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Cited by 1,494

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

C/EBPα induces adipogenesis through PPARγ: a unified pathway

Open access
Rosen, Evan D., Hsu, Chung-Hsin, Wang, Xinzhong, Sakai, Shuichi, Freeman, Mason W., Gonzalez, Frank J., Spiegelman, Bruce M.·2002·Genes & Development
DOI 10.1101/gad.948702
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Abstract

PPARγ and C/EBPα are critical transcription factors in adipogenesis, but the precise role of these proteins has been difficult to ascertain because they positively regulate each other's expression. Questions remain about whether these factors operate independently in separate, parallel pathways of differentiation, or whether a single pathway exists. PPARγ can promote adipogenesis in C/EBPα-deficient cells, but the converse has not been tested. We have created an immortalized line of fibroblasts lacking PPARγ, which we use to show that C/EBPα has no ability to promote adipogenesis in the absence of PPARγ. These results indicate that C/EBPα and PPARγ participate in a single pathway of fat cell development with PPARγ being the proximal effector of adipogenesis.

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Metadata

Authors
Rosen, E. D., Hsu, C.-H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., & Spiegelman, B. M.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
2002-01-01
Volume
16
Issue
1
Pages
22-26
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.948702
OpenAlex
W2173681478
Cited by
1,494
References
2
Type
posted content
Language
en
Open access
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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