Retinal prosthesis phosphene shape analysis
Abstract
A retinal prosthesis system to restore sight for the blind is under development. The system is analogous to cochlear implants, in which photoreceptor input is bypassed and replaced by direct electrical stimulation of the retinal ganglion cells. Currently, six test subjects have been implanted with a 4x4 electrode array and stimulator. We report here psychophysical clinical data examining how stimulation amplitude affects phosphene shape and repeatability on a single electrode. Phosphene shape data was quantified by a set of numerical descriptors calculated from image moments. Comparison of phosphene descriptors for a single electrode across repeated trials and amplitude levels measured the repeatability within an amplitude group. Our experimental findings show that stimulation of the retina creates repeatable percept shapes and that an increase in stimulation amplitude causes a significant change in size and shape of phosphenes.
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Phosphene shape greatly varied across participants and electrodes, but was relatively consistent across trials of a single electrode.
“Consistent with the literature on single-electrode phosphene drawings (Nanduri et al 2008, Luo et al 2016, Beyeler et al 2019b), phosphene shape greatly varied across participants and electrodes, but was relatively consistent across trials of a single electrode.”
From Axonal stimulation affects the linear summation of single-point perception in three Argus II users (2024) · cites this paper as Nanduri et al 2008
Single-electrode phosphenes elicited by stimulating a single Argus II electrode have a distinctive shape that is relatively consistent over time.
“A series of papers demonstrated that phosphenes elicited by stimulating a single Argus II electrode have a distinctive shape that is relatively consistent over time (Nanduri et al 2008, Luo et al 2016, Beyeler et al 2019b).”
From Axonal stimulation affects the linear summation of single-point perception in three Argus II users (2024) · cites this paper as Nanduri et al 2008
Phosphene appearance varied greatly across electrodes and participants.
“The appearance of phosphenes was highly variable across electrodes and participants, which is consistent with prior studies (D. Nanduri et al. 2008; Beyeler et al. 2019; Luo et al. 2016).”
From Sequential epiretinal stimulation improves discrimination in simple shape discrimination tasks only (2022) · cites this paper as D. Nanduri et al. 2008
Phosphene shapes and sizes differ between electrodes and across participants.
“Since phosphene shapes and sizes differ between electrodes and across participants (D. Nanduri et al. 2008; Beyeler et al. 2019; Luo et al. 2016), which could influence the overall image produced by multi-electrode stimulation, we performed a systematic mapping experiment.”
From Sequential epiretinal stimulation improves discrimination in simple shape discrimination tasks only (2022) · cites this paper as D. Nanduri et al. 2008
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- Authors
- Nanduri, D., Humayun, M. S., Greenberg, R. J., McMahon, M. J., & Weiland, J. D.
- Affiliations
- University of Southern California (US)
- Second Sight Medical Products (US)
- Venue
- 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- Publisher
- IEEE
- Published
- 2008-08
- Volume
- 2008
- Pages
- 1785-1788
- ISSN
- 2375-7477 (ISSN-L)
- OpenAlex
- W2142422810
- Cited by
- 74
- References
- 7
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 2
- FWCI
- 12.16
- Type
- conference paper
- Language
- en
- Open access
- closed
- Locations
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Southern California
- National Eye Institute (R24EY12893-01, R24EY012893)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- retinal prosthesis, stimulation amplitude, image moments, electrode arrays, vision restoration, blind patients
- MeSH terms
- Artificial Organs, Biomedical Engineering, Electrodes, Implanted, Electric Stimulation Therapy, Humans, Phosphenes, Retina, Retinitis Pigmentosa
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