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The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation
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USP8 knockdown decreases β-secretase levels and Aβ production in an in vitro model of AD.
“In particular, USP8 knockdown decreases β-secretase levels and Aβ production in an in vitro model of AD [18].”
From USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons (2023) · cites this paper as [18]
USP8 knockdown decreases Amyloid β (Aβ) production in an in vitro model of AD, presumably by promoting lysosome-dependent degradation of β-secretase.
“USP8 knockdown decreases Amyloid β (Aβ) production in an in vitro model of AD, presumably by promoting lysosome-dependent degradation of β-secretase, the enzyme involved in amyloid precursor protein (APP) processing [18].”
From USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons (2023) · cites this paper as [18]
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USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin
Durcan, T. M., Tang, M. Y., Pérusse, J. R., Dashti, E. A., Aguileta, M. A., McLelland, G., Gros, P., Shaler, T. A., Faubert, D., Coulombe, B., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201489729 · Cited by 375
Morel, E., Chamoun, Z., Lasiecka, Z. M., Chan, R. B., Williamson, R. L., Vetanovetz, C., Dall’Armi, C., Simoes, S., Point Du Jour, K. S., McCabe, B. D., et al. (2013) · Nature Communications · doi:10.1038/ncomms3250 · Cited by 222
Niendorf, S., Oksche, A., Kisser, A., Löhler, J., Prinz, M., Schorle, H., Feller, S., Lewitzky, M., Horak, I., & Knobeloch, K.-P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01566-06 · Cited by 207
Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47.
Weinstock, J., Wu, J., Cao, P., Kingsbury, W. D., McDermott, J. L., Kodrasov, M. P., McKelvey, D. M., Suresh Kumar, K. G., Goldenberg, S. J., Mattern, M. R., et al. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml200276j · Cited by 187
Berlin, I., Schwartz, H., & Nash, P. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016287 · Cited by 121
Scudder, S. L., Goo, M. S., Cartier, A. E., Molteni, A., Schwarz, L. A., Wright, R., & Patrick, G. N. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2452-14.2014 · Cited by 81
Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1
Walker, K. R., Kang, E. L., Whalen, M. J., Shen, Y., & Tesco, G. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5491-11.2012 · Cited by 66
Self-citationKang, E. L., Biscaro, B., Piazza, F., & Tesco, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407072 · Cited by 55
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Self-citationMauri, S., Bernardo, G., Martinez, A., Favaro, M., Trevisan, M., Cobraiville, G., Fillet, M., Caicci, F., Whitworth, A. J., & Ziviani, E. (2023) · Cells · doi:10.3390/cells12081143 · Cited by 19
Metadata
- Authors
- Yeates, E. F. A., & Tesco, G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 291
- Issue
- 30
- Pages
- 15753-15766
- ISSN
- 0021-9258
- Cited by
- 70
- References
- 8
- Language
- en
- Licence
- Funders
- National Institute on Aging (R01AG025952)
- National Institute of Neurological Disorders and Stroke (R01NS092497, 3T32NS061764-05S1)
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