Stimulation Stability and Selectivity of Chronically Implanted Multicontact Nerve Cuff Electrodes in the Human Upper Extremity
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Nine spiral nerve cuff electrodes were implanted in two human subjects for up to three years with no adverse functional effects. The objective of this study was to look at the long term nerve and muscle response to stimulation through nerve cuff electrodes. The nerve conduction velocity remained within the clinically accepted range for the entire testing period. The stimulation thresholds stabilized after approximately 20 weeks. The variability in the activation over time was not different from muscle-based electrodes used in implanted functional electrical stimulation systems. Three electrodes had multiple, independent contacts to evaluate selective recruitment of muscles. A single muscle could be selectively activated from each electrode using single-contact stimulation and the selectivity was increased with the use of field steering techniques. The selectivity after three years was consistent with selectivity measured during the implant surgery. Nerve cuff electrodes are effective for chronic muscle activation and multichannel functional electrical stimulation in humans.
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Helical and spiral extra-neural interfaces have been stable for decades in clinical applications.
“The helical (Agnew et al., 1989) and spiral (Naples et al., 1988) type interfaces have been proven to be stable for decades in clinical applications (Fisher et al., 2009; Polasek et al., 2009).”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Polasek et al., 2009
The Discussion reports stable recruitment from spiral nerve cuff electrodes in two human subjects for up to three years; the Introduction also describes a spiral cuff implanted in one person for over six years. These passages support clinical stability of spiral interfaces, but not stability for decades. They do not establish clinical stability of helical interfaces. (LLM, conf=0.90)
Experimental — accuracy not yet measuredElectrical stimulation in the form of spikes has been given to the residual stump nerve of a patient through typically implanted electrodes, and psychophysical judgments and verbal reports were gathered.
“Electrical stimulation in the form of spikes has been given to the residual stump nerve of a patient through typically implanted electrodes, and psychophysical judgments and verbal reports were gathered (Polasek et al., 2009; Schiefer et al., 2016).”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Polasek et al., 2009
Methods A and D describe implanted nerve-cuff electrodes delivering electrical pulses. But Methods C identifies the subjects as two people with tetraplegia, not a patient with a residual stump nerve; Methods D describes EMG measurements, not psychophysical judgments or verbal reports. No page numbers are available in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn a 3-year clinical study with two subjects, spiral cuff electrodes provided stable and selective stimulation without serious adverse reactions, after achieving stable stimulation thresholds around the 20th week.
“In a 3-year clinical study with two subjects, spiral cuff electrodes were shown to provide stable and selective stimulation without serious adverse reactions, after achieving stable stimulation thresholds around the 20th week [72].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [72]
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- Authors
- Polasek, K. H., Hoyen, H. A., Keith, M. W., Kirsch, R. F., & Tyler, D. J.
- Affiliations
- Case Western Reserve University (US)
- MetroHealth Medical Center (US)
- Louis Stokes Cleveland VA Medical Center (US)
- Venue
- IEEE Transactions on Neural Systems and Rehabilitation Engineering
- Published
- 2009-10
- Volume
- 17
- Issue
- 5
- Pages
- 428-437
- ISSN
- 1534-4320 (ISSN-L)
- 1558-0210
- PMC
- PMC2927980
- OpenAlex
- W2128390902
- Cited by
- 142
- References
- 34
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 12 · 2017: 9 · 2016: 11 · 2015: 9 · 2014: 10 · 2013: 15 · 2012: 6
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- IEEE Transactions on Neural Systems and Rehabilitation Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Case Western Reserve University
- National Institutes of Health (n01ns012333-006)
- National Institute of Neurological Disorders and Stroke (N01-NS-1-2333, R21NS058705, N01 NS012333)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- cuff electrodes, chronic implantation, nerve conduction velocity, upper limb, functional electrical stimulation, multichannel stimulation, muscle recruitment
- MeSH terms
- Electrodes, Implanted, Electric Stimulation Therapy, Humans, Muscle Contraction, Paralysis, Prosthesis Design, Sensitivity and Specificity, Reproducibility of Results, Muscle, Skeletal, Equipment Failure Analysis, Upper Extremity
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