Cited by 841Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin

Open access

Pedersen, Cort A., Prange, Arthur J.·1979·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.76.12.6661PMC PMC411928

Open this paper in CoChat — free account

Abstract

Oxytocin produces uterine contractions and milk ejection, functions related to parturition and nuturing. Studies were conducted to determine if this peptide, native to the brain and the posterior pituitary gland, plays a role in the induction of maternal behavior. Intact virgin female rats were given 0.4 μg of oxytocin, 0.4 μg of [Arg 8 ]vasopressin, or saline through lateral ventricular cannulae. Forty-two percent of intact rats receiving oxytocin displayed full maternal behavior towards foster pups. None of the saline- or vasopressin-treated animals displayed full maternal behavior. Criteria in five behavioral categories had to be fulfilled by an animal within 2 hr of injection for its behavior to be considered fully maternal. When partial maternal responses were considered, oxytocin was significantly more effective than saline and marginally more effective than vasopressin. Five animals responding fully maternally after oxytocin injection were allowed to stay with pups for 10 days. All five continued to display full maternal behavior during this time. Nearly all animals that responded fully maternally to oxytocin injection were in the last day of diestrus or in proestrus or estrus. This suggested that elevated or recently elevated levels of estrogen may be necessary for the induction of full maternal behavior by oxytocin. Twenty-seven virgin female rats were ovariectomized and given either 100 μg of estradiol benzoate per kg in oil subcutaneously or oil alone immediately after operation. Forty-eight hours later, all animals received 0.4 μg of oxytocin intracerebroventricularly. Eleven of 13 estrogen-primed animals became fully maternal; none of 14 nonprimed animals became fully maternal.

Integrity signals

Registry

Crossref · 10.1073/pnas.76.12.6661

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

The Control of Progesterone Secretion During the Estrous Cycle and Early Pseudopregnancy in the Rat: Prolactin, Gonadotropin and Steroid Levels Associated with Rescue of the Corpus Luteum of Pseudopregnancy 1 2
Smith, M. S., Freeman, M. E., & Neill, J. D. (1975) · Endocrinology · doi:10.1210/endo-96-1-219 · Cited by 1,286
Nonhormonal basis of maternal behavior in the rat
Rosenblatt, J. S. (1967) · Science · doi:10.1126/science.156.3781.1512 · Cited by 721
Estrogen Secretion by the Rat Ovaryin VivoDuring the Estrous Cycle and Pregnancy
Yoshinaga, K., Hawkins, R. A., & Stocker, J. (1969) · Endocrinology · doi:10.1210/endo-85-1-103 · Cited by 432
Estrone and Estradiol Levels in the Ovarian Venous Blood from Rats During the Estrous Cycle and Pregnancy*
Shaikh, A. A. (1971) · Biology of Reproduction · doi:10.1093/biolreprod/5.3.297 · Cited by 385
Hormonal induction of maternal behavior in the ovariectomized nulliparous rat
Moltz, H., Lubin, M. F., Leon, M., & Numan, M. (1970) · Physiology & Behavior · doi:10.1016/0031-9384(70)90122-8 · Cited by 262
Evidence for the Release of Vasopressin and Oxytocin into Cerebrospinal Fluid: Measurements in Plasma and CSF of Intact and Hypophysectomized Rats
Dogterom, J., Greidanus, T. B. V. W., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000122702 · Cited by 247
Opposite effects of oxytocin and vasopressin on avoidance behaviour and hippocampal theta rhythm in the rat
BOHUS, B., URBAN, I., VANWIMERSMAGREIDANUS, T., & DEWIED, D. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90107-7 · Cited by 231
Isolation and structure of hypothalamic MSH release-inhibiting hormone
Nair, R. M. G., Kastin, A. J., & Schally, A. V. (1971) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(71)80026-8 · Cited by 224
Temporal Aspects of the Regulation of Corpus Luteum Function by Luteinizing Hormone, Prolactin and Placental Luteotrophin During the First Half of Pregnancy in the Rat12
MORISHIGE, W. K., & ROTHCHILD, I. (1974) · Endocrinology · doi:10.1210/endo-95-1-260 · Cited by 205
Handbook of Psychopharmacology
Iversen, L. L., Iversen, S. D., & Snyder, S. H. (1978) · Springer eBooks · doi:10.1007/978-1-4613-4045-4 · Cited by 199

Show all 36 references

Sorted by citations

The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,497
Neuroendocrine perspectives on social attachment and love
Sue Carter, C. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00055-9 · Cited by 1,425
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856
“The first suggestion that OT plays a role in regulating the onset of maternal behavior came from a study showing OT injected into the cerebral ventricles (ICV) of a virgin rat could produce nurturing behavior towards pups within two hours [7].”
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Oxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770
Self-citation
Brain oxytocin: A key regulator of emotional and social behaviours in both females and males
Neumann, I. D. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01726.x · Cited by 743
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors
Champagne, F., Diorio, J., Sharma, S., & Meaney, M. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221224598 · Cited by 707
Brain substrates of infant-mother attachment: contributions of opioids, oxytocin, and norepinephrine.
Nelson, E. E., & Panksepp, J. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00052-3 · Cited by 688
Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent–infant contact
Feldman, R., Gordon, I., Schneiderman, I., Weisman, O., & Zagoory-Sharon, O. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.01.013 · Cited by 638
The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620
Oxytocin is associated with human trustworthiness
ZAK, P., KURZBAN, R., & MATZNER, W. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.07.009 · Cited by 595
A neurobiological basis of social attachment.
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.726 · Cited by 553
Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat
Francis, D. D., Champagne, F. C., & Meaney, M. J. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00599.x · Cited by 496
The neuroendocrine basis of social recognition
Ferguson, J. N., Young, L. J., & Insel, T. R. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2002.0229 · Cited by 494
Oxytocin Administered Centrally Facilitates Formation of a Partner Preference in Female Prairie Voles (Microtus ochrogaster)
Williams, J. R., Insel, T. R., Harbaugh, C. R., & Carter, C. S. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00579.x · Cited by 483
Oxytocin — A neuropeptide for affiliation: Evidence from behavioral, receptor autoradiographic, and comparative studies
Insel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487
Maternal and paternal plasma, salivary, and urinary oxytocin and parent–infant synchrony: considering stress and affiliation components of human bonding
Feldman, R., Gordon, I., & Zagoory‐Sharon, O. (2011) · Developmental Science · doi:10.1111/j.1467-7687.2010.01021.x · Cited by 486
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468
Modulating social behavior with oxytocin: How does it work? What does it mean?
Churchland, P. S., & Winkielman, P. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.003 · Cited by 464
Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas.
Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., & Mason, G. A. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.6.1163 · Cited by 475
Self-citation
Chapter 21 Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity
Champagne, F., & Meaney, M. J. (2001) · Progress in Brain Research · doi:10.1016/s0079-6123(01)33022-4 · Cited by 455
Brain Oxytocin Inhibits Basal and Stress‐Induced Activity of the Hypothalamo‐Pituitary‐Adrenal Axis in Male and Female Rats: Partial Action Within the Paraventricular Nucleus
Neumann, Wigger, Torner, Holsboer, & Landgraf (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00442.x · Cited by 452
CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446
Lust, attraction, and attachment in mammalian reproduction
Fisher, H. E. (1998) · Human Nature · doi:10.1007/s12110-998-1010-5 · Cited by 429
The neurobiology of pair bonding: Insights from a socially monogamous rodent
Young, K. A., Gobrogge, K. L., Liu, Y., & Wang, Z. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.006 · Cited by 389
Oxytocin and sexual behavior
Carter, C. S. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80176-9 · Cited by 417
Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: From central release to sites of action
Bosch, O. J., & Neumann, I. D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.002 · Cited by 400
Is oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394
Chapter 12 Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis
Neumann, I. D. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39014-9 · Cited by 387
Oxytocin, motherhood and bonding
Kendrick, K. M. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00014.x · Cited by 378
Oxytocin–dopamine interactions mediate variations in maternal behavior in the rat
Shahrokh, D. K., Zhang, T.-Y., Diorio, J., Gratton, A., & Meaney, M. J. (2010) · Endocrinology · doi:10.1210/en.2009-1271 · Cited by 366
Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat
Szyf, M., Weaver, I. C. G., Champagne, F. A., Diorio, J., & Meaney, M. J. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.002 · Cited by 348
The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care
Cameron, N. M., Champagne, F. A., Parent, C., Fish, E. W., Ozaki-Kuroda, K., & Meaney, M. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.022 · Cited by 320
Characterization of the oxytocin system regulating affiliative behavior in female prairie voles
Ross, H. E., Cole, C. D., Smith, Y., Neumann, I. D., Landgraf, R., Murphy, A. Z., & Young, L. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.055 · Cited by 309
Oxytocin during pregnancy and early postpartum: Individual patterns and maternal-fetal attachment
Levine, A., Zagoory-Sharon, O., Feldman, R., & Weller, A. (2007) · Peptides · doi:10.1016/j.peptides.2007.04.016 · Cited by 315
Neural control of maternal behaviour and olfactory recognition of offspring
Kendrick, K. M., Da Costa, A. P. C., Broad, K. D., Ohkura, S., Guevara, R., Lévy, F., & Keverne, E. B. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00218-9 · Cited by 311
The social deficits of the oxytocin knockout mouse
Winslow, J. T., & Insel, T. R. (2002) · Neuropeptides · doi:10.1054/npep.2002.0909 · Cited by 307
Does Oxytocin Increase Trust in Humans? A Critical Review of Research
Nave, G., Camerer, C., & McCullough, M. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691615600138 · Cited by 316
The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307
“OT is released centrally and peripherally during birth , and centrally re - leased OT is necessary for the rapid onset of maternal behavior in virgin rats and sufficient to induce it ( Pedersen and Prange 1979 ; Fahrbach et al .”
A distributed network for social cognition enriched for oxytocin receptors
Mitre, M., Marlin, B. J., Schiavo, J. K., Morina, E., Norden, S. E., Hackett, T. A., Aoki, C. J., Chao, M. V., & Froemke, R. C. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2409-15.2016 · Cited by 305
Oxytocin receptors in the nucleus accumbens facilitate “spontaneous” maternal behavior in adult female prairie voles
Olazábal, D. E., & Young, L. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.017 · Cited by 289
Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers
Swain, J. E., Kim, P., Spicer, J., Ho, S. S., Dayton, C. J., Elmadih, A., & Abel, K. M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.007 · Cited by 290
Oxytocin, brain physiology, and functional connectivity: A review of intranasal oxytocin fMRI studies
Bethlehem, R. A. I., van Honk, J., Auyeung, B., & Baron-Cohen, S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.011 · Cited by 285
Attachment, aggression and affiliation: the role of oxytocin in female social behavior
Campbell, A. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2007.09.001 · Cited by 269
Maternal neglect: oxytocin, dopamine and the neurobiology of attachment
Strathearn, L. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02228.x · Cited by 268
Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265
The neurobiology of trust
ZAK, P. J., KURZBAN, R., & MATZNER, W. T. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.025 · Cited by 282
Neuroendocrine bases of monogamy
Young, L. J., Wang, Z., & Insel, T. R. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01167-3 · Cited by 265
Lesions of the hypothalamic paraventricular nucleus disrupt the initiation of maternal behavior
Insel, T. R., & Harbaugh, C. R. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90234-5 · Cited by 250
Species and individual differences in juvenile female alloparental care are associated with oxytocin receptor density in the striatum and the lateral septum
Olazábal, D. E., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.12.010 · Cited by 230
Oxytocin and human social behavior.
Campbell, A. (2010) · Personality and Social Psychology Review · doi:10.1177/1088868310363594 · Cited by 232
Vaginal stimulation: an important determinant of maternal bonding in sheep
Keverne, E. B., Levy, F., Poindron, P., & Lindsay, D. R. (1983) · Science · doi:10.1126/science.6849123 · Cited by 230
Both oxytocin and vasopressin may influence alloparental behavior in male prairie voles
Bales, K. L., Kim, A. J., Lewis-Reese, A. D., & Sue Carter, C. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.01.004 · Cited by 217
Oxytocin and Vasopressin Receptors and Species-Typical Social Behaviors
Young, L. J. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1548 · Cited by 211
The comparative distribution of forebrain receptors for neurohypophyseal peptides in monogamous and polygamous mice
Insel, T. R., Gelhard, R., & Shapiro, L. E. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90321-e · Cited by 209
Mechanisms underlying epigenetic effects of early social experience: the role of neuropeptides and steroids
CUSHING, B., & KRAMER, K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.001 · Cited by 209
Early parental preoccupations and behaviors and their possible relationship to the symptoms of obsessive–compulsive disorder
Leckman, J. F., Mayes, L. C., Feldman, R., Evans, D. W., King, R. A., & Cohen, D. J. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb10951.x · Cited by 207
Maternal aggression in rodents: brain oxytocin and vasopressin mediate pup defence
Bosch, O. J. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0085 · Cited by 194
Female oxytocin-deficient mice display enhanced anxiety-related behavior
Mantella, R. C., Vollmer, R. R., Li, X., & Amico, J. A. (2003) · Endocrinology · doi:10.1210/en.2002-0197 · Cited by 200
Neural circuits underlying crying and cry responding in mammals
Newman, J. D. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.011 · Cited by 198
Functional Magnetic Resonance Imaging Shows Oxytocin Activates Brain Regions Associated with Mother–Pup Bonding during Suckling
Febo, M., Numan, M., & Ferris, C. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3604-05.2005 · Cited by 197
Oxytocin has dose-dependent developmental effects on pair-bonding and alloparental care in female prairie voles
Bales, K. L., van Westerhuyzen, J. A., Lewis-Reese, A. D., Grotte, N. D., Lanter, J. A., & Carter, C. S. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.004 · Cited by 192
Maternal behavior deficits in nulliparous oxytocin knockout mice
Pedersen, C. A., Vadlamudi, S. V., Boccia, M. L., & Amico, J. A. (2006) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00162.x · Cited by 190
Oxytocin induction of short-latency maternal behavior in nulliparous, estrogen-primed female rats
FAHRBACH, S. (1984) · Hormones and Behavior · doi:10.1016/0018-506x(84)90016-3 · Cited by 187
Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review
Crockford, C., Deschner, T., Ziegler, T. E., & Wittig, R. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00068 · Cited by 187
Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder
Campbell, D. B., Datta, D., Jones, S. T., Batey Lee, E., Sutcliffe, J. S., Hammock, E. A. D., & Levitt, P. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9071-2 · Cited by 170
Oxytocin Control of Maternal Behavior Regulation by Sex Steroids and Offspring Stimulia
PEDERSEN, C. A. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51916.x · Cited by 172
Self-citation
The neurobiology of social attachment: A comparative approach to behavioral, neuroanatomical, and neurochemical studies
Young, K. A., Liu, Y., & Wang, Z. (2008) · Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology · doi:10.1016/j.cbpc.2008.02.004 · Cited by 163
The advantage of social living: Brain neuropeptides mediate the beneficial consequences of sex and motherhood
Neumann, I. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.012 · Cited by 162
Increasing oxytocin receptor expression in the nucleus accumbens of pre-pubertal female prairie voles enhances alloparental responsiveness and partner preference formation as adults
Keebaugh, A. C., & Young, L. J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.07.018 · Cited by 154
Anatomy and neurochemistry of the pair bond
Young, L. J., Murphy Young, A. Z., & Hammock, E. A. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20771 · Cited by 163
Oxytocin, cortisol, and triadic family interactions
Gordon, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.08.008 · Cited by 158
Neuroanatomical distribution of oxytocin and vasopressin 1a receptors in the socially monogamous coppery titi monkey (Callicebus cupreus)
Freeman, S. M., Walum, H., Inoue, K., Smith, A. L., Goodman, M. M., Bales, K. L., & Young, L. J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.055 · Cited by 153
Endogenous oxytocin is involved in short-term olfactory memory in female rats
Engelmann, M., Ebner, K., Wotjak, C. T., & Landgraf, R. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00084-3 · Cited by 156
Onset and Exacerbation of Obsessive-Compulsive Disorder in Pregnancy and the Postpartum Period
Forray, A., Focseneanu, M., Pittman, B., McDougle, C. J., & Epperson, C. N. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05381blu · Cited by 155
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139
Social stimuli induce activation of oxytocin neurons within the paraventricular nucleus of the hypothalamus to promote social behavior in male mice
Resendez, S. L., Namboodiri, V. M. K., Otis, J. M., Eckman, L. E. H., Rodriguez-Romaguera, J., Ung, R. L., Basiri, M. L., Kosyk, O., Rossi, M. A., Dichter, G. S., et al. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1515-18.2020 · Cited by 142
Experimental peripheral administration of oxytocin elevates a suite of cooperative behaviours in a wild social mammal
Madden, J. R., & Clutton-Brock, T. H. (2011) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2010.1675 · Cited by 144
Neural correlates of giving support to a loved one
Inagaki, T. K., & Eisenberger, N. I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182359335 · Cited by 141
Maternal behavior and developmental psychopathology
Leckman, J. F., & Herman, A. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01277-x · Cited by 139
Personality traits in women 4 days postpartum and their correlation with plasma levels of oxytocin and prolactin
Uvnäs-Mobcrg, K., Widström, A.-M., Nissen, E., & Björvell, H. (1990) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.3109/01674829009084422 · Cited by 137
The role of central oxytocin in obsessive compulsive disorder and related normal behavior
Leckman, J. F., Goodman, W. K., North, W. G., Chappell, P. B., Price, L. H., Pauls, D. L., Anderson, G. M., Riddle, M. A., McDougle, C. J., Barr, L. C., et al. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90021-3 · Cited by 133
Oxytocin modulation of neural circuits for social behavior
Marlin, B. J., & Froemke, R. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22452 · Cited by 130
Variation in oxytocin is related to variation in affiliative behavior in monogamous, pairbonded tamarins
Snowdon, C. T., Pieper, B. A., Boe, C. Y., Cronin, K. A., Kurian, A. V., & Ziegler, T. E. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.014 · Cited by 133
Cerebrospinal fluid and plasma concentrations of oxytocin and vasopressin during parturition and vaginocervical stimulation in the sheep
Kendrick, K. M., Keverne, E. B., Hinton, M. R., & Goode, J. A. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90178-m · Cited by 128
Oxytocin mediates entrainment of sensory stimuli to social cues of opposing valence
Choe, H. K., Reed, M. D., Benavidez, N., Montgomery, D., Soares, N., Yim, Y. S., & Choi, G. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.022 · Cited by 124
Autism and Oxytocin: New Developments in Translational Approaches to Therapeutics
Green, J. J., & Hollander, E. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.006 · Cited by 124
A relationship between oxytocin and anxiety of romantic attachment
Marazziti (2006) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-2-28 · Cited by 124
Modeling Social Influences on Human Health
Karelina, K., & DeVries, A. C. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182002116 · Cited by 115
Oxytocin and vasopressin: genetics and behavioral implications
Caldwell, H. K., & Young, W. S. (2006) · Handbook of Neurochemistry and Molecular Neurobiology · doi:10.1007/978-0-387-30381-9_25 · Cited by 113
Impairments in the Initiation of Maternal Behavior in Oxytocin Receptor Knockout Mice
Rich, M. E., deCárdenas, E. J., Lee, H.-J., & Caldwell, H. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098839 · Cited by 105
A brief history of oxytocin and its role in modulating psychostimulant effects
Carson, D. S., Guastella, A. J., Taylor, E. R., & McGregor, I. S. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112473788 · Cited by 105
Gene targeting approaches to neuroendocrinology: oxytocin, maternal behavior, and affiliation
Young, L. J., Winslow, J. T., Wang, Z., Gingrich, B., Guo, Q., Matzuk, M. M., & Insel, T. R. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1377 · Cited by 105
Oxytocin in the medial prefrontal cortex regulates maternal care, maternal aggression and anxiety during the postpartum period
Sabihi, S., Dong, S. M., Durosko, N. E., & Leuner, B. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00258 · Cited by 101
Intranasal oxytocin effects on social cognition: A critique
Evans, S. L., Dal Monte, O., Noble, P., & Averbeck, B. B. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.008 · Cited by 97
Normal maternal behavior, but increased pup mortality, in conditional oxytocin receptor knockout females
Macbeth, A. H., Stepp, J. E., Lee, H.-J., Young, W. S., & Caldwell, H. K. (2010) · Behavioral Neuroscience · doi:10.1037/a0020799 · Cited by 98

Authors: Pedersen, C. A., & Prange, A. J.
Affiliations: University of North Carolina at Chapel Hill (US)
ORCID: Pedersen, Cort A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1979-12
Volume: 76
Issue: 12
Pages: 6661-6665
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.76.12.6661
PMC: PMC411928
OpenAlex: W2029315800
Cited by: 841
References: 36
Citations by year: 2026: 12 · 2025: 12 · 2024: 19 · 2023: 20 · 2022: 26 · 2021: 20 · 2020: 55 · 2019: 21 · 2018: 39 · 2017: 38 · 2016: 31 · 2015: 32 · 2014: 36 · 2013: 34 · 2012: 20
FWCI: 10.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: oxytocin, maternal behavior, virgin female rats, intracerebroventricular administration, vasopressin, estrogen, estradiol benzoate, ovariectomy, estrous cycle, childbirth, milk ejection
MeSH terms: Animals, Arginine Vasopressin, Drug Synergism, Estrogens, Estrus, Female, Injections, Intraventricular, Maternal Behavior, Oxytocin, Pregnancy, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks