BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

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Lessons from hereditary colorectal cancer

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A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

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Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

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Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

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Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

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The Bloom's syndrome gene product is homologous to RecQ helicases

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BRCA1 mutations in primary breast and ovarian carcinomas.

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Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

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Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification

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Human DNA repair genes

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Characterization of the Interactome of the Human MutL Homologues MLH1, PMS1, and PMS2

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Distinct Genomic Profiles in Hereditary Breast Tumors Identified by Array-Based Comparative Genomic Hybridization

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BRCA1, a Potential Predictive Biomarker in the Treatment of Breast Cancer

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The Forkhead-associated Domain of NBS1 Is Essential for Nuclear Foci Formation after Irradiation but Not Essential for hRAD50·hMRE11·NBS1 Complex DNA Repair Activity

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UV-induced binding of ING1 to PCNA regulates the induction of apoptosis

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Cdc2–cyclin B kinase activity links Crb2 and Rqh1–topoisomerase IIIPreprint

Caspari, T., Murray, J. M., & Carr, A. M. (2002) · Genes & Development · doi:10.1101/gad.221402 · Cited by 156

BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents

Mullan, P. B., Quinn, J. E., Gilmore, P. M., McWilliams, S., Andrews, H. N., Gervin, C., McCabe, N., McKenna, S., White, P., Song, Y., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204712 · Cited by 154

DNA Damage-Dependent Cell Cycle Checkpoints and Genomic Stability

Ishikawa, K., Ishii, H., & Saito, T. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.406 · Cited by 156

Evidence for the Involvement of Double-Strand Breaks in Heat-Induced Cell Killing

Takahashi, A., Matsumoto, H., Nagayama, K., Kitano, M., Hirose, S., Tanaka, H., Mori, E., Yamakawa, N., Yasumoto, J.-I., Yuki, K., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1876 · Cited by 154

Repair of radiation damage to DNA

Willers, H., Dahm‐Daphi, J., & Powell, S. N. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601729 · Cited by 159

Genetic Heterogeneity among Fanconi Anemia Heterozygotes and Risk of Cancer

Berwick, M., Satagopan, J. M., Ben‐Porat, L., Carlson, A. D., Mah, K., Henry, R., Diotti, R., Milton, K., Pujara, K., Landers, T., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1501 · Cited by 155

Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.

Menoyo, A., Alazzouzi, H., Espín, E., Armengol, M., Yamamoto, H., & Schwartz, S. (2001) · PubMed · Cited by 151

Homologous DNA recombination in vertebrate cells

Sonoda, E., Takata, M., Yamashita, Y. M., Morrison, C. G., & Takeda, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111006398 · Cited by 151

BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase IIPreprint

Kleiman, F. E., Wu-Baer, F., Fonseca, D., Kaneko, S., Baer, R. J., & Manley, J. L. (2005) · Genes & Development · doi:10.1101/gad.1309505 · Cited by 154

Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities

Daniel, P. M., Sabri, S., Chaddad, A., Meehan, B., Jean‐Claude, B. J., Rak, J. W., & Abdulkarim, B. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00041 · Cited by 152

Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis

Screaton, R. A., Kießling, S., Sansom, O. J., Millar, C. B., Maddison, K., Bird, A. P., Clarke, A. R., & Frisch, S. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0431215100 · Cited by 150

DNA double-strand break repair from head to tail

Hopfner, K., Putnam, C. D., & Tainer, J. A. (2002) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00297-x · Cited by 150

ATM–Chk2–p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

Cao, L., Kim, S., Xiao, C., Wang, R., Coumoul, X., Wang, X., Li, W. M., Xu, X. L., Soto, J. A. D., Takai, H., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601115 · Cited by 150

Cell-cycle checkpoint kinases: checking in on the cell cycle

Walworth, N. C. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00154-x · Cited by 146

Functional Interaction of p53 and BLM DNA Helicase in Apoptosis

Wang, X. W., Tseng, A., Ellis, N. A., Spillare, E. A., Linke, S. P., Robles, A. I., Seker, H., Yang, Q., Hu, P., Beresten, S. F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103298200 · Cited by 145

Tethering on the brink: the evolutionarily conserved Mre11–Rad50 complex

Connelly, J. C., & Leach, D. R. F. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02144-8 · Cited by 147

Identification of Protein Interactions Involved in Cellular Signaling

Westermarck, J., Ivaska, J., & Corthals, G. L. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r113.027771 · Cited by 143

FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres

Pan, X., Drosopoulos, W. C., Sethi, L., Madireddy, A., Schildkraut, C. L., & Zhang, D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708065114 · Cited by 151

DNA mismatch repair defects: role in colorectal carcinogenesis

Jacob, S., & Praz, F. (2002) · Biochimie · doi:10.1016/s0300-9084(01)01362-1 · Cited by 147

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

Joukov, V., Chen, J., Fox, E. A., Green, J. B. A., & Livingston, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211427098 · Cited by 146

A New XRCC1-Containing Complex and Its Role in Cellular Survival of Methyl Methanesulfonate Treatment

Luo, H., Chan, D. W., Yang, T., Rodriguez, M. A., Chen, B. P.-C., Leng, M., Mu, J., Chen, D. J., Songyang, Z., Wáng, Y., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8356-8365.2004 · Cited by 144

Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance

Henning, W., & Stürzbecher, H.-W. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00291-9 · Cited by 143

Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities

Edelbrock, M. A., Saravanan, K., & Williams, K. J. (2013) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.12.008 · Cited by 149

Emerging roles of BRCA1 alternative splicing

Orbán, T. I., & Oláh, E. (2003) · Molecular Pathology · doi:10.1136/mp.56.4.191 · Cited by 145

Replication Protein A and the Mre11·Rad50·Nbs1 Complex Co-localize and Interact at Sites of Stalled Replication Forks

Robison, J. G., Elliott, J., Dixon, K., & Oakley, G. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404750200 · Cited by 141

Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients

Chistiakov, D. A., Voronova, N. V., & Chistiakov, P. A. (2008) · Acta Oncologica · doi:10.1080/02841860801885969 · Cited by 141

Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability

Morales, J. C., Xia, Z., Lu, T., Aldrich, M. B., Wang, B., Rosales, C., Kellems, R. E., Hittelman, W. N., Elledge, S. J., & Carpenter, P. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212484200 · Cited by 142

AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer

Furukawa, T., Kanai, N., Shiwaku, H. O., Soga, N., Uehara, A., & Horii, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209494 · Cited by 135

Chromosomal breakage syndromes and the BRCA1 genome surveillance complex

Futaki, M., & Liu, J. M. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02178-5 · Cited by 135

Functional Characterization of a Novel BRCA1-Null Ovarian Cancer Cell Line in Response to Ionizing Radiation

DelloRusso, C., Welcsh, P. L., Wang, W., Garcia, R. L., King, M., & Swisher, E. M. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0234 · Cited by 134

Mismatch Repair Proteins Are Activators of Toxic Responses to Chromium-DNA Damage

Peterson-Roth, E., Reynolds, M., Quievryn, G., & Zhitkovich, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3596-3607.2005 · Cited by 133

Regulation of E2F1 by BRCT Domain-Containing Protein TopBP1

Liu, K., Lin, F., Ruppert, J. M., & Lin, W.-C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.9.3287-3304.2003 · Cited by 132

The ubiquitin E3 ligase activity of BRCA1 and its biological functions

Wu, W., Koike, A., Takeshita, T., & Ohta, T. (2008) · Cell Division · doi:10.1186/1747-1028-3-1 · Cited by 144

Caretaker tumour suppressor genes that defend genome integrity

Levitt, N. C., & Hickson, I. D. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02298-0 · Cited by 138

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

Sengupta, S., Robles, A. I., Linke, S. P., Sinogeeva, N. I., Zhang, R., Pedeux, R., Ward, I. M., Celeste, A., Nussenzweig, A., Chen, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405128 · Cited by 130

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

Aglipay, J. A., Lee, S. W., Okada, S., Fujiuchi, N., Ohtsuka, T., Kwak, J. C., Wang, Y., Johnstone, R. W., Deng, C., Qin, J., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1207057 · Cited by 129

Comparative Genomic Hybridization Profiles in Human BRCA1 and BRCA2 Breast Tumors Highlight Differential Sets of Genomic Aberrations

van Beers, E. H., van Welsem, T., Wessels, L. F. A., Li, Y., Oldenburg, R. A., Devilee, P., Cornelisse, C. J., Verhoef, S., Hogervorst, F. B. L., Veer, L. J. V., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.822.65.3 · Cited by 129

Functional Genomic Analysis of CAF-1 Mutants in Arabidopsis thaliana

Schönrock, N., Exner, V., Probst, A. V., Gruissem, W., & Hennig, L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513426200 · Cited by 127

S-Phase Checkpoint Genes Safeguard High-Fidelity Sister Chromatid Cohesion

Warren, C. D., Eckley, D. M., Lee, M. S., Hanna, J. S., Hughes, A. L., Peyser, B. D., Jie, C., Irizarry, R. A., & Spencer, F. A. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0637 · Cited by 128

ATM and ATR: Sensing DNA damage

Yang, J. J., Xu, Z., Huang, Y., Hamrick, H. E., Duerksen-Hughes, P. J., & Yu, Y. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i2.155 · Cited by 129

Role of the Escherichia coli RecQ DNA helicase in SOS signaling and genome stabilization at stalled replication forksPreprint

Hishida, T., Han, Y.-W., Shibata, T., Kubota, Y., Ishino, Y., Iwasaki, H., & Shinagawa, H. (2004) · Genes & Development · doi:10.1101/gad.1223804 · Cited by 127

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability

Petkovic, M., Dietschy, T., Freire, R., Jiao, R., & Štagljar, I. (2005) · Journal of Cell Science · doi:10.1242/jcs.02556 · Cited by 126

Early diagnosis of ataxia-telangiectasia using radiosensitivity testing

Sun, X., Becker-Catania, S. G., Chun, H. H., Hwang, M. J., Huo, Y., Wang, Z., Mitui, M., Sanal, Ö., Chessa, L., Crandall, B. F., et al. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.123879 · Cited by 126

Identification of genes induced by BRCA1 in breast cancer cells

Atalay, A., Crook, T. J., Öztürk, M., & Yuluğ, I. G. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02751-1 · Cited by 126

Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM

Hirano, S., Yamamoto, K., Ishiai, M., Yamazoe, M., Seki, M., Matsushita, N., Ohzeki, M., Yamashita, Y. M., Arakawa, H., Buerstedde, J.-M., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600534 · Cited by 127

Targeted Disruption of Np95 Gene Renders Murine Embryonic Stem Cells Hypersensitive to DNA Damaging Agents and DNA Replication Blocks

Muto, M., Kanari, Y., Kubo, E., Takabe, T., Kurihara, T., Fujimori, A., & Tatsumi, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205189200 · Cited by 123

Genetic Predisposition to Breast and Ovarian Cancers: How Many and Which Genes to Test?

Angeli, D., Salvi, S., & Tedaldi, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031128 · Cited by 132

Recql5 and Blm RecQ DNA Helicases Have Nonredundant Roles in Suppressing Crossovers

Hu, Y., Lu, X., Barnes, E. L., Yan, M., Lou, H. J., & Luo, G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3431-3442.2005 · Cited by 122

BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks

Pichierri, P., Franchitto, A., & Rosselli, F. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600277 · Cited by 128

Ubiquitin and breast cancer

Ohta, T., & Fukuda, M. (2004) · Oncogene · doi:10.1038/sj.onc.1207371 · Cited by 123

Unwinding of a DNA Triple Helix by the Werner and Bloom Syndrome Helicases

Brosh, R. M., Majumdar, A., Desai, S., Hickson, I. D., Bohr, V. A., & Seidman, M. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006784200 · Cited by 120

BARD1 Participates with BRCA1 in Homology-Directed Repair of Chromosome Breaks

Westermark, U., Reyngold, M., Olshen, A. B., Baer, R. J., Jasin, M., & Moynahan, M. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7926-7936.2003 · Cited by 120

The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability.

Chen, Y., & Poon, R. Y. C. (2008) · PubMed · doi:10.2741/3060 · Cited by 119

Spontaneous DNA Damage, Genome Instability, and Cancer—When DNA Replication Escapes Control

Schär, P. (2001) · Cell · doi:10.1016/s0092-8674(01)00220-3 · Cited by 122

Functional Link between BLM Defective in Bloom's Syndrome and the Ataxia-telangiectasia-mutated Protein, ATM

Beamish, H., Kedar, P. S., Kaneko, H., Chen, P., Fukao, T., Peng, C., Beresten, S., Gueven, N., Purdie, D. M., Lees‐Miller, S. P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203801200 · Cited by 121

Large-scale identification of mammalian proteins localized to nuclear sub-compartments

Sutherland, H. G. E. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.18.1995 · Cited by 118

BRCA1 interacts directly with the Fanconi anemia protein FANCA

Folias, A. E. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.21.2591 · Cited by 118

Hereditary Breast Cancer: Clinical, Pathological and Molecular Characteristics

Larsen, M. J., Thomassen, M., Gerdes, A., & Kruse, T. A. (2014) · Breast Cancer Basic and Clinical Research · doi:10.4137/bcbcr.s18715 · Cited by 126

Structure and function of the components of the human DNA mismatch repair system

Jascur, T. A., & Boland, C. R. (2006) · International Journal of Cancer · doi:10.1002/ijc.22023 · Cited by 119

ATM is a target for positive regulation by E2F-1

Berkovich, E., & Ginsberg, D. (2003) · Oncogene · doi:10.1038/sj.onc.1206144 · Cited by 117

Profiling and Verification of Gene Expression Patterns in Normal and Malignant Human Prostate Tissues by cDNA Microarray Analysis

Chaı̈b, H., Cockrell, E. K., Rubin, M. A., & Macoska, J. A. (2001) · Neoplasia · doi:10.1038/sj.neo.7900126 · Cited by 117

ATM protein kinase: the linchpin of cellular defenses to stress

Bhatti, S., Kozlov, S., Farooqi, A. A., Naqi, A., Lavin, M., & Khanna, K. K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0683-9 · Cited by 116

Artemis Is a Phosphorylation Target of ATM and ATR and Is Involved in the G2/M DNA Damage Checkpoint Response

Zhang, X., Succi, J., Feng, Z., Prithivirajsingh, S., Story, M. D., & Legerski, R. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9207-9220.2004 · Cited by 119

BRCA1 regulation of transcription

Rosen, E. M., Fan, S., & Ma, Y. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.04.037 · Cited by 121

New complexities for BRCA1 and BRCA2

Kerr, P., & Ashworth, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00389-x · Cited by 117

RecQ helicases: multiple roles in genome maintenance

Khakhar, R. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00171-5 · Cited by 115

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest

Franchitto, A., & Pichierri, P. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110009 · Cited by 114

Role of homologous recombination in carcinogenesis

Bishop, A. J. R., & Schiestl, R. H. (2003) · Experimental and Molecular Pathology · doi:10.1016/s0014-4800(03)00010-8 · Cited by 114

FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein

Gupta, R., Sharma, S., Sommers, J. A., Kenny, M. K., Cantor, S. B., & Brosh, R. M. (2007) · Blood · doi:10.1182/blood-2006-11-057273 · Cited by 114

Demographic variations in the rising incidence of esophageal adenocarcinoma in white males

Bollschweiler, E., Wolfgarten, E., Gutschow, C. A., & H�lscher, A. H. (2001) · Cancer · doi:10.1002/1097-0142(20010801)92:3 · Cited by 452

Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1

Pedrazzi, G. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.21.4378 · Cited by 110

The role of BRCA1 in DNA double-strand repair: Past and present

Caestecker, K. W., & Van de Walle, G. R. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.11.013 · Cited by 108

Cell-cycle responses to DNA damage in G2

Cuddihy, A. R., & O'Connell, M. J. (2003) · International Review of Cytology · doi:10.1016/s0074-7696(02)22013-6 · Cited by 89

BRCA1 Regulates RAD51 Function in Response to DNA Damage and Suppresses Spontaneous Sister Chromatid Replication Slippage: Implications for Sister Chromatid Cohesion, Genome Stability, and Carcinogenesis

Cousineau, I., Abaji, C., & Belmaaza, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2156 · Cited by 108

DNA mismatch repair system

Jun, S., Kim, T., & Ban, C. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05190.x · Cited by 107

Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover

Robert, T., Ravault, D., Fabre, F., & Gangloff, S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601158 · Cited by 107

Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility

Heikkinen, K., Karppinen, S., Soini, Y., Mäkinen, M., & Winqvist, R. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.12.e131 · Cited by 110

DNA mismatch repair and the DNA damage response to ionizing radiation: Making sense of apparently conflicting data

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Non-canonical DNA structures: Diversity and disease association

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