020091, DA022446-01A2, P01DA022446)
- National Center for Research Resources (MO1-RR-00188, M01RR000188)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD043097)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- prenatal cocaine exposure, maternal care, infant development, oxytocinergic system, dopaminergic system, neuroendocrine mechanisms, stress reactivity, intergenerational transmission of addiction, child abuse, foster care placement
- MeSH terms
- Animals, Child Development, Dopamine, Female, Humans, Infant, Infant, Newborn, Maternal Behavior, Mother-Child Relations, Neurosecretory Systems, Object Attachment, Oxytocin, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Cocaine-Related Disorders
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