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Immune Parameters in a Longitudinal Study of a Very Old Population of Swedish People: A Comparison Between Survivors and Nonsurvivors
Abstract
As a part of an ongoing longitudinal investigation, this study examined relationships between survival and selected immune system parameters in a sample (n = 102) of very old individuals (86-92 years at the time of initial immune system data collection). Analyses were performed comparing initial time-point measurements from those individuals who were alive (n = 75) and those who were deceased (n = 27) two years after initial data collection. Immune system measurements consisted of determination of peripheral blood lymphocytes and lymphocyte subsets, as well as T-cell responses to activation by Concanavalin A. Cluster analysis identified a subgroup associated with nonsurvival which indicated characteristics that included: poor T-cell proliferative responses, high CD8 percentages, and low CD4 and CD19 percentages. This multivariate analysis suggested that combinations of immune system parameters predict two-year survival otherwise not apparent when single immune system parameters were evaluated in the elderly.
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Miller, R. A. (1996) · Science · doi:10.1126/science.273.5271.70 · Cited by 1,165
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Serrano-Villar, S., Sainz, T., Lee, S. A., Hunt, P. W., Sinclair, E., Shacklett, B. L., Ferre, A. L., Hayes, T. L., Somsouk, M., Hsue, P. Y., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004078 · Cited by 611
Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474
Self-citationCollerton, J., Martin-Ruiz, C., Davies, K., Hilkens, C. M., Isaacs, J., Kolenda, C., Parker, C., Dunn, M., Catt, M., Jagger, C., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.05.005 · Cited by 420
Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407
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Self-citationGoronzy, J. J., Fulbright, J. W., Crowson, C. S., Poland, G. A., O'Fallon, W. M., & Weyand, C. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.24.12182-12187.2001 · Cited by 402
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Pawelec, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.11.010 · Cited by 163
Franceschi, C., Valensin, S., Fagnoni, F., Barbi, C., & Bonafè, M. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00068-6 · Cited by 154
Pallast, E. G., Schouten, E. G., de Waart, F. G., Fonk, H. C., Doekes, G., von Blomberg, B. M., & Kok, F. J. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1273 · Cited by 141
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Derhovanessian, E., Maier, A. B., Hähnel, K., Zelba, H., de Craen, A. J. M., Roelofs, H., Slagboom, E. P., Westendorp, R. G. J., & Pawelec, G. (2013) · AGE · doi:10.1007/s11357-012-9425-7 · Cited by 102
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Self-citationPawelec, G., Sansom, D., Rehbein, A., Adibzadeh, M., & Beckman, I. (1996) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00097-6 · Cited by 68
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Shen-Orr, S. S., & Furman, D. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.009 · Cited by 61
Hoare, M., Gelson, W. T. H., Das, A., Fletcher, J. M., Davies, S. E., Curran, M. D., Vowler, S. L., Maini, M. K., Akbar, A. N., & Alexander, G. J. M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.03.005 · Cited by 53
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Metadata
- Authors
- Ferguson, F. G., Wikby, A., Maxson, P., Olsson, J., & Johansson, B.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-11-01
- Volume
- 50A
- Issue
- 6
- Pages
- B378-B382
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W1983991488
- Cited by
- 378
- References
- 0
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
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