Multielectrode spiral cuff for ordered and reversed activation of nerve fibres
Abstract
In this paper we present the modelling, design, and experimental testing of a nerve cuff multielectrode system for selective activation of fibres in superficial peripheral nerve trunk regions which is capable of activating fibres in physiological order. The multielectrode system consists of 45 platinum electrodes embedded within a self-curling spiral silicone sheet organized in fifteen longitudinal groups consisting of three electrodes spaced equidistally around the circumference of the cuff. Electrodes in the centre band acted as stimulating cathodes while the two electrodes of the same group in the two outer bands were connected together and corresponded to the position of a particular cathode, serving as anodes to block the nascent action potentials by membrane hyperpolarization. The interpolar distance was 6 mm on both sides, resulting in a total cuff length of about 20 mm. The cuff was constructed with a diameter to fit the size of the dog sciatic nerve. Preliminary animal testing of the nerve cuff was performed on the sciatic nerve of a Bigley female dog. In the 45-electrode stimulation system, biphasic cathodic first pulses with quasitrapezoidal-shaped cathodic and square anodic parts were delivered through the particular group of tripolar electrodes to effect both selective stimulation of motor axons within the gastrocnemius muscle fascicle, and differential block by membrane hyperpolarization. The test was repeated using rectangular cathodic first biphasic current pu…
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Multichannel cuff electrodes enable selective stimulation of separate axonal fascicles within a nerve, each supplying innervation to a different muscle.
“Multichannel cuff electrodes enable selective stimulation of separate axonal fascicles within the nerve, each one supplying innervation to a different muscle (Rozman et al., 1993; Veraart et al., 1993; Grill and Mortimer, 1996a; Walter et al., 1997; Navarro et al., 2001) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Rozman et al., 1993
Quasi-trapezoidal stimulation pulses induce more gradual contraction than rectangular pulses, an effect attributed to activation of fatigue-resistant motor units before large fast-fatigue units with cuff electrodes.
“For example, quasi-trapezoidal stimulation pulses have been shown to induce more gradual contraction than rectangular pulses, an effect that was attributed to activation of fatigue-resistant motor units before activation of large fast-fatigue units with cuff electrodes (Fang and Mortimer, 1991; Rozman et al., 1993) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Rozman et al., 1993
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- Authors
- Rozman, J., Sovinec, B., Trlep, M., & Zorko, B.
- Affiliations
- University of Ljubljana (SI)
- University of Maribor (SI)
- Corresponding author
- Rozman, J.
- ORCID
- Venue
- Journal of Biomedical Engineering
- Publisher
- IOP Publishing
- Published
- 1993-03-01
- Volume
- 15
- Issue
- 2
- Pages
- 113-120
- ISSN
- 0141-5425 (ISSN-L)
- OpenAlex
- W2079292106
- Cited by
- 41
- References
- 31
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 1 · 2017: 1 · 2012: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- membrane hyperpolarization, action potential block, sciatic nerve, gastrocnemius, isometric torque, peripheral nerve stimulation
- MeSH terms
- Animals, Dogs, Electric Conductivity, Electric Stimulation, Electrodes, Implanted, Equipment Design, Female, Models, Neurological, Muscle Contraction, Neural Conduction, Sciatic Nerve, Reproducibility of Results
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