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3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
Open accessAbstract
3-Methyladenine (5 mM) inhibits endogenous protein degradation in isolated rat hepatocytes by about 60%, while having no adverse effect on the degradation of an exogenous protein (asialofetuin), on protein synthesis, or on intracellular ATP levels. 3-Methyladenine appears to act specifically upon the autophagic/lysosomal pathway of degradation, as judged from its lack of effect in the presence of amino acids or a lysosomotropic amine (propylamine). The effect of the purine is not mediated by amino acids because the inhibition of protein degradation is accompanied by a significant depression of intracellular amino acid levels. The ability of 3-methyladenine to suppress the formation of electron microscopically visible autophagosomes suggests that it may be regarded as a specific inhibitor of autophagy.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996
Self-citationInduction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationThe machinery of macroautophagy
Feng, Y., He, D., Yao, Z., & Klionsky, D. J. (2014) · Cell Research · doi:10.1038/cr.2013.168 · Cited by 2,083
Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01453-06 · Cited by 1,832
Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489
Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., & Yoshimori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.657 · Cited by 1,361
Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y. (1998) · Cell Structure and Function · doi:10.1247/csf.23.33 · Cited by 1,312
Lee, J.-H., Yu, W. H., Kumar, A., Lee, S., Mohan, P. S., Peterhoff, C. M., Wolfe, D. M., Martinez-Vicente, M., Massey, A. C., Sovak, G., et al. (2010) · Cell · doi:10.1016/j.cell.2010.05.008 · Cited by 1,212
Wu, Y.-T., Tan, H.-L., Shui, G., Bauvy, C., Huang, Q., Wenk, M. R., Ong, C.-N., Codogno, P., & Shen, H.-M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.080796 · Cited by 1,127
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
Tanaka, Y., Guhde, G., Suter, A., Eskelinen, E.-L., Hartmann, D., Lüllmann-Rauch, R., Janssen, P. M. L., Blanz, J., von Figura, K., & Saftig, P. (2000) · Nature · doi:10.1038/35022595 · Cited by 925
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Xu, Y., Jagannath, C., Liu, X.-D., Sharafkhaneh, A., Kolodziejska, K. E., & Eissa, N. T. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.022 · Cited by 880
Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
Paludan, C., Schmid, D., Landthaler, M., Vockerodt, M., Kube, D., Tuschl, T., & Münz, C. (2005) · Science · doi:10.1126/science.1104904 · Cited by 860
Dowdle, W. E., Nyfeler, B., Nagel, J., Elling, R. A., Liu, S., Triantafellow, E., Menon, S., Wang, Z., Honda, A., Pardee, G., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3053 · Cited by 759
Ding, W.-X., Ni, H.-M., Gao, W., Yoshimori, T., Stolz, D. B., Ron, D., & Yin, X.-M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070188 · Cited by 708
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Mizushima, N. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0092-5 · Cited by 696
Vogiatzi, T., Xilouri, M., Vekrellis, K., & Stefanis, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801992200 · Cited by 683
Methods for Monitoring Autophagy from Yeast to Human
Klionsky, D. J., Cuervo, A. M., & Seglen, P. O. (2007) · Autophagy · doi:10.4161/auto.3678 · Cited by 656
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Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E.-M., Cuervo, A. M., & Mandelkow, E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp367 · Cited by 617
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Hamacher-Brady, A., Brady, N. R., & Gottlieb, R. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603783200 · Cited by 555
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Fornai, F., Longone, P., Cafaro, L., Kastsiuchenka, O., Ferrucci, M., Manca, M. L., Lazzeri, G., Spalloni, A., Bellio, N., Lenzi, P., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708022105 · Cited by 550
A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation
Munafó, D. B., & Colombo, M. I. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.20.3619 · Cited by 516
In vivo requirement for Atg5 in antigen presentation by dendritic cells
Lee, H. K., Mattei, L. M., Steinberg, B. E., Alberts, P., Lee, Y. H., Chervonsky, A., Mizushima, N., Grinstein, S., & Iwasaki, A. (2010) · Immunity · doi:10.1016/j.immuni.2009.12.006 · Cited by 506
Biogenesis and Cargo Selectivity of Autophagosomes
Weidberg, H., Shvets, E., & Elazar, Z. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052709-094552 · Cited by 466
Florey, O., Kim, S. E., Sandoval, C. P., Haynes, C. M., & Overholtzer, M. (2011) · Nature Cell Biology · doi:10.1038/ncb2363 · Cited by 459
Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway
Lee, H.-J., Khoshaghideh, F., Patel, S., & Lee, S.-J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3809-03.2004 · Cited by 445
AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis
Meley, D., Bauvy, C., Houben-Weerts, J. H. P. M., Dubbelhuis, P. F., Helmond, M. T. J., Codogno, P., & Meijer, A. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605488200 · Cited by 419
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
Strappazzon, F., Nazio, F., Corrado, M., Cianfanelli, V, Romagnoli, A., Fimia, G. M., Campello, S., Nardacci, R., Piacentini, M., Campanella, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.139 · Cited by 399
Scarlatti, F., Bauvy, C., Ventruti, A., Sala, G., Cluzeaud, F., Vandewalle, A., Ghidoni, R., & Codogno, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313561200 · Cited by 388
Autophagy in liver diseases: Time for translation?
Allaire, M., Rautou, P.-E., Codogno, P., & Lotersztajn, S. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.01.026 · Cited by 378
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
Degtyarev, M., De Mazière, A., Orr, C., Lin, J., Lee, B. B., Tien, J. Y., Prior, W. W., van Dijk, S., Wu, H., Gray, D. C., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200801099 · Cited by 366
Nimmerjahn, F., Milosevic, S., Behrends, U., Jaffee, E. M., Pardoll, D. M., Bornkamm, G. W., & Mautner, J. (2003) · European Journal of Immunology · doi:10.1002/eji.200323730 · Cited by 359
Cao, K., Graziotto, J. J., Blair, C. D., Mazzulli, J. R., Erdos, M. R., Krainc, D., & Collins, F. S. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002346 · Cited by 350
Pasquier, B. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2104-y · Cited by 329
Role of LAMP-2 in Lysosome Biogenesis and Autophagy
Eskelinen, E.-L., Illert, A. L., Tanaka, Y., Schwarzmann, G., Blanz, J., von Figura, K., & Saftig, P. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0114 · Cited by 323
Almeida, S., Gascon, E., Tran, H., Chou, H. J., Gendron, T. F., DeGroot, S., Tapper, A. R., Sellier, C., Charlet-Berguerand, N., Karydas, A., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1149-y · Cited by 321
Yang, Z., Zhang, Y., Yang, Y., Sun, L., Han, D., Li, H., & Wang, C. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.11.007 · Cited by 311
BEUGNET, A., TEE, A. R., TAYLOR, P. M., & PROUD, C. G. (2003) · Biochemical Journal · doi:10.1042/bj20021266 · Cited by 307
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Yue, Z., Horton, A., Bravin, M., DeJager, P. L., Selimi, F., & Heintz, N. (2002) · Neuron · doi:10.1016/s0896-6273(02)00861-9 · Cited by 306
BasuRay, S., Smagris, E., Cohen, J. C., & Hobbs, H. H. (2017) · Hepatology · doi:10.1002/hep.29273 · Cited by 302
ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death
Radoshevich, L., Murrow, L., Chen, N., Fernandez, E., Roy, S., Fung, C., & Debnath, J. (2010) · Cell · doi:10.1016/j.cell.2010.07.018 · Cited by 290
Fass, E., Shvets, E., Degani, I., Hirschberg, K., & Elazar, Z. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607031200 · Cited by 286
Autophagy is an immediate macrophage response to Legionella pneumophila
Amer, A. O., & Swanson, M. S. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00509.x · Cited by 279
Doyle, A., Zhang, G., Fattah, E. A. A., Eissa, N. T., & Li, Y. (2011) · The FASEB Journal · doi:10.1096/fj.10-164152 · Cited by 256
Autophagy is activated in systemic lupus erythematosus and required for plasmablast development
Clarke, A. J., Ellinghaus, U., Cortini, A., Stranks, A., Simon, A. K., Botto, M., & Vyse, T. J. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204343 · Cited by 252
Kim, E. H., Sohn, S., Kwon, H. J., Kim, S. U., Kim, M.-J., Lee, S.-J., & Choi, K. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4217 · Cited by 251
Lavieu, G., Scarlatti, F., Sala, G., Carpentier, S., Levade, T., Ghidoni, R., Botti, J., & Codogno, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506182200 · Cited by 225
Starving Neurons Show Sex Difference in Autophagy
Du, L., Hickey, R. W., Bayir, H., Watkins, S. C., Tyurin, V. A., Guo, F., Kochanek, P. M., Jenkins, L. W., Ren, J., Gibson, G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m804396200 · Cited by 204
Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy
Myeku, N., & Figueiredo-Pereira, M. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.149252 · Cited by 203
Hosokawa, N., Hara, Y., & Mizushima, N. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.008 · Cited by 194
Inoue, Y., Suzuki, T., Hattori, M., Yoshimoto, K., Ohsumi, Y., & Moriyasu, Y. (2006) · Plant and Cell Physiology · doi:10.1093/pcp/pcl031 · Cited by 189
Hou, Y.-C. C., Chittaranjan, S., Barbosa, S. G., McCall, K., & Gorski, S. M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712091 · Cited by 180
Beclin 1, an Essential Component and Master Regulator of PI3K-III in Health and Disease
McKnight, N. C., & Yue, Z. (2013) · Current Pathobiology Reports · doi:10.1007/s40139-013-0028-5 · Cited by 168
Ordered Organelle Degradation during Starvation-induced Autophagy
Kristensen, A. R., Schandorff, S., Høyer-Hansen, M., Nielsen, M. O., Jaüaüttelaü, M., Dengjel, J., & Andersen, J. S. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800184-mcp200 · Cited by 165
FUERTES, G., DE LLANO, J. J. M., VILLARROYA, A., RIVETT, A. J., & KNECHT, E. (2003) · Biochemical Journal · doi:10.1042/bj20030282 · Cited by 149
Guo, S., Liang, Y., Murphy, S. F., Huang, A., Shen, H., Kelly, D. F., Sobrado, P., & Sheng, Z. (2015) · Autophagy · doi:10.1080/15548627.2015.1017181 · Cited by 148
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Mitroulis, I., Kourtzelis, I., Kambas, K., Rafail, S., Chrysanthopoulou, A., Speletas, M., & Ritis, K. (2010) · European Journal of Immunology · doi:10.1002/eji.200940025 · Cited by 132
Samari, H. R., & Seglen, P. O. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23758 · Cited by 125
Self-citationSenescent Keratinocytes Die by Autophagic Programmed Cell Death
Gosselin, K., Deruy, E., Martien, S., Vercamer, C., Bouali, F., Dujardin, T., Slomianny, C., Houel-Renault, L., Chelli, F., De Launoit, Y., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080332 · Cited by 119
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Lai, S.-C., & Devenish, R. J. (2012) · Cells · doi:10.3390/cells1030396 · Cited by 116
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Sasaki, M., Miyakoshi, M., Sato, Y., & Nakanuma, Y. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.56 · Cited by 114
Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes
Donati, A., Cavallini, G., Paradiso, C., Vittorini, S., Pollera, M., Gori, Z., & Bergamini, E. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.7.b288 · Cited by 110
Trincheri, N. F., Follo, C., Nicotra, G., Peracchio, C., Castino, R., & Isidoro, C. (2008) · Carcinogenesis · doi:10.1093/carcin/bgm271 · Cited by 109
Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells
Patschan, S., Chen, J., Polotskaia, A., Mendelev, N., Cheng, J., Patschan, D., & Goligorsky, M. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00713.2007 · Cited by 105
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Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors
HOLEN, I., GORDON, P. B., & SEGLEN, P. O. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18013.x · Cited by 88
Self-citationAutophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs
Szalai, P., Hagen, L. K., Sætre, F., Luhr, M., Sponheim, M., Øverbye, A., Mills, I. G., Seglen, P. O., & Engedal, N. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.02.003 · Cited by 82
Self-citationA comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions
Szyniarowski, P., Corcelle-Termeau, E., Farkas, T., Høyer-Hansen, M., Nylandsted, J., Kallunki, T., & Jäättelä, M. (2011) · Autophagy · doi:10.4161/auto.7.8.15770 · Cited by 79
Luca, A. D., Iannitti, R. G., Bozza, S., Beau, R., Casagrande, A., D’Angelo, C., Moretti, S., Cunha, C., Giovannini, G., Massi-Benedetti, C., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60862 · Cited by 77
Cavallini, G., Donati, A., Gori, Z., Pollera, M., & Bergamini, E. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00224-2 · Cited by 76
Taylor, G. S., Long, H. M., Haigh, T. A., Larsen, M., Brooks, J., & Rickinson, A. B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3746 · Cited by 69
Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19
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Badr, C. E., Wurdinger, T., Nilsson, J., Niers, J. M., Whalen, M., Degterev, A., & Tannous, B. A. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor067 · Cited by 62
Alternative Macroautophagic Pathways
Juenemann, K., & Reits, E. A. (2012) · International Journal of Cell Biology · doi:10.1155/2012/189794 · Cited by 58
Rabouille, C., Strous, G. J., Crapo, J. D., Geuze, H. J., & Slot, J. W. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.4.897 · Cited by 56
Autolysosomal Membrane-associated Betaine Homocysteine Methyltransferase
Ueno, T., Ishidoh, K., Mineki, R., Tanida, I., Murayama, K., Kadowaki, M., & Kominami, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15222 · Cited by 50
Beltzig, L., Christmann, M., & Kaina, B. (2022) · Cells · doi:10.3390/cells11162588 · Cited by 50
BAMBI Is Expressed in Endothelial Cells and Is Regulated by Lysosomal/Autolysosomal Degradation
Xavier, S., Gilbert, V., Rastaldi, M. P., Krick, S., Kollins, D., Reddy, A., Bottinger, E., Cohen, C. D., & Schlondorff, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012995 · Cited by 46
Lin, Y.-C., Kuo, H.-C., Wang, J.-S., & Lin, W.-W. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102739 · Cited by 46
Pattingre, S., Petiot, A., & Codogno, P. (2004) · Methods in Enzymology · doi:10.1016/s0076-6879(04)90002-x · Cited by 46
Punnonen, E.-L., & Reunanen, H. (1990) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(90)90061-h · Cited by 44
Shvets, E., & Elazar, Z. (2008) · Autophagy · doi:10.4161/auto.6823 · Cited by 43
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Ko, G. J., Bae, S. Y., Hong, Y.-A., Pyo, H. J., & Kwon, Y. J. (2016) · Human & Experimental Toxicology · doi:10.1177/0960327115604198 · Cited by 31
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Metadata
- Authors
- Seglen, P. O., & Gordon, P. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-03
- Volume
- 79
- Issue
- 6
- Pages
- 1889-1892
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2087920955
- Cited by
- 1,360
- References
- 0
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.