Feeling left out: Depressed adolescents may atypically recruit emotional salience and regulation networks during social exclusion
Open accessAbstract
Depression is associated with negative attention and attribution biases and maladaptive emotion responsivity and regulation, which adversely impact self-evaluations and interpersonal relationships. Using functional magnetic resonance imaging, we investigated the neural substrates of these impairments. We compared neural activity recruited by 126 clinically depressed and healthy adolescents (ages 11-17 years) during social exclusion (Exclusion > Inclusion) using Cyberball. Results revealed significant interaction effects within left anterior insula (AI)/inferior frontal gyrus and left middle temporal gyrus. Insula hyperresponsivity was associated with peer exclusion for depressed adolescents but peer inclusion for healthy adolescents. In additional, healthy adolescents recruited greater lateral temporal activity during peer exclusion. Complementary effect size analyses within independent parcellations offered converging evidence, as well as highlighted medium-to-large effects within subgenual/ventral anterior cingulate cortex and lateral prefrontal, lateral temporal and lateral parietal regions implicated in emotion regulation. Depressogenic neural patterns were associated with negative self-perceptions and negative information processing biases. These findings suggest a neural mechanism underlying cognitive biases in depression, as reflected by emotional hyperresponsivity and maladaptive regulation/reappraisal of negative social evaluative information. This study lends further support for salience and central executive network dysfunction underlying social threat processing, and in particular, highlights the anterior insula as a key region of disturbance in adolescent depression.
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Collectively, neuroimaging studies demonstrate consistent evidence of engagement in subgenual ACC, vlPFC, posterior midline regions, and ventral striatum during social exclusion; paradigms looking at anticipation/receipt of social evaluative feedback additionally elicit responses in amygdala and medial orbitofrontal cortex.
“Collectively, these studies demonstrate consistent evidence of engagement in subgenual ACC (sgACC), vlPFC, posterior midline regions, and ventral striatum (for a meta-analysis, see (124)); the paradigms that look at anticipation/receipt of social evaluative feedback additionally elicit responses in amygdala and medial orbitofrontal cortex.(39,122,123,125)”
From Puberty Initiates Cascading Relationships Between Neurodevelopmental, Social, and Internalizing Processes Across Adolescence (2021) · cites this paper as [123]
The anterior insula, part of the salience network, has been implicated in atypical responses to social exclusion in depression and anxiety, but the direction of effects has been mixed.
“The anterior insula, part of the salience network, has also been implicated in atypical responses to social exclusion in depression(123,126) and anxiety,(127) but the direction of effects has been mixed.”
From Puberty Initiates Cascading Relationships Between Neurodevelopmental, Social, and Internalizing Processes Across Adolescence (2021) · cites this paper as [123]
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- Authors
- Jankowski, K. F., Batres, J., Scott, H., Smyda, G., Pfeifer, J. H., & Quevedo, K.
- Affiliations
- University of Oregon (US)
- University of Minnesota (US)
- University of Pittsburgh (US)
- Corresponding author
- Quevedo, Karina
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-08
- Volume
- 13
- Issue
- 8
- Pages
- 863-876
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC6123522
- OpenAlex
- W2888351643
- Cited by
- 80
- References
- 120
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 14 · 2023: 10 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 7 · 2018: 1
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K01MH092601)
- National Alliance for Research on Schizophrenia and Depression
- National Science Foundation Graduate Research Fellowship (2011122786)
- Autism Speaks Weatherstone Predoctoral Fellowship
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Death Anxiety and Social Exclusion
- Keywords
- adolescent depression, social exclusion, Cyberball, anterior insula, emotion regulation, cognitive biases, self-perception, left inferior frontal gyrus, middle temporal gyrus, subgenual anterior cingulate cortex, lateral prefrontal cortex, lateral temporal cortex, lateral parietal cortex
- MeSH terms
- Adolescent, Brain Mapping, Cerebral Cortex, Child, Computer Simulation, Depressive Disorder, Emotions, Female, Frontal Lobe, Gyrus Cinguli, Humans, Interpersonal Relations, Magnetic Resonance Imaging, Male, Nerve Net, Rejection, Psychology, Social Behavior, Temporal Lobe
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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