Oxytocin is associated with human trustworthiness

ZAK, P; KURZBAN, R; MATZNER, W

doi:10.1016/j.yhbeh.2005.07.009

Cited by 595Neuroendocrine regulation and behaviorExperimental Behavioral Economics StudiesEvolutionary Psychology and Human Behavior

Oxytocin is associated with human trustworthiness

ZAK, P, KURZBAN, R, MATZNER, W·2005·Hormones and Behavior

DOI 10.1016/j.yhbeh.2005.07.009

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Abstract

Human beings exhibit substantial interpersonal trust-even with strangers. The neuroactive hormone oxytocin facilitates social recognition in animals, and we examine if oxytocin is related to trustworthiness between humans. This paper reports the results of an experiment to test this hypothesis, where trust and trustworthiness are measured using the sequential anonymous "trust game" with monetary payoffs. We find that oxytocin levels are higher in subjects who receive a monetary transfer that reflects an intention of trust relative to an unintentional monetary transfer of the same amount. In addition, higher oxytocin levels are associated with trustworthy behavior (the reciprocation of trust). Absent intentionality, both the oxytocin and behavioral responses are extinguished. We conclude that perceptions of intentions of trust affect levels of circulating oxytocin.

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Interaction with other humans, including warm interpersonal contact or the perception of trust, can result in the release of endogenous oxytocin.
“Interaction with other humans, including warm interpersonal contact 83, 84 or the perception of trust 85, can result in the release of endogenous oxytocin.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [85]
Slight variation to social circumstances may impact endogenous oxytocin release.
“Recent evidence also suggests that slight variation to social circumstances may impact on endogenous oxytocin release (Grewen et al., 2005; Zak et al., 2005; Seltzer et al., 2010; Kéri and Kiss, 2011).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Zak et al., 2005
Individuals receiving trusting money offers had higher plasma oxytocin levels 2 min later than those who did not.
“Zak et al. (2005) found that individuals receiving trusting money offers had higher plasma oxytocin levels 2 min later than those who did not.”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Zak et al., 2005
Studies investigating a link between plasma oxytocin levels and trust behavior in experimental settings have yielded mixed results.
“However, studies investigating a link between plasma OT levels and trust behavior in experimental settings (trust game paradigms), have yielded mixed results with some studies reporting tentative links (Zak et al., 2005;Zhong et al., 2012), while others failed to reveal a significant correlation (Christensen et al., 2014).”
From Long-term oxytocin administration enhances the experience of attachment (2017) · cites this paper as Zak et al., 2005

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Authors: ZAK, P., KURZBAN, R., & MATZNER, W.
Affiliations: Loma Linda University Medical Center (US)
University of Pennsylvania (US)
Claremont Graduate University (US)
Corresponding author: ZAK, P
ORCID: ZAK, P
KURZBAN, R
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2005-12
Volume: 48
Issue: 5
Pages: 522-527
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2005.07.009
OpenAlex: W2091662798
Cited by: 595
References: 36
Citations by year: 2026: 9 · 2025: 14 · 2024: 17 · 2023: 14 · 2022: 19 · 2021: 39 · 2020: 37 · 2019: 16 · 2018: 29 · 2017: 28 · 2016: 24 · 2015: 37 · 2014: 47 · 2013: 40 · 2012: 43
FWCI: 23.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Social Sciences › Safety Research › Experimental Behavioral Economics Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
Keywords: oxytocin, trustworthiness, interpersonal trust, trust game, intentionality, social recognition, mutual trust, social cognition
MeSH terms: Adult, Decision Making, Enzyme-Linked Immunosorbent Assay, Female, Hormones, Humans, Male, Oxytocin, Social Behavior, Trust

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Oxytocin is associated with human trustworthiness

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