The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease
Open accessAbstract
In this study we examined changes in the large-scale structure of resting-state brain networks in patients with Alzheimer's disease compared with non-demented controls, using concepts from graph theory. Magneto-encephalograms (MEG) were recorded in 18 Alzheimer's disease patients and 18 non-demented control subjects in a no-task, eyes-closed condition. For the main frequency bands, synchronization between all pairs of MEG channels was assessed using a phase lag index (PLI, a synchronization measure insensitive to volume conduction). PLI-weighted connectivity networks were calculated, and characterized by a mean clustering coefficient and path length. Alzheimer's disease patients showed a decrease of mean PLI in the lower alpha and beta band. In the lower alpha band, the clustering coefficient and path length were both decreased in Alzheimer's disease patients. Network changes in the lower alpha band were better explained by a 'Targeted Attack' model than by a 'Random Failure' model. Thus, Alzheimer's disease patients display a loss of resting-state functional connectivity in lower alpha and beta bands even when a measure insensitive to volume conduction effects is used. Moreover, the large-scale structure of lower alpha band functional networks in Alzheimer's disease is more random. The modelling results suggest that highly connected neural network 'hubs' may be especially at risk in Alzheimer's disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Emergence of Scaling in Random Networks
Barabási, A.-L., & Albert, R. (1999) · Science · doi:10.1126/science.286.5439.509 · Cited by 36,135
Consistent resting-state networks across healthy subjects
Damoiseaux, J. S., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Beckmann, C. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601417103 · Cited by 4,326
Self-citationNetwork Analysis of Intrinsic Functional Brain Connectivity in Alzheimer's Disease
Supekar, K., Menon, V., Rubin, D., Musen, M., & Greicius, M. D. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000100 · Cited by 1,148
Laufs, H., Krakow, K., Sterzer, P., Eger, E., Beyerle, A., Salek-Haddadi, A., & Kleinschmidt, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831638100 · Cited by 1,028
Adaptive reconfiguration of fractal small-world human brain functional networks
Bassett, D. S., Meyer-Lindenberg, A., Achard, S., Duke, T., & Bullmore, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606005103 · Cited by 814
Studying the human brain anatomical network via diffusion-weighted MRI and graph theory
Iturria-Medina, Y., Sotero, R. C., Canales-Rodríguez, E. J., Alemán-Gómez, Y., & Melie-García, L. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.060 · Cited by 506
Mutual information analysis of the EEG in patients with Alzheimer's disease
Jeong, J., Gore, J. C., & Peterson, B. S. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00513-2 · Cited by 397 · cited 2×
“BRAIN”
Simulation of robustness against lesions of cortical networks
Kaiser, M., Martin, R., Andras, P., & Young, M. P. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05574.x · Cited by 244
Book Review: Brain Function, Nonlinear Coupling, and Neuronal Transients
Friston, K. J. (2001) · The Neuroscientist · doi:10.1177/107385840100700510 · Cited by 141
Cited by
Complex brain networks: graph theoretical analysis of structural and functional systems
Bullmore, E., & Sporns, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2575 · Cited by 11,820
Complex network measures of brain connectivity: Uses and interpretations
Rubinov, M., & Sporns, O. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.003 · Cited by 11,522
Large-scale brain networks and psychopathology: a unifying triple network model
Menon, V. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.08.003 · Cited by 4,168
Exploring the brain network: A review on resting-state fMRI functional connectivity
van den Heuvel, M. P., & Hulshoff Pol, H. E. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.03.008 · Cited by 3,326
Rich-club organization of the human connectome
van den Heuvel, M. P., & Sporns, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3539-11.2011 · Cited by 2,354
Network hubs in the human brain
van den Heuvel, M. P., & Sporns, O. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.09.012 · Cited by 2,123
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
Wang, X.-J. (2010) · Physiological Reviews · doi:10.1152/physrev.00035.2008 · Cited by 1,939
Comparing Brain Networks of Different Size and Connectivity Density Using Graph Theory
van Wijk, B. C. M., Stam, C. J., & Daffertshofer, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013701 · Cited by 1,161
Self-citationDisrupted brain connectivity networks in drug-naive, first-episode major depressive disorder
Zhang, J., Wang, J., Wu, Q., Kuang, W., Huang, X., He, Y., & Gong, Q. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.018 · Cited by 951
Rethinking segregation and integration: contributions of whole-brain modelling
Deco, G., Tononi, G., Boly, M., & Kringelbach, M. L. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3963 · Cited by 658
Sanz-Arigita, E. J., Schoonheim, M. M., Damoiseaux, J. S., Rombouts, S. A. R. B., Maris, E., Barkhof, F., Scheltens, P., & Stam, C. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013788 · Cited by 608
Self-citationFunctional brain connectivity using fMRI in aging and Alzheimer’s disease
Dennis, E. L., & Thompson, P. M. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9249-6 · Cited by 583
Functional network disruption in the degenerative dementias
Pievani, M., de Haan, W., Wu, T., Seeley, W. W., & Frisoni, G. B. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70158-2 · Cited by 481
Self-citationPolanía, R., Nitsche, M. A., & Paulus, W. (2011) · Human Brain Mapping · doi:10.1002/hbm.21104 · Cited by 434
Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease
Wang, J., Zuo, X., Dai, Z., Xia, M., Zhao, Z., Zhao, X., Jia, J., Han, Y., & He, Y. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.026 · Cited by 432
Human brain mapping: A systematic comparison of parcellation methods for the human cerebral cortex
Arslan, S., Ktena, S. I., Makropoulos, A., Robinson, E. C., Rueckert, D., & Parisot, S. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.04.014 · Cited by 374
Alzheimer's disease: connecting findings from graph theoretical studies of brain networks
Tijms, B. M., Wink, A. M., de Haan, W., van der Flier, W. M., Stam, C. J., Scheltens, P., & Barkhof, F. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.020 · Cited by 416
Self-citationExploring the network dynamics underlying brain activity during rest
Cabral, J., Kringelbach, M. L., & Deco, G. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.005 · Cited by 351
Development of a large-scale functional brain network during human non-rapid eye movement sleep
Spoormaker, V. I., Schröter, M. S., Gleiser, P. M., Andrade, K. C., Dresler, M., Wehrle, R., Sämann, P. G., & Czisch, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2015-10.2010 · Cited by 273
Network analysis of resting state EEG in the developing young brain: structure comes with maturation
Boersma, M., Smit, D. J. A., de Bie, H. M. A., Van Baal, G. C. M., Boomsma, D. I., de Geus, E. J. C., Delemarre‐van de Waal, H. A., & Stam, C. J. (2011) · Human Brain Mapping · doi:10.1002/hbm.21030 · Cited by 235
Self-citationDisrupted Small-World Brain Networks in Moderate Alzheimer's Disease: A Resting-State fMRI Study
Zhao, X., Liu, Y., Wang, X., Liu, B., Xi, Q., Guo, Q., Jiang, H., Jiang, T., & Wang, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033540 · Cited by 215
Collin, G., & van den Heuvel, M. P. (2013) · The Neuroscientist · doi:10.1177/1073858413503712 · Cited by 198
Vecchio, F., Miraglia, F., Marra, C., Quaranta, D., Vita, M. G., Bramanti, P., & Rossini, P. M. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-132087 · Cited by 182
Daianu, M., Jahanshad, N., Nir, T. M., Toga, A. W., Jack, C. R., Weiner, M. W., & Thompson, F. T. A. D. (2013) · Brain Connectivity · doi:10.1089/brain.2012.0137 · Cited by 173
Dai, Z., & He, Y. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1421-0 · Cited by 173
A Shift to Randomness of Brain Oscillations in People with Autism
Lai, M.-C., Lombardo, M. V., Chakrabarti, B., Sadek, S. A., Pasco, G., Wheelwright, S. J., Bullmore, E. T., Baron-Cohen, S., & Suckling, J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.027 · Cited by 153
Miraglia, F., Vecchio, F., Bramanti, P., & Rossini, P. M. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.07.040 · Cited by 150
Disruption of cerebral networks and cognitive impairment in Alzheimer disease.
Reijmer, Y. D., Leemans, A., Caeyenberghs, K., Heringa, S. M., Koek, H. L., Biessels, G. J., & On behalf of the Utrecht Vascular Cognitive Impairment Study Group (2013) · Neurology · doi:10.1212/wnl.0b013e31828c2ee5 · Cited by 147
The brain matures with stronger functional connectivity and decreased randomness of its network
Smit, D. J. A., Boersma, M., Schnack, H. G., Micheloyannis, S., Boomsma, D. I., Hulshoff Pol, H. E., Stam, C. J., & de Geus, E. J. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036896 · Cited by 143
Self-citationDisturbed resting state eeg synchronization in bipolar disorder: A graph-theoretic analysis
Kim, D.-J., Bolbecker, A. R., Howell, J., Rass, O., Sporns, O., Hetrick, W. P., Breier, A., & O'Donnell, B. F. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.03.007 · Cited by 141
Bosma, I., Reijneveld, J. C., Klein, M., Douw, L., van Dijk, B. W., Heimans, J. J., & Stam, C. J. (2009) · Nonlinear Biomedical Physics · doi:10.1186/1753-4631-3-9 · Cited by 139
Self-citationSingle-Subject Grey Matter Graphs in Alzheimer's Disease
Tijms, B. M., Möller, C., Vrenken, H., Wink, A. M., de Haan, W., van der Flier, W. M., Stam, C. J., Scheltens, P., & Barkhof, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058921 · Cited by 132
Self-citationGenetic control of functional brain network efficiency in children
van den Heuvel, M. P., van Soelen, I. L. C., Stam, C. J., Kahn, R. S., Boomsma, D. I., & Hulshoff Pol, H. E. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.06.007 · Cited by 127
Self-citationSun, Y., Yin, Q., Fang, R., Yan, X., Wang, Y., Bezerianos, A., Tang, H., Miao, F., & Sun, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096505 · Cited by 122
Heringa, S. M., on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group, Reijmer, Y. D., Leemans, A., Koek, H. L., Kappelle, L. J., & Biessels, G. J. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130542 · Cited by 100
Principles of recovery from traumatic brain injury: Reorganization of functional networks
Castellanos, N. P., Leyva, I., Buldú, J. M., Bajo, R., Paúl, N., Cuesta, P., Ordóñez, V. E., Pascua, C. L., Boccaletti, S., Maestú, F., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.046 · Cited by 96
Brain connectivity in normally developing children and adolescents
Khundrakpam, B. S., Lewis, J. D., Zhao, L., Chouinard-Decorte, F., & Evans, A. C. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.03.062 · Cited by 91
Nobukawa, S., Yamanishi, T., Kasakawa, S., Nishimura, H., Kikuchi, M., & Takahashi, T. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00255 · Cited by 89
Rudrauf, D. (2014) · Advances in Neuroscience · doi:10.1155/2014/462765 · Cited by 74
Advances in Electrophysiological Research
Kamarajan, C. (2015) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v37.1.05 · Cited by 72
Gray matter network disruptions and amyloid beta in cognitively normal adults
Tijms, B. M., Kate, M. T., Wink, A. M., Visser, P. J., Ecay, M., Clerigue, M., Estanga, A., Garcia Sebastian, M., Izagirre, A., Villanua, J., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.015 · Cited by 59
Self-citationA Healthy Brain in a Healthy Body: Brain Network Correlates of Physical and Mental Fitness
Douw, L., Nieboer, D., van Dijk, B. W., Stam, C. J., & Twisk, J. W. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088202 · Cited by 57
Self-citationDisturbed Small-World Networks and Neurocognitive Function in Frontal Lobe Low-Grade Glioma Patients
Huang, Q., Zhang, R., Hu, X., Ding, S., Qian, J., Lei, T., Cao, X., Tao, L., Qian, Z., & Liu, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094095 · Cited by 55
McCarthy, P., Benuskova, L., & Franz, E. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00301 · Cited by 48
Zhou, Y., & Lui, Y. W. (2013) · ISRN Geriatrics · doi:10.1155/2013/542080 · Cited by 44
Kesler, S. R., Acton, P., Rao, V., & Ray, W. J. (2018) · Network Neuroscience · doi:10.1162/netn_a_00048 · Cited by 34
Peláez Suárez, A. A., Berrillo Batista, S., Pedroso Ibáñez, I., Casabona Fernández, E., Fuentes Campos, M., & Chacón, L. M. (2021) · Behavioral Sciences · doi:10.3390/bs11030040 · Cited by 27
Metadata
- Authors
- Stam, C. J., de Haan, W., Daffertshofer, A., Jones, B. F., Manshanden, I., van Cappellen van Walsum, A. M., Montez, T., Verbunt, J. P. A., de Munck, J. C., van Dijk, B. W., Berendse, H. W., & Scheltens, P.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10-24
- Volume
- 132
- Issue
- 1
- Pages
- 213-224
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2116083905
- Cited by
- 906
- References
- 10
- FWCI
- 18.02
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
