Default Mode Network Modulation by Psychedelics: A Systematic Review
Open accessAbstract
Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well as profound psychological and mystical experiences. A grouping of interconnected brain regions characterized by increased temporal coherence at rest have been termed the Default Mode Network (DMN). The DMN has been the focus of numerous studies assessing its role in self-referencing, mind wandering, and autobiographical memories. Altered connectivity in the DMN has been associated with a range of neuropsychiatric conditions such as depression, anxiety, post-traumatic stress disorder, attention deficit hyperactive disorder, schizophrenia, and obsessive-compulsive disorder. To date, several studies have investigated how psychedelics modulate this network, but no comprehensive review, to our knowledge, has critically evaluated how major classical psychedelic agents—lysergic acid diethylamide, psilocybin, and ayahuasca—modulate the DMN. Here we present a systematic review of the knowledge base. Across psychedelics there is consistent acute disruption in resting state connectivity within the DMN and increased functional connectivity between canonical resting-state networks. Various models have been proposed to explain the cognitive mechanisms of psychedelics, and in one model DMN modulation is a central axiom. Although the DMN is consistently implicated in psychedelic studies, it is unclear how central the DMN is to the therapeutic potential of classical psychedelic agents. This article aims to provide the field with a comprehensive overview that can propel future research in such a way as to elucidate the neurocognitive mechanisms of psychedelics.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Psychedelics disrupt the functioning of the salience network, potentially leading to altered perceptions of self and world.
“Research indicates that psychedelics disrupt the functioning of the salience network, potentially leading to altered perceptions of self and world [70].”
From Mindfulness meditation and psychedelics: potential synergies and commonalities (2023) · cites this paper as [70]
The review’s study summary (table in Introduction; page unavailable) reports that LSD decreased segregation between the default mode and salience networks. The Introduction also discusses psychedelic-related changes in perceptions of self and world, but the table says the network change was not significantly correlated with ego dissolution. The source therefore does not establish that disruption of salience-network functioning leads to those altered perceptions. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · cited 2× · see citing works
“This systematic review followed the PRISMA statement (Moher et al., 2015) for transparent and comprehensive reporting.”
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., et al. (2021) · International Journal of Surgery · doi:10.1016/j.ijsu.2021.105906 · Cited by 11,748 · see citing works
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
Page, M. J., McKenzie, J., Bossuyt, P., Boutron, I., Hoffmann, T., mulrow, C., Shamseer, L., Tetzlaff, J., Akl, E., Brennan, S. E., et al. (2020) · doi:10.31222/osf.io/v7gm2_v1 · Cited by 8,090 · see citing works
The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., et al. (2021) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2021.03.001 · Cited by 4,265 · see citing works
The brain's default mode network
Raichle, M. E. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014030 · Cited by 3,904 · see citing works
Exploring the brain network: A review on resting-state fMRI functional connectivity
van den Heuvel, M. P., & Hulshoff Pol, H. E. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.03.008 · Cited by 3,326 · see citing works
Utilization of the PICO framework to improve searching PubMed for clinical questions
Schardt, C., Adams, M. B., Owens, T., Keitz, S., & Fontelo, P. (2007) · BMC Medical Informatics and Decision Making · doi:10.1186/1472-6947-7-16 · Cited by 3,053 · see citing works
Andrews‐Hanna, J. R., Smallwood, J., & Spreng, R. N. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12360 · Cited by 2,102 · see citing works
Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762 · see citing works
Brewer, J. A., Worhunsky, P. D., Gray, J. R., Tang, Y.-Y., Weber, J., & Kober, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112029108 · Cited by 1,409 · see citing works
The maturing architecture of the brain's default network
Fair, D. A., Cohen, A. L., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Barch, D. M., Raichle, M. E., Petersen, S. E., & Schlaggar, B. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800376105 · Cited by 1,314 · see citing works
Carhart-Harris, R. L., Leech, R., Hellyer, P. J., Shanahan, M., Feilding, A., Tagliazucchi, E., Chialvo, D. R., & Nutt, D. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00020 · Cited by 1,252 · see citing works
Self-citationREBUS and the anarchic brain: Toward a unified model of the brain action of psychedelics
Carhart-Harris, R. L., & Friston, K. J. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.017160 · Cited by 1,180 · see citing works
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., Tyacke, R. J., Leech, R., Malizia, A. L., Murphy, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119598109 · Cited by 1,172 · see citing works
Self-citationThe brain's default network and its adaptive role in internal mentation
Andrews-Hanna, J. R. (2012) · The Neuroscientist · doi:10.1177/1073858411403316 · Cited by 1,114 · see citing works
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
Carhart-Harris, R. L., Bolstridge, M., Day, C. M. J., Rucker, J., Watts, R., Erritzoe, D. E., Kaelen, M., Giribaldi, B., Bloomfield, M., Pilling, S., et al. (2018) · Psychopharmacology · doi:10.1007/s00213-017-4771-x · Cited by 970 · see citing works
Self-citationInvestigating the electrophysiological basis of resting state networks using magnetoencephalography
Brookes, M. J., Woolrich, M., Luckhoo, H., Price, D., Hale, J. R., Stephenson, M. C., Barnes, G. R., Smith, S. M., & Morris, P. G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112685108 · Cited by 938 · see citing works
The default mode network in cognition: a topographical perspective
Smallwood, J., Bernhardt, B. C., Leech, R., Bzdok, D., Jefferies, E., & Margulies, D. S. (2021) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00474-4 · Cited by 935 · see citing works
MacLean, K. A., Johnson, M. W., & Griffiths, R. R. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111420188 · Cited by 895 · see citing works
Neural correlates of the LSD experience revealed by multimodal neuroimaging
Carhart-Harris, R. L., Muthukumaraswamy, S., Roseman, L., Kaelen, M., Droog, W., Murphy, K., Tagliazucchi, E., Schenberg, E. E., Nest, T., Orban, C., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518377113 · Cited by 859 · see citing works
Self-citationHamilton, J. P., Furman, D. J., Chang, C., Thomason, M. E., Dennis, E., & Gotlib, I. H. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.003 · Cited by 823 · see citing works
The default mode network: where the idiosyncratic self meets the shared social world
Yeshurun, Y., Nguyen, M., & Hasson, U. (2021) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00420-w · Cited by 682 · see citing works
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms
Carhart-Harris, R. L., Roseman, L., Bolstridge, M., Demetriou, L., Pannekoek, J. N., Wall, M. B., Tanner, M., Kaelen, M., McGonigle, J., Murphy, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13282-7 · Cited by 587 · see citing works
Self-citationThe subjective effects of psychedelics are necessary for their enduring therapeutic effects
Yaden, D. B., & Griffiths, R. R. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00194 · Cited by 541 · see citing works
The entropic brain - revisited
Carhart-Harris, R. L. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.010 · Cited by 522 · see citing works
Increased global functional connectivity correlates with LSD-induced ego dissolution
Tagliazucchi, E., Roseman, L., Kaelen, M., Orban, C., Muthukumaraswamy, S. D., Murphy, K., Laufs, H., Leech, R., McGonigle, J., Crossley, N., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.02.010 · Cited by 503 · see citing works
Self-citationEgo-dissolution and psychedelics: validation of the ego-dissolution inventory (EDI).
Nour, M. M., Evans, L., Nutt, D., & Carhart-Harris, R. L. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00269 · Cited by 470 · see citing works
Self-citationBroadband Cortical Desynchronization Underlies the Human Psychedelic State
Muthukumaraswamy, S. D., Carhart-Harris, R. L., Moran, R., Brookes, M. J., Williams, T. M., Errtizoe, D., Sessa, B., Papadopoulos, A., Bolstridge, M., Singh, K. D., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2063-13.2013 · Cited by 465 · see citing works
Self-citationPalhano-Fontes, F., Andrade, K. C., Tofoli, L. F., Santos, A. C., Crippa, J. A. S., Hallak, J. E. C., Ribeiro, S., & de Araujo, D. B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118143 · Cited by 454 · see citing works
Increased global integration in the brain after psilocybin therapy for depression
(2022) · doi:10.1038/s41591-022-01744-z · Cited by 445 · see citing works
Self-citationVollenweider, F. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00246-1 · Cited by 444 · see citing works
Enhanced repertoire of brain dynamical states during the psychedelic experience
Tagliazucchi, E., Carhart-Harris, R. L., Leech, R., Nutt, D., & Chialvo, D. R. (2014) · Human Brain Mapping · doi:10.1002/hbm.22562 · Cited by 399 · see citing works
Self-citationPsychedelics, meditation, and self-consciousness
Millière, R., Carhart-Harris, R. L., Roseman, L., Trautwein, F.-M., & Berkovich-Ohana, A. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01475 · Cited by 390 · cited 6× · see citing works
“…how psychedelics modulate the DMN (Carhart-Harris et al., 2012, 2016; Bouso et al., 2015; Palhano-Fontes et al., 2015; Thomas et al., 2017; Millière et al., 2018; Müller et al., 2018; Kelly et al., 2019; Smigielski et al., 2019; Mason et al., 2020; Mertens et al., 2020; Daws et al., 2022;…”
BackgroundMethodInfluentialPreller, K. H., Burt, J. B., Ji, J. L., Schleifer, C. H., Adkinson, B. D., Stämpfli, P., Seifritz, E., Repovs, G., Krystal, J. H., Murray, J. D., et al. (2018) · eLife · doi:10.7554/elife.35082 · Cited by 390 · see citing works
Emotions and brain function are altered up to one month after a single high dose of psilocybin.
Barrett, F. S., Doss, M. K., Sepeda, N. D., Pekar, J. J., & Griffiths, R. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-59282-y · Cited by 375 · see citing works
Does the brain have a baseline? Why we should be resisting a rest
Morcom, A. M., & Fletcher, P. C. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.013 · Cited by 369 · see citing works
Brain default-mode network dysfunction in addiction
Zhang, R., & Volkow, N. D. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.06.036 · Cited by 365 · see citing works
Doss, M. K., Považan, M., Rosenberg, M. D., Sepeda, N. D., Davis, A. K., Finan, P. H., Smith, G. S., Pekar, J. J., Barker, P. B., Griffiths, R. R., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01706-y · Cited by 356 · see citing works
Finding the self by losing the self: neural correlates of ego-dissolution under psilocybin
Lebedev, A. V., Lövdén, M., Rosenthal, G., Feilding, A., Nutt, D. J., & Carhart-Harris, R. L. (2015) · Human Brain Mapping · doi:10.1002/hbm.22833 · Cited by 339 · see citing works
Self-citationStructure-based discovery of nonhallucinogenic psychedelic analogs
Cao, D., Yu, J., Wang, H., Luo, Z., Liu, X., He, L., Qi, J., Fan, L., Tang, L., Chen, Z., et al. (2022) · Science · doi:10.1126/science.abl8615 · Cited by 312 · see citing works
LSD‐induced entropic brain activity predicts subsequent personality change
Lebedev, A. V., Kaelen, M., Lövdén, M., Nilsson, J., Feilding, A., Nutt, D. J., & Carhart‐Harris, R. L. (2016) · Human Brain Mapping · doi:10.1002/hbm.23234 · Cited by 303 · see citing works
Self-citationMohan, A., Roberto, A. J., Mohan, A., Lorenzo, A., Jones, K., Carney, M. J., Liogier-Weyback, L., Hwang, S., & Lapidus, K. A. B. (2016) · Europe PMC (PubMed Central) · Cited by 297 · see citing works
Self unbound: ego dissolution in psychedelic experience
Letheby, C., & Gerrans, P. (2017) · Neuroscience of Consciousness · doi:10.1093/nc/nix016 · Cited by 293 · cited 7× · see citing works
“Default Mode Network Modulation by Psychedelics | 181 connectivity within the DMN (and increase its connectivity to other networks), altered states of consciousness, and therapeutic outcomes (Letheby and Gerrans, 2017; Müller et al., 2018; Smigielski et al., 2019; dos Santos and Hallak, 2021; Mason et al., 2021; Daws…”
BackgroundMethodInfluentialEffective connectivity changes in LSD-induced altered states of consciousness in humans
Preller, K. H., Razi, A., Zeidman, P., Stämpfli, P., Friston, K. J., & Vollenweider, F. X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815129116 · Cited by 292 · see citing works
Phenomenology, Structure, and Dynamic of Psychedelic States
Preller, K. H., & Vollenweider, F. X. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_459 · Cited by 282 · see citing works
Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics
Aleksandrova, L. R., & Phillips, A. G. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.08.003 · Cited by 276 · see citing works
Classic Hallucinogens and Mystical Experiences: Phenomenology and Neural Correlates
Barrett, F. S., & Griffiths, R. R. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_474 · Cited by 273 · see citing works
Roseman, L., Leech, R., Feilding, A., Nutt, D., & Carhart-Harris, R. L. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00204 · Cited by 270 · see citing works
Self-citationGregorio, D. D., Aguilar‐Valles, A., Preller, K. H., Heifets, B. D., Hibicke, M., Mitchell, J., & Gobbi, G. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1659-20.2020 · Cited by 261 · see citing works
Response of cluster headache to psilocybin and LSD
Sewell, R. A., Halpern, J. H., & Pope, H. G. (2006) · Neurology · doi:10.1212/01.wnl.0000219761.05466.43 · Cited by 260 · see citing works
Mason, N. L., Kuypers, K. P. C., Müller, F., Reckweg, J., Tse, D. H. Y., Toennes, S. W., Hutten, N. R. P. W., Jansen, J. F. A., Stiers, P., Feilding, A., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0718-8 · Cited by 258 · see citing works
Long-term effects of psychedelic drugs: A systematic review
Aday, J. S., Mitzkovitz, C. M., Bloesch, E. K., Davoli, C. C., & Davis, A. K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.017 · Cited by 257 · see citing works
Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis
Carhart-Harris, R. L., Leech, R., Erritzoe, D., Williams, T. M., Stone, J. M., Evans, J., Sharp, D. J., Feilding, A., Wise, R. G., & Nutt, D. J. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs117 · Cited by 256 · see citing works
Self-citationSmigielski, L., Scheidegger, M., Kometer, M., & Vollenweider, F. X. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.04.009 · Cited by 248 · see citing works
Meda, S. A., Ruaño, G., Windemuth, A., O’Neil, K., Berwise, C., Dunn, S. M., Boccaccio, L. E., Narayanan, B., Kocherla, M., Sprooten, E., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313093111 · Cited by 242 · see citing works
Effects of psilocybin on time perception and temporal control of behaviour in humans
Wittmann, M., Carter, O. L., Hasler, F., Cahn, B. R., Grimberg, U., Spring, P., Hell, D., Flohr, H., & Vollenweider, F. X. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106065859 · Cited by 240 · see citing works
A systematic study of microdosing psychedelics
Polito, V., & Stevenson, R. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211023 · Cited by 235 · cited 1× · see citing works
“Micro-dosing of psychedelics (particularly LSD and psilocybin), which generally involves taking sub-hallucinogenic doses, has been reported to lead to decreased mind-wandering (Polito and Stevenson, 2019), which at the neural level is reflected by reduced DMN activity.”
BackgroundPsychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works
The antipodes Of the mind: Charting the Phenomenology of the Ayahuasca Experience
Shanon, B. (2002) · doi:10.1093/oso/9780199252923.001.0001 · Cited by 232 · see citing works
The Current Status of Psychedelics in Psychiatry
Nutt, D., & Carhart-Harris, R. L. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.2171 · Cited by 223 · see citing works
Self-citationBouso, J. C., Palhano-Fontes, F., Rodríguez-Fornells, A., Ribeiro, S., Sanches, R., Crippa, J. A. S., Hallak, J. E. C., de Araujo, D. B., & Riba, J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.008 · Cited by 218 · see citing works
Atasoy, S., Roseman, L., Kaelen, M., Kringelbach, M. L., Deco, G., & Carhart-Harris, R. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-17546-0 · Cited by 214 · see citing works
Uthaug, M. V., van Oorsouw, K., Kuypers, K. P. C., van Boxtel, M., Broers, N. J., Mason, N. L., Toennes, S. W., Riba, J., & Ramaekers, J. G. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4988-3 · Cited by 212 · see citing works
Mertens, L. J., Wall, M. B., Roseman, L., Demetriou, L., Nutt, D. J., & Carhart-Harris, R. L. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881119895520 · Cited by 208 · see citing works
Self-citationBonhomme, V., Vanhaudenhuyse, A., Demertzi, A., Bruno, M.-A., Jaquet, O., Bahri, M. A., Plenevaux, A., Boly, M., Boveroux, P., Soddu, A., et al. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001275 · Cited by 207 · see citing works
Sampedro, F., de la Fuente Revenga, M., Valle, M., Roberto, N., Domínguez-Clavé, E., Elices, M., Luna, L. E., Crippa, J. A. S., Hallak, J. E. C., de Araujo, D. B., et al. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx036 · Cited by 200 · see citing works
Models of psychedelic drug action: modulation of cortical-subcortical circuits
Doss, M. K., Madden, M. B., Gaddis, A., Nebel, M. B., Griffiths, R. R., Mathur, B. N., & Barrett, F. S. (2021) · Brain · doi:10.1093/brain/awab406 · Cited by 198 · see citing works
Barrett, F. S., Krimmel, S. R., Griffiths, R. R., Seminowicz, D. A., & Mathur, B. N. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116980 · Cited by 187 · see citing works
Changes in Resting Neural Connectivity during Propofol Sedation
Stamatakis, E. A., Adapa, R., Absalom, A. R., & Menon, D. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014224 · Cited by 179 · see citing works
Altered network hub connectivity after acute LSD administration
Müller, F., Dolder, P. C., Schmidt, A., Liechti, M. E., & Borgwardt, S. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.03.005 · Cited by 174 · see citing works
LSD alters dynamic integration and segregation in the human brain
Luppi, A. I., Carhart-Harris, R. L., Roseman, L., Pappas, I., Menon, D. K., & Stamatakis, E. A. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117653 · Cited by 159 · see citing works
Kometer, M., Pokorny, T., Seifritz, E., & Volleinweider, F. X. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4026-7 · Cited by 157 · see citing works
Madsen, M. K., Stenbæk, D. S., Arvidsson, A., Armand, S., Marstrand-Joergensen, M. R., Johansen, S. S., Línnet, K., Ozenne, B., Knudsen, G. M., & Fisher, P. M. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.06.001 · Cited by 145 · see citing works
Viol, A., Palhano-Fontes, F., Onias, H., de Araújo, D. B., & Viswanathan, G. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-06854-0 · Cited by 136 · see citing works
Ayahuasca’s ‘afterglow’: improved mindfulness and cognitive flexibility in ayahuasca drinkers
Murphy-Beiner, A., & Soar, K. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05445-3 · Cited by 135 · see citing works
Brewer, J. A., & Garrison, K. A. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12246 · Cited by 134 · see citing works
Poldrack, R. A., & Devlin, J. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.06.019 · Cited by 133 · see citing works
Carhart-Harris, R. L. (2018) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000467 · Cited by 133 · see citing works
Spontaneous and deliberate creative cognition during and after psilocybin exposure
Mason, N. L., Kuypers, K. P. C., Reckweg, J. T., Müller, F., Tse, D. H. Y., Rios, B. D., Toennes, S. W., Stiers, P. L. J., Feilding, A., & Ramaekers, J. G. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01335-5 · Cited by 129 · see citing works
Riba, J., Anderer, P., Morte, A., Urbano, G., Jané, F., Saletu, B., & Barbanoj, M. J. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01609.x · Cited by 125 · see citing works
Speth, J., Speth, C., Kaelen, M., Schloerscheidt, A. M., Feilding, A., Nutt, D., & Carhart-Harris, R. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116628430 · Cited by 118 · see citing works
Self-citationThe function of efference copy signals: Implications for symptoms of schizophrenia
Pynn, L. K., & DeSouza, J. F. X. (2012) · Vision Research · doi:10.1016/j.visres.2012.10.019 · Cited by 116 · see citing works
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks
Pasquini, L., Palhano-Fontes, F., & de Araújo, D. B. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120909409 · Cited by 115 · see citing works
Health status of ayahuasca users
Barbosa, P. C. R., Mizumoto, S., Bogenschutz, M. P., & Strassman, R. J. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1383 · Cited by 112 · see citing works
Lydon‐Staley, D. M., Kuehner, C., Zamoscik, V., Huffziger, S., Kirsch, P., & Bassett, D. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0560-0 · Cited by 104 · see citing works
Resting oscillations and cross-frequency coupling in the human posteromedial cortex
Foster, B. L., & Parvizi, J. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.019 · Cited by 102 · see citing works
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution
Stoliker, D., Egan, G. F., Friston, K. J., & Razi, A. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000508 · Cited by 89 · see citing works
Varley, T. F., Carhart-Harris, R. L., Roseman, L., Menon, D. K., & Stamatakis, E. A. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117049 · Cited by 88 · see citing works
Psychedelics and the science of self-experience
Nour, M. M., & Carhart-Harris, R. L. (2017) · British Journal of Psychiatry · doi:10.1192/bjp.bp.116.194738 · Cited by 87 · see citing works
Zeifman, R. J., Singhal, N., SANTOS, R. G. D., Sanches, R. F., Osório, F. D. L., Hallak, J. E. C., & Weissman, C. R. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05692-9 · Cited by 83 · see citing works
McCulloch, D. E.-W., Madsen, M. K., Stenbæk, D. S., Kristiansen, S., Ozenne, B., Jensen, P. S., Knudsen, G. M., & Fisher, P. M. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211026454 · Cited by 83 · see citing works
Schretlen, D. J., van der Hulst, E.-J., Pearlson, G. D., & Gordon, B. (2010) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803391003689770 · Cited by 81 · see citing works
Single-dose serotonergic stimulation shows widespread effects on functional brain connectivity
Klaassens, B. L., van Gorsel, H. C., Khalili-Mahani, N., van der Grond, J., Wyman, B. T., Whitcher, B., Rombouts, S. A. R. B., & van Gerven, J. M. A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.08.012 · Cited by 76 · see citing works
Psilocybin-Assisted Therapy: A Review of a Novel Treatment for Psychiatric Disorders
Thomas, K., Malcolm, B., & Lastra, D. (2017) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2017.1320734 · Cited by 75 · see citing works
Murray, C. H., Tare, I., Perry, C., Malina, M., Lee, R., & de Wit, H. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05991-9 · Cited by 72 · see citing works
Resting state connectivity best predicts alcohol use severity in moderate to heavy alcohol users
Fede, S. J., Grodin, E. N., Dean, S., Diazgranados, N., & Momenan, R. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101782 · Cited by 66 · see citing works
Taki, Y., Thyreau, B., Kinomura, S., Sato, K., Goto, R., Wu, K., Kawashima, R., & Fukuda, H. (2012) · Human Brain Mapping · doi:10.1002/hbm.22145 · Cited by 63 · see citing works
Effects of chronic and acute stimulants on brain functional connectivity hubs
Konova, A. B., Moeller, S. J., Tomasi, D. G., & Goldstein, R. Z. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.002 · Cited by 61 · see citing works
Neuropharmacological modulation of the aberrant bodily self through psychedelics
Ho, J. T., Preller, K. H., & Lenggenhager, B. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.006 · Cited by 60 · see citing works
Psychedelic therapy: a roadmap for wider acceptance and utilization
Marks, M., & Cohen, I. G. (2021) · Nature Medicine · doi:10.1038/s41591-021-01530-3 · Cited by 59 · see citing works
Stiefel, K. M., Merrifield, A., & Holcombe, A. O. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00020 · Cited by 58 · see citing works
Medial Frontal Hyperactivity in Reality Distortion
Taylor, S. F., Welsh, R. C., Chen, A. C., Velander, A. J., & Liberzon, I. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.029 · Cited by 58 · see citing works
SANTOS, R. G. D., & Hallak, J. E. C. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.04.053 · Cited by 56 · see citing works
Feurer, C., Jimmy, J., Chang, F., Langenecker, S. A., Phan, K. L., Ajilore, O., & Klumpp, H. (2021) · Depression and Anxiety · doi:10.1002/da.23142 · Cited by 55 · see citing works
Grandjean, J., Buehlmann, D., Buerge, M., Sigrist, H., Seifritz, E., Vollenweider, F. X., Pryce, C. R., & Rudin, M. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117456 · Cited by 54 · see citing works
Doss, M. K., May, D. G., Johnson, M. W., Clifton, J. M., Hedrick, S. L., Prisinzano, T. E., Griffiths, R. R., & Barrett, F. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-73216-8 · Cited by 52 · see citing works
The Effects of Hallucinogens on Gene Expression
Martin, D. A., & Nichols, C. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_479 · Cited by 51 · see citing works
Restructuring consciousness –the psychedelic state in light of integrated information theory
Gallimore, A. R. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00346 · Cited by 50 · see citing works
Serotonin–Glutamate Interactions A New Target for Antipsychotic Drugs
Aghajanian, G. K. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00106-2 · Cited by 44 · see citing works
Sacred Vine of Spirits: Ayahuasca
Metzner, R. (2005) · Cited by 40 · see citing works
Increased sensitivity to strong perturbations in a whole-brain model of LSD
Jobst, B., Atasoy, S., Ponce‐Alvarez, A., Sanjuán, A., Roseman, L., Kaelen, M., Carhart-Harris, R. L., Kringelbach, M. L., & Deco, G. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.117809 · Cited by 34 · see citing works
The psychedelic renaissance: the next trip for psychiatry?
Kelly, J. R., Baker, A., Babiker, M., Burke, L., Brennan, C., & O’Keane, V. (2019) · Irish Journal of Psychological Medicine · doi:10.1017/ipm.2019.39 · Cited by 21 · see citing works
Hou, Y., Yuan, X., Wei, Q., Ou, R., Yang, J., Gong, Q., & Shang, H. (2020) · Neuroradiology · doi:10.1007/s00234-020-02378-z · Cited by 20 · see citing works
Effects of moderate alcohol levels on default mode network connectivity in heavy drinkers
Fang, X., Deza-Araujo, Y. I., Petzold, J., Spreer, M., Riedel, P., Marxen, M., O’Connor, S., Zimmermann, U. S., & Smolka, M. N. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14602 · Cited by 20 · see citing works
Xue, S., Wang, D., Tan, Z., Wang, Y., Lian, Z., Sun, Y., Hu, X., Wang, X., & Zhou, X. H. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s220743 · Cited by 19 · see citing works
Default mode network functional connectivity negatively associated with trait openness to experience
Marstrand-Joergensen, M. R., Madsen, M. K., Stenbæk, D. S., Ozenne, B., Jensen, P. S., Frøkjær, V. G., Knudsen, G. M., & Fisher, P. M. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab048 · Cited by 18 · see citing works
Research on psychedelics moves into the mainstream
Morris, K. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60638-8 · Cited by 17 · see citing works
Establishing a Causal Role for Medial Prefrontal Cortex in Reality Monitoring
Subramaniam, K., Kothare, H., Hinkley, L. B. N., Tarapore, P. E., & Nagarajan, S. S. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00106 · Cited by 16 · see citing works
Reed, P. G. (2023) · Springer Publishing Company eBooks · doi:10.1891/9780826139276.0007 · Cited by 11 · see citing works
Biswal (1997) · doi:10.1002/(sici)1099-1492(199706/08)10:4/5
Flagged first, then by citations
1 of the 122 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Hofmann A (1980) LSD: my problem child. Psychedelic reflections. The Beckley Foundation Press.
Cited by
Sorted by citations
Psychedelic therapy in the treatment of addiction: the past, present and future
Zafar, R. R., Siegel, M., Harding, R., Barba, T., Agnorelli, C., Suseelan, S., Roseman, L., Wall, M. B., Nutt, D., & Erritzøe, D. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1183740 · Cited by 108 · see citing works
Self-citationThe Psychedelic Future of Post-Traumatic Stress Disorder Treatment
Zaretsky, T. G., Jagodnik, K. M., Barsic, R., Antonio, J. H., Bonanno, P. A., MacLeod, C., Pierce, C., Carney, H., Morrison, M. T., Saylor, C. F., et al. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666231027111147 · Cited by 85 · see citing works
An Integrated theory of false insights and beliefs under psychedelics
McGovern, H. T., Grimmer, H. J., Doss, M. K., Hutchinson, B. T., Timmermann, C., Lyon, A., Corlett, P. R., & Laukkonen, R. (2024) · Communications Psychology · doi:10.1038/s44271-024-00120-6 · Cited by 74 · see citing works
Self-citationSabé, M., Sulstarova, A., Glangetas, A., Pieri, M. D., Mallet, L., Curtis, L., Richard-Lepouriel, H., Penzenstadler, L. E., Seragnoli, F., Thorens, G., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02800-5 · Cited by 53 · see citing works
Exploring DMT: Endogenous role and therapeutic potential
Schimmelpfennig, J., & Jankowiak-Siuda, K. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110314 · Cited by 54 · see citing works
Mindfulness meditation and psychedelics: potential synergies and commonalities
Holas, P., & Kamińska, J. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00551-8 · Cited by 43 · see citing works
Villiger, D., & Trachsel, M. (2023) · Journal of Medical Ethics · doi:10.1136/jme-2022-108816 · Cited by 41 · see citing works
Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential
Allen, J., Dames, S., Foldi, C. J., & Shultz, S. R. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02360-0 · Cited by 38 · see citing works
Egger, K., Aicher, H., Cumming, P. D., & Scheidegger, M. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05353-6 · Cited by 36 · see citing works
From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation
Krasner, H., Ong, C. V., Hewitt, P., & Vida, T. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073219 · Cited by 36 · see citing works
Pagni, B. A., Petridis, P. D., Podrebarac, S. K., Grinband, J., Claus, E. D., & Bogenschutz, M. P. (2024) · Scientific Reports · doi:10.1038/s41598-024-52967-8 · Cited by 34 · see citing works
Self-citationPsychedelic‐assisted treatment for substance use disorder: A narrative systematic review
Piper, T., Small, F., Brown, S., Kelleher, M., Mitcheson, L., Rucker, J., Young, A. H., & Marsden, J. (2025) · Addiction · doi:10.1111/add.16762 · Cited by 35 · see citing works
Psychedelics in neuroinflammation: Mechanisms and therapeutic potential
de Deus, J. L., Maia, J. M., Soriano, R. N., Amorim, M. R., & Branco, L. G. S. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111278 · Cited by 34 · see citing works
Lord, B., Sanguinetti, J. L., Ruiz, L., Miskovic, V., Segre, J., Young, S., Fini, M. E., & Allen, J. J. B. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1392199 · Cited by 31 · see citing works
Soares, C., Mier, G. G., Castelhano, J., & Castelo-Branco, M. S. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105325 · Cited by 30 · see citing works
Avram, M., Fortea, L., Wollner, L., Coenen, R., Korda, A. I., Rogg, H. V., Holze, F., Vizeli, P., Ley, L., Raduà, J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02734-y · Cited by 29 · see citing works
Impact of psilocybin on cognitive function: A systematic review
Meshkat, S., Tello-Gerez, T. J., Gholaminezhad, F., Dunkley, B. T., Reichelt, A. C., Erritzøe, D., Vermetten, E. H. G. J. M., Zhang, Y., Greenshaw, A. J., Burback, L., et al. (2024) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13741 · Cited by 29 · see citing works
Pharmacokinetics of Psilocybin: A Systematic Review
Meshkat, S., Al-Shamali, H. F., Perivolaris, A., Tullu, T., Zeifman, R. J., Zhang, Y., Burback, L., Winkler, O., Greenshaw, A. J., Husain, M. I., et al. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17040411 · Cited by 29 · see citing works
Rapid-acting antidepressant drugs modulate affective bias in rats
Hinchcliffe, J. K., Stuart, S. A., Wood, C. M., Bartlett, J. M., Kamenish, K., Arban, R., Thomas, C. W., Selimbeyoglu, A., Hurley, S., Hengerer, B., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adi2403 · Cited by 27 · see citing works
(2024) · doi:10.1177/02698811231215420 · Cited by 25 · see citing works
Larrea, A., Sánchez-Sánchez, L., Díez-Martín, E., Elexpe, A., Torrecilla, M., Astigarraga, E., & Barreda‐Gómez, G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13061727 · Cited by 28 · see citing works
Padawer-Curry, J. A., Krentzman, O. J., Kuo, C., Wang, X., Bice, A. R., Nicol, G. E., Snyder, A. Z., Siegel, J. S., McCall, J. G., & Bauer, A. Q. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02069-z · Cited by 28 · see citing works
Gattuso, J. J., Wilson, C., Hannan, A. J., & Renoir, T. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16017 · Cited by 23 · see citing works
Self-citationTolle, H. M., Farah, J. C., Mallaroni, P., Mason, N. L., Ramaekers, J. G., & Amico, E. (2023) · Network Neuroscience · doi:10.1162/netn_a_00349 · Cited by 22 · see citing works
Psychedelics and neonihilism: connectedness in a meaningless world
Plesa, P., & Petranker, R. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1125780 · Cited by 21 · see citing works
Is microdosing a placebo? A rapid review of low-dose LSD and psilocybin research
Polito, V., & Liknaitzky, P. (2024) · Journal of Psychopharmacology · doi:10.1177/02698811241254831 · Cited by 19 · see citing works
Transcranial focused ultrasound targeting the default mode network for the treatment of depression
Schachtner, J. N., Dahill-Fuchel, J. F., Ehrmann, K., Bawiec, C. R., Hollender, P. J., Ornellas, S. B., Konecky, S. D., Achrol, A. S., & Allen, J. J. B. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1451828 · Cited by 20 · see citing works
Efficacy and safety of psilocybin for the treatment of substance use disorders: A systematic review
Meshkat, S., Malik, G., Zeifman, R. J., Swainson, J., Balachandra, K., Reichelt, A. C., Zhang, Y., Burback, L., Winkler, O., Greenshaw, A. J., et al. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106163 · Cited by 21 · see citing works
Hogea, L., Tabugan, D. C., Costea, I., Albai, O., Nussbaum, L. A., Cojocaru, A., Corsaro, L., & Anghel, T. (2025) · Medicina · doi:10.3390/medicina61020278 · Cited by 19 · see citing works
Uncovering psychedelics: from neural circuits to therapeutic applications
Melani, A., Bonaso, M., Biso, L., Zucchini, B., Conversano, C., & Scarselli, M. (2025) · Pharmaceuticals · doi:10.3390/ph18010130 · Cited by 17 · see citing works
Tap, S. C. (2024) · Addiction Biology · doi:10.1111/adb.13386 · Cited by 16 · see citing works
Mind over matter: the microbial mindscapes of psychedelics and the gut-brain axis
Caspani, G., Ruffell, S., Tsang, W., Netzband, N., Rohani-Shukla, C., Swann, J. R., & Jefferies, W. A. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107338 · Cited by 18 · see citing works
Self-citationArmstrong, M., Castellanos, J. P., & Christie, D. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1346053 · Cited by 17 · see citing works
Synthetic surprise as the foundation of the psychedelic experience
Filippo, R. D., & Schmitz, D. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105538 · Cited by 15 · see citing works
Kinderlehrer, D. A. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s500337 · Cited by 15 · see citing works
Psychedelics align brain activity with context
Stoliker, D., Novelli, L., Khajehnejad, M. A., Biabani, M., Greaves, M. D., Barta, T., Williams, M., Chopra, S., Bazin, O., Simonsson, O., et al. (2026) · Nature · doi:10.1038/s41586-026-10910-z · Cited by 16 · see citing works
Tempone-Wiltshire, J., & Matthews, F. (2023) · Journal of Psychedelic Studies · doi:10.1556/2054.2023.00275 · Cited by 18 · see citing works
Orlowski, P., Hobot, J., Ruban, A., Szczypiński, J., & Bola, M. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231216322 · Cited by 14 · see citing works
Brain Networks, Neurotransmitters and Psychedelics: Towards a Neurochemistry of Self-Awareness
Mograbi, D. C., Rodrigues, R. F. S., Bienemann, B., & Huntley, J. D. (2024) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-024-01353-y · Cited by 16 · see citing works
Clinical Effects of Psychedelic Substances Reported to United States Poison Centers: 2012 to 2022
Simon, M. W., Olsen, H. A., Hoyte, C. O., Black, J. C., Reynolds, K. M., Dart, R. C., & Monte, A. A. (2024) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2024.06.025 · Cited by 14 · see citing works
Spirituality as a Therapeutic Approach for Severe Mental Illness: Insights from Neural Networks
Knegtering, H., Bruggeman, R., & Spoelstra, S. K. (2024) · Religions · doi:10.3390/rel15040489 · Cited by 14 · see citing works
Elfrink, S., & Bergin, L. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1528253 · Cited by 14 · see citing works
Psychedelics, entactogens and psychoplastogens for depression and related disorders
Hoyer, D. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70088 · Cited by 13 · see citing works
Self-citationAdebo, M., Bonnet, M., Laouej, O., Defaix, C., McGowan, J. C., Butlen‐Ducuing, F., David, D. J. P., Poupon, E., Tritschler, L., & Gardier, A. M. (2025) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.70038 · Cited by 12 · see citing works
Know thyself (Jnana Yoga): Psychotherapeutic insights from the east
Keshavan, M. S., & Bhargav, H. (2024) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2023.103907 · Cited by 13 · see citing works
Incremental efficacy systematic review and meta-analysis of psilocybin-for-depression RCTs
Borgogna, N. C., Owen, T., Petrovitch, D., Vaughn, J., Johnson, D. A., Pagano, L. A., Aita, S. L., & Hill, B. D. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06788-w · Cited by 12 · see citing works
Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives
Czopek, A., Jończyk, J., Fryc, M., Kluzik, D., & Zagórska, A. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00152 · Cited by 12 · see citing works
Psychedelics as a potential treatment for tobacco use disorder: a systematic review
Spoelstra, S. K., Schoevers, R. A., Venema, S. D., & Knegtering, H. (2024) · Discover Mental Health · doi:10.1007/s44192-024-00095-0 · Cited by 12 · see citing works
Psychedelics and Consciousness: Expanding the Horizons of Mind and Therapy
Zhang, M.-Y., Wang, Y.-B., Gao, T.-M., & Wang, X. (2024) · Research · doi:10.34133/research.0495 · Cited by 12 · see citing works
Advances in brain and religion studies: a review and synthesis of recent representative studies
McNamara, P., & Grafman, J. H. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1495565 · Cited by 12 · see citing works
Catalyst for change: Psilocybin’s antidepressant mechanisms—A systematic review
Liebnau, J., Betzler, F., & Kerber, A. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811241312866 · Cited by 12 · see citing works
Recreational use of psychedelics at music festivals: Motivation, nature of experiences and learnings
Mosina, I., & Michael, P. (2024) · Journal of Psychedelic Studies · doi:10.1556/2054.2023.00282 · Cited by 10 · see citing works
IUPHAR review: Moving beyond dopamine-based therapeutic strategies for schizophrenia
Moran, P. M., & Granger, K. T. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107727 · Cited by 12 · see citing works
Dynamic Functional Connectivity Correlates of Trait Mindfulness in Early Adolescence
Treves, I. N., Marusak, H. A., Decker, A. L., Kucyi, A., Hubbard, N. A., Bauer, C. C. C., Leonard, J., Grotzinger, H., Giebler, M. A., Torres, Y. C., et al. (2024) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2024.100367 · Cited by 10 · see citing works
Treves, I. N., Yang, W. F. Z., Sparby, T., & Sacchet, M. D. (2024) · Network Neuroscience · doi:10.1162/netn_a_00432 · Cited by 10 · see citing works
Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans
Colombo, M. A., Favaro, J., Mikulan, E., Pigorini, A., Zauli, F. M., Sartori, I., d’Orio, P., Castana, L., Toldo, I., Sartori, S., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003060 · Cited by 10 · see citing works
Efthimiou, A. A., Cardinale, A. M., & Kepa, A. (2024) · Psychedelic Medicine · doi:10.1089/psymed.2023.0058 · Cited by 10 · see citing works
Considering distinct positive emotions in psychedelic science
Goldy, S. P., Hendricks, P. S., Keltner, D. J., & Yaden, D. B. (2024) · International Review of Psychiatry · doi:10.1080/09540261.2024.2394221 · Cited by 9 · see citing works
Serotonergic Psychedelics Rapidly Modulate Evoked Glutamate Release in Cultured Cortical Neurons
Petrušková, A., Guhathakurta, D., Akdaş, E. Y., Perelló‐Amorós, B., Frischknecht, R., Weiss, E., Páleníček, T., & Fejtová, A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70020 · Cited by 9 · see citing works
Psychedelic medicine: mechanisms, evidence, and translation to practice
Jacobs, E., Zahid, Z., Hinkle, J. T., Nayak, S. M., & Yaden, D. B. (2026) · BMJ · doi:10.1136/bmj-2024-081723 · Cited by 9 · see citing works
Amaya, I. A., Schmidt, M. E., Bartossek, M. T., Kemmerer, J., Kirilina, E. P., Nierhaus, T., & Schmidt, T. T. (2023) · Imaging Neuroscience · doi:10.1162/imag_a_00033 · Cited by 7 · see citing works
Aixalà, M. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_532 · Cited by 9 · see citing works
Świeczkowski, D., Kwaśny, A., & Cubała, W. J. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111419 · Cited by 8 · see citing works
The nature of nonduality: The epistemic implications of meditative and psychedelic experiences
Tempone-Wiltshire, J., & Matthews, F. (2024) · Anthropology of Consciousness · doi:10.1111/anoc.12233 · Cited by 8 · see citing works
Braak, S., Bakker, G., Su, T., Osinga, C., Nawijn, L., van Tol, M., van der Wee, N. J. A., Pijnenburg, Y. A. L., & Penninx, B. W. J. H. (2024) · Depression and Anxiety · doi:10.1155/2024/8564344 · Cited by 6 · see citing works
Seragnoli, F., Picard, F., Thorens, G., Buchard, A., Geyer, M., Abatista, A., Ponomarenko, P., Petignat, C., Riccardi, M., Bisson, M. D., et al. (2025) · Cognitive Therapy and Research · doi:10.1007/s10608-025-10588-z · Cited by 7 · see citing works
Aparicio‐Terrés, R., López‐Mochales, S., Díaz‐Andreu, M., & Escera, C. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1574836 · Cited by 7 · see citing works
Roseby, W., Kettner, H., Roseman, L., Spriggs, M. J., Lyons, T., Peill, J., Giribaldi, B., Erritzøe, D., Nutt, D. J., & Carhart-Harris, R. L. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1580663 · Cited by 7 · see citing works
Self-citationPsilocybin in late-life mental health: Addressing depression, loneliness, and existential anxiety
Konstantinou, G., Rosenblat, J. D., Hales, S., Husain, M. I., & Blumberger, D. M. (2025) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2025.12.005 · Cited by 7 · see citing works
Neuroscientists must not be afraid to study religion
McNamara, P., Newsome, W. T., Linkenhoker, B. A., & Grafman, J. H. (2024) · Nature · doi:10.1038/d41586-024-02153-7 · Cited by 7 · see citing works
Zhong, S., Lin, J.-P., Zhang, L., Wang, S., Kemp, G. J., Li, L., & Gong, Q.-Y. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03091-8 · Cited by 6 · see citing works
Psychedelics and substance use disorder treatment
DuPont, C. M., & Johnson, M. W. (2025) · International review of neurobiology · doi:10.1016/bs.irn.2025.03.005 · Cited by 7 · see citing works
Ramos, L., & Vicente, S. (2024) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2024.2363343 · Cited by 6 · see citing works
Irrmischer, M., Puxty, D. J., Yıldırım, B. O., Deijen, J. B., & Engelbregt, H. (2025) · Psychopharmacology · doi:10.1007/s00213-024-06733-3 · Cited by 6 · see citing works
Zhao, C. Y. (2025) · Humanities and Social Sciences Communications · doi:10.1057/s41599-025-04387-w · Cited by 7 · see citing works
Roméo, B., Kervadec, E., Fauvel, B., Strika-Bruneau, L., Amirouche, A., Verroust, V., Piolino, P., & Benyamina, A. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111300 · Cited by 7 · see citing works
Forsberg, S., Downey, A. E., Bruett, L. D., Hail, L., Fernandes‐Osterhold, G., Woolley, J. D., Lafrance, A., & Raymond‐Flesch, M. (2025) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-025-00930-4 · Cited by 6 · see citing works
What fMRI studies say about the nature of the psychedelic effect: a scoping review
Beneš, M., Páleníček, T., & Horáček, J. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1606798 · Cited by 7 · see citing works
Ulisse, K., Albitar, J., Aromin, J. T., & Berry, J. H. (2025) · Brain Sciences · doi:10.3390/brainsci15090980 · Cited by 6 · see citing works
Breaking the chains of depression: A systematic review and meta-analysis of psilocybin therapy
Khan, F. A., Pandupuspitasari, N. S., Tencomnao, T., & Chuchawankul, S. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120882 · Cited by 6 · see citing works
McNamara, P. (2023) · Cortex · doi:10.1016/j.cortex.2023.10.015 · Cited by 6 · see citing works
Long‐COVID symptoms improved after MDMA and psilocybin therapy: A case report
Chopra, H., Furnish, T. J., Verduzco‐Gutierrez, M., Jevotovsky, D. S., & Castellanos, J. P. (2024) · Clinical Case Reports · doi:10.1002/ccr3.8791 · Cited by 6 · see citing works
Novel treatments of depression: bridging the gap in current therapeutic approaches
Jagtiani, A. (2024) · Exploration of neuroscience · doi:10.37349/en.2024.00049 · Cited by 6 · see citing works
Rab, S. F., Raison, C. L., & Marseille, E. A. (2024) · Psychedelics. · doi:10.61373/pp024r.0025 · Cited by 7 · see citing works
Jiwani, Z., Goldberg, S. B., Stroud, J., Young, J., Curtin, J., Dunne, J. D., Simonsson, O., Webb, C. A., Carhart-Harris, R., & Schlosser, M. (2025) · PLOS ONE · doi:10.1371/journal.pone.0310160 · Cited by 6 · see citing works
Classic Psychedelics for the Treatment of Depression: Potential Benefits and Challenges
Ghaznavi, S., & Richter, S. G. (2025) · Drugs · doi:10.1007/s40265-025-02172-2 · Cited by 6 · see citing works
Jones, J. L. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1565852 · Cited by 6 · see citing works
Neural Network Modulation of Ayahuasca: A Systematic Review of Human Studies
Santos, G. H. D. M., Rodrigues, L. S., Rocha, J. M., Rossi, G. N., Oña, G., Bouso, J. C., Hallak, J. E. C., & SANTOS, R. G. D. (2023) · Psychoactives · doi:10.3390/psychoactives2010006 · Cited by 7 · see citing works
Systematic review and rationale of using psychedelics in the treatment of cannabis use disorder
Phan, A. N., & Terry, G. E. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1144276 · Cited by 6 · see citing works
Leveraging meditation research for the study of psychedelic-related adverse effects
Palitsky, R., Canby, N. K., Dam, N. T. V., Levin-Aspenson, H. F., Kaplan, D. M., Maples‐Keller, J. L., Raison, C. L., Grant, G. H., Dunlop, B. W., & Britton, W. B. (2024) · International Review of Psychiatry · doi:10.1080/09540261.2024.2420745 · Cited by 7 · see citing works
Hernández‐Álvarez, E., Rojas‐Hernández, J., Borkel, L. F., Hernández, D. J. Q., Fernández‐Borkel, T., & Henríquez‐Hernández, L. A. (2025) · Veterinary Sciences · doi:10.3390/vetsci12090872 · Cited by 5 · see citing works
The Therapeutic Effects of Classic Psychedelics in Alcohol Use Disorder
Pagni, B. A., Wong, J. M., & Bogenschutz, M. P. (2024) · Current Addiction Reports · doi:10.1007/s40429-024-00581-z · Cited by 5 · see citing works
Self-citationThe Psychedelic Renaissance: A Catholic Perspective
Carroll, T. (2024) · The Linacre Quarterly · doi:10.1177/00243639241274818 · Cited by 5 · see citing works
Madl, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-73789-8 · Cited by 5 · see citing works
Levin, A. W. (2024) · Journal of Psychopharmacology · doi:10.1177/02698811241303599 · Cited by 5 · see citing works
Majić, T., Schmidt, T. T., Gröticke, A., Gasser, P., Richards, W. A., Riemer, T., & Evens, R. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251326937 · Cited by 5 · see citing works
Pasculli, G., Busan, P., Jackson, E. S., Alm, P. A., Gregorio, D. D., Maguire, G. A., Goodwin, G. M., Gobbi, G., Erritzøe, D., & Carhart-Harris, R. L. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1402549 · Cited by 6 · see citing works
Ekoh, F., Rerrie, S., Angud, J., & Mirabelli, E. (2025) · Psychoactives · doi:10.3390/psychoactives4040039 · Cited by 4 · see citing works
Psychedelics in functional disorders: A scoping review
Bhagavan, C., Carter, O. L., Bryson, A., Dandash, O., & Kanaan, R. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111642 · Cited by 4 · see citing works
Amaya, I. A., Nierhaus, T., & Schmidt, T. T. (2024) · Network Neuroscience · doi:10.1162/netn_a_00417 · Cited by 4 · see citing works
- Authors
- Gattuso, J. J., Perkins, D., Ruffell, S., Lawrence, A. J., Hoyer, D., Jacobson, L. H., Timmermann, C., Castle, D., Rossell, S. L., Downey, L. A., Pagni, B. A., Galvão-Coelho, N. L., Nutt, D., & Sarris, J.
- Affiliations
- The University of Melbourne (AU)
- King's College London (GB)
- MDHS, University of Melbourne , Parkville, Victoria , Australia
- Imperial College London (GB)
- University of Toronto (CA)
- Swinburne University of Technology (AU)
- Arizona State University (US)
- Department of Physiology and Behavior, Universidade Federal do Rio Grande do Norte , Brazil
- Corresponding author
- Gattuso, James J
- ORCID
- Venue
- International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-10-22
- Volume
- 26
- Issue
- 3
- Pages
- 155-188
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- PMC
- PMC10032309
- OpenAlex
- W4307093712
- Cited by
- 256
- References
- 122
- Citations by year
- 2026: 79 · 2025: 95 · 2024: 61 · 2023: 21
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (GNT1154651)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- default mode network, psychedelics, resting-state functional connectivity, LSD, psilocybin, ayahuasca, mind wandering, self-referential processing, neuropsychiatric disorders
- MeSH terms
- Default Mode Network, Brain, Hallucinogens, Lysergic Acid Diethylamide, Magnetic Resonance Imaging, Psilocybin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
