The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations

The capsaicin receptor: a heat-activated ion channel in the pain pathway

Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. (1997) · Nature · doi:10.1038/39807 · Cited by 9,107

Molecular characterization of a peripheral receptor for cannabinoids

Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125

The orphan receptor GPR55 is a novel cannabinoid receptor

Ryberg, E., Larsson, N., Sjögren, S., Hjorth, S., Hermansson, N., Leonova, J., Elebring, T., Nilsson, K., Drmota, T., & Greasley, P. J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707460 · Cited by 1,568

Pharmacology of cannabinoid CB1 and CB2 receptors

Pertwee, R. G. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)82001-3 · Cited by 1,470

Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide

Bisogno, T., Hanuš, L., De Petrocellis, L., Tchilibon, S., Ponde, D. E., Brandi, I., Moriello, A. S., Davis, J. B., Mechoulam, R., & Di Marzo, V. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704327 · Cited by 1,311

Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

Katona, I., Sperlágh, B., Sı́k, A., Käfalvi, A., Vizi, E. S., Mackie, K., & Freund, T. F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04544.1999 · Cited by 1,218

TRP Channels and Pain

Julius, D. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155833 · Cited by 1,140

Control of pain initiation by endogenous cannabinoids

Calignano, A., Rana, G. L., Giuffrida, A., & Piomelli, D. (1998) · Nature · doi:10.1038/28393 · Cited by 1,056

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

Southan, C., Sharman, J. L., Benson, H. E., Faccenda, E., Pawson, A. J., Alexander, S. P. H., Buneman, O. P., Davenport, A. P., McGrath, J. C., Peters, J. A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1037 · Cited by 1,035

Emerging roles of PPARS in inflammation and immunity

Daynes, R. A., & Jones, D. C. (2002) · Nature Reviews Immunology · doi:10.1038/nri912 · Cited by 919

The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide

Lo Verme, J., Fu, J., Astarita, G., La Rana, G., Russo, R., Calignano, A., & Piomelli, D. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.006353 · Cited by 882

The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors

Alexander, S. P., Davenport, A. P., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13348 · Cited by 851

Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners

Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T., & Ueda, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306642200 · Cited by 805

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

Lauckner, J. E., Jensen, J. B., Chen, H.-Y., Lu, H.-C., Hille, B., & Mackie, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711278105 · Cited by 712

Nerve growth factor: from neurotrophin to neurokine

Levi-Montalcini, R., Skaper, S. D., Dal Toso, R., Petrelli, L., & Leon, A. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10058-8 · Cited by 686

Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide

Facci, L., Dal Toso, R., Romanello, S., Buriani, A., Skaper, S. D., & Leon, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3376 · Cited by 632

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

Alexander, S. P., Fabbro, D., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13354 · Cited by 604

Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala

Gulyas, A. I., Cravatt, B. F., Bracey, M. H., Dinh, T. P., Piomelli, D., Boscia, F., & Freund, T. F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03428.x · Cited by 561

Cannabinoid and cannabinoid‐like receptors in microglia, astrocytes, and astrocytomas

Stella, N. (2010) · Glia · doi:10.1002/glia.20983 · Cited by 527

Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain

Cristino, L., de Petrocellis, L., Pryce, G., Baker, D., Guglielmotti, V., & Di Marzo, V. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.074 · Cited by 491

The Endocannabinoid System and Pain

Guindon, J., & Hohmann, A. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709789824660 · Cited by 476

Cannabinoid signalling

Demuth, D. G., & Molleman, A. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.05.055 · Cited by 420

Nonpsychotropic Plant Cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), Activate and Desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in Vitro: Potential for the Treatment of Neuronal Hyperexcitability

Iannotti, F. A., Hill, C. L., Leo, A., Alhusaini, A., Soubrane, C., Mazzarella, E., Russo, E., Whalley, B. J., Di Marzo, V., & Stephens, G. J. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn5000524 · Cited by 413

Endocannabinoids control spasticity in a multiple sclerosis model

Baker, D., Pryce, G., Croxford, J. L., Brown, P., Pertwee, R. G., Makriyannis, A., Khanolkar, A., Layward, L., Fezza, F., Bisogno, T., et al. (2001) · The FASEB Journal · doi:10.1096/fj.00-0399fje · Cited by 378

Evidence That 2-Arachidonoylglycerol but Not N-Palmitoylethanolamine or Anandamide Is the Physiological Ligand for the Cannabinoid CB2 Receptor

Sugiura, T., Kondo, S., Kishimoto, S., Miyashita, T., Nakane, S., Kodaka, T., Suhara, Y., Takayama, H., & Waku, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.605 · Cited by 371

Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes

Bisogno, T., Maurelli, S., Melck, D., De Petrocellis, L., & Di Marzo, V. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3315 · Cited by 369

Micron‐Size Drug Particles: Common and Novel Micronization Techniques

Rasenack, N., & Müller, B. W. (2004) · Pharmaceutical Development and Technology · doi:10.1081/pdt-120027417 · Cited by 357

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders

Iannotti, F. A., Di Marzo, V., & Petrosino, S. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.02.002 · Cited by 357

The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain

Jaggar, S. I., Hasnie, F. S., Sellaturay, S., & Rice, A. S. C. (1998) · Pain · doi:10.1016/s0304-3959(98)00041-4 · Cited by 354

Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System

Karsak, M., Gaffal, E., Date, R., Wang-Eckhardt, L., Rehnelt, J., Petrosino, S., Starowicz, K., Steuder, R., Schlicker, E., Cravatt, B., et al. (2007) · Science · doi:10.1126/science.1142265 · Cited by 338

Molecular Characterization of N-Acylethanolamine-hydrolyzing Acid Amidase, a Novel Member of the Choloylglycine Hydrolase Family with Structural and Functional Similarity to Acid Ceramidase

Tsuboi, K., Sun, Y.-X., Okamoto, Y., Araki, N., Tonai, T., & Ueda, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413473200 · Cited by 332

N-(2-Hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation

Mazzari, S., Canella, R., Petrelli, L., Marcolongo, G., & Leon, A. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00015-5 · Cited by 332

Biochemical pharmacology of the vanilloid receptor TRPV1: An update

Cortright, D. N., & Szallasi, A. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04082.x · Cited by 331

Signal transduction of the CB1 cannabinoid receptor

Turu, G., & Hunyady, L. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0190 · Cited by 325

Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-α

LoVerme, J., Russo, R., La Rana, G., Fu, J., Farthing, J., Mattace-Raso, G., Meli, R., Hohmann, A., Calignano, A., & Piomelli, D. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111385 · Cited by 316

Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

Richardson, D., Pearson, R. G., Kurian, N., Latif, M. L., Garle, M. J., Barrett, D. A., Kendall, D. A., Scammell, B. E., Reeve, A. J., & Chapman, V. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2401 · Cited by 303

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors

Costa, B., Comelli, F., Bettoni, I., Colleoni, M., & Giagnoni, G. (2008) · Pain · doi:10.1016/j.pain.2008.06.003 · Cited by 286

Palmitoylethanolamide improves colon inflammation through an enteric glia/toll like receptor 4-dependent PPAR-α activation

Esposito, G., Capoccia, E., Turco, F., Palumbo, I., Lu, J., Steardo, A., Cuomo, R., Sarnelli, G., & Steardo, L. (2014) · Gut · doi:10.1136/gutjnl-2013-305005 · Cited by 268

The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt

del Pulgar, T. G., Velasco, G., & Guzmán, M. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3470369 · Cited by 259

‘Entourage’ effects of N‐palmitoylethanolamide and N‐oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors

Ho, W., Barrett, D. A., & Randall, M. D. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.324 · Cited by 259

The search for the palmitoylethanolamide receptor

LoVerme, J., La Rana, G., Russo, R., Calignano, A., & Piomelli, D. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.012 · Cited by 248

Purification and Characterization of an Acid Amidase Selective for N-Palmitoylethanolamine, a Putative Endogenous Anti-inflammatory Substance

Ueda, N., Yamanaka, K., & Yamamoto, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106261200 · Cited by 246

Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide

Calignano, A., La Rana, G., & Piomelli, D. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00988-8 · Cited by 241

GPR55: a new member of the cannabinoid receptor clan?

Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707464 · Cited by 240

Receptor-dependent formation of endogenous cannabinoids in cortical neurons

Stella, N., & Piomelli, D. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01182-7 · Cited by 238

N-Acylethanolamines in human reproductive fluids

Schuel, H., Burkman, L. J., Lippes, J., Crickard, K., Forester, E., Piomelli, D., & Giuffrida, A. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00158-5 · Cited by 235

Palmitoylethanolamide Increases after Focal Cerebral Ischemia and Potentiates Microglial Cell Motility

Franklin, A., Parmentier-Batteur, S., Walter, L., Greenberg, D. A., & Stella, N. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07767.2003 · Cited by 231

Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats

Petrosino, S., Palazzo, E., de Novellis, V., Bisogno, T., Rossi, F., Maione, S., & Di Marzo, V. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.08.011 · Cited by 227

Selective N -acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

Solorzano, C., Zhu, C., Battista, N., Astarita, G., Lodola, A., Rivara, S., Mor, M., Russo, R., Maccarrone, M., Antonietti, F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907417106 · Cited by 223

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells

Marzo, V. D., Melck, D. J., Orlando, P., Bisogno, T., Zagoory, O., Bifulco, M., Vogel, Z., & PETROCELLIS, L. D. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580249 · Cited by 212

THE IDENTIFICATION OF N-(2-HYDROXYETHYL)-PALMITAMIDE AS A NATURALLY OCCURRING ANTI-INFLAMMATORY AGENT

Kuehl, F. A., Jacob, T. A., Ganley, O. H., Ormond, R. E., & Meisinger, M. A. P. (1957) · Journal of the American Chemical Society · doi:10.1021/ja01577a066 · Cited by 211

GPR55 ligands promote receptor coupling to multiple signalling pathways

Henstridge, C. M., Balenga, N. A., Schröder, R., Kargl, J. K., Platzer, W., Martini, L., Arthur, S., Penman, J., Whistler, J. L., Kostenis, E., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00625.x · Cited by 209

A proposed autacoid mechanism controlling mastocyte behaviour

Aloe, L., Leon, A., & Levi-Montalcini, R. (1993) · Agents and Actions · doi:10.1007/bf01972748 · Cited by 208

Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors

De Petrocellis, L., Davis, J. B., & Di Marzo, V. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02934-9 · Cited by 204

Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals

Re, G., Barbero, R., Miolo, A., & Di Marzo, V. (2007) · The Veterinary Journal · doi:10.1016/j.tvjl.2005.10.003 · Cited by 199 · cited 1×

Endocannabinoids as Regulators of Transient Receptor Potential (TRP)Channels: a Further Opportunity to Develop New Endocannabinoid-Based Therapeutic Drugs

Marzo, V., & Petrocellis, L. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790980078 · Cited by 197

Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells

Di MARZO, V., De PETROCELLIS, L., SEPE, N., & BUONO, A. (1996) · Biochemical Journal · doi:10.1042/bj3160977 · Cited by 196

The Concise Guide to PHARMACOLOGY 2015/16: Voltage‐gated ion channels

Alexander, S. P., Catterall, W. A., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13349 · Cited by 195

Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease

Basu, S., & Dittel, B. N. (2011) · Immunologic Research · doi:10.1007/s12026-011-8210-5 · Cited by 192

Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat

Conti, S., Costa, B., Colleoni, M., Parolaro, D., & Giagnoni, G. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704466 · Cited by 190

Astrocytes in Culture Produce Anandamide and Other Acylethanolamides

Walter, L., Franklin, A., Witting, A., Möller, T., & Stella, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110813200 · Cited by 186

Topical Peroxisome Proliferator Activated Receptor-α Activators Reduce Inflammation in Irritant and Allergic Contact Dermatitis Models

Sheu, M. Y., Fowler, A. J., Kao, J., Schmuth, M., Fluhr, J. W., Man, M.-Q., Elias, P. M., Feingold, K. R., Schoonjans, K., & Auwerx, J. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01626.x · Cited by 177

Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti‐inflammatory agent

Borrelli, F., Romano, B., Petrosino, S., Pagano, E., Capasso, R., Coppola, D., Battista, G., Orlando, P., Di Marzo, V., & Izzo, A. A. (2015) · British Journal of Pharmacology · doi:10.1111/bph.12907 · Cited by 176

The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors

Alexander, S. P., Cidlowski, J. A., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13352 · Cited by 169

Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1

Zygmunt, P. M., Ermund, A., Movahed, P., Andersson, D. A., Simonsen, C., Jönsson, B., Blomgren, A., Birnir, B., Bevan, S., Eschalier, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081618 · Cited by 166

Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy

Gabrielsson, L., Mattsson, S., & Fowler, C. J. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13020 · Cited by 163

Activation of phosphoinositide 3-kinase/PKB pathway by CB1 and CB2 cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction

SANCHEZ, M. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(03)00036-6 · Cited by 158

Massive accumulation of N‐acylethanolamines after stroke. Cell signalling in acute cerebral ischemia?

Berger, C., Schmid, P. C., Schäbitz, W.-R., Wolf, M., Schwab, S., & Schmid, H. H. O. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02244.x · Cited by 155

TRPV1 Receptors in the Central Nervous System: Potential for Previously Unforeseen Therapeutic Applications

Marzo, V. D., Starowicz, K., & Cristino, L. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208783330790 · Cited by 154

Palmitoylethanolamide in CNS health and disease

Raso, G. M., Russo, R., Calignano, A., & Meli, R. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.05.006 · Cited by 153

Palmitoylethanolamide Protects Against the Amyloid-β25-35-Induced Learning and Memory Impairment in Mice, an Experimental Model of Alzheimer Disease

D’Agostino, G., Russo, R., Avagliano, C., Cristiano, C., Meli, R., & Calignano, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.25 · Cited by 150

The anti‐inflammatory mediator palmitoylethanolamide enhances the levels of 2‐arachidonoyl‐glycerol and potentiates its actions at TRPV1 cation channels

Petrosino, S., Moriello, A. S., Cerrato, S., Fusco, M., Puigdemont, A., PETROCELLIS, L. D., & Marzo, V. D. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13084 · Cited by 149

N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities

Petrosino, S., Iuvone, T., & Marzo, V. D. (2010) · Biochimie · doi:10.1016/j.biochi.2010.01.006 · Cited by 148

Activation and desensitization of TRPV1 channels in sensory neurons by the PPARα agonist palmitoylethanolamide

Ambrosino, P., Soldovieri, M. V., Russo, C., & Taglialatela, M. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12029 · Cited by 146

N-acylethanolamine accumulation in infarcted myocardium

Epps, D. E. V., Schmid, P. C., Natarajan, V., & Schmid, H. H. O. (1979) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(79)91281-6 · Cited by 145

Neuroprotective Activities of Palmitoylethanolamide in an Animal Model of Parkinson's Disease

Esposito, E., Impellizzeri, D., Mazzon, E., Paterniti, I., & Cuzzocrea, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041880 · Cited by 144

Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies

Darmani, N. A., Izzo, A. A., Degenhardt, B. F., Valenti, M., Scaglione, G., Capasso, R., Sorrentini, I., & Marzo, V. D. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.001 · Cited by 144

Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo‐oxygenase systems

Costa, B., Conti, S., Giagnoni, G., & Colleoni, M. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704900 · Cited by 143

Acute Intracerebroventricular Administration of Palmitoylethanolamide, an Endogenous Peroxisome Proliferator-Activated Receptor-α Agonist, Modulates Carrageenan-Induced Paw Edema in Mice

D’Agostino, G., Rana, G. L., Russo, R., Sasso, O., Iacono, A., Esposito, E., Raso, G. M., Cuzzocrea, S., Verme, J. L., Piomelli, D., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.123265 · Cited by 139

Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia

D’Agostino, G., Rana, G. L., Russo, R., Sasso, O., Iacono, A., Esposito, E., Raso, G. M., Cuzzocrea, S., LoVerme, J., Piomelli, D., et al. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.022 · Cited by 137

Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism

Mannelli, L. D. C., D’Agostino, G., Pacini, A., Russo, R., Zanardelli, M., Ghelardini, C., & Calignano, A. (2013) · Mediators of Inflammation · doi:10.1155/2013/328797 · Cited by 137

The Role of the Cannabinoid CB2 Receptor in Pain Transmission and Therapeutic Potential of Small Molecule CB2 Receptor Agonists

Whiteside, G. T., Lee, G. P., & Valenzano, K. J. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707780363023 · Cited by 135

Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice

Guida, F., Luongo, L., Marmo, F., Romano, R., Iannotta, M., Napolitano, F., Belardo, C., Marabese, I., D’Aniello, A., Gregorio, D. D., et al. (2015) · Molecular Brain · doi:10.1186/s13041-015-0139-5 · Cited by 134

GPR55 – a putative “type 3” cannabinoid receptor in inflammation

Yang, H.-W., Zhou, J., & Lehmann, C. (2015) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2015-0080 · Cited by 134

Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain

Impellizzeri, D., Bruschetta, G., Cordaro, M., Crupi, R., Siracusa, R., Esposito, E., & Cuzzocrea, S. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0136-0 · Cited by 131

Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain

Jhaveri, M. D., Richardson, D. S., Robinson, I., Garle, M. J., Patel, A., Sun, Y., Sagar, D. R., Bennett, A. J., Alexander, S. P. H., Kendall, D. A., et al. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.018 · Cited by 123

Protective role of palmitoylethanolamide in contact allergic dermatitis

Petrosino, S., Cristino, L., Karsak, M., Gaffal, E., Ueda, N., Tüting, T., Bisogno, T., Filippis, D. D., D’Amico, A., Saturnino, C., et al. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02254.x · Cited by 122

Finding of endocannabinoids in human eye tissues: Implications for glaucoma

Chen, J., Matias, I., Dinh, T., Lu, T., Venezia, S., Nieves, A. L., Woodward, D. F., & Marzo, V. D. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.095 · Cited by 122

Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma

Paterniti, I., Impellizzeri, D., Crupi, R., Morabito, R., Campolo, M., Esposito, E., & Cuzzocrea, S. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-20 · Cited by 118

N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution

Skaper, S. D., Facci, L., Barbierato, M., Zusso, M., Bruschetta, G., Impellizzeri, D., Cuzzocrea, S., & Giusti, P. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9253-8 · Cited by 117

Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysis

Varrassi, G. (2016) · Pain Physician · doi:10.36076/ppj/2016.19.11 · Cited by 117

Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α

Scuderi, C., Valenza, M., Stecca, C., Esposito, G., Carratù, M. R., & Steardo, L. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-49 · Cited by 112

Effects of Palmitoylethanolamide on Signaling Pathways Implicated in the Development of Spinal Cord Injury

Genovese, T., Esposito, E., Mazzon, E., Paola, R. D., Meli, R., Bramanti, P., Piomelli, D., Calignano, A., & Cuzzocrea, S. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.136903 · Cited by 112

Release of Fatty Acid Amides in a Patient With Hemispheric Stroke

Schäbitz, W.-R., Giuffrida, A., Berger, C., Aschoff, A. A., Schwaninger, M., Schwab, S., & Piomelli, D. (2002) · Stroke · doi:10.1161/01.str.0000023491.63693.18 · Cited by 111

Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat

Murillo‐Rodríguez, E., Désarnaud, F., & Prospero-Garcia, O. E. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.12.028 · Cited by 111

Administration of Endocannabinoids Prevents a Referred Hyperalgesia Associated with Inflammation of the Urinary Bladder

Farquhar-Smith, W. P., & Rice, A. S. C. (2001) · Anesthesiology · doi:10.1097/00000542-200103000-00023 · Cited by 109

Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide

Loría, F., Petrosino, S., Mestre, L., Spagnolo, A., Correa, F., Hernangómez, M., Guaza, C., Di Marzo, V., & Docagne, F. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06377.x · Cited by 109

Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice

Capasso, R., Izzo, A. A., Fezza, F., Pinto, A., Capasso, F., Mascolo, N., & Marzo, V. D. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704339 · Cited by 108

Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer’s disease

Scuderi, C., Stecca, C., Valenza, M., Ratano, P., Bronzuoli, M. R., Bartoli, S., Steardo, L., Pompili, E., Fumagalli, L., Campolongo, P., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.376 · Cited by 106

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

Scuderi, C., Esposito, G., Blasio, A., Valenza, M., Arietti, P., Steardo, L., Carnuccio, R., Filippis, D. D., Petrosino, S., Iuvone, T., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01267.x · Cited by 102

The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55

Sharir, H., Console‐Bram, L., Mundy, C., Popoff, S. N., Kapur, A., & Abood, M. E. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9351-6 · Cited by 101

Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis

Gatti, A., Lazzari, M., Gianfelice, V., Paolo, A. D., Sabato, E., & Sabato, A. F. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2012.01432.x · Cited by 101

Plasma endocannabinoid levels in multiple sclerosis

Jean-Gilles, L., Feng, S., Tench, C. R., Chapman, V., Kendall, D. A., Barrett, D. A., & Constantinescu, C. S. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.07.021 · Cited by 100

Co-ultramicronized Palmitoylethanolamide/Luteolin in the Treatment of Cerebral Ischemia: from Rodent to Man

Stroke Study Group, Caltagirone, C., Cisari, C., Schievano, C., Paola, R. D., Cordaro, M., Bruschetta, G., Esposito, E., & Cuzzocrea, S. (2015) · Translational Stroke Research · doi:10.1007/s12975-015-0440-8 · Cited by 100

Stress-induced generation of N-acylethanolamines in mouse epidermal JB6 P+ cells

Berdyshev, E. V., Schmid, P. C., Dong, Z., & Schmid, H. H. O. (2000) · Biochemical Journal · doi:10.1042/bj3460369 · Cited by 97

TRPV1 in the Central Nervous System: Synaptic Plasticity, Function, and Pharmacological Implications

Edwards, J. G. (2014) · Springer eBooks · doi:10.1007/978-3-0348-0828-6_3 · Cited by 95

Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFα release from canine skin mast cells

Cerrato, S., Brazís, P., della Valle, M. F., Miolo, A., & Puigdemont, A. (2009) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2009.06.011 · Cited by 93

A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury

Paterniti, I., Impellizzeri, D., Paola, R. D., Navarra, M., Cuzzocrea, S., & Esposito, E. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-91 · Cited by 93

Isotope dilution GC/MS determination of anandamide and other fatty acylethanolamides in rat blood plasma

Giuffrida, A., & Piomelli, D. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00046-5 · Cited by 93

Palmitoylethanolamide in Homeostatic and Traumatic Central Nervous System Injuries

Esposito, E., & Cuzzocrea, S. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312010010 · Cited by 92

Accumulation of VariousN-Acylethanolamines IncludingN-Arachidonoylethanolamine (Anandamide) in Cadmium Chloride-Administered Rat Testis

Kondo, S., Sugiura, T., Kodaka, T., Kudo, N., Waku, K., & Tokumura, A. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0688 · Cited by 92

Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice

Ahmad, A., Crupi, R., Impellizzeri, D., Campolo, M., Marino, A., Esposito, E., & Cuzzocrea, S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.07.021 · Cited by 91

Neuroprotection by Association of Palmitoylethanolamide with Luteolin in Experimental Alzheimer's Disease Models: the Control of Neuroinflammation

Paterniti, I., Cordaro, M., Campolo, M., Siracusa, R., Cornelius, C., Navarra, M., Cuzzocrea, S., & Esposito, E. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140806124322 · Cited by 90 · cited 3×

Palmitoylethanolamide normalizes intestinal motility in a model of post‐inflammatory accelerated transit: involvement of CB 1 receptors and TRPV 1 channels

Capasso, R., Orlando, P., Pagano, E., Aveta, T., Buono, L., Borrelli, F., Marzo, V. D., & Izzo, A. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12759 · Cited by 86

Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis

Caraceni, P., Viola, A., Piscitelli, F., Giannone, F. A., Berzigotti, A., Cescon, M., Domenicali, M., Petrosino, S., Giampalma, E., Riili, A., et al. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02137.x · Cited by 83

Effectiveness of the association micronized N-Palmitoylethanolamine (PEA)–transpolydatin in the treatment of chronic pelvic pain related to endometriosis after laparoscopic assessment: a pilot study

Cobellis, L., Castaldi, M. A., Giordano, V., Trabucco, E., FRANCISCIS, P. D., Torella, M., & Colacurci, N. (2011) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2011.04.011 · Cited by 83

Microglia produce and hydrolyze palmitoylethanolamide

Muccioli, G. G., & Stella, N. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.015 · Cited by 83

N‐Acylethanolamines: lipid metabolites with functions in plant growth and development

Blancaflor, E. B., Kilaru, A., Keereetaweep, J., Khan, B. R., Faure, L., & Chapman, K. D. (2014) · The Plant Journal · doi:10.1111/tpj.12427 · Cited by 83

Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 mice

Rahimi, A., Faizi, M., Talebi, F., Noorbakhsh, F., Kahrizi, F., & Naderi, N. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.030 · Cited by 82

Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice

Impellizzeri, D., Esposito, E., Paola, R. D., Ahmad, A., Campolo, M., Peli, A., Morittu, V. M., Britti, D., & Cuzzocrea, S. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4382 · Cited by 82

Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis

Campora, L., Miragliotta, V., Ricci, E., Cristino, L., Marzo, V. D., Albanese, F., della Valle, M. F., & Abramo, F. (2012) · American Journal of Veterinary Research · doi:10.2460/ajvr.73.7.988 · Cited by 81

Spinal anandamide produces analgesia in neuropathic rats: Possible CB1- and TRPV1-mediated mechanisms

Starowicz, K., Makuch, W., Osikowicz, M., Piscitelli, F., Petrosino, S., Marzo, V. D., & Przewłocka, B. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.021 · Cited by 80

The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson’s Disease Model

Siracusa, R., Paterniti, I., Impellizzeri, D., Cordaro, M., Crupi, R., Navarra, M., Cuzzocrea, S., & Esposito, E. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150821102823 · Cited by 78

Effect of palmitoylethanolamide–polydatin combination on chronic pelvic pain associated with endometriosis: Preliminary observations

Indraccolo, U., & Barbieri, F. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.01.008 · Cited by 78

Palmitoylethanolamide and stearoylethanolamide levels in the interstitium of the trapezius muscle of women with chronic widespread pain and chronic neck-shoulder pain correlate with pain intensity and sensitivity

Ghafouri, N., Ghafouri, B., Larsson, B. K., Stensson, N., Fowler, C. J., & Gerdle, B. U. C. (2013) · Pain · doi:10.1016/j.pain.2013.05.002 · Cited by 78

Pharmacology of the Capsaicin Receptor, Transient Receptor Potential Vanilloid Type-1 Ion Channel

Nagy, I., Friston, D., Valente, J. D. S., Torres-Pérez, J. V., & Andreou, A. P. (2014) · Springer eBooks · doi:10.1007/978-3-0348-0828-6_2 · Cited by 76

Palmitoylethanolamide Reduces Granuloma-Induced Hyperalgesia by Modulation of Mast Cell Activation in Rats

Filippis, D. D., Luongo, L., Cipriano, M., Palazzo, E., Cinelli, M. P., de Novellis, V., Maione, S., & Iuvone, T. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-3 · Cited by 76

Simultaneous measurement of three N-acylethanolamides in human bio-matrices using ultra performance liquid chromatography-tandem mass spectrometry

Lam, P. M. W., Marczylo, T. H., & Konje, J. C. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4103-z · Cited by 75

Neuroprotective Effects of Co-UltraPEALut on Secondary Inflammatory Process and Autophagy Involved in Traumatic Brain Injury

Cordaro, M., Impellizzeri, D., Paterniti, I., Bruschetta, G., Siracusa, R., Stefano, D. D., Cuzzocrea, S., & Esposito, E. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3460 · Cited by 74

Anti-inflammatory activity on compounds obtained from egg yolk, peanut oil, and soybean lecithin.

Ganley, O. H., Graessle, O. E., & Robinson, H. J. (1958) · PubMed · Cited by 74

The N ‐Acylethanolamine‐Mediated Regulatory Pathway in Plants

Kilaru, A., Blancaflor, E. B., Venables, B. J., Tripathy, S., Mysore, K. S., & Chapman, K. D. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790161 · Cited by 72

Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis

Sanchez, A. M., Cioffi, R., Viganò, P., Candiani, M., Verde, R., Piscitelli, F., Marzo, V. D., Garavaglia, E., & Panina‐Bordignon, P. (2016) · Reproductive Sciences · doi:10.1177/1933719116630414 · Cited by 72

Acetylcholine receptors from human muscle as pharmacological targets for ALS therapy

Palma, E., Reyes‐Ruiz, J. M., Lopergolo, D., Roseti, C., Bertollini, C., Ruffolo, G., Cifelli, P., Onesti, E., Limatola, C., Miledi, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600251113 · Cited by 71

Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry

Schreiber, D., Harlfinger, S., Nolden, B. M., Gerth, C. W., Jaehde, U., Schömig, E., Klosterkötter, J., Giuffrida, A., Astarita, G., Piomelli, D., et al. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.11.027 · Cited by 66

Non-Neuronal Cell Modulation Relieves Neuropathic Pain: Efficacy of the Endogenous Lipid Palmitoylethanolamide

Bettoni, I., Comelli, F., Colombo, A., Bonfanti, P., & Costa, B. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312010008 · Cited by 66

Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia

Schomacher, M., Müller, H. D., Sommer, C., Schwab, S., & Schäbitz, W. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.019 · Cited by 65

Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats

Filippis, D. D., D’Amico, A., Cipriano, M., Petrosino, S., Orlando, P., Marzo, V. D., & Iuvone, T. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.11.005 · Cited by 63

Efficacy of ultra‐micronized palmitoylethanolamide in canine atopic dermatitis: an open‐label multi‐centre study

Noli, C., della Valle, M. F., Miolo, A., Medori, C., & Schievano, C. (2015) · Veterinary Dermatology · doi:10.1111/vde.12250 · Cited by 61

Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats

Ahmad, A., Genovese, T., Impellizzeri, D., Crupi, R., Velardi, E., Marino, A., Esposito, E., & Cuzzocrea, S. (2012) · Brain Research · doi:10.1016/j.brainres.2012.08.006 · Cited by 58

Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans

Sailler, S., Schmitz, K., Jäger, E., et al. (2014) · Oncoscience · doi:10.18632/oncoscience.33 · Cited by 58

Safety of micronized palmitoylethanolamide (microPEA): lack of toxicity and genotoxic potential

Nestmann, E. R. (2016) · Food Science & Nutrition · doi:10.1002/fsn3.392 · Cited by 54

Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity

de Novellis, V., Luongo, L., Guida, F., Cristino, L., Palazzo, E., Russo, R., Marabese, I., D’Agostino, G., Calignano, A., Rossi, F., et al. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.11.034 · Cited by 52

Palmitoylethanolamide Modulates Inflammation-Associated Vascular Endothelial Growth Factor (VEGF) Signaling via the Akt/mTOR Pathway in a Selective Peroxisome Proliferator-Activated Receptor Alpha (PPAR-α)-Dependent Manner

Sarnelli, G., D’Alessandro, A., Iuvone, T., Capoccia, E., Gigli, S., Pesce, M., Seguella, L., Nobile, N., Aprea, G., Maione, F., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156198 · Cited by 51

Possible Anandamide and Palmitoylethanolamide involvement in human stroke

Naccarato, M., Pizzuti, D., Petrosino, S., Simonetto, M., Ferigo, L., Grandi, F., Pizzolato, G., & Marzo, V. D. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-47 · Cited by 49

Ultramicronized palmitoylethanolamide in spinal cord injury neuropathic pain: a randomized, double-blind, placebo-controlled trial

Andresen, S. R., Bing, J., Hansen, R. M., Biering‐Sørensen, F., Johannesen, I. L., Hagen, E. M., Rice, A. S. C., Nielsen, J. F., Bach, F. W., & Finnerup, N. B. (2016) · Pain · doi:10.1097/j.pain.0000000000000623 · Cited by 49

Micronized Palmitoylethanolamide Reduces the Symptoms of Neuropathic Pain in Diabetic Patients

Schifilliti, C., Cucinotta, L., Fedele, V., Ingegnosi, C., Luca, S., & Leotta, C. (2014) · Pain Research and Treatment · doi:10.1155/2014/849623 · Cited by 48

A new co-micronized composite containing palmitoylethanolamide and polydatin shows superior oral efficacy compared to their association in a rat paw model of carrageenan-induced inflammation

Esposito, E., Impellizzeri, D., Bruschetta, G., Cordaro, M., Siracusa, R., Gugliandolo, E., Crupi, R., & Cuzzocrea, S. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.033 · Cited by 47

Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis

Abramo, F., Campora, L., Albanese, F., della Valle, M. F., Cristino, L., Petrosino, S., Marzo, V. D., & Miragliotta, V. (2014) · BMC Veterinary Research · doi:10.1186/1746-6148-10-21 · Cited by 46

The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain

Giugliano, E., Cagnazzo, E., Soave, I., Monte, G. L., Wenger, J. M., & Marci, R. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.01.009 · Cited by 46

Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation

Merriam, F. V., Wang, Z., Hillard, C. J., Stuhr, K. L., & Bjorling, D. E. (2010) · British Journal of Urology · doi:10.1111/j.1464-410x.2010.09583.x · Cited by 44

Functional and biochemical interaction between PPARα receptors and TRPV1 channels: Potential role in PPARα agonists-mediated analgesia

Ambrosino, P., Soldovieri, M. V., Maria, M. D., Russo, C., & Taglialatela, M. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.06.015 · Cited by 44

Cannabinoids and intestinal motility: welcome to CB2 receptors

Izzo, A. A. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705890 · Cited by 43

Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis: role of mast cells

Iuvone, T., Affaitati, G., Filippis, D. D., Lopopolo, M., Grassia, G., Lapenna, D., Negro, L., Costantini, R., Vaia, M., Cipollone, F., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000220 · Cited by 42

Palmitoylethanolamide treatment reduces retinal inflammation in streptozotocin-induced diabetic rats

Paterniti, I., Paola, R. D., Campolo, M., Siracusa, R., Cordaro, M., Bruschetta, G., Tremolada, G., Maestroni, A., Bandello, F. M., Esposito, E., et al. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.035 · Cited by 41

High Levels of N-Palmitoylethanolamide and N-Stearoylethanolamide in Microdialysate Samples from Myalgic Trapezius Muscle in Women

Ghafouri, N., Ghafouri, B., Larsson, B. K., Turkina, M. V., Karlsson, L., Fowler, C. J., & Gerdle, B. U. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027257 · Cited by 37

Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs

Cerrato, S., Brazís, P., della Valle, M. F., Miolo, A., Petrosino, S., Marzo, V. D., & Puigdemont, A. (2011) · The Veterinary Journal · doi:10.1016/j.tvjl.2011.04.002 · Cited by 37

Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis

Petrosino, S., Puigdemont, A., della Valle, M. F., Fusco, M., Verde, R., Allarà, M., Aveta, T., Orlando, P., & Marzo, V. D. (2015) · The Veterinary Journal · doi:10.1016/j.tvjl.2015.10.060 · Cited by 33

Co-Ultramicronized Palmitoylethanolamide/Luteolin Promotes Neuronal Regeneration after Spinal Cord Injury

Crupi, R., Impellizzeri, D., Bruschetta, G., Cordaro, M., Paterniti, I., Siracusa, R., Cuzzocrea, S., & Esposito, E. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00047 · Cited by 33

Amyotrophic Lateral Sclerosis Treatment with Ultramicronized Palmitoylethanolamide: A Case Report

Clemente, S. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311201070933 · Cited by 32

Protective Effect of Palmitoylethanolamide in a Rat Model of Cystitis

Pessina, F., Capasso, R., Borrelli, F., Aveta, T., Buono, L., Valacchi, G., Fiorenzani, P., Marzo, V. D., Orlando, P., & Izzo, A. A. (2014) · The Journal of Urology · doi:10.1016/j.juro.2014.11.083 · Cited by 32

Incorporation of labelled N-acylethanolamine (NAE) into rat brain regions in vivo and adaptive properties of saturated NAE under x-ray irradiation.

Artamonov, M. V., Zhukov, O. D., Shuba, I., et al. (2005) · PubMed · Cited by 31

Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats

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Domínguez, C. M., Martín, A. D., Ferrer, F. G., Puertas, M. I., Muro, A., González, J. M., Prieto, J. P., & Rosselló, I. (2012) · Pain Management · doi:10.2217/pmt.12.5 · Cited by 20

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