Cited by 74Neuroscience and Neural EngineeringTactile and Sensory InteractionsPain Management and Treatment

Retinal prosthesis phosphene shape analysis

Nanduri, D., Humayun, M.S., Greenberg, R.J., McMahon, M.J., Weiland, J.D.·2008·2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Abstract

A retinal prosthesis system to restore sight for the blind is under development. The system is analogous to cochlear implants, in which photoreceptor input is bypassed and replaced by direct electrical stimulation of the retinal ganglion cells. Currently, six test subjects have been implanted with a 4x4 electrode array and stimulator. We report here psychophysical clinical data examining how stimulation amplitude affects phosphene shape and repeatability on a single electrode. Phosphene shape data was quantified by a set of numerical descriptors calculated from image moments. Comparison of phosphene descriptors for a single electrode across repeated trials and amplitude levels measured the repeatability within an amplitude group. Our experimental findings show that stimulation of the retina creates repeatable percept shapes and that an increase in stimulation amplitude causes a significant change in size and shape of phosphenes.

Integrity signals

Registry

Crossref · 10.1109/iembs.2008.4649524

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Phosphene shape greatly varied across participants and electrodes, but was relatively consistent across trials of a single electrode.

    “Consistent with the literature on single-electrode phosphene drawings (Nanduri et al 2008, Luo et al 2016, Beyeler et al 2019b), phosphene shape greatly varied across participants and electrodes, but was relatively consistent across trials of a single electrode.”
  • Single-electrode phosphenes elicited by stimulating a single Argus II electrode have a distinctive shape that is relatively consistent over time.

    “A series of papers demonstrated that phosphenes elicited by stimulating a single Argus II electrode have a distinctive shape that is relatively consistent over time (Nanduri et al 2008, Luo et al 2016, Beyeler et al 2019b).”
  • Phosphene appearance varied greatly across electrodes and participants.

    “The appearance of phosphenes was highly variable across electrodes and participants, which is consistent with prior studies (D. Nanduri et al. 2008; Beyeler et al. 2019; Luo et al. 2016).”
  • Phosphene shapes and sizes differ between electrodes and across participants.

    “Since phosphene shapes and sizes differ between electrodes and across participants (D. Nanduri et al. 2008; Beyeler et al. 2019; Luo et al. 2016), which could influence the overall image produced by multi-electrode stimulation, we performed a systematic mapping experiment.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Nanduri, D., Humayun, M. S., Greenberg, R. J., McMahon, M. J., & Weiland, J. D.
Affiliations
  • University of Southern California (US)
  • Second Sight Medical Products (US)
Venue
2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Publisher
IEEE
Published
2008-08
Volume
2008
Pages
1785-1788
ISSN
2375-7477 (ISSN-L)
OpenAlex
W2142422810
Cited by
74
References
7
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 7 · 2012: 2
FWCI
12.16
Type
conference paper
Language
en
Open access
closed
Locations
  • Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Southern California
  • National Eye Institute (R24EY12893-01, R24EY012893)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
retinal prosthesis, stimulation amplitude, image moments, electrode arrays, vision restoration, blind patients
MeSH terms
Artificial Organs, Biomedical Engineering, Electrodes, Implanted, Electric Stimulation Therapy, Humans, Phosphenes, Retina, Retinitis Pigmentosa

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review