Cited by 1,221DNA Repair MechanismsBRCA gene mutations in cancerPARP inhibition in cancer therapy

The DOI matches its Crossref record; 52 of the 54 references it cites were found in a registry or an index.

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Open access

Wang, Yi, Cortez, David, Yazdi, Parvin, Neff, Norma, Elledge, Stephen J., Qin, Jun·2000·Genes & Development

Open this paper in CoChat — free account Open PDF

Abstract

We report the identities of the members of a group of proteins that associate with BRCA1 to form a large complex that we have named BASC (B RCA1-a ssociated genome s urveillance c omplex). This complex includes tumor suppressors and DNA damage repair proteins MSH2, MSH6, MLH1, ATM, BLM, and the RAD50–MRE11–NBS1 protein complex. In addition, DNA replication factor C (RFC), a protein complex that facilitates the loading of PCNA onto DNA, is also part of BASC. We find that BRCA1, the BLM helicase, and the RAD50–MRE11–NBS1 complex colocalize to large nuclear foci that contain PCNA when cells are treated with agents that interfere with DNA synthesis. The association of BRCA1 with MSH2 and MSH6, which are required for transcription-coupled repair, provides a possible explanation for the role of BRCA1 in this pathway. Strikingly, all members of this complex have roles in recognition of abnormal DNA structures or damaged DNA, suggesting that BASC may serve as a sensor for DNA damage. Several of these proteins also have roles in DNA replication-associated repair. Collectively, these results suggest that BRCA1 may function as a coordinator of multiple activities required for maintenance of genomic integrity during the process of DNA replication and point to a central role for BRCA1 in DNA repair.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/gad.14.8.927

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

BRCA1 required for transcription-coupled repair of oxidative DNA damage
Gowen, L. C., Avrutskaya, A. V., Latour, A. M., Koller, B. H., & Leadon, S. A. (1998) · Science · doi:10.1126/science.281.5379.1009 · Cited by 496
Retracted
A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459
The Bloom's syndrome gene product is homologous to RecQ helicases
Ellis, N. A., Groden, J. L., Ye, T.-Z., Straughen, J. E., Lennon, D. J., Ciocci, S., Proytcheva, M. A., & GERMAN, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90105-1 · Cited by 1,385
BRCA1 mutations in primary breast and ovarian carcinomas.
Futreal, P., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L., Haugen-Strano, A., Swensen, J., & Miki, Y. (1994) · Science · doi:10.1126/science.7939630 · Cited by 1,378
Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase
Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322

Flagged first, then by citations

Show all 54 references

2 of the 54 references couldn’t be matched to a known paper.

Sorted by citations

Items 301–400 of 1,000

New insights into the mechanism of homologous recombination in yeast
Aylon, Y., & Kupiec, M. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.10.001 · Cited by 100
Telomere dysfunction in genome instability syndromes
Callén, E., & Surrallés, J. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.06.003 · Cited by 106
Down-regulation of BRCA1 in BCR-ABL–expressing hematopoietic cells
Deutsch, É., Jarrousse, S., Selimoglu‐Buet, D., Dugray, A., Bonnet, M., Vozenin, M., Guilhot, F., Turhan, A. G., Feunteun, J., & Bourhis, J. (2003) · Blood · doi:10.1182/blood-2002-10-3011 · Cited by 100
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks
Davalos, A. R., & Campisi, J. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200304016 · Cited by 103
A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining
Baldeyron, C., Jacquemin, E., Smith, J., Jacquemont, C. F., Oliveira, I. D., Gad, S., Feunteun, J., Stoppa‐Lyonnet, D., & Papadopoulo, D. (2002) · Oncogene · doi:10.1038/sj.onc.1205200 · Cited by 99
Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrations
Pfeiffer, P., Goedecke, W., Kuhfittig-Kulle, S., & Obe, G. (2004) · Cytogenetic and Genome Research · doi:10.1159/000077460 · Cited by 100
Focus Formation of DNA Repair Proteins in Normal and Repair-Deficient Cells Irradiated with High-LET Ions
Karlsson, K. H., & Stenerlöw, B. (2004) · Radiation Research · doi:10.1667/rr3171 · Cited by 100
Telomere‐associated proteins: cross‐talk between telomere maintenance and telomere‐lengthening mechanisms
Boeck, G. D., Forsyth, R. G., Praet, M. M., & Hogendoorn, P. C. W. (2008) · The Journal of Pathology · doi:10.1002/path.2500 · Cited by 102
Functional proteomics; current achievements
Yanagida, M. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00074-0 · Cited by 99
Farnesyltransferase Inhibitors Induce DNA Damage via Reactive Oxygen Species in Human Cancer Cells
Pan, J., She, M., Xu, Z., Sun, L., & Yeung, S. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2744 · Cited by 97
Nonerythroid αII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links
Sridharan, D., Brown, M., Lambert, W. C., McMahon, L., & Lambert, M. W. (2003) · Journal of Cell Science · doi:10.1242/jcs.00294 · Cited by 97
Human T-cell Leukemia Virus-I Tax Oncoprotein Functionally Targets a Subnuclear Complex Involved in Cellular DNA Damage-Response
Haoudi, A., Daniels, R. C., Wong, E. B., Kupfer, G. M., & Semmes, O. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301649200 · Cited by 98
ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation
Ababou, M., Dutertre, S., Lécluse, Y., Onclercq, R., Chatton, B., & Amor-Guéret, M. (2000) · Oncogene · doi:10.1038/sj.onc.1204003 · Cited by 106
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damagePreprint
Hill, S. J., Rolland, T., Adelmant, G., Xia, X., Owen, M., Dricot, A., Zack, T. I., Sahni, N., Jacob, Y., Hao, T., et al. (2014) · Genes & Development · doi:10.1101/gad.241620.114 · Cited by 102
Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1
Xia, Z., Morales, J. C., Dunphy, W. G., & Carpenter, P. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007665200 · Cited by 96
BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses
Dutta, D., Dutta, S., Veettil, M. V., Roy, A., Ansari, M. A., Iqbal, J., Leela, C., Kumar, B., Johnson, K. E., & Chandran, B. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005030 · Cited by 94
Retracted
Mapping the DNA Topoisomerase III Binding Domain of the Sgs1 DNA Helicase
Fricke, W. M., Kaliraman, V., & Brill, S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009719200 · Cited by 94
Junction of RecQ Helicase Biochemistry and Human Disease
Opresko, P. L., Cheng, W., & Bohr, V. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r300034200 · Cited by 94
Alternative RNA splicing and cancer
Liu, S., & Cheng, C. (2013) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1178 · Cited by 96
Cyclin D1 Antagonizes BRCA1 Repression of Estrogen Receptor α Activity
Wang, C., Fan, S., Li, Z., Fu, M., Rao, M., Ma, Y., Lisanti, M. P., Albanese, C., Katzenellenbogen, B. S., Kushner, P. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0486 · Cited by 93
Homologous recombination deficiency in triple negative breast cancer
Belli, C., Duso, B. A., Ferraro, E., & Curigliano, G. (2019) · The Breast · doi:10.1016/j.breast.2019.02.007 · Cited by 93
DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases
Maiuri, T., Suart, C., Hung, C. L.-K., Graham, K. J., Bazan, C. B., & Truant, R. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00768-7 · Cited by 99
Developmental Regulation and In Vitro Culture Effects on Expression of DNA Repair and Cell Cycle Checkpoint Control Genes in Rhesus Monkey Oocytes and Embryos1
Zheng, P., Schramm, R. D., & Latham, K. E. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.039073 · Cited by 92
CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype
Brandes, J. C., van Engeland, M., Wouters, K. A. D., Weijenberg, M. P., & Herman, J. G. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi058 · Cited by 92
Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9–Rad1–Hus1
Shi, G., Chang, D., Cheng, C.-C., Guan, X., Venclovas, Č., & Lu, A.-L. (2006) · Biochemical Journal · doi:10.1042/bj20060774 · Cited by 93
Srs2 and Sgs1 DNA Helicases Associate with Mre11 in Different Subcomplexes following Checkpoint Activation and CDK1-Mediated Srs2 Phosphorylation
Chiolo, I., Carotenuto, W., Maffioletti, G., Petrini, J. H. J., Foiani, M., & Liberi, G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5738-5751.2005 · Cited by 96
ATP Activates Ataxia-Telangiectasia Mutated (ATM) in Vitro
Kozlov, S., Gueven, N., Keating, K. E., Ramsay, J., & Lavin, M. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300003200 · Cited by 91
Role of the dinB Gene Product in Spontaneous Mutation in Escherichia coli with an Impaired Replicative Polymerase
Strauss, B. S., Roberts, R., Francis, L., & Pouryazdanparast, P. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.23.6742-6750.2000 · Cited by 91
BRCA1 Inhibition of Telomerase Activity in Cultured Cells
Xiong, J., Fan, S., Meng, Q., Schramm, L., Wang, C., Bouzahza, B., Zhou, J., Zafonte, B. T., Goldberg, I. D., Haddad, B. R., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8668-8690.2003 · Cited by 96
The Ligand Status of the Aromatic Hydrocarbon Receptor Modulates Transcriptional Activation of BRCA-1 Promoter by Estrogen
Hockings, J. K., Thorne, P. A., Kemp, M. Q., Morgan, S. S., Selmin, O. I., & Romagnolo, D. F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1619 · Cited by 90
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein
Pichierri, P. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.21.2531 · Cited by 90
Characterization of Arabidopsis thaliana ortholog of the human breast cancer susceptibility gene 1: AtBRCA1, strongly induced by gamma rays
Lafarge, S. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg202 · Cited by 94
Radiation and the cell cycle, revisited
Wilson, G. D. (2004) · Cancer and Metastasis Reviews · doi:10.1023/b:canc.0000031762.91306.b4 · Cited by 91
Expression of DNA Double-Strand Break Repair Proteins ATM and BRCA1 Predicts Survival in Colorectal Cancer
Grabsch, H. I., Dattani, M., Barker, L., Maughan, N., Maude, K., Hansen, O., Gabbert, H. E., Quirke, P., & Mueller, W. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2105 · Cited by 89
RECQ1 Helicase Interacts with Human Mismatch Repair Factors That Regulate Genetic Recombination*[boxs]
Doherty, K. M., Sharma, S., Uzdilla, L. A., Wilson, T., Cui, S., Vindigni, A., & Brosh, R. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500265200 · Cited by 88
Distinct functions of BRCA1 and BRCA2 in double-strand break repair
Liu, Y., & West, S. C. (2001) · Breast Cancer Research · doi:10.1186/bcr417 · Cited by 87
The Involvement of DNA-Damage and -Repair Defects in Neurological Dysfunction
Kulkarni, A., & Wilson, D. M. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.009 · Cited by 89
Oxidative stress in ataxia telangiectasia
Watters, D. J. (2003) · Redox Report · doi:10.1179/135100003125001206 · Cited by 87
BRCA1 and cell signaling
Wang, Q., Zhang, H., Fishel, R. A., & Greene, M. I. (2000) · Oncogene · doi:10.1038/sj.onc.1203974 · Cited by 87
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia
Digweed, M. (2002) · Carcinogenesis · doi:10.1093/carcin/23.7.1121 · Cited by 87
BRCA1: exploring the links to transcription
Monteiro, Á. N. A. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01632-7 · Cited by 87
Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks
Rao, V. A., Conti, C., Guirouilh‐Barbat, J., Nakamura, A., Miao, Z., Davies, S., Saccà, B., Hickson, I. D., Bensimon, A., & Pommier, Y. G. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0028 · Cited by 91
Historical and Current Highlights in Radiation Biology: Has Anything Important Been Learned by Irradiating Cells?
Bedford, J. S., & Dewey, W. C. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)158[0251:hachir]2.0.co;2 · Cited by 87
Molecular characterisation of RecQ homologues in Arabidopsis thaliana
Hartung, F. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.21.4275 · Cited by 86
MSH-MLH complexes formed at a DNA mismatch are disrupted by the PCNA sliding clamp
Bowers, J., Tran, P. T., Joshi, A., Liskay, R. M., & Alani, E. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4467 · Cited by 86
Mutation analysis of the CHK2gene in families with hereditary breast cancer
Allinen, M., Huusko, P., Mäntyniemi, S., Launonen, V, & Winqvist, R. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1858 · Cited by 85
History of DNA Helicases
Brosh, R. M., & Matson, S. W. (2020) · Genes · doi:10.3390/genes11030255 · Cited by 91
CtIP mediates replication fork recovery in a FANCD2-regulated manner
Yeo, J. E., Lee, E. H., Hendrickson, E. A., & Sobeck, A. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu078 · Cited by 91
Clinical features of Bloom syndrome and function of the causative gene, BLM helicase
Kaneko, H., & Kondo, N. (2004) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.4.3.393 · Cited by 84
Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1
Krause, D., Jonnalagadda, J. C., Gatei, M. H., Silljé, H. H. W., Zhou, B. S., Nigg, E. A., & Khanna, K. K. (2003) · Oncogene · doi:10.1038/sj.onc.1206691 · Cited by 88
Homologous recombination as a mechanism for genome rearrangements: environmental and genetic effects
Bishop, A. J. R. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.16.2427 · Cited by 86
NBS1 promotes the endonuclease activity of the MRE11‐RAD50 complex by sensing CtIP phosphorylation
Anand, R., Jasrotia, A., Bundschuh, D., Howard, S. M., Ranjha, L., Stucki, M., & Ćejka, P. (2019) · The EMBO Journal · doi:10.15252/embj.2018101005 · Cited by 89
Is RecG a general guardian of the bacterial genome?
Rudolph, C. J., Upton, A. L., Briggs, G. S., & Lloyd, R. G. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.014 · Cited by 83
BRCC36 Is Essential for Ionizing Radiation–Induced BRCA1 Phosphorylation and Nuclear Foci Formation
Chen, X., Arciero, C. A., Wang, C., Broccoli, D., & Godwin, A. K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4194 · Cited by 82
Molecular Oncology of Breast Cancer
Joshi, H. N., & Press, M. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35955-9.00022-2 · Cited by 85
Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells
Kao, G. D., McKenna, W. G., & Yen, T. J. (2001) · Oncogene · doi:10.1038/sj.onc.1204445 · Cited by 81
RecQ family helicases: roles as tumor suppressor proteins
Nakayama, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205959 · Cited by 81
Checkpoint Kinase 2 (Chk2) Monomers or Dimers Phosphorylate Cdc25C after DNA Damage Regardless of Threonine 68 Phosphorylation
Ahn, J., & Prives, C. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208321200 · Cited by 82
The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase
Yang, Q., Zhang, R., Wang, X. W., Linke, S. P., Sengupta, S., Hickson, I. D., Pedrazzi, G., Perrera, C., Štagljar, I., Littman, S. J., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207462 · Cited by 80
Regulation of Intra-S Phase Checkpoint by Ionizing Radiation (IR)-dependent and IR-independent Phosphorylation of SMC3
Luo, H., Li, Y., Mu, J.-J., Zhang, J., Tonaka, T., Hamamori, Y., Jung, S. Y., Wáng, Y., & Qin, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802299200 · Cited by 80
Self-citation
Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA
Nielsen, F. C., Jäger, A. C., Lützen, A., Bundgaard, J. R., & Rasmussen, L. J. (2003) · Oncogene · doi:10.1038/sj.onc.1207265 · Cited by 79
ATM-Mediated Stabilization of hMutL DNA Mismatch Repair Proteins Augments p53 Activation during DNA Damage
Luo, Y., Lin, F., & Lin, W.-C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.14.6430-6444.2004 · Cited by 81
Constitutive Association of BRCA1 and c-Abl and Its ATM-Dependent Disruption after Irradiation
Foray, N., Marot, D., Randrianarison-Huetz, V., Venezia, N. D., Picard, D., Perricaudet, M., Favaudon, V., & Jeggo, P. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4020-4032.2002 · Cited by 79
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
Liu, Y., Fang, Y., Shao, H., Lindsey-Boltz, L., Sancar, A., & Modrich, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.076109 · Cited by 78
The DNA Damage Response in Filamentous Fungi
Goldman, G. H., McGuire, S. L., & Harris, S. D. (2002) · Fungal Genetics and Biology · doi:10.1006/fgbi.2002.1344 · Cited by 78
Breast cancer gene 1 (BRCA1): Role in cell cycle regulation and DNA repair—perhaps through transcription
Somasundaram, K. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10469 · Cited by 78
Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure
Bălăcescu, O., Bălăcescu, L., Tudoran, O. M., Todor, N., Rus, M., Buiga, R., Șușman, S., Fetică, B., Pop, L., Maja, L. I., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-246 · Cited by 77
ATRIP Oligomerization Is Required for ATR-dependent Checkpoint Signaling
Ball, H. L., & Cortez, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504961200 · Cited by 78
Self-citation
Good Timing in the Cell Cycle for Precise DNA Repair by BRCA1
Durant, S. T., & Nickoloff, J. A. (2005) · Cell Cycle · doi:10.4161/cc.4.9.2027 · Cited by 77
Aberrations in DNA repair pathways in cancer and therapeutic significances
Motegi, A., Masutani, M., Yoshioka, K., & Bessho, T. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.02.005 · Cited by 76
Antisense oligonucleotides targeting lncRNA AC104041.1 induces antitumor activity through Wnt2B/β-catenin pathway in head and neck squamous cell carcinomas
Li, M., Ding, X., Zhang, Y., Li, X., Zhou, H., Li, Y., Li, Y., Yang, P., Zhang, X., Hu, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02820-3 · Cited by 78
BRCA1 and implications for response to chemotherapy in ovarian cancer
Quinn, J. E., Carser, J., James, C. R., Kennedy, R. D., & Harkin, D. P. (2009) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.12.015 · Cited by 76
BRCA1 at the crossroad of multiple cellular pathways: approaches for therapeutic interventions
Yarden, R. I., & Papa, M. Z. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0471 · Cited by 79
Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair
Wan, L., Han, J., Liu, T., Dong, S., Xie, F., Chen, H., & Huang, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220921110 · Cited by 78
Homologous Recombination and Its Role in Carcinogenesis
Bishop, A. J. R., & Schiestl, R. H. (2002) · BioMed Research International · doi:10.1155/s1110724302204052 · Cited by 77
Tying the loose ends together in DNA double strand break repair with 53BP1.
Adams, M. M., & Carpenter, P. B. (2006) · Cell Division · doi:10.1186/1747-1028-1-19 · Cited by 77
em BRCA1 em in cancer cell cycle and genomic stability
Jhanwar‐Uniyal, M. (2003) · Frontiers in bioscience · doi:10.2741/1131 · Cited by 76
Nibrin Forkhead-associated Domain and Breast Cancer C-terminal Domain Are Both Required for Nuclear Focus Formation and Phosphorylation
Cerosaletti, K. M., & Concannon, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211689200 · Cited by 74
RFWD3–Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
Fu, X., Yucer, N., Liu, S., Li, M., Yi, P., Mu, J.-J., Yang, T., Chu, J., Jung, S. Y., O’Malley, B. W., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912094107 · Cited by 73
Self-citation
ATR dependent activation of Chk2
Wang, X. Q., Redpath, J. L., Fan, S. T., & Stanbridge, E. J. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20700 · Cited by 77
Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku80
Wei, L., Lan, L., Hong, Z., Yasui, A., Ishioka, C., & Chiba, N. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01075-08 · Cited by 78
Initiation of eukaryotic DNA replication: Regulation and mechanisms
Nasheuer, H., Smith, R. W., Bauerschmidt, C., Große, F., & Weißhart, K. (2002) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(02)72067-9 · Cited by 76
ATM‐dependent DNA damage surveillance in T‐cell development and leukemogenesis: the DSB connection
Matei, I. R., Guidos, C. J., & Danska, J. S. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00361.x · Cited by 77
Analysis of DNA double-strand break repair pathways in mice
Brugmans, L., Kanaar, R., & Essers, J. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.01.022 · Cited by 74
Homologous recombinational repair proteins in mouse meiosis
Bannister, L., & Schimenti, J. C. (2004) · Cytogenetic and Genome Research · doi:10.1159/000080597 · Cited by 74
BRCAness: a deeper insight into basal-like breast tumors
Summa, S. D., Pinto, R., Sambiasi, D., Petriella, D., Paradiso, V., Paradiso, A., & Tommasi, S. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt306 · Cited by 73
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
Leng, M., Chan, D. W., Luo, H., Zhu, C., Qin, J., & Wang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601828103 · Cited by 71
Self-citation
Mismatch repair proteins, meiosis, and mice: understanding the complexities of mammalian meiosis
Svetlanov, A. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.03.020 · Cited by 71
An Overactivated ATR/CHK1 Pathway Is Responsible for the Prolonged G2 Accumulation in Irradiated AT Cells
Wang, X., Khadpe, J. D., Hu, B., Iliakis, G. E., & Wang, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301876200 · Cited by 71
Self-citation
Regulation of the Fanconi anemia pathway by monoubiquitination
Gregory, R. C., Taniguchi, T., & D’Andrea, A. D. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00102-5 · Cited by 72
Purification and Characterisation of a Soluble N-terminal Fragment of the Breast Cancer Susceptibility Protein BRCA1
Sturdy, A., Naseem, R., & Webb, M. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.05.005 · Cited by 71
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1
Kijas, A. W., Lim, Y. C., Bolderson, E., Cerosaletti, K. M., Gatei, M. H., Jakob, B., Tobias, F., Taucher-Scholz, G., Gueven, N., Oakley, G. G., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv754 · Cited by 77
Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks
Lee, J., & Dunphy, W. G. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-11-0958 · Cited by 74
A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage
Meyers, M., Hwang, A., Wagner, M. W., Bruening, A. J., Veigl, M. L., Sedwick, W. D., & Boothman, D. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206941 · Cited by 70
RecQ-like helicases: the DNA replication checkpoint connection
Frei, C., & Gasser, S. M. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.15.2641 · Cited by 70
Sporadic Epithelial Ovarian Cancer: Clinical Relevance of BRCA1 Inhibition in the DNA Damage and Repair Pathway
Weberpals, J. I., Clark-Knowles, K. V., & Vanderhyden, B. C. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.3902 · Cited by 71
The Adenovirus E1b55K/E4orf6 Complex Induces Degradation of the Bloom Helicase during Infection
Orazio, N. I., Naeger, C. M., Karlseder, J., & Weitzman, M. D. (2010) · Journal of Virology · doi:10.1128/jvi.02134-10 · Cited by 70
Werner Syndrome Protein Phosphorylation by Abl Tyrosine Kinase Regulates Its Activity and Distribution
Cheng, W., von Kobbe, C., Opresko, P. L., Fields, K. M., Ren, J., Kufe, D. W., & Bohr, V. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.18.6385-6395.2003 · Cited by 69
TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin
Masuda, Y., Takahashi, H., Sato, S., Tomomori‐Sato, C., Saraf, A., Washburn, M. P., Florens, L. A., Conaway, R., Conaway, J. W., & Hatakeyama, S. (2015) · Nature Communications · doi:10.1038/ncomms8299 · Cited by 70
Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase
Guo, R. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki619 · Cited by 68

Authors: Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J.
Affiliations: New York Blood Center (US)
ORCID: Wang, Yi
Cortez, David
Neff, Norma
Elledge, Stephen J.
Qin, Jun
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2000-04-15
Volume: 14
Issue: 8
Pages: 927-939
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.14.8.927
PMC: PMC316544
OpenAlex: W2127566231
Cited by: 1,221
References: 54
Citations by year: 2026: 5 · 2025: 7 · 2024: 10 · 2023: 16 · 2022: 21 · 2021: 27 · 2020: 20 · 2019: 26 · 2018: 20 · 2017: 24 · 2016: 29 · 2015: 33 · 2014: 49 · 2013: 43 · 2012: 35
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Jane Coffin Childs Memorial Fund for Medical Research
U.S. Bureau of Land Management
U.S. Public Health Service (Q1187)
National Institute of General Medical Sciences (GM-44664, R37GM044664, R01GM044664)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, BASC, DNA repair, MSH2, MSH6, MLH1, ATM, BLM helicase, PCNA, DNA damage recognition, genome stability, tumor suppressor proteins, nuclear foci
MeSH terms: Adenosine Triphosphatases, Cell Cycle, Cell Nucleus, DNA Repair, DNA Helicases, DNA-Binding Proteins, Endodeoxyribonucleases, Exodeoxyribonucleases, Fluorescent Antibody Technique, Fungal Proteins, HeLa Cells, Humans, Nuclear Proteins, Precipitin Tests, Protein Binding, Mass Spectrometry, Transcription, Genetic, Signal Transduction, Cell Cycle Proteins, BRCA1 Protein, Saccharomyces cerevisiae Proteins, Replication Protein C, RecQ Helicases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks