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Biology of interleukin 1
Abstract
Interleukin 1 (IL 1) is a polypeptide that is produced after infection, injury, or antigenic challenge. Although the macrophage is a primary source of IL 1, epidermal, epithelial, lymphoid, and vascular tissues synthesize IL 1. When IL 1 gains access to the circulation, it acts like a hormone and induces a broad spectrum of systemic changes in neurological, metabolic, hematologic, and endocrinologic systems. Some of the IL 1 that is synthesized remains associated with the plasma membrane and induces changes in local tissues without producing systemic responses. IL 1 affects mesenchymal tissue remodeling where it contributes to both destructive and repair processes. IL 1 activates lymphocytes and plays an important role in the initiation of the immune response. Receptors for IL 1 have been identified, but receptors are scarce and their affinities often do not match the potency of the biological response. The most consistent property of IL 1 is up‐regulation of cellular metabolism and increased expression of several genes coding for biologically active molecules. IL 1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites. IL 1 also acts synergistically with other cytokines, particularly tumor necrosis factor. The multitude of biological responses to IL 1 is an example of the rapid adaptive changes that take place to increase the host's defensive mechanisms.—D inarello , C. A. Biology of interleukin 1. FASEB J. 2: 108‐115; 1988.
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Metadata
- Authors
- Dinarello, C. A.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1988-02
- Volume
- 2
- Issue
- 2
- Pages
- 108-115
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1848552725
- Cited by
- 1,532
- References
- 1
- FWCI
- 83.42
- Type
- journal article
- Language
- en
- Open access
- closed
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