Focal activation of the feline retina via a suprachoroidal electrode array
Open accessAbstract
This paper presents the results of the first investigations into the use of bipolar electrical stimulation of the retina with a suprachoroidal vision prosthesis, and the effects of different electrode configurations on localization of responses on the primary visual cortex. Cats were implanted with electrodes in the suprachoroidal space, and electrically evoked potentials were recorded on the visual cortex. Responses were elicited to bipolar and monopolar stimuli, with each stimulating electrode coupled with either six-return electrodes, two-return electrodes, or a single-return electrode. The average charge threshold to elicit a response with bipolar stimulation and six-return electrodes was 76.47+/-8.76 nC. Bipolar stimulation using six-return electrodes evoked responses half the magnitude of those elicited with a single or two-return electrodes. Monopolar stimulation evoked a greater magnitude, and area of cortical activation than bipolar stimulation. This study showed that suprachoroidal, bipolar stimulation can elicit localized activity in the primary visual cortex, with the extent of localization and magnitude of response dependent on the electrode configuration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The 3D multilayer CB configuration activated smaller EEPs and a smaller area on the cortex than the monopolar electrodes.
“the 3D multilayer CB configuration activated smaller EEPs and a smaller area on the cortex than the monopolar electrodes.”
From Three-dimensional multilayer concentric bipolar electrodes restrict spatial activation in optic nerve stimulation (2022) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The sensations produced by electrical stimulation of the visual cortex
Brindley, G. S., & Lewin, W. S. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008519 · Cited by 1,170 · see citing works
Visual perception in a blind subject with a chronic microelectronic retinal prosthesis
Humayun, M. S., Weiland, J. D., Fujii, G. Y., Greenberg, R., Williamson, R., Little, J., Mech, B., Cimmarusti, V., Van Boemel, G., Dagnelie, G., et al. (2003) · Vision Research · doi:10.1016/s0042-6989(03)00457-7 · Cited by 856 · see citing works
Preservation of the Inner Retina in Retinitis Pigmentosa
Santos, A. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100150513011 · Cited by 644 · see citing works
Rizzo, J. F., Wyatt, J., Loewenstein, J., Kelly, S., & Shire, D. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.02-0817 · Cited by 478 · see citing works
Blood circulation and fluid dynamics in the eye
Bill, A. (1975) · Physiological Reviews · doi:10.1152/physrev.1975.55.3.383 · Cited by 468 · see citing works
Dobelle, W. H., & Mladejovsky, M. G. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010766 · Cited by 468 · see citing works
Retinal remodeling during retinal degeneration
Jones, B. W., & Marc, R. E. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.03.006 · Cited by 430 · see citing works
Rose, T. L., & Robblee, L. S. (1990) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.61038 · Cited by 359 · see citing works
Design of a high-resolution optoelectronic retinal prosthesis
Palanker, D., Vankov, A., Huie, P., & Baccus, S. A. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/1/012 · Cited by 330 · see citing works
Visual Performance Using a Retinal Prosthesis in Three Subjects With Retinitis Pigmentosa
Yanai, D., Weiland, J. D., Mahadevappa, M., Greenberg, R. J., Fine, I., & Humayun, M. S. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.01.027 · Cited by 233 · see citing works
Brummer, S. B., & Turner, M. J. (1977) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1977.326179 · Cited by 217 · see citing works
A Method for Generating Precise Temporal Patterns of Retinal Spiking Using Prosthetic Stimulation
Fried, S. I., Hsueh, H.-A., & Werblin, F. S. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00849.2005 · Cited by 212 · see citing works
Passive ionic properties of frog retinal pigment epithelium
Miller, S. S., & Steinberg, R. H. (1977) · The Journal of Membrane Biology · doi:10.1007/bf01868158 · Cited by 206 · see citing works
Factors affecting perceptual thresholds in epiretinal prostheses
de Balthasar, C., Patel, S., Roy, A., Freda, R., Greenwald, S., Horsager, A., Mahadevappa, M., Yanai, D., McMahon, M. J., Humayun, M. S., et al. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0696 · Cited by 204 · see citing works
Demonstration of artificial visual percepts generated through thalamic microstimulation
Pezaris, J. S., & Reid, R. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608563104 · Cited by 195 · see citing works
Majji, A. B., Humayun, M. S., Weiland, J. D., Suzuki, S., D’Anna, S. A., & de Juan, E. (1999) · PubMed · Cited by 172 · see citing works
Schüettler, M., Stieß, S., King, B. V., & Suaning, G. J. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/1/013 · Cited by 163 · see citing works
Self-citationKanda, H., Morimoto, T., Fujikado, T., Tano, Y., Fukuda, Y., & Sawai, H. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1268 · Cited by 138 · see citing works
Optoelectronic retinal prosthesis: system design and performance
Loudin, J., Simanovskii, D. M., Vijayraghavan, K., Sramek, C., Butterwick, A., Huie, P., McLean, G. Y., & Palanker, D. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/1/s09 · Cited by 130 · see citing works
The intercellular junctional complexes of retinal pigment epithelia.
Hudspeth, A. J., & Yee, A. G. (1973) · PubMed · Cited by 119 · see citing works
Mutation in CEP290 Discovered for Cat Model of Human Retinal Degeneration
Menotti-Raymond, M. A., David, V. A., Schäffer, A. A., Stephens, R., Wells, D., Kumar‐Singh, R., O’Brien, S. J., & Narfström, K. L. (2007) · Journal of Heredity · doi:10.1093/jhered/esm019 · Cited by 104 · see citing works
Hesse, L., Schanze, T., Wilms, M., & Eger, M. (2000) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s004170000197 · Cited by 98 · see citing works
Visual resolution with retinal implants estimated from recordings in cat visual cortex
Eckhorn, R., Wilms, M., Schanze, T., Eger, M., Hesse, L., Eysel, U. T., Kisvárday, Z. F., Zrenner, E., Gekeler, F., Schwahn, H., et al. (2006) · Vision Research · doi:10.1016/j.visres.2006.01.034 · Cited by 94 · see citing works
Brindley, G. S. (1956) · The Journal of Physiology · doi:10.1113/jphysiol.1956.sp005647 · Cited by 93 · see citing works
Transretinal electrical stimulation by an intrascleral multichannel electrode array in rabbit eyes
Nakauchi, K., Fujikado, T., Kanda, H., Morimoto, T., Choi, J., Ikuno, Y., Sakaguchi, H., Kamei, M., Ohji, M., Yagi, T., et al. (2004) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-004-1060-2 · Cited by 92 · see citing works
Transretinal Electrical Stimulation with a Suprachoroidal Multichannel Electrode in Rabbit Eyes
Sakaguchi, H., Fujikado, T., Fang, X., Kanda, H., Osanai, M., Nakauchi, K., Ikuno, Y., Kamei, M., Yagi, T., Nishimura, S., et al. (2004) · Japanese Journal of Ophthalmology · doi:10.1007/s10384-004-0055-1 · Cited by 84 · see citing works
Localization of electrical activity in the cat retina by an electrode marking method
Brown, K. T., & Tasaki, K. (1961) · The Journal of Physiology · doi:10.1113/jphysiol.1961.sp006769 · Cited by 79 · see citing works
Retinal Neurostimulator for a Multifocal Vision Prosthesis
Wong, Y. T., Dommel, N., Preston, P., Hallum, L. E., Lehmann, T., Lovell, N. H., & Suaning, G. J. (2007) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.903958 · Cited by 79 · see citing works
Self-citationZhou, J., Woo, S. J., Park, S. I., Kim, E., Seo, J.-M., Chung, H., & Kim, S. J. (2008) · BioMed Research International · doi:10.1155/2008/547428 · Cited by 74 · see citing works
Self-citationLong-term stimulation by active epiretinal implants in normal and RCD1 dogs
Güven, D., Weiland, J. D., Fujii, G. Y., Mech, B. V., Mahadevappa, M., Greenberg, R. J., Roizenblatt, R., Qiu, G., LABREE, L. D., Wang, X., et al. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/1/009 · Cited by 71 · see citing works
Yamauchi, Y., Franco, L. M., Jackson, D., Naber, J. F., Ziv, R. O., Rizzo, J. F., Kaplan, H. J., & Enzmann, V. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/1/007 · Cited by 70 · see citing works
The retinal vascular system of the domestic cat
Henkind, P. (1966) · Experimental Eye Research · doi:10.1016/s0014-4835(66)80015-5 · Cited by 61 · see citing works
A Possible Cytological Basis for the ‘R’ Membrane in the Vertebrate Eye
Cohen, A. I. (1965) · Nature · doi:10.1038/2051222a0 · Cited by 61 · see citing works
Dowling, J. (2005) · Expert Review of Medical Devices · doi:10.1586/17434440.2.1.73 · Cited by 58 · see citing works
Activation zones in cat visual cortex evoked by electrical retina stimulation
Schanze, T., Wilms, M., Eger, M., Hesse, L., & Eckhorn, R. (2002) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-002-0577-5 · Cited by 51 · see citing works
Early-Onset, Autosomal Recessive, Progressive Retinal Atrophy in Persian Cats
Rah, H., Maggs, D. J., Blankenship, T. N., Narfström, K. L., & Lyons, L. A. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1019 · Cited by 49 · see citing works
Subretinal implantation and testing of polyimide film electrodes in cats
Sachs, H. G., Schanze, T., Wilms, M., Rentzos, A., Brunner, U., Gekeler, F., & Hesse, L. (2004) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-004-1049-x · Cited by 45 · see citing works
Experimental implantation of epiretinal retina implants (EPI-RET) with an IOL-type receiver unit
Gerding, H., Benner, F. P., & Taneri, S. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/1/s06 · Cited by 44 · see citing works
Schuettler, M. (2007) · Conference proceedings · doi:10.1109/iembs.2007.4352254 · Cited by 37 · see citing works
Intraorbital implantation of a stimulating electrode for an optic nerve visual prosthesis
Brelen, M. E., Potter, P. D., Gersdorff, M. C. H., Cosnard, G., Veraart, C., & Delbeke, J. (2006) · Journal of neurosurgery · doi:10.3171/jns.2006.104.4.593 · Cited by 36 · see citing works
Suaning, G. J., Schüettler, M., Ordonez, J. S., & Lovell, N. H. (2007) · International IEEE/EMBS Conference on Neural Engineering · doi:10.1109/cne.2007.369597 · Cited by 34 · see citing works
Self-citationZrenner, E., Wilke, R. G. H., Zabel, T., et al. (2007) · Investigative Ophthalmology & Visual Science · Cited by 28 · see citing works
Marg, E., & DIERSSEN, G. (2007) · Confinia Neurologica · doi:10.1159/000104007 · Cited by 26 · see citing works
Phosphenes Resulting From Stimulation of the Midbrain in Man
Nashold, B. S. (1970) · Archives of Ophthalmology · doi:10.1001/archopht.1970.00990040435006 · Cited by 24 · see citing works
Hallum, L. E., Chen, S. C., Preston, P., Suaning, G. J., & Lovell, N. H. (2005) · Investigative Ophthalmology & Visual Science · Cited by 20 · see citing works
Self-citationDONATIEN, P. D., Aigner, B., & Jeffery, G. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02022.x · Cited by 18 · see citing works
Current Distribution During Parallel Stimulation: Implications for an Epiretinal Neuroprosthesis
Lovell, N. H., Dokos, S., Cloherty, S. L., Preston, P., & Suaning, G. J. (2005) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2005.1615661 · Cited by 14 · see citing works
Self-citationSpatiotemporal Integration of Perceptual Brightness in Retinal Prosthesis Patients
Horsager, A., Weiland, J. D., Greenberg, R. J., et al. (2008) · Investigative Ophthalmology & Visual Science · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Simulating prosthetic vision: I. Visual models of phosphenes
Chen, S. C., Suaning, G. J., Morley, J. W., & Lovell, N. H. (2009) · Vision Research · doi:10.1016/j.visres.2009.02.003 · Cited by 172 · see citing works
Self-citationElectric crosstalk impairs spatial resolution of multi-electrode arrays in retinal implants
Wilke, R. G. H., Moghadam, G. K., Lovell, N. H., Suaning, G. J., & Dokos, S. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/4/046016 · Cited by 110 · see citing works
Self-citationFujikado, T., Kamei, M., Sakaguchi, H., Kanda, H., Endo, T., Hirota, M., Morimoto, T., Nishida, K., Kishima, H., Terasawa, Y., et al. (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.16-20367 · Cited by 101 · see citing works
Artificial vision through neuronal stimulation
Fernandes, R. A. B., Diniz, B., Ribeiro, R., & Humayun, M. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.01.063 · Cited by 90 · see citing works
Current steering in retinal stimulation via a quasimonopolar stimulation paradigm
Matteucci, P. B., Chen, S. C., Tsai, D., Dodds, C. W. D., Dokos, S., Morley, J. W., Lovell, N. H., & Suaning, G. J. (2013) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-11653 · Cited by 79 · see citing works
Self-citationFactors Affecting Perceptual Thresholds in a Suprachoroidal Retinal Prosthesis
Shivdasani, M. N., Sinclair, N. C., Dimitrov, P. N., Varsamidis, M., Ayton, L. N., Luu, C. D., Perera, T., McDermott, H. J., & Blamey, P. J. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.14-14396 · Cited by 78 · see citing works
The appearance of phosphenes elicited using a suprachoroidal retinal prosthesis
Sinclair, N. C., Shivdasani, M. N., Perera, T., Gillespie, L. N., McDermott, H. J., Ayton, L. N., Blamey, P. J., & for the Bionic Vision Australia Consortium (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.15-18991 · Cited by 60 · see citing works
Weremfo, A., Carter, P., Hibbert, D. B., & Zhao, C. (2015) · Langmuir · doi:10.1021/la504876n · Cited by 59 · see citing works
Spencer, T. C., Fallon, J. B., Thien, P. C., & Shivdasani, M. N. (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.16-19325 · Cited by 31 · see citing works
Spectral distribution of local field potential responses to electrical stimulation of the retina
Wong, Y. T., Halupka, K., Kameneva, T., Cloherty, S. L., Grayden, D. B., Burkitt, A. N., Meffin, H., & Shivdasani, M. N. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/3/036003 · Cited by 16 · see citing works
Borda, E., Gaillet, V., Airaghi Leccardi, M. J. I., Zollinger, E. G., Moreira, R. C., & Ghezzi, D. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac6d7e · Cited by 11 · see citing works
- Authors
- Wong, Y. T., Chen, S. C., Seo, J. M., Morley, J. W., Lovell, N. H., & Suaning, G. J.
- Affiliations
- UNSW Sydney (AU)
- Seoul National University (KR)
- Western Sydney University (AU)
- Corresponding author
- Suaning, G.J.
- Venue
- Vision Research
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 49
- Issue
- 8
- Pages
- 825-833
- ISSN
- 0042-6989 (ISSN-L)
- OpenAlex
- W1991784092
- Cited by
- 109
- References
- 48
- Citations by year
- 2026: 2 · 2025: 3 · 2022: 5 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 19 · 2012: 10
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1574 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Vision Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Retina Australia
- Australian Government
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- retinal prosthesis, monopolar stimulation, primary visual cortex, electrically evoked potentials, electrode configuration, cats
- MeSH terms
- Animals, Cats, Electrodes, Implanted, Electric Stimulation Therapy, Evoked Potentials, Visual, Microelectrodes, Retina, Visual Cortex, Prostheses and Implants, Prosthesis Implantation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
