Can physical exercise in old age improve memory and hippocampal function?
Open accessAbstract
Physical exercise can convey a protective effect against cognitive decline in ageing and Alzheimer’s disease. While the long-term health-promoting and protective effects of exercise are encouraging, it’s potential to induce neuronal and vascular plasticity in the ageing brain is still poorly understood. It remains unclear whether exercise slows the trajectory of normal ageing by modifying vascular and metabolic risk factors and/or consistently boosts brain function by inducing structural and neurochemical changes in the hippocampus and related medial temporal lobe circuitry—brain areas that are important for learning and memory. Hence, it remains to be established to what extent exercise interventions in old age can improve brain plasticity above and beyond preservation of function. Existing data suggest that exercise trials aiming for improvement and preservation may require different outcome measures and that the balance between the two may depend on exercise intensity and duration, the presence of preclinical Alzheimer’s disease pathology, vascular and metabolic risk factors and genetic variability. Physical activity can offer protection against cognitive decline and neurodegenerative diseases, but whether it slows the trajectory of normal ageing or boosts plasticity above and beyond preservation of function is unclear. Duzel et al. examine the evidence that exercise improves hippocampal plasticity in ageing and discuss avenues for future research.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exercise intensities may vary depending on the purpose of the intervention; improving cognitive performance may require high-intensity interval training, while preserving cognitive function in an aging brain may require a lower intensity, more continuous protocol.
“It is possible that exercise intensities may vary depending on the purpose of the intervention, for example it has been suggested that improving cognitive performance may require high-intensity, interval training but preserving cognitive function in an aging brain may require a lower intensity, more continuous protocol (Duzel et al., 2016).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Duzel et al., 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855 · see citing works
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888 · see citing works
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814 · see citing works
Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689 · see citing works
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258 · see citing works
The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580 · see citing works
Potential for primary prevention of Alzheimer's disease: an analysis of population-based data
Norton, S., Matthews, F. E., Barnes, D. E., Yaffe, K., & Brayne, C. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70136-x · Cited by 2,466 · see citing works
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268 · see citing works
Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2177-05.2005 · Cited by 2,140 · see citing works
Aerobic Exercise Training Increases Brain Volume in Aging Humans
Colcombe, S. J., Erickson, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., Elavsky, S., Marquez, D. X., Hu, L., & Kramer, A. F. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.11.1166 · Cited by 2,134 · see citing works
Blood-brain barrier breakdown in the aging human hippocampus
Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.032 · Cited by 2,102 · see citing works
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060 · see citing works
The Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works
Dynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · see citing works
Cardiovascular fitness, cortical plasticity, and aging
Colcombe, S. J., Kramer, A. F., Erickson, K. I., Scalf, P., McAuley, E., Cohen, N. J., Webb, A., Jerome, G. J., Marquez, D. X., & Elavsky, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400266101 · Cited by 1,648 · see citing works
Lautenschlager, N. T., Cox, K. L., Flicker, L., Foster, J. K., van Bockxmeer, F. M., Xiao, J., Greenop, K. R., & Almeida, O. P. (2008) · JAMA · doi:10.1001/jama.300.9.1027 · Cited by 1,637 · see citing works
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis
Jansen, W. J., Ossenkoppele, R., Knol, D. L., Tijms, B. M., Scheltens, P., Verhey, F. R. J., Visser, P. J., Aalten, P., Aarsland, D., Alcolea, D., et al. (2015) · JAMA · doi:10.1001/jama.2015.4668 · Cited by 1,610 · see citing works
Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
Leutgeb, J. K., Leutgeb, S., Moser, M.-B., & Moser, E. I. (2007) · Science · doi:10.1126/science.1135801 · Cited by 1,601 · cited 1× · see citing works
“The dentate gyrus (DG) seems to be important for pattern separation of novel information (Leutgeb et al., 2007; Neunuebel and Knierim, 2014), whereas CA3 (not visible in this section) is implicated in pattern completion.”
BackgroundIncreasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works
Pattern separation in the hippocampus
Yassa, M. A., & Stark, C. E. L. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.006 · Cited by 1,544 · see citing works
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426 · see citing works
An <i>in vivo</i> correlate of exercise-induced neurogenesis in the adult dentate gyrus
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353 · see citing works
Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233 · see citing works
AMPK and PPARδ Agonists Are Exercise Mimetics
Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222 · see citing works
The AMP-activated protein kinase pathway – new players upstream and downstream
Hardie, D. G. (2004) · Journal of Cell Science · doi:10.1242/jcs.01540 · Cited by 1,136 · see citing works
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081 · see citing works
Exercise and brain neurotrophins
Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066 · see citing works
The anatomy of memory: an interactive overview of the parahippocampal–hippocampal network
van Strien, N. M., Cappaert, N. L. M., & Witter, M. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2614 · Cited by 1,041 · see citing works
Trejo, J. L., Carro, E., & Torres-Alemán, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01628.2001 · Cited by 1,017 · see citing works
Aerobic fitness reduces brain tissue loss in aging humans.
Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.2.m176 · Cited by 1,017 · see citing works
Neeper, S. A., Gómez‐Pinilla, F., Choi, J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/0006-8993(96)00273-9 · Cited by 1,015 · see citing works
Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging
Ahlskog, J. E., Geda, Y. E., Graff-Radford, N. R., & Petersen, R. C. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0252 · Cited by 885 · see citing works
Bomfim, T. R., Forny‐Germano, L., Sathler, L. B., Brito‐Moreira, J., Houzel, J., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57256 · Cited by 830 · see citing works
Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain
Carro, E., Nuñez, A., Busiguina, S., & Torres-Aleman, I. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02926.2000 · Cited by 762 · see citing works
The A4 Study: Stopping AD Before Symptoms Begin?
Sperling, R. A., Rentz, D. M., Johnson, K. A., Karlawish, J. H., Donohue, M., Salmon, D. P., & Aisen, P. S. S. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007941 · Cited by 756 · see citing works
Agudelo, L. Z., Femenía, T., Orhan, F., Porsmyr-Palmertz, M., Goiny, M., Martinez-Redondo, V., Correia, J. C., Izadi, M., Bhat, M., Schuppe-Koistinen, I., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.051 · Cited by 739 · see citing works
Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain
Louissaint, A., Rao, S., Leventhal, C., & Goldman, S. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00722-5 · Cited by 735 · see citing works
Podewils, L. J. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi092 · Cited by 675 · see citing works
Neurogenesis and Exercise: Past and Future Directions
van Praag, H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8028-z · Cited by 645 · see citing works
Charidimou, A., Gang, Q., & Werring, D. J. (2012) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301308 · Cited by 611 · see citing works
Exercise and the brain: something to chew on
van Praag, H. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.007 · Cited by 599 · see citing works
Self-citationInterventions to slow aging in humans: are we ready?
Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works
Cooper, C., Sommerlad, A., Lyketsos, C. G., & Livingston, G. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14070878 · Cited by 570 · see citing works
Running enhances spatial pattern separation in mice
Creer, D. J., Romberg, C., Saksida, L. M., van Praag, H., & Bussey, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911725107 · Cited by 553 · see citing works
Self-citationThe preclinical phase of the pathological process underlying sporadic Alzheimer’s disease
Braak, H., & Del Tredici, K. (2015) · Brain · doi:10.1093/brain/awv236 · Cited by 540 · see citing works
Emergence of Individuality in Genetically Identical Mice
Freund, J., Brandmaier, A. M., Lewejohann, L., Kirste, I., Kritzler, M., Krüger, A., Sachser, N., Lindenberger, U., & Kempermann, G. (2013) · Science · doi:10.1126/science.1235294 · Cited by 536 · cited 2× · see citing works
“Until the sources of outcome variability (Freund et al., 2013) are better understood, individuals at risk for adverse effects can be identified and criteria for either terminating or adapting intensity (Box 1) are developed, it seems premature to unrestrictedly prescribe moderate-to-intensive exercise interventions in…”
BackgroundFrom angiogenesis to neuropathology
Greenberg, D. A., & Jin, K. (2005) · Nature · doi:10.1038/nature04481 · Cited by 532 · see citing works
Physical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499 · see citing works
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
Cohen, E., Paulsson, J. F., Blinder, P., Burstyn-Cohen, T., Du, D., Estepa, G., Adame, A., Pham, H. M., Holzenberger, M., Kelly, J. W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.014 · Cited by 488 · see citing works
Eadie, B. D., Redila, V. A., & Christie, B. R. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20493 · Cited by 466 · see citing works
Exergaming and Older Adult Cognition
Anderson-Hanley, C., Arciero, P. J., Brickman, A. M., Nimon, J. P., Okuma, N., Westen, S. C., Merz, M. E., Pence, B. D., Woods, J. A., Kramer, A. F., et al. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.10.016 · Cited by 464 · see citing works
Aerobic exercise effects on cognitive and neural plasticity in older adults
Erickson, K. I., & Kramer, A. F. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.052498 · Cited by 456 · see citing works
Neunuebel, J. P., & Knierim, J. J. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.017 · Cited by 454 · see citing works
Knierim, J. J., Neunuebel, J. P., & Deshmukh, S. S. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0369 · Cited by 425 · see citing works
Willette, A. A., Bendlin, B. B., Starks, E. J., Birdsill, A. C., Johnson, S. C., Christian, B. T., Okonkwo, O. C., La Rue, A., Hermann, B. P., Koscik, R. L., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0613 · Cited by 418 · see citing works
Neurobiological markers of exercise-related brain plasticity in older adults
Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Kim, J. S., Alves, H., Szabo, A., Phillips, S. M., Wójcicki, T. R., Mailey, E. L., et al. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.021 · Cited by 418 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 396 · see citing works
Suzuki, T., Shimada, H., Makizako, H., Doi, T., Yoshida, D., Ito, K., Shimokata, H., Washimi, Y., Endo, H., & Kato, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061483 · Cited by 390 · see citing works
Age-related production of new granule cells in the adult dentate gyrus
Seki, T., & Arai, Y. (1995) · Neuroreport · doi:10.1097/00001756-199512150-00010 · Cited by 386 · see citing works
Vascular hippocampal plasticity after aerobic exercise in older adults.
Maass, A., Düzel, S., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövden, M., Lindenberger, U., Bäckman, L., Braun-Dullaeus, R., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.114 · Cited by 382 · see citing works
Physical Activity and Cognitive Vitality
Prakash, R. S., Voss, M. W., Erickson, K. I., & Kramer, A. F. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015249 · Cited by 376 · see citing works
The Mental Activity and eXercise (MAX) Trial
Barnes, D. E., Santos‐Modesitt, W., Poelke, G., Kramer, A. F., Castro, C. M., Middleton, L. E., & Yaffe, K. S. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.189 · Cited by 376 · see citing works
All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis
Vivar, C., Potter, M. C., & van Praag, H. (2012) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_220 · Cited by 370 · see citing works
Self-citationKumaran, D., & McClelland, J. L. (2012) · Psychological Review · doi:10.1037/a0028681 · Cited by 358 · see citing works
Maaß, A., Düzel, S., Brigadski, T., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövdén, M., Lindenberger, U., Bäckman, L., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.084 · Cited by 358 · see citing works
Self-citationRojas Vega, S., Strüder, H. K., Vera Wahrmann, B., Schmidt, A., Bloch, W., & Hollmann, W. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.105 · Cited by 357 · see citing works
Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
Brickman, A. M., Khan, U., Provenzano, F. A., Yeung, L., SUZUKI, W. A., Schroeter, H., Wall, M. M., Sloan, R. P., & Small, S. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3850 · Cited by 349 · see citing works
Weinstein, A. M., Voss, M. W., Prakash, R. S., Chaddock, L., Szabo‐Reed, A. N., White, S. M., Wójcicki, T. R., Mailey, E. L., McAuley, E., Kramer, A. F., et al. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.008 · Cited by 342 · see citing works
Running induces widespread structural alterations in the hippocampus and entorhinal cortex
Stranahan, A. M., Khalil, D., & Gould, E. (2007) · Hippocampus · doi:10.1002/hipo.20348 · Cited by 327 · see citing works
Antidepressant effects of exercise: Evidence for an adult-neurogenesis hypothesis?
Ernst, C., Olson, A. K., Pinel, J. P. J., Lam, R. W., & Christie, B. R. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0610 · Cited by 322 · see citing works
PART is part of Alzheimer disease
Duyckaerts, C. J., Braak, H., Brion, J., Buée, L., Tredici, K. D., Goedert, M., Halliday, G. M., Neumann, M., Spillantini, M. G., Tolnay, M., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1390-7 · Cited by 316 · see citing works
The effects of aerobic activity on brain structure.
Thomas, A. G., Dennis, A., Bandettini, P. A., & Johansen-Berg, H. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00086 · Cited by 303 · see citing works
A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory
Tsivilis, D., Vann, S. D., Denby, C. E., Roberts, N., Mayes, A. R., Montaldi, D., & Aggleton, J. P. (2008) · Nature Neuroscience · doi:10.1038/nn.2149 · Cited by 299 · see citing works
Andrieu, S., Coley, N., Lovestone, S., Aisen, P. S., & Vellas, B. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00153-2 · Cited by 293 · see citing works
Rauskolb, S., Zagrebelsky, M., Dreznjak, A., Deogracias, R., Matsumoto, T., Wiese, S., Erne, B., Sendtner, M., Schaeren‐Wiemers, N., Körte, M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5100-09.2010 · Cited by 289 · see citing works
Self-citationMonosynaptic inputs to new neurons in the dentate gyrus
Vivar, C., Potter, M. C., Choi, J., Lee, J.-Y., Stringer, T. P., Callaway, E. M., Gage, F. H., Suh, H., & van Praag, H. (2012) · Nature Communications · doi:10.1038/ncomms2101 · Cited by 289 · see citing works
Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders
Singh, M. A. F., Ding, W., Manfredi, T., Solares, G. R., O’Neill, E. F., Clements, K. M., Ryan, N. D., Kehayias, J. J., Fielding, R. A., & Evans, W. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e135 · Cited by 286 · see citing works
What is the mammalian dentate gyrus good for?
Treves, A., Tashiro, A., Witter, M. P., & Moser, E. I. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.073 · Cited by 282 · see citing works
The exercise-induced expression of BDNF within the hippocampus varies across life-span
Adlard, P. A., Perreau, V. M., & Cotman, C. W. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.05.006 · Cited by 260 · see citing works
Functional subregions of the human entorhinal cortex
Maaß, A., Berron, D., Libby, L. A., Ranganath, C., & Düzel, E. (2015) · eLife · doi:10.7554/elife.06426 · Cited by 258 · see citing works
Bergmann, O., Spalding, K. L., & Frisén, J. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018994 · Cited by 256 · see citing works
Sexton, C. E., Betts, J. F., Demnitz, N., Dawes, H., Ebmeier, K. P., & Johansen‐Berg, H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.071 · Cited by 256 · see citing works
Lövdén, M., Schaefer, S., Noack, H., Bodammer, N., Kühn, S., Heinze, H., Düzel, E., Bäckman, L., & Lindenberger, U. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.013 · Cited by 245 · see citing works
Flöel, A., Ruscheweyh, R., Krüger, K., Willemer, C., Winter, B., Völker, K., Lohmann, H., Zitzmann, M., Mooren, F. C., Breitenstein, C., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.043 · Cited by 243 · see citing works
Breese, C. R., Ingram, R. L., & Sonntag, W. E. (1991) · Journal of Gerontology · doi:10.1093/geronj/46.5.b180 · Cited by 237 · see citing works
Exercise moderates age-related atrophy of the medial temporal lobe
Bugg, J. M., & Head, D. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.008 · Cited by 236 · see citing works
Brown, B. M., Peiffer, J. J., Taddei, K., Lui, J. K., Laws, S. M., Gupta, V. B., Taddei, T., Ward, V. K., Rodrigues, M. A., Burnham, S., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.107 · Cited by 235 · see citing works
Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease
Yarchoan, M. M., & Arnold, S. E. (2014) · Diabetes · doi:10.2337/db14-0287 · Cited by 228 · see citing works
Physical activity attenuates age-related biomarker alterations in preclinical AD
Okonkwo, O. C., Schultz, S. A., Oh, J. M., Larson, J., Edwards, D. F., Cook, D. B., Koscik, R. L., Gallagher, C. L., Dowling, N. M., Carlsson, C. M., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000964 · Cited by 227 · see citing works
Armstrong, M. E. G., Green, J., Reeves, G. K., Beral, V., & Cairns, B. J. (2015) · Circulation · doi:10.1161/circulationaha.114.010296 · Cited by 219 · see citing works
Leisure‐time physical activity from mid‐ to late life, body mass index, and risk of dementia
Tolppanen, A., Solomon, A., Kulmala, J., Kåreholt, I., Ngandu, T., Rusanen, M., Laatikainen, T. K., Soininen, H. S., & Kivipelto, M. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.01.008 · Cited by 214 · see citing works
Cardiorespiratory Fitness and Preserved Medial Temporal Lobe Volume in Alzheimer Disease
Honea, R. A., Thomas, G., Harsha, A., Anderson, H. S., Donnelly, J. E., Brooks, W. M., & Burns, J. M. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31819cb8a2 · Cited by 214 · see citing works
Déry, N., Pilgrim, M., Gibala, M. J., Gillen, J. B., Wojtowicz, J. M., MacQUEEN, G. M., & Becker, S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00066 · Cited by 208 · see citing works
Functional topography of the human entorhinal cortex
Schröder, T. N., Haak, K. V., Jimenez, N. I. Z., Beckmann, C. F., & Doeller, C. F. (2015) · eLife · doi:10.7554/elife.06738 · Cited by 203 · see citing works
Adult neurogenesis: a substrate for experience-dependent change
Opendak, M., & Gould, E. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.01.001 · Cited by 200 · see citing works
Delving deeper into resistance
Seton-Rogers, S. E. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3653 · Cited by 196 · see citing works
Death of developing neurons: New insights and implications for connectivity
Dekkers, M. P. J., Nikoletopoulou, V., & Barde, Y. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201306136 · Cited by 195 · see citing works
High-Intensity Interval Exercise and Cerebrovascular Health: Curiosity, Cause, and Consequence
Lucas, S. J. E., Cotter, J. D., Brassard, P., & Bailey, D. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.49 · Cited by 194 · see citing works
Effect of pioglitazone medication on the incidence of dementia
Heneka, M. T., Fink, A., & Doblhammer, G. (2015) · Annals of Neurology · doi:10.1002/ana.24439 · Cited by 185 · see citing works
Aleman, A., & Torres‐Alemán, I. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.07.008 · Cited by 184 · see citing works
Vann, S., Tsivilis, D., Denby, C., Quamme, J., Yonelinas, A., Aggleton, J., Montaldi, D., & Mayes, A. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0812097106 · Cited by 184 · see citing works
Li, S., Jin, M., Zhang, D., Yang, T., Koeglsperger, T., Fu, H., & Selkoe, D. J. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.040 · Cited by 177 · see citing works
PART, a distinct tauopathy, different from classical sporadic Alzheimer disease.
Jellinger, K. A., Alafuzoff, I., Attems, J., Beach, T. G., Cairns, N. J., Crary, J. F., Dickson, D. W., Hof, P. R., Hyman, B. T., Jack, C. R., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1407-2 · Cited by 171 · see citing works
In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer’s disease
Hornberger, M., Wong, S., Tan, R. H., Irish, M., Piguet, O., Kril, J. J., Hodges, J. R., & Halliday, G. M. (2012) · Brain · doi:10.1093/brain/aws239 · Cited by 165 · see citing works
Muscari, A., Giannoni, C., Pierpaoli, L., Berzigotti, A., Latessa, P. M., Foschi, E., Ravaioli, C., Poggiopollini, G., Bianchi, G. P., Magalotti, D., et al. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2462 · Cited by 163 · see citing works
Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging
Jagust, W. J., Landau, S. M., & Initiative, F. T. A. D. N. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3266-12.2012 · Cited by 162 · see citing works
Wrann, C. D. (2015) · Brain Plasticity · doi:10.3233/bpl-150019 · Cited by 159 · see citing works
Episodic memory on the path to Alzheimer's disease
Gallagher, M., & Koh, M. T. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.021 · Cited by 156 · see citing works
The effects of physical activity, education, and body mass index on the aging brain
Ho, A. J., Raji, C. A., Becker, J. T., López, O. L., Kuller, L. H., Hua, X., Dinov, I. D., Stein, J. L., Rosano, C., Toga, A. W., et al. (2010) · Human Brain Mapping · doi:10.1002/hbm.21113 · Cited by 144 · see citing works
Running rewires the neuronal network of adult-born dentate granule cells
Vivar, C., Peterson, B. D., & van Praag, H. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.031 · Cited by 143 · see citing works
Self-citationGontier, G., George, C., Chaker, Z., Holzenberger, M., & Aïd, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0343-15.2015 · Cited by 142 · see citing works
Hopkins, M. E., & Bucci, D. J. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.06.006 · Cited by 139 · see citing works
Association between physical activity and brain health in older adults
Benedict, C., Brooks, S. J., Kullberg, J., Nordenskjöld, R., Burgos, J., Grevès, M. L., Kilander, L., Larsson, E., Johansson, L. O. M., Ahlström, H. K., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.013 · Cited by 139 · see citing works
Intense physical activity is associated with cognitive performance in the elderly
Brown, B. M., Peiffer, J. J., Sohrabi, H. R., Mondal, A., Gupta, V. B., Rainey‐Smith, S. R., Taddei, K., Burnham, S. C., Ellis, K. A., Szoeke, C. E. I., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.118 · Cited by 136 · see citing works
Exercise and Circulating Insulin-Like Growth Factor I
Berg, U., & Bang, P. (2004) · Hormone Research in Paediatrics · doi:10.1159/000080759 · Cited by 131 · see citing works
Wirth, M., Haase, C. M., Villeneuve, S., Vogel, J. W., & Jagust, W. J. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.015 · Cited by 127 · see citing works
Endurance factors improve hippocampal neurogenesis and spatial memory in mice
Kobilo, T., Yuan, C., & van Praag, H. (2011) · Learning & Memory · doi:10.1101/lm.2001611 · Cited by 114 · see citing works
Self-citationLaminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding
Maaß, A., Schütze, H., Speck, O., Yonelinas, A. P., Tempelmann, C., Heinze, H., Berron, D., Cárdenas‐Blanco, A., Brodersen, K. H., Stephan, K. E., et al. (2014) · Nature Communications · doi:10.1038/ncomms6547 · Cited by 110 · see citing works
Schmidt, W. U., Endres, M., Dimeo, F., & Jungehulsing, G. J. (2013) · Cerebrovascular Diseases · doi:10.1159/000347061 · Cited by 104 · see citing works
Cortical thickness changes following spatial navigation training in adulthood and aging
Wenger, E., Schaefer, S., Noack, H., Kühn, S., Mårtensson, J., Heinze, H., Düzel, E., Bäckman, L., Lindenberger, U., & Lövdén, M. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.015 · Cited by 100 · see citing works
Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice
Marlatt, M. W., Lucassen, P. J., & van Praag, H. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.086 · Cited by 96 · see citing works
Stringer, T. P., Guerrieri, D., Vivar, C., & van Praag, H. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.135 · Cited by 94 · see citing works
Ota, K. T., & Duman, R. S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.022 · Cited by 94 · see citing works
Marlatt, M. W., Potter, M. C., Bayer, T. A., van Praag, H., & Lucassen, P. J. (2013) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_237 · Cited by 92 · see citing works
CAP—advancing the evaluation of preclinical Alzheimer disease treatments
Reiman, E. M., Langbaum, J. B. S., Tariot, P. N., Lopera, F. J., Bateman, R. J., Morris, J. C., Sperling, R. A., Aisen, P. S. S., Roses, A. D., Welsh-Bohmer, K. A., et al. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.177 · Cited by 91 · see citing works
Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing
Cox, C. J., Choudhry, F., Peacey, E., Perkinton, M. S., Richardson, J. C., Howlett, D. R., Lichtenthaler, S. F., Francis, P. T., & Williams, R. J. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.032 · Cited by 87 · see citing works
Chen, M. J., & Russo‐Neustadt, A. A. (2007) · Growth Factors · doi:10.1080/08977190701602329 · Cited by 86 · see citing works
Whiteman, A., Young, D. E., Budson, A. E., Stern, C. E., & Schön, K. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.049 · Cited by 81 · see citing works
Running improves pattern separation during novel object recognition
Bolz, L., Heigele, S., & Bischofberger, J. (2015) · Brain Plasticity · doi:10.3233/bpl-150010 · Cited by 80 · see citing works
Age-specific effects of voluntary exercise on memory and the older brain
Siette, J., Westbrook, R. F., Cotman, C., Sidhu, K., Zhu, W., Sachdev, P., & Valenzuela, M. J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.034 · Cited by 78 · see citing works
Geda, Y. E., Silber, T. C., Roberts, R. O., Knopman, D. S., Christianson, T. J. H., Pankratz, V. S., Boeve, B. F., Tangalos, E. G., & Petersen, R. C. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2011.12.020 · Cited by 71 · see citing works
Transport of Insulin‐Related Peptides and Glucose across the Blood‐Brain Barriera
Pardridge, W. M. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb26211.x · Cited by 70 · see citing works
Tan, R. H., Wong, S., Kril, J. J., Piguet, O., Hornberger, M., Hodges, J. R., & Halliday, G. M. (2014) · Brain · doi:10.1093/brain/awu118 · Cited by 67 · see citing works
A community-based approach to trials of aerobic exercise in aging and Alzheimer's disease
Vidoni, E. D., Sciver, A. R. V., Johnson, D. K., He, J., Honea, R. A., Haines, B., Goodwin, J., Laubinger, M. P., Anderson, H. S., Kluding, P. M., et al. (2012) · Contemporary Clinical Trials · doi:10.1016/j.cct.2012.08.002 · Cited by 59 · see citing works
Architecture of spatial circuits in the hippocampal region
Witter, M. P., Canto, C. B., Couey, J. J., Koganezawa, N., & O’Reilly, K. C. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0515 · Cited by 58 · see citing works
Exercise-mimetic AICAR transiently benefits brain function
Guerrieri, D., & van Praag, H. (2015) · Oncotarget · doi:10.18632/oncotarget.4715 · Cited by 57 · see citing works
Dangerous Leaks: Blood-Brain Barrier Woes in the Aging Hippocampus
Iadecola, C. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.056 · Cited by 47 · see citing works
Downstream Consequences of Exercise Through the Action of BDNF
Sleiman, S. F., & Chao, M. V. (2015) · Brain Plasticity · doi:10.3233/bpl-150017 · Cited by 41 · see citing works
Insulin and insulin-like growth factor I signalling in neurons
Dávila, D. (2007) · Frontiers in bioscience · doi:10.2741/2306 · Cited by 38 · see citing works
A perspective on the future role of brain pet imaging in exercise science
Boecker, H., & Drzezga, A. E. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.021 · Cited by 35 · see citing works
Niblock, M. M., Brunso-Bechtold, J. K., Lynch, C. D., Ingram, R. L., McShane, T. M., & Sonntag, W. E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00645-3 · Cited by 34 · see citing works
Moon, H. Y., & van Praag, H. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.012 · Cited by 31 · see citing works
Igf-I and fgf-2 responses to wingate anaerobic test in older men.
Amir, R., Ben‐Sira, D., & Sagiv, M. (2007) · PubMed Central · Cited by 19 · see citing works
IGF-I AND FGF-2 RESPONSES TO WINGATE ANAEROBIC TEST IN OLDER MEN
Amir, R., Sagiv, M. S., Ben‐Sira, D., et al. (2006) · German Medical Science (German Research Foundation) · Cited by 13 · see citing works
Wang, S., Wang, H., Niemi-Junkola, U., Westby, G. W. M., McHaffie, J. G., Stein, B. E., & Redgrave, P. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001002)425:4 · Cited by 11 · see citing works
Sendtner, M. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-45106-5_15 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Leutgeb JK Leutgeb S Moser MB Moser EI. Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science 2007; 315: 961 – 6. 17303747
- WHO. Global recommendations on physical activity for health. WHO, editor. Geneva: WHO Press, 2012.
Cited by
Sorted by citations
Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072 · see citing works
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416 · see citing works
Basso, J. C., & Suzuki, W. A. (2016) · Brain Plasticity · doi:10.3233/bpl-160040 · Cited by 911 · see citing works
Physical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772 · see citing works
Running-induced systemic cathepsin B secretion is associated with memory function
Moon, H. Y., Becke, A., Berron, D., Becker, B., Sah, N., Benoni, G., Janke, E., Lubejko, S. T., Greig, N. H., Mattison, J. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.025 · Cited by 628 · see citing works
Self-citationBarha, C. K., Davis, J. C., Falck, R. S., Nagamatsu, L. S., & Liu-Ambrose, T. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.04.002 · Cited by 432 · see citing works
Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations
Hoffmann, C., & Weigert, C. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029793 · Cited by 393 · see citing works
Aging and Alzheimer's disease: comparison and associations from molecular to system level
Xia, X., Jiang, Q., McDermott, J., & Han, J. J. (2018) · Aging Cell · doi:10.1111/acel.12802 · Cited by 301 · see citing works
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241 · see citing works
Exercise and Hippocampal Memory Systems
Voss, M. W., Soto, C., Yoo, S., Sodoma, M., Vivar, C., & van Praag, H. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.006 · Cited by 235 · see citing works
Self-citationLiu, Y., Cheng, A., Li, Y.-J., Yang, Y., Kishimoto, Y., Zhang, S., Wang, Y., Wan, R., Raefsky, S. M., Lu, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09897-1 · Cited by 176 · see citing works
Gaitán, J. M., Moon, H. Y., Stremlau, M., Dubal, D. B., Cook, D. B., Okonkwo, O. C., & van Praag, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.660181 · Cited by 160 · see citing works
Relationship between Exercise and Alzheimer’s Disease: A Narrative Literature Review
Meng, Q., Lin, M.-S., & Tzeng, I.-S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00131 · Cited by 158 · see citing works
Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works
“…vary depending on the purpose of the intervention, for example it has been suggested that improving cognitive performance may require high-intensity, interval training but preserving cognitive function in an aging brain may require a lower intensity, more continuous protocol (Duzel et al., 2016).”
Sanders, L. M. J., Hortobágyi, T., Karssemeijer, E. G. A., Van der Zee, E. A., Scherder, E. J. A., & van Heuvelen, M. J. G. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00597-3 · Cited by 154 · see citing works
Running Changes the Brain: the Long and the Short of It
Vivar, C., & van Praag, H. (2017) · Physiology · doi:10.1152/physiol.00017.2017 · Cited by 114 · see citing works
Self-citationPhysical activity, common brain pathologies, and cognition in community-dwelling older adults
Buchman, A. S., Yu, L., Wilson, R. S., Lim, A., Dawe, R. J., Gaiteri, C., Leurgans, S. E., Schneider, J. A., & Bennett, D. A. (2019) · Neurology · doi:10.1212/wnl.0000000000006954 · Cited by 108 · see citing works
At least eighty percent of brain grey matter is modifiable by physical activity: A review study
Batouli, S. A. H., & Saba, V. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.002 · Cited by 92 · see citing works
Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity
Navakkode, S., & Kennedy, B. K. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1428244 · Cited by 75 · see citing works
Chen, H., Dong, G., & Li, K. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1094583 · Cited by 47 · see citing works
Callow, D. D., Won, J., Pena, G. S., Jordan, L. S., Arnold-Nedimala, N. A., Kommula, Y., Nielson, K. A., & Smith, J. C. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.645258 · Cited by 27 · see citing works
Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved
Ebrahimnejad, M., Azizi, P., Alipour, V., Zarrindast, M.-R., & Vaseghi, S. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03552-w · Cited by 21 · see citing works
- Authors
- Duzel, E., van Praag, H., & Sendtner, M.
- Affiliations
- University of Würzburg (DE)
- ORCID
- Sendtner, Michael
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-02-11
- Volume
- 139
- Issue
- 3
- Pages
- 662-673
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC4766381
- OpenAlex
- W2254521523
- Cited by
- 329
- References
- 149
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 33 · 2023: 23 · 2022: 37 · 2021: 43 · 2020: 29 · 2019: 35 · 2018: 40 · 2017: 35 · 2016: 13
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Brain (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Online Publication Service of Würzburg University (Würzburg University) (submittedVersion, cc-by-nc)
- DZNE Pub (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (TRR‐58)
- National Institutes of Health
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- physical activity, aging, memory, hippocampus, hippocampal plasticity, cognitive decline, Alzheimer's disease, vascular risk factors, metabolic risk factors, exercise intensity, medial temporal lobe, neuroplasticity
- MeSH terms
- Aging, Alzheimer Disease, Animals, Hippocampus, Humans, Memory, Memory Disorders, Neuronal Plasticity, Exercise
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
