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miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo
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miR-212-5p was found decreased in several other neurodegenerative diseases such as AD, Huntington's disease, and PD.
“Moreover, miR-212-5p was found decreased in several other neurodegenerative diseases such as AD, Huntington’s disease, and PD [62, 66, 69–75], indicating a key role in neurodegenerative diseases.”
From A role for astrocytic miR-129-5p in frontotemporal dementia (2025) · cites this paper as [66]
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“Antibodies directed against tau include: AT8 (Ser202/Thr205, ThermoFisher), PHF-1 [Ser396/Ser404, (87)], phosphoSer422 (#OPA-03151; ThermoScientific), CP27 (specific to human total tau) and total tau (A0024, Dako Cytomation).”
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Metadata
- Authors
- Smith, P. Y., Hernandez-Rapp, J., Jolivette, F., Lecours, C., Bisht, K., Goupil, C., Dorval, V., Parsi, S., Morin, F., Planel, E., Bennett, D. A., Fernandez-Gomez, F.-J., Sergeant, N., Buée, L., Tremblay, M.-È., Calon, F., & Hébert, S. S.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-09-11
- Volume
- 24
- Issue
- 23
- Pages
- 6721-6735
- ISSN
- 0964-6906
- 1460-2083
- Cited by
- 220
- References
- 12
- Language
- en
- Funders
- Canadian Institutes of Health Research (00892-000)
- Alzheimer Society of Canada (1428, 1236)
- Fonds de Recherche du Québec Santé/INSERM (23635, 31199)
- National Institute on Aging (P30AG10161, RF1AG15819)
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