Cited by 2,999Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 304 of the 306 references it cites were found in a registry or an index.

Dietary Polyphenols and the Prevention of Diseases

Scalbert, Augustin, Manach, Claudine, Morand, Christine, Rémésy, Christian, Jiménez, Liliana·2005·Critical Reviews in Food Science and Nutrition

DOI 10.1080/1040869059096

Open this paper in CoChat — free account

Abstract

Polyphenols are the most abundant antioxidants in the diet and are widespread constituents of fruits, vegetables, cereals, dry legumes, chocolate, and beverages, such as tea, coffee, or wine. Experimental studies on animals or cultured human cell lines support a role of polyphenols in the prevention of cardiovascular diseases, cancers, neurodegenerative diseases, diabetes, or osteoporosis. However, it is very difficult to predict from these results the effects of polyphenol intake on disease prevention in humans. One of the reasons is that these studies have often been conducted at doses or concentrations far beyond those documented in humans. The few clinical studies on biomarkers of oxidative stress, cardiovascular disease risk factors, and tumor or bone resorption biomarkers have often led to contradictory results. Epidemiological studies have repeatedly shown an inverse association between the risk of myocardial infarction and the consumption of tea and wine or the intake level of some particular flavonoids, but no clear associations have been found between cancer risk and polyphenol consumption. More human studies are needed to provide clear evidence of their health protective effects and to better evaluate the risks possibly resulting from too high a polyphenol consumption.

Integrity signals

Registry

Crossref · 10.1080/1040869059096

Cites

304 of 304 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay
Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · cited 1×
“[145] Jang, M.”
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203
Antioxidant Activity and Total Phenolics in Selected Fruits, Vegetables, and Grain Products
Velioğlu, Y. S., Mazza, G., Gao, L., & Oomah, B. D. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9801973 · Cited by 3,893
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
Self-citation
Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease
Schächinger, V., Britten, M. B., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.16.1899 · Cited by 2,589
The Relative Antioxidant Activities of Plant-Derived Polyphenolic Flavonoids
Rice-Evans, C. A., Miller, N. J., Bolwell, P., Bramley, P. M., & Pridham, J. B. (1995) · Free Radical Research · doi:10.3109/10715769509145649 · Cited by 2,160

Show all 306 references

Research works printed but not linked: 36

Manach C., 2004, Am. J. Clin. Nutr.
Kehrer J. P., 1994, Natural antioxidants, 25
Bachur N. R., 1978, Cancer Res., 38, 1745
Serafini M., 1996, Eur. J. Clin. Nutr., 50, 28
Sharpe P. C., 1995, Q. J. Med., 88, 101
Sakagami H., 1995, Anticanc. Res., 15, 2121
Leighton F., 1999, Drugs Exp. Clin. Res., 25, 133
Montforte M. T., 1995, Il. Farmaco., 50, 595
Russo P., 2001, Nutr. Metab. Cardiovasc. Dis., 11, 25
Rotondo S., 2001, Ital. Heart J., 2, 1
10.1001/archinte.155.4.381 · DOI · Paper page
Suschetet M., 1997, Polyphénols 96, 165
Dong Z., 1997, Cancer Res., 57, 4414
Gupta S., 1999, Cancer Res., 59, 2115
10.1210/en.139.10.4252 · DOI · Paper page
Naasani I., 2003, Cancer. Res., 63, 824
Ferry D. R., 1996, Clin. Cancer Res., 2, 659
Hsieh C. Y., 1998, Cancer Res., 58, 3833
Shimoi K., 2001, Drug Metab. Dispos., 29, 1521
Fujimoto N., 2002, Int. J. Oncol, 20, 1233
Lu L. J., 2000, Cancer Res., 60, 4112
Suganuma M., 1999, Cancer Res., 59, 44
Sadzuka Y., 1998, Clin Cancer Res., 4, 153
Goldbohm R. A., 1997, COST 916 Bioactive plant cell wall components in nutrition and health, 159
den Tonkelaar I., 2001, Cancer Epidemiol. Biomarkers Prev., 10, 223
Matsuoka Y., 1995, J. Pharmacol. Exp. Ther., 274, 602
Levites Y., 2002, J. Biol. Chem., 63, 21
Orgogozo J.-M., 1997, Rev. Neurol. (Paris), 153, 185
Geetha B. S., 1994, Indian J. Physiol. Pharmacol, 38, 220
Shenoy C., 2000, Indian J. Exp. Biol., 38, 278
Bonina F. P., 2002, Diabetes Nutr. Metab., 15, 14
Manuel y, 1999, Diabetes Nutr. Metab., 12, 256
Tamir S., 2000, Cancer Res., 60, 5704
Petrakis N. L., 1996, Cancer Epidemiol. Biomarkers. Prev., 5, 785
Whitten P. L., 1995, Journal of Nutrition, 125, 771S
Brune M., 1989, Eur. J. Clin. Nutr., 43, 547

Sorted by citations

Items 601–700 of 1,006

Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro
Wilms, L. C., Kleinjans, J. C. S., Moonen, E. J. C., & Briedé, J. J. (2007) · Toxicology in Vitro · doi:10.1016/j.tiv.2007.09.002 · Cited by 74
A Liquid Chromatography−Quadrupole Time-of-Flight (LC−QTOF)-based Metabolomic Approach Reveals New Metabolic Effects of Catechin in Rats Fed High-Fat Diets
Fardet, A., Llorach, R., Martin, J., Besson, C., Lyan, B., Pujos‐Guillot, E., & Scalbert, A. (2008) · Journal of Proteome Research · doi:10.1021/pr800034h · Cited by 73
Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers
Wilms, L. C., Boots, A. W., de Boer, V. C. J., Maas, L. M., Pachen, D. M. F. A., Gottschalk, R. W. H., Ketelslegers, H. B., Godschalk, R., Haenen, G. R. M. M., van Schooten, F., et al. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm145 · Cited by 73
Quantitation of the Hydroxycinnamic Acid Derivatives and the Glycosides of Flavonols and Flavones by UV Absorbance after Identification by LC-MS
Lin, L.-Z., Harnly, J. M., Zhang, R.-W., Fan, X.-E., & Chen, H.-J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204612t · Cited by 73
Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes?
Moraes, L. F. D. S., Sun, X., Pelúzio, M. D. C. G., & Zhu, M. J. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1357533 · Cited by 74
“Dietary polyphenols or phenolic compounds are natural antioxidants present in plant-based foods, such as fruits, vegetables, tea, essential oils and their by-products (Zhang and Tsao, 2016), which can prevent the onset of chronic diseases, thus enhancing human health (Scalbert et al., 2007).”
Background
Study Approach of Antioxidant Properties in Foods: Update and Considerations
Durazzo, A. (2017) · Foods · doi:10.3390/foods6030017 · Cited by 72
Influence of cultivar and origin on the flavonol profile of fruits and cladodes from cactus Opuntia ficus-indica
Moussa-Ayoub, T. E., El-Hady, E.-S. A. A., Omran, H., El-Samahy, S. K., Kroh, L. W., & Rohn, S. (2014) · Food Research International · doi:10.1016/j.foodres.2014.08.021 · Cited by 72
Pomegranate Peel Extract Prevents Bone Loss in a Preclinical Model of Osteoporosis and Stimulates Osteoblastic Differentiation in Vitro
Spilmont, M., Léotoing, L., Davicco, M.-J., Lebecque, P., Miot-Noirault, É., Pilet, P., Rios, L. Y., Wittrant, Y., & Coxam, V. (2015) · Nutrients · doi:10.3390/nu7115465 · Cited by 72
Flavanone metabolism in healthy and tumor-bearing rats
Silberberg, M., Gil‐Izquierdo, Á., Combaret, L., Rémésy, C., Scalbert, A., & Morand, C. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.083 · Cited by 72
Polyphenols: Potential Future Arsenals in the Treatment of Diabetes
Solayman, M., Ali, Y., Alam, F., Islam, M. A., Alam, N., Khalil, M. I., & Gan, S. H. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151125001111 · Cited by 76
Antioxidant-rich spice added to hamburger meat during cooking results in reduced meat, plasma, and urine malondialdehyde concentrations
Mellor, D. D., Hamer, H., Smyth, S., Atkin, S. L., & Courts, F. L. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29976 · Cited by 72
Icariside II inhibits tumorigenesis via inhibiting AKT/Cyclin E/ CDK 2 pathway and activating mitochondria-dependent pathway
Sun, Y., Thakur, K., Hu, F., Zhang, J., & Wei, Z. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104616 · Cited by 71
Developments and Trends in Fruit Bar Production and Characterization
Orrego, C. E., Salgado, N., & Botero, C. A. A. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.571798 · Cited by 71
Total Polyphenol and Antioxidant Activity of Red Amaranth (Amaranthus tricolor L.) as Affected by Different Sunlight Level
Khandaker, L., Ali, M. B., & Oba, S. (2008) · Journal of the Japanese Society for Horticultural Science · doi:10.2503/jjshs1.77.395 · Cited by 71
Polyphenol and vitamin C contents in European commercial blackcurrant juice products
Mattila, P. H., Hellström, J., McDougall, G. J., Dobson, G., Pihlava, J., Tiirikka, T., Stewart, D., & Karjalainen, R. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.01.129 · Cited by 71
Effects of Different Extraction Methods and Conditions on the Phenolic Composition of Mate Tea Extracts
Grujić-Letić, N. N., Lepojević, Ž., Čonić, B. S., Vladić, J., & Sudji, J. (2012) · Molecules · doi:10.3390/molecules17032518 · Cited by 71
Phytochemical Contents and Antioxidant Capacities of Two Aloe greatheadii var. davyana Extracts
Botes, L., van der Westhuizen, F. H., & Loots, D. T. (2008) · Molecules · doi:10.3390/molecules13092169 · Cited by 69
8‐C‐(E‐phenylethenyl)quercetin from onion/beef soup induces autophagic cell death in colon cancer cells through ERK activation
Zhao, Y., Fan, D., Zheng, Z., Li, E. T. S., Chen, F., Cheng, K., & Wang, M. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600437 · Cited by 71
Inhibitory Effect of Garlic, Purple Onion, and White Onion on Key Enzymes Linked with Type 2 Diabetes and Hypertension
Oboh, G., Ademiluyi, A. O., Agunloye, O. M., Ademosun, A. O., & Ogunsakin, B. G. (2018) · Journal of Dietary Supplements · doi:10.1080/19390211.2018.1438553 · Cited by 71
“, 2009), and these polyphenols have protective mechanisms against oxidative stress–induced cell damage and various degenerative diseases such as diabetes mellitus, cardiovascular disease, and neurodegenerative diseases (Scalbert et al., 2005).”
Background
The Role of Dietary Phenolic Compounds in Epigenetic Modulation Involved in Inflammatory Processes
Číž, M., Dvořáková, A., Skočková, V., & Kubala, L. (2020) · Antioxidants · doi:10.3390/antiox9080691 · Cited by 77
“As mentioned above, phenolic compounds are well-known for their antioxidant properties [5–7]; they may protect cells against oxidative damage and, in this way, reduce the risk of various diseases associated with oxidative stress [4].”
Background
Plant Polyphenols as Antioxidants Influencing the Human Health
Vladimir-Kneevic, S., Blaekovi, B., Bival, M., & Babac, M. (2012) · InTech eBooks · doi:10.5772/27843 · Cited by 74
The Effect of Diet on Endothelial Function
Davis, N. J., Katz, S. D., & Wylie‐Rosett, J. (2007) · Cardiology in Review · doi:10.1097/01.crd.0000218824.79018.cd · Cited by 69
Antimicrobial activity of pomegranate fruit constituents against drug-resistantMycobacterium tuberculosisandβ-lactamase producingKlebsiella pneumoniae
Dey, D., Ray, R., & Hazra, B. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2014.986687 · Cited by 70
Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets
Rajendran, P., Rengarajan, T., Nandakumar, N., Divya, H., & Nishigaki, I. (2014) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2014.931431 · Cited by 71
Natural phenolic antioxidants in bioanalytical chemistry: state of the art and prospects of development
Ziyatdinova, G. K., & Budnikov, H. C. (2014) · Russian Chemical Reviews · doi:10.1070/rcr4436 · Cited by 77
Determination of quercetin and its glucosides in onion by electrochemical methods
Zielińska, D., Nagels, L. J., & Piskuła, M. K. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.01.037 · Cited by 70
Flavonols, betacyanins content and antioxidant activity of cactus Opuntia macrorhiza fruits
Moussa-Ayoub, T. E., El-Samahy, S. K., Rohn, S., & Kroh, L. W. (2011) · Food Research International · doi:10.1016/j.foodres.2011.02.014 · Cited by 70
Cocoa consumption reduces NF-κB activation in peripheral blood mononuclear cells in humans
Vázquez-Agell, M., Urpí-Sardà, M., Sacanella, E., Camino-López, S., Chiva‐Blanch, G., Llorente‐Cortés, V., Tobías, E., Roura, E., Andrés‐Lacueva, C., Lamuela-Raventós, R. M., et al. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.03.015 · Cited by 70
Metabolomics Provide New Insight on the Metabolism of Dietary Phytochemicals in Rats
Fardet, A., Llorach, R., Orsoni, A., Martin, J., Pujos‐Guillot, E., Lapierre, C., & Scalbert, A. (2008) · Journal of Nutrition · doi:10.1093/jn/138.7.1282 · Cited by 70
Biochemical Basis for Functional Ingredient Design from Fruits
Jacob, J. K., Tiwari, K., Correa-Betanzo, J., Misran, A. B., Chandrasekaran, R., & Paliyath, G. (2012) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022811-101127 · Cited by 69
Functionality of Special Beer Processes and Potential Health Benefits
Salanță, L. C., Coldea, T. E., Ignat, M. V., Pop, C. R., Tofană, M., Mudura, E., Borşa, A., Pasqualone, A., Anjos, O., & Zhao, H. (2020) · Processes · doi:10.3390/pr8121613 · Cited by 72
Structural, Binding and Functional Properties of Milk Protein-Polyphenol Systems: A Review
van de Langerijt, T. M., O'Mahony, J. A., & Crowley, S. (2023) · Molecules · doi:10.3390/molecules28052288 · Cited by 61
“, cancer, cardiovascular disease and inflammation [5,6], making PP of considerable interest as functional ingredients in the food industry.”
Background
Selection and validation of reference genes for quantitative real-time PCR analysis of gene expression in Cichorium intybus
Delporte, M., Legrand, G., Hilbert, J., & Gagneul, D. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00651 · Cited by 69
Quantitative variation in Brazilian vegetable sources of flavonols and flavones
Huber, L. S., Ribani, R. H., & Rodriguez–Amaya, D. B. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.08.030 · Cited by 69
Effects ofSambucus nigraandAronia melanocarpaextracts on immune system disorders within diabetes mellitus
Bădescu, M., Bădulescu, O. V., Bădescu, L., & Ciocoiu, M. (2014) · Pharmaceutical Biology · doi:10.3109/13880209.2014.931441 · Cited by 69
Green tea yogurt: major phenolic compounds and microbial growth
Amirdivani, S., & Baba, A. S. (2014) · Journal of Food Science and Technology · doi:10.1007/s13197-014-1670-6 · Cited by 69
Murraya koenigii leaf extract inhibits proteasome activity and induces cell death in breast cancer cells
Noolu, B., Ajumeera, R., Chauhan, A., Balakrishna, N., Raghunath, M., & Ismail, A. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-7 · Cited by 69
Phenolic Profiles and Antioxidant Activity of Lotus Root Varieties
Yi, Y., Sun, J., Xie, J., Min, T., Wang, L., & Wang, H. (2016) · Molecules · doi:10.3390/molecules21070863 · Cited by 69
Antioxidants, its role in preventing free radicals and infectious diseases in human body
Suleman, M. (2018) · Pure and Applied Biology · doi:10.19045/bspab.2018.700197 · Cited by 68
Potential role of phytochemicals in metabolic syndrome prevention and therapy
Francini, F.-P., Spinella, P., & Calò, L. A. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s214550 · Cited by 74
“22 Phenolic acids are divided into two subclasses: derivatives of benzoic acid and derivatives of cinnamic acid.”
Background
Methods of Isolation of Active Substances from Garlic (Allium sativum L.) and Its Impact on the Composition and Biological Properties of Garlic Extracts
Bar, M., Binduga, U. E., & Szychowski, K. A. (2022) · Antioxidants · doi:10.3390/antiox11071345 · Cited by 92
Malvidin, a red wine polyphenol, modulates mammalian myocardial and coronary performance and protects the heart against ischemia/reperfusion injury
Quintieri, A. M., Baldino, N., Filice, E., Seta, L., Vitetti, A., Tota, B., de Cindio, B., Cerra, M. C., & Angelone, T. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.09.006 · Cited by 68
Quantitation of Flavanols, Proanthocyanidins, Isoflavones, Flavanones, Dihydrochalcones, Stilbenes, Benzoic Acid Derivatives Using Ultraviolet Absorbance after Identification by Liquid Chromatography–Mass Spectrometry
Lin, L.-Z., & Harnly, J. M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3006905 · Cited by 68
Protective effects of tartary buckwheat flavonoids on high TMAO diet-induced vascular dysfunction and liver injury in mice
Hu, Y., Zhao, Y., Yuan, L., & Yang, X. (2015) · Food & Function · doi:10.1039/c5fo00581g · Cited by 68
High variability in flavonoid contents and composition between different North-European currant (Ribes spp.) varieties
Mattila, P. H., Hellström, J., Karhu, S., Pihlava, J., & Veteläinen, M. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.02.056 · Cited by 68
Effect of Flavonoids on Oxidative Stress and Inflammation in Adults at Risk of Cardiovascular Disease: A Systematic Review
Suen, J., Thomas, J. M., Kranz, A., Vun, S. V., & Miller, M. (2016) · Healthcare · doi:10.3390/healthcare4030069 · Cited by 68
Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy
Hoppenbrouwers, T., Cvejić, J., Garssen, J., Willemsen, L. E. M., & Wichers, H. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01118 · Cited by 68
Coffee consumption and mortality from cardiovascular diseases and total mortality: Does the brewing method matter?
Tverdal, A., Selmer, R. M., Cohen, J. M., & Thelle, D. S. (2020) · European Journal of Preventive Cardiology · doi:10.1177/2047487320914443 · Cited by 68
“The evidence for this is from in vitro studies or animal studies.(29) Coffee consumption is also associated with lower risk of diabetes, which is a risk factor for CVD.”
Background
Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/β‐catenin signaling
Lv, M., Shi, C.-J., Pan, F., Shao, J., Lu, F., Chen, G., Ou, C., Zhang, J., & Fu, W. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28989 · Cited by 67
“From the phytochemistry viewpoint, this may result from the antioxidant polyphenols, especially ellagitannins (ETs), in these foods.(4-6) As a kind of bioactive polyphenols, ETs provide a very high free‐radical scavenging so as to alleviate oxidative stress, which is the main cause of carcinogenesis and cardiovascular…”
Background
Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management
Liang, L., Saunders, C., & Sanossian, N. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3229 · Cited by 79
P-coumaric Acid: Advances in Pharmacological Research Based on Oxidative Stress
Chen, F., Zhang, X., Wang, J., Wang, F., & Mao, J. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266276823231230183519 · Cited by 67
Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway
Lamy, S., Akla, N., Ouanouki, A., Lord‐Dufour, S., & Béliveau, R. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.04.004 · Cited by 68
Extracts and Constituents of Rubus chingii with 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Free Radical Scavenging Activity
Ding, H. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12063941 · Cited by 67
Effects of phytochemicals on cellular signaling: reviewing their recent usage approaches
Pham, D., Shibu, M. A., Mahalakshmi, B., & Velmurugan, B. K. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1699014 · Cited by 70
Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects – variability and possible use as biomarkers of polyphenol intake
Mennen, L. I., Sapinho, D., Ito, H., Galan, P., Herçberg, S., & Scalbert, A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602744 · Cited by 66
CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells
Sergent, T., Dupont, I. E., der Heiden, E. V., Scippo, M., Pussemier, L., Larondelle, Y., & Schneider, Y. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.09.002 · Cited by 66
Flavonoids and antioxidant activity ofRosa agrestisleaves
Bitiş, L., Kültür, Ş., Melikoğlu, G., Özsoy, N., & Can, A. (2010) · Natural Product Research · doi:10.1080/14786410903075507 · Cited by 66
Epigallocatechin gallate suppresses inflammation in human coronary artery endothelial cells by inhibiting NF-κB
Reddy, A. T., Lakshmi, S. P., Prasad, E. M., Varadacharyulu, N. C., & Kodidhela, L. D. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118136 · Cited by 67
Phenotypic divergence in vegetable amaranth for total antioxidant capacity, antioxidant profile, dietary fiber, nutritional and agronomic traits
Sarker, U., Islam, T., Rabbani, M. G., & Oba, S. (2017) · Acta Agriculturae Scandinavica Section B - Soil & Plant Science · doi:10.1080/09064710.2017.1367029 · Cited by 65
Antimicrobial Effect of Tea Polyphenols against Foodborne Pathogens: A Review
Zhang, Q., Zhang, J., Zhang, J., Xu, D., Li, Y., Liu, Y., Zhang, X., Zhang, R., Wu, Z., & Weng, P. (2021) · Journal of Food Protection · doi:10.4315/jfp-21-043 · Cited by 66
Functional Components of Bamboo Shavings and Bamboo Leaf Extracts and Their Antioxidant Activities In Vitro
Gong, J., Xia, D., Huang, J., Ge, Q., Mao, J., Liu, S., & Zhang, Y. Q. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3189 · Cited by 67
Antioxidant and antimicrobial activity evaluation and essential oil analysis of Semenovia tragioides Boiss. from Iran
Bamoniri, A., Ebrahimabadi, A. H., Mazoochi, A., Behpour, M., Kashi, F. J., & Batooli, H. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.03.009 · Cited by 65
An attractive, sensitive and high-throughput strategy based on microextraction by packed sorbent followed by UHPLC-PDA analysis for quantification of hydroxybenzoic and hydroxycinnamic acids in wines
Gonçalves, J. L., Silva, C. L., Castilho, P. C., & Câmara, J. S. (2012) · Microchemical Journal · doi:10.1016/j.microc.2012.05.037 · Cited by 65
A state-of-the-art overview of the effect of metabolic conjugation on the biological activity of flavonoids
Beekmann, K., Actis‐Goretta, L., van BLADEREN, P. J., Dionisi, F., Destaillats, F., & Rietjens, I. M. C. M. (2012) · Food & Function · doi:10.1039/c2fo30065f · Cited by 65
Perimidine based selective colorimetric and fluorescent turn-off chemosensor of aqueous Cu 2+ : studies on its antioxidant property along with its interaction with calf thymus-DNA
Roy, D., Chakraborty, A., & Ghosh, R. (2017) · RSC Advances · doi:10.1039/c7ra06687b · Cited by 65
The Mechanisms Behind the Biological Activity of Flavonoids
Gonzaléz‐Paramás, A. M., Ayuda‐Durán, B., Martínez, S., González‐Manzano, S., & Santos‐Buelga, C. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180706104829 · Cited by 65
Effect of the Addition of Propolis Extract on Bioactive Compounds and Antioxidant Activity of Craft Beer
Ulloa, P. A., Vidal, J., Ávila, M. I., Labbé, M., Cohen, S. D., & Salazar, F. (2017) · Journal of Chemistry · doi:10.1155/2017/6716053 · Cited by 64
Utilization of Fruit Seed-Based Bioactive Compounds for Formulating the Nutraceuticals and Functional Food: A Review
Allaqaband, S., Dar, A. H., Patel, U., Kumar, N., Nayik, G. A., Khan, S. A., Ansari, M. J., Alabdallah, N. M., Kumar, P., Pandey, V. K., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.902554 · Cited by 70
“Many powerful natural anti-oxidants like ascorbic acids, tocopherols, carotenoids, polyphenols, and lipoic acid, prevent oxidative damage by scavenging free radicals from the body (2, 4).”
Background
Suppressive impact of anethum graveolens consumption on biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits.
Setorki, M., Rafieian‐Kopaei, M., Merikhi, A., Heidarian, E., Shahinfard, N., Ansari, R., Nasri, H., Esmael, N., & Baradaran, A. (2013) · Europe PMC (PubMed Central) · Cited by 64
Evidence that cranberry juice may improve augmentation index in overweight men
Ruel, G., Lapointe, A., Pomerleau, S., Couture, P., Lemieux, S., Lamarche, B., & Couillard, C. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.11.002 · Cited by 66
A comparative evaluation of antioxidant and antidiabetic potential of peel from young and matured potato
Arun, K. B., Chandran, J., Dhanya, R., Krishna, P., Jayamurthy, P., & Nisha, P. (2014) · Food Bioscience · doi:10.1016/j.fbio.2014.10.003 · Cited by 64
Ellagic Acid Inhibits Pancreatic Fibrosis in Male Wistar Bonn/Kobori Rats
Suzuki, N., Masamune, A., Kikuta, K., Watanabe, T., Satoh, K., & Shimosegawa, T. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0423-7 · Cited by 64
Antioxidant and antimicrobial activities of Lycium shawii fruits extract
Dahech, I., ., W. O. F., Trigui, M., Hsouna, A. B., Belghith, H., Belghith, K. S., & Abdallah, F. B. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.05.020 · Cited by 64
Flavanone plasma pharmacokinetics from blood orange juice in human subjects
Gardana, C., Guarnieri, S., Riso, P., Simonetti, P., & Porrini, M. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507699358 · Cited by 64
Gold Nanoparticles-based Extraction-Free Colorimetric Assay in Organic Media: An Optical Index for Determination of Total Polyphenols in Fat-Rich Samples
Pelle, F. D., González, M. C., Sergi, M., Carlo, M. D., Compagnone, D., & Escarpa, A. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01489 · Cited by 64
Phenolic phytochemicals and bone
Habauzit, V., & Horcajada, M.-N. (2007) · Phytochemistry Reviews · doi:10.1007/s11101-007-9078-9 · Cited by 64
Chemical composition of the essential oil and hexane extract of Salvia chionantha and their antioxidant and anticholinesterase activities
Tel, G., Öztürk, M., Duru, M. E., Harmandar, M., & Topçu, G. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.08.020 · Cited by 63
Interaction between Dietary Fibre and Bioactive Compounds in Plant By-Products: Impact on Bioaccessibility and Bioavailability
Núñez-Gómez, V., González‐Barrio, R., & Periago, M. J. (2023) · Antioxidants · doi:10.3390/antiox12040976 · Cited by 74
“They are also responsible for some of the organoleptic properties of plants, such as color, taste, and astringency, and their consumption has preventive properties against diseases, such as obesity, diabetes, cardiovascular and neurodegenerative diseases, and some types of cancer [67].”
Background
Catechol Type Polyphenol Is a Potential Modifier of Protein Sulfhydryls: Development and Application of a New Probe for Understanding the Dietary Polyphenol Actions
Ishii, T., Ishikawa, M., Miyoshi, N., Yasunaga, M., Akagawa, M., Uchida, K., & Nakamura, Y. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900148k · Cited by 63
Blood pressure and cardiovascular risk: What about cocoa and chocolate?
Grassi, D., Desideri, G., & Ferri, C. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.020 · Cited by 64
Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms
Wang, D., Zhuang, Y., Tian, Y., Thomas, G. N., Ying, M., & Tomlinson, B. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/282383 · Cited by 63
Polyphenols in the prevention and treatment of sepsis syndromes: Rationale and pre-clinical evidence
Shapiro, H., Lev, S., Cohen, J. D., & Singer, P. (2009) · Nutrition · doi:10.1016/j.nut.2009.02.010 · Cited by 63
Mechanism change in estimating of antioxidant activity of phenolic compounds
Dawidowicz, A. L., & Olszowy‐Tomczyk, M. (2012) · Talanta · doi:10.1016/j.talanta.2012.04.036 · Cited by 63
Effect of Arbuscular Mycorrhizal Fungi on the Growth and Polyphenol Profile of Marjoram, Lemon Balm, and Marigold
Engel, R., Szabó, K., Abrankó, L., Rendes, K., Füzy, A., & Takács, T. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b00408 · Cited by 63
Microencapsulation of Bioactive Food Ingredients and Controlled Release - A Review
Jeyakumari, A. (2016) · MOJ Food Processing & Technology · doi:10.15406/mojfpt.2016.02.00059 · Cited by 63
A review on the status of the phenolic compounds and antioxidant capacity of the flour: Effects of cereal processing
Kadiri, O. (2017) · International Journal of Food Properties · doi:10.1080/10942912.2017.1315130 · Cited by 63
Alterations in structural and functional properties of insoluble dietary fibers-bound phenolic complexes derived from lychee pulp by alkaline hydrolysis treatment
Xu, Z., Xiong, X., Zeng, Q., He, S., Yuan, Y., Wang, Y., Wang, Y., Yang, X., & Su, D. (2020) · LWT · doi:10.1016/j.lwt.2020.109335 · Cited by 62
Interactions between dietary polyphenols and aging gut microbiota: A review
Davinelli, S., & Scapagnini, G. (2021) · BioFactors · doi:10.1002/biof.1785 · Cited by 62
“A plethora of data from experimental models and human studies consistently supports the idea that various polyphenols protect against several agerelated diseases, including neurodegeneration, cancer, and cardiovascular disease.(2) A potential explanation for these health benefits started to emerge when it was observed…”
Potential Applications of Moringa oleifera in Poultry Health and Production as Alternative to Antibiotics: A Review
Khan, R. U., Khan, A., Naz, S., Ullah, Q., Laudadio, V., Tufarelli, V., & Ragni, M. (2021) · Antibiotics · doi:10.3390/antibiotics10121540 · Cited by 62
“Furthermore, at equal molar concentrations, quercetin has been demonstrated to be a superior ABTS+ trap, with five times the activity of Trolox [102].”
Background
A comprehensive review on medicinal plants possessing antioxidant potential
Zafar, F., Asif, H. M., Shaheen, G., Ghauri, A. O., Rajpoot, S. R., Tasleem, M. W., Shamim, T., Hadi, F., Noor, R., Ali, T., et al. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13743 · Cited by 62
“This study showed that fennel could inhibit free radicals and act as antioxidant.(92) In another study, aqueous and ethanolic extracts of fennel were evaluated for their antioxidant activity by using different methods like total antioxidants, free radical scavenging, superoxide anion scavenging, hydrogen peroxide scav…”
Method
Extraction Techniques for the Determination of Phenolic Compounds in Food
Herrero, M., Plaza, M., Cifuentes, A., & Ibáñez, E. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381373-2.00132-0 · Cited by 62
Iron Chelators as Potential Therapeutic Agents for Parkinsons Disease
Perez, C., Tong, Y., & Guo, M. (2008) · Current Bioactive Compounds · doi:10.2174/157340708786305952 · Cited by 62
Potential Role of Naturally Derived Polyphenols and Their Nanotechnology Delivery in Cancer
Khushnud, T., & Mousa, S. A. (2013) · Molecular Biotechnology · doi:10.1007/s12033-012-9623-7 · Cited by 62
Influence of some experimental variables and matrix components in the determination of antioxidant properties by β-carotene bleaching assay: experiments with BHT used as standard antioxidant
Dawidowicz, A. L., & Olszowy‐Tomczyk, M. (2010) · European Food Research and Technology · doi:10.1007/s00217-010-1333-4 · Cited by 63
Methyl jasmonate affects phenolic metabolism and gene expression in blueberry (Vaccinium corymbosum)
Cocetta, G., Rossoni, M., Gardana, C., Mignani, I., Ferrante, A., & Spinardi, A. (2014) · Physiologia Plantarum · doi:10.1111/ppl.12243 · Cited by 62
Phenolic profile and antioxidant properties of a crude extract obtained from a brewery waste stream
Barbosa‐Pereira, L., Angulo, I., Paseiro‐Losada, P., & Cruz, J. M. (2013) · Food Research International · doi:10.1016/j.foodres.2013.01.042 · Cited by 62
Differential Isotope Labeling of 38 Dietary Polyphenols and Their Quantification in Urine by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry
Achaintre, D., Buleté, A., Cren‐Olivé, C., Li, L., Rinaldi, S., & Scalbert, A. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b03609 · Cited by 62
Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity
Souza, C. D. S., Grangeiro, M. S., Pereira, É. P. L., dos Santos, C. C., da Silva, A. B., Sampaio, G. P., Figueiredo, D. D. R., David, J. M., David, J. P., da Silva, V. D. A., et al. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.02.001 · Cited by 64
Phenolic Compounds Impact on Rheumatoid Arthritis, Inflammatory Bowel Disease and Microbiota Modulation
Direito, R., Rocha, J. P., Sepodes, B. M. N., & Figueira, M. E. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020145 · Cited by 70
“Due to their chemical structure, phenolic groups of phenolic compounds may accept an electron or proton, forming relatively stable phenolic radicals preventing chain oxidation reactions in cell compartments [49].”
Background
Anticancer Properties of Carnosol: A Summary of In Vitro and In Vivo Evidence
O’Neill, E. J., Hartogh, D. J. D., Azizi, K., & Tsiani, E. (2020) · Antioxidants · doi:10.3390/antiox9100961 · Cited by 61

Authors: Scalbert, A., Manach, C., Morand, C., Rémésy, C., & Jiménez, L.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Institut National de la Recherche Agronomique (FR)
Danone (France) (FR)
ORCID: Scalbert, Augustin
Manach, Claudine
Morand, Christine
Jiménez, Liliana
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2005-06
Volume: 45
Issue: 4
Pages: 287-306
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/1040869059096
OpenAlex: W2152252699
Cited by: 2,999
References: 306
Citations by year: 2026: 74 · 2025: 103 · 2024: 125 · 2023: 148 · 2022: 157 · 2021: 192 · 2020: 212 · 2019: 178 · 2018: 187 · 2017: 174 · 2016: 184 · 2015: 155 · 2014: 185 · 2013: 200 · 2012: 164
FWCI: 40.09
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: dietary polyphenols, antioxidants, disease prevention, cardiovascular disease, cancer, neurodegenerative diseases, diabetes mellitus, osteoporosis, flavonoids, tea, wine, oxidative stress biomarkers, myocardial infarction, dose-response extrapolation
MeSH terms: Animals, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Diet, Female, Flavonoids, Humans, Neoplasms, Phenols, Primary Prevention, Osteoporosis, Postmenopausal, Neurodegenerative Diseases, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dietary Polyphenols and the Prevention of Diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks