Cited by 2,999Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

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Dietary Polyphenols and the Prevention of Diseases

Scalbert, Augustin, Manach, Claudine, Morand, Christine, Rémésy, Christian, Jiménez, Liliana·2005·Critical Reviews in Food Science and Nutrition

DOI 10.1080/1040869059096

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Abstract

Polyphenols are the most abundant antioxidants in the diet and are widespread constituents of fruits, vegetables, cereals, dry legumes, chocolate, and beverages, such as tea, coffee, or wine. Experimental studies on animals or cultured human cell lines support a role of polyphenols in the prevention of cardiovascular diseases, cancers, neurodegenerative diseases, diabetes, or osteoporosis. However, it is very difficult to predict from these results the effects of polyphenol intake on disease prevention in humans. One of the reasons is that these studies have often been conducted at doses or concentrations far beyond those documented in humans. The few clinical studies on biomarkers of oxidative stress, cardiovascular disease risk factors, and tumor or bone resorption biomarkers have often led to contradictory results. Epidemiological studies have repeatedly shown an inverse association between the risk of myocardial infarction and the consumption of tea and wine or the intake level of some particular flavonoids, but no clear associations have been found between cancer risk and polyphenol consumption. More human studies are needed to provide clear evidence of their health protective effects and to better evaluate the risks possibly resulting from too high a polyphenol consumption.

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The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay
Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · cited 1×
“[145] Jang, M.”
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203
Antioxidant Activity and Total Phenolics in Selected Fruits, Vegetables, and Grain Products
Velioğlu, Y. S., Mazza, G., Gao, L., & Oomah, B. D. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9801973 · Cited by 3,893
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
Self-citation
Prognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease
Schächinger, V., Britten, M. B., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.16.1899 · Cited by 2,589
The Relative Antioxidant Activities of Plant-Derived Polyphenolic Flavonoids
Rice-Evans, C. A., Miller, N. J., Bolwell, P., Bramley, P. M., & Pridham, J. B. (1995) · Free Radical Research · doi:10.3109/10715769509145649 · Cited by 2,160

Show all 306 references

Research works printed but not linked: 36

Manach C., 2004, Am. J. Clin. Nutr.
Kehrer J. P., 1994, Natural antioxidants, 25
Bachur N. R., 1978, Cancer Res., 38, 1745
Serafini M., 1996, Eur. J. Clin. Nutr., 50, 28
Sharpe P. C., 1995, Q. J. Med., 88, 101
Sakagami H., 1995, Anticanc. Res., 15, 2121
Leighton F., 1999, Drugs Exp. Clin. Res., 25, 133
Montforte M. T., 1995, Il. Farmaco., 50, 595
Russo P., 2001, Nutr. Metab. Cardiovasc. Dis., 11, 25
Rotondo S., 2001, Ital. Heart J., 2, 1
10.1001/archinte.155.4.381 · DOI · Paper page
Suschetet M., 1997, Polyphénols 96, 165
Dong Z., 1997, Cancer Res., 57, 4414
Gupta S., 1999, Cancer Res., 59, 2115
10.1210/en.139.10.4252 · DOI · Paper page
Naasani I., 2003, Cancer. Res., 63, 824
Ferry D. R., 1996, Clin. Cancer Res., 2, 659
Hsieh C. Y., 1998, Cancer Res., 58, 3833
Shimoi K., 2001, Drug Metab. Dispos., 29, 1521
Fujimoto N., 2002, Int. J. Oncol, 20, 1233
Lu L. J., 2000, Cancer Res., 60, 4112
Suganuma M., 1999, Cancer Res., 59, 44
Sadzuka Y., 1998, Clin Cancer Res., 4, 153
Goldbohm R. A., 1997, COST 916 Bioactive plant cell wall components in nutrition and health, 159
den Tonkelaar I., 2001, Cancer Epidemiol. Biomarkers Prev., 10, 223
Matsuoka Y., 1995, J. Pharmacol. Exp. Ther., 274, 602
Levites Y., 2002, J. Biol. Chem., 63, 21
Orgogozo J.-M., 1997, Rev. Neurol. (Paris), 153, 185
Geetha B. S., 1994, Indian J. Physiol. Pharmacol, 38, 220
Shenoy C., 2000, Indian J. Exp. Biol., 38, 278
Bonina F. P., 2002, Diabetes Nutr. Metab., 15, 14
Manuel y, 1999, Diabetes Nutr. Metab., 12, 256
Tamir S., 2000, Cancer Res., 60, 5704
Petrakis N. L., 1996, Cancer Epidemiol. Biomarkers. Prev., 5, 785
Whitten P. L., 1995, Journal of Nutrition, 125, 771S
Brune M., 1989, Eur. J. Clin. Nutr., 43, 547

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“, 2014) and protects against the oxidative stress-related degenerative diseases such as diabetes and cardiovascular diseases (Manach et al., 2005; Scalbert et al., 2005).”
Background
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Rothwell, J. A., Urpi-Sarda, M., Boto-Ordonez, M., Knox, C., Llorach, R., Eisner, R., Cruz, J., Neveu, V., Wishart, D., Manach, C., et al. (2012) · Database · doi:10.1093/database/bas031 · Cited by 188
Self-citation
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Siddiqui, I. A., Sanna, V., Ahmad, N., Sechi, M., & Mukhtar, H. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12811 · Cited by 190
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Benitez, D. A., Pozo‐Guisado, E., Alvarez, A. M., Fernández‐Salguero, P. M., & Castellón, E. A. (2007) · Journal of Andrology · doi:10.2164/jandrol.106.000968 · Cited by 186
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Frankel, E. N., & Finley, J. W. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf800336p · Cited by 183
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Authors: Scalbert, A., Manach, C., Morand, C., Rémésy, C., & Jiménez, L.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Institut National de la Recherche Agronomique (FR)
Danone (France) (FR)
ORCID: Scalbert, Augustin
Manach, Claudine
Morand, Christine
Jiménez, Liliana
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2005-06
Volume: 45
Issue: 4
Pages: 287-306
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/1040869059096
OpenAlex: W2152252699
Cited by: 2,999
References: 306
Citations by year: 2026: 74 · 2025: 103 · 2024: 125 · 2023: 148 · 2022: 157 · 2021: 192 · 2020: 212 · 2019: 178 · 2018: 187 · 2017: 174 · 2016: 184 · 2015: 155 · 2014: 185 · 2013: 200 · 2012: 164
FWCI: 40.09
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: dietary polyphenols, antioxidants, disease prevention, cardiovascular disease, cancer, neurodegenerative diseases, diabetes mellitus, osteoporosis, flavonoids, tea, wine, oxidative stress biomarkers, myocardial infarction, dose-response extrapolation
MeSH terms: Animals, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Diet, Female, Flavonoids, Humans, Neoplasms, Phenols, Primary Prevention, Osteoporosis, Postmenopausal, Neurodegenerative Diseases, Polyphenols

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