Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,591

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Vitamin E: function and metabolism

Brigelius‐Flohé, Regina, Traber, Maret G.·1999·The FASEB Journal
DOI 10.1096/fasebj.13.10.1145
Open this paper in CoChat — free account

Abstract

Although vitamin E has been known as an essential nutrient for reproduction since 1922, we are far from understanding the mechanisms of its physiological functions. Vitamin E is the term for a group of tocopherols and tocotrienols, of which α‐tocopherol has the highest biological activity. Due to the potent antioxidant properties of tocopherols, the impact of α‐tocopherol in the prevention of chronic diseases believed to be associated with oxidative stress has often been studied, and beneficial effects have been demonstrated. Recent observations that the α‐tocopherol transfer protein in the liver specifically sorts out RRR‐α ‐tocopherol from all incoming tocopherols for incorporation into plasma lipoproteins, and that α ‐tocopherol has signaling functions in vascular smooth muscle cells that cannot be exerted by other forms of tocopherol with similar antioxidative properties, have raised interest in the roles of vitamin E beyond its antioxidative function. Also, γ‐tocopherol might have functions apart from being an antioxidant. It is a nucleophile able to trap electrophilic mutagens in lipophilic compartments and generates a metabolite that facilitates natriuresis. The metabolism of vitamin E is equally unclear. Excess α ‐tocopherol is converted into α ‐CEHC and excreted in the urine. Other tocopherols, like γ‐ and δ‐tocopherol, are almost quantitatively degraded and excreted in the urine as the corresponding CEHCs. All rac α ‐tocopherol compared to RRR‐α ‐tocopherol is preferentially degraded to α ‐CEHC. Thus, there must be a specific, molecular role of RRR‐α ‐tocopherol that is regulated by a system that sorts, distributes, and degrades the different forms of vitamin E, but has not yet been identified. In this article we try to summarize current knowledge on the function of vitamin E, with emphasis on its antioxidant vs. other properties, the preference of the organism for RRR‐α ‐tocopherol, and its metabolism to CEHCs.—Brigelius‐Flohé, R., Traber, M. G. Vitamin E: function and metabolism. FASEB J. 13, 1145–1155 (1999)

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1096/fasebj.13.10.1145

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 3 references

Cited by

Metadata

Authors
Brigelius‐Flohé, R., & Traber, M. G.
Venue
The FASEB Journal
Publisher
Wiley
Published
1999-07
Volume
13
Issue
10
Pages
1145-1155
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fasebj.13.10.1145
OpenAlex
W1941294128
Cited by
1,591
References
3
FWCI
20.63
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.