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Cited by 55Neuroscience and Neural EngineeringVagus Nerve Stimulation ResearchMuscle activation and electromyography studies

Chronic Measurement of the Stimulation Selectivity of the Flat Interface Nerve Electrode

Leventhal, D.K., Durand, D.M.·2004·IEEE Transactions on Biomedical Engineering
DOI 10.1109/tbme.2004.827535
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Abstract

The flat interface nerve electrode (FINE) is an attempt to improve the stimulation selectivity of extraneural electrodes. By reshaping peripheral nerves into elliptical cylinders, central fibers are moved closer to the nerve-electrode interface, and additional surface area is created for contact placement. The goals of this study were to test the hypothesis that greater nerve reshaping leads to improved selectivity and to examine the chronic recruitment properties of the FINE. Three FINEs were developed to reshape peripheral nerves to different degrees. Four electrodes of each type were implanted on the sciatic nerves of 12 cats and tested for selectivity over at least three months. There was physiologic evidence of nerve injury in two cats with the tightest cuffs, but the other animals behaved normally. All cuff types were capable of selectively activating branches of the sciatic nerve, as well as groups of fibers within branches. The electrodes that moderately reshaped the nerves demonstrated the most selectivity. Both the selectivity measurements and the recruitment curve characteristics were stable throughout the implant period. From an electrophysiological standpoint, the FINE is a viable alternative for neuroprosthetic devices. A histological analysis of the nerves is under way to evaluate the safety of the FINE.

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Crossref · 10.1109/tbme.2004.827535

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  • Flat-interface nerve electrodes that moderately flattened the nerve demonstrated the best selectivity for limb motion measurements, and this selectivity was maintained throughout the implant time.

    “Electrodes that moderately flattened the nerve demonstrated the best selectivity for limb motion measurements, which were maintained throughout the implant time (Tyler and Durand, 2003; Leventhal and Durand, 2004) .”

    From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Leventhal and Durand, 2004

  • Chronic studies in laboratory animals with flat-interface nerve electrodes implanted for 1 to 3 months showed that high reshaping force induced nerve damage, whereas moderate and small forces caused no detectable change in nerve physiology and histology.

    “Chronic studies in laboratory animals with FINE implanted over 1-3 months showed that electrodes applying high reshaping force induced nerve damage, whereas those with moderate and small forces did not cause any detectable change in nerve physiology and histology.”

    From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Leventhal and Durand, 2004

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Authors
Leventhal, D. K., & Durand, D. M.
Affiliations
Case Western Reserve University (US)
ORCID
Venue
IEEE Transactions on Biomedical Engineering
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Published
2004-09
Volume
51
Issue
9
Pages
1649-1658
ISSN
0018-9294 (ISSN-L)
DOI
10.1109/tbme.2004.827535
OpenAlex
W2100271754
Cited by
55
References
7
Citations by year
2025: 1 · 2024: 4 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2015: 8 · 2014: 3 · 2013: 5 · 2012: 2
FWCI
1.41
Type
journal article
Language
en
Open access
closed
Licence
ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations
  • IEEE Transactions on Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS32845, R01NS032845)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
Keywords
stimulation selectivity, sciatic nerve, chronic electrode implantation, recruitment curves, nerve injury, neuroprosthetics
MeSH terms
Animals, Cats, Electric Stimulation, Electrodes, Implanted, Electric Stimulation Therapy, Equipment Design, Muscle Contraction, Recruitment, Neurophysiological, Sciatic Nerve, Sensitivity and Specificity, Reproducibility of Results, Muscle, Skeletal, Equipment Failure Analysis, Prostheses and Implants

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