Cited by 438Antifungal resistance and susceptibilityFungal Infections and StudiesOcular Infections and Treatments

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Excess Mortality, Hospital Stay, and Cost Due to Candidemia: A Case-Control Study Using Data From Population-Based Candidemia Surveillance

Morgan, Juliette, Meltzer, Martin I., Plikaytis, Brian D., Sofair, Andre N., Huie-White, Sharon, Wilcox, Steven, Harrison, Lee H., Seaberg, Eric C., Hajjeh, Rana A., Teutsch, Steven M.·2005·Infection Control & Hospital Epidemiology

DOI 10.1086/502581

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Abstract

Objective: To determine the mortality, hospital stay, and total hospital charges and cost of hospitalization attributable to candidemia by comparing patients with candidemia with control-patients who have otherwise similar illnesses. Prior studies lack broad patient and hospital representation or cost-related information that accurately reflects current medical practices. Design: Our case-control study included case-patients with candidemia and their cost-related data, ascertained from laboratory-based candidemia surveillance conducted among all residents of Connecticut and Baltimore and Baltimore County, Maryland, during 1998 to 2000. Control-patients were matched on age, hospital type, admission year, discharge diagnoses, and duration of hospitalization prior to candidemia onset. Results: We identified 214 and 529 sets of matched case-patients and control-patients from the two locations, respectively. Mortality attributable to candidemia ranged between 19% and 24%. On multivariable analysis, candidemia was associated with mortality (OR, 5.3 for Connecticut and 8.5 for Baltimore and Baltimore County;P< .05), whereas receiving adequate treatment was protective (OR, 0.5 and 0.4 for the two locations, respectively;P< .05). Candidemia itself did not increase the total hospital charges and cost of hospitalization; when treatment status was accounted for, having received adequate treatment for candidemia significantly increased the total hospital charges and cost of hospitalization ($6,000 to $29,000 and $3,000 to $22,000, respectively) and the length of stay (3 to 13 days). Conclusion: Our findings underscore the burden of candidemia, particularly regarding the risk of death, length of hospitalization, and cost associated with treatment (Infect Control Hosp Epidemiol 2005;26:540-547).

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Authors: Morgan, J., Meltzer, M. I., Plikaytis, B. D., Sofair, A. N., Huie-White, S., Wilcox, S., Harrison, L. H., Seaberg, E. C., Hajjeh, R. A., & Teutsch, S. M.
Affiliations: Centers for Disease Control and Prevention (US)
Johns Hopkins University (US)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Corresponding author: Morgan, Juliette
ORCID: Morgan, Juliette
Meltzer, Martin I.
Harrison, Lee H.
Seaberg, Eric C.
Hajjeh, Rana A.
Teutsch, Steven M.
Venue: Infection Control & Hospital Epidemiology
Publisher: Cambridge University Press (CUP)
Published: 2005-06
Volume: 26
Issue: 6
Pages: 540-547
ISSN: 0899-823X (ISSN-L)
1559-6834
DOI: 10.1086/502581
OpenAlex: W2138648278
Semantic Scholar: fbb5a839e0dc3b43795b4bba8e920640a069b23b
Cited by: 437
References: 26
Citations by year: 2026: 9 · 2025: 13 · 2024: 16 · 2023: 15 · 2022: 18 · 2021: 15 · 2020: 21 · 2019: 24 · 2018: 10 · 2017: 19 · 2016: 24 · 2015: 27 · 2014: 18 · 2013: 26 · 2012: 36
FWCI: 11.94
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 4038 d)
Locations: Infection Control and Hospital Epidemiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords: candidemia, excess mortality, length of hospital stay, hospital costs, fungemia, Connecticut, Baltimore
MeSH terms: Adolescent, Adult, Candidiasis, Child, Child, Preschool, Connecticut, Cross Infection, Female, Humans, Infant, Length of Stay, Male, Middle Aged, Population Surveillance, Baltimore, Multivariate Analysis, Linear Models, Case-Control Studies, Fungemia, Hospital Mortality, Cost of Illness, Age Distribution, Hospital Costs, Hospital Charges

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Excess Mortality, Hospital Stay, and Cost Due to Candidemia: A Case-Control Study Using Data From Population-Based Candidemia Surveillance

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