Cited by 178Child and Adolescent Psychosocial and Emotional DevelopmentFamily Support in IllnessGenetic Associations and Epidemiology

Influence of Parental Concordance for Psychiatric Disorders on Psychopathology in Offspring

Dierker, Lisa C., Merikangas, Kathleen R., Szatmari, Peter·1999·Journal of the American Academy of Child & Adolescent Psychiatry

Abstract

Objective To examine the influence of parental mating types for substance abuse and anxiety/affective disorders on the risk of psychopathology among child and adolescent offspring.Method Emotional and behavioral disorders were assessed in offspring, aged 7 to 17 years, of male and female parents who served as probands from a family study of comorbidity of substance abuse and anxiety disorders.Results The findings indicated that (1) patterns of psychopathology among offspring were similar for mothers and fathers; (2) spouse concordance for psychopathology was greater among parents with substance abuse than among those with anxiety, particularly among female substance abusers; (3) there was a direct relationship between the number of affected parents and the magnitude of psychopathology in children, particularly with respect to the anxiety disorders; and (4) by contrast, rates of conduct disorder were elevated only among offspring of dually affected parents, irrespective of the specific parental disorders.Conclusions These findings underscore the importance of the contribution of both mothers and fathers, particularly those with concordance for psychiatric disorders, to the development of psychopathology in offspring.

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Crossref · 10.1097/00004583-199903000-00015

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Authors
Dierker, L. C., Merikangas, K. R., & Szatmari, P.
Affiliations
Wesleyan University (US)
Corresponding author
Dierker, Lisa C.
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
1999-03
Volume
38
Issue
3
Pages
280-288
ISSN
0890-8567 (ISSN-L)
OpenAlex
W1975108638
Cited by
178
References
59
Citations by year
2026: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 6 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 9 · 2014: 4 · 2013: 2 · 2012: 16
FWCI
10.42
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01aa009978-05)
  • National Institute on Alcohol Abuse and Alcoholism (AA09978, R01AA007080, AA-07080)
  • National Institute on Drug Abuse (DA 05348)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Sociology and Political Science › Family Support in Illness
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
substance abuse, anxiety disorders, mood disorders, offspring psychopathology, child and adolescent psychopathology, conduct disorder, comorbidities, maternal substance abuse
MeSH terms
Adolescent, Affective Symptoms, Anxiety Disorders, Mental Disorders, Child, Child Behavior Disorders, Female, Humans, Male, Psychopathology, Risk Factors, Social Environment, Comorbidity, Child of Impaired Parents, Mood Disorders, Substance-Related Disorders, Genetic Predisposition to Disease

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