Age-related Volumetric Changes of Brain Gray and White Matter in Healthy Infants and Children
Abstract
To date there is little information about brain development during infancy and childhood, although several quantitative studies have shown volume changes in adult brains. We performed three-dimensional magnetic resonance imaging (3D-MRI) in 28 healthy children aged 1 month to 10 years. We examined the volumes of whole brain and frontal and temporal lobes with an advanced method for segmenting images into gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) compartments. Growth spurts of whole brain and frontal and temporal lobes could be seen during the first 2 years after birth. During this period the frontal lobes grew more rapidly than the temporal lobes, the right--left asymmetry was more noticeable in the temporal lobes than in the frontal lobes and the increase in GM was larger than that in WM in the temporal lobes. Subsequently, WM volume increased at a higher rate than GM volume throughout childhood. Quantitative information on normal brain development may play a pivotal role in clarifying brain neurodevelopmental abnormalities.
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Grey and white matter have different growth trajectories soon after birth, with rapid grey-matter volume development compared with a more gradual increase in white-matter volume.
“Grey and white matter have different growth trajectories soon after birth, with rapid development of grey-matter volume compared to white-matter volume, which increases much more gradually15,3.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [15]
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- Authors
- Matsuzawa, J.
- Affiliations
- University of Toyama (JP)
- Corresponding author
- Matsuzawa, J.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-04-01
- Volume
- 11
- Issue
- 4
- Pages
- 335-342
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2095864300
- Cited by
- 315
- References
- 42
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 21 · 2023: 13 · 2022: 11 · 2021: 22 · 2020: 17 · 2019: 9 · 2018: 16 · 2017: 13 · 2016: 15 · 2015: 18 · 2014: 9 · 2013: 12 · 2012: 14
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- brain development, brain growth, gray matter volume, white matter volume, cerebrospinal fluid, frontal lobe, temporal lobe, hemispheric lateralization, infant brain, normal brain development
- MeSH terms
- Age Factors, Brain, Child, Child, Preschool, Cross-Sectional Studies, Female, Frontal Lobe, Humans, Infant, Magnetic Resonance Imaging, Male, Temporal Lobe, Multivariate Analysis, Imaging, Three-Dimensional
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