Sharing secrets: oxytocin and trust in schizophrenia
Open accessAbstract
Previous studies indicated that oxytocin plays an important role in human trust, which is impaired in patients with severe mental disorders. In this study, we measured plasma oxytocin levels in patients with schizophrenia (n=50) and in healthy controls (n=50) after neutral and trust-related interpersonal interactions. Trust-related interactions were associated with increased oxytocin levels in controls. This effect was absent in patients with schizophrenia. Low oxytocin levels measured after trust-related interactions significantly predicted the negative symptoms of schizophrenia but were not related to positive symptoms, depression, anxiety, and neuropsychological functions. These results suggest that decreased trust-related oxytocin release is related to the negative symptoms and may be associated with social withdrawal, isolation, and flattened affect in schizophrenia.
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Early investigations provide some encouragement that oxytocin could prove a useful supplement to current treatment of both schizophrenia and drug addiction.
“Interestingly, early investigations provide some encouragement that oxytocin could prove a useful supplement to current treatment of both schizophrenia (Keri et al., 2008;Feifel et al., 2010) and drug addiction (You et al., 2001;Qi et al., 2009;Carson et al., 2010).”
From Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions (2013) · cites this paper as Keri et al., 2008
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- Authors
- Kéri, S., Kiss, I., & Kelemen, O.
- Affiliations
- Semmelweis University (HU)
- b Bács-Kiskun County Hospital , Kecskemét, Hungary
- Corresponding author
- Kéri, Szabolcs
- ORCID
- Kéri, Szabolcs
- Venue
- Social Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2009-06-25
- Volume
- 4
- Issue
- 4
- Pages
- 287-293
- ISSN
- 1747-0919 (ISSN-L)
- 1747-0927
- OpenAlex
- W2010808031
- Cited by
- 167
- References
- 41
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 14 · 2021: 11 · 2020: 7 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 12 · 2014: 16 · 2013: 23 · 2012: 8
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Social Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, trust, schizophrenia, plasma oxytocin, interpersonal interaction, negative symptoms, social withdrawal, social cognition
- MeSH terms
- Female, Humans, Interpersonal Relations, Male, Middle Aged, Neuropsychological Tests, Oxytocin, Schizophrenia, Schizophrenic Psychology, Trust
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