Cited by 323Nutrition and Health in AgingFrailty in Older AdultsBalance, Gait, and Falls Prevention

Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women

Open access
Visser, Marjolein, Deeg, Dorly J.H., Lips, Paul, Harris, Tamara B., Bouter, Lex M.·2000·Journal of the American Geriatrics Society

Abstract

OBJECTIVE: Low muscle strength is associated with poorer physical function, but limited empirical evidence is available to prove the relationship between muscle mass and physical function. We tested the hypothesis that persons with lower muscle mass or muscle strength have poorer lower-extremity performance (LEP). DESIGN: A cross-sectional, population-based study. PARTICIPANTS: A cohort of 449 men and women aged 65 years and older living in Amsterdam and its surroundings participating in the second examination (1995-1996) of the Longitudinal Aging Study Amsterdam. MEASUREMENTS: Leg skeletal muscle mass was measured using dual-energy X-ray absorptiometry (DXA). Grip strength was used as an indicator of muscle strength. Timed functional performance tests, including walking and repeated chair stands, were used to assess LEP. RESULTS: After adjustment for body height and age, leg muscle mass was positively associated with LEP in men (regression coefficient 0.178 [95% confidence interval 0.013-0.343], P = .035). In women an inverse association was observed, which became positive after additional adjustment for body mass index (BMI) (0.202 [-0.001-0.405], P = .052). Grip strength was positively associated with LEP in men and women. After additional adjustment for behavioral, physiological, and psychological variables, the associations between leg muscle mass and LEP disappeared, whereas grip strength remained to be independently associated with LEP in men (0.079 [0.042-0.116], P = .0001), with a tendency in women (0.046 [-0.009-0.101], P = .11). Results were similar when quartiles of leg muscle mass or grip strength were used. CONCLUSIONS: These results suggest that low muscle strength, but not low muscle mass, is associated with poor physical function in older men and women. However, prospective studies are needed to investigate the association between loss of muscle mass and physical function.

Integrity signals

Registry

Crossref · 10.1111/j.1532-5415.2000.tb04694.x

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Visser, M., Deeg, D. J. H., Lips, P., Harris, T. B., & Bouter, L. M.
Affiliations
  • National Institutes of Health (US)
  • Vrije Universiteit Amsterdam (NL)
Corresponding author
Visser, Marjolein
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2000-04
Volume
48
Issue
4
Pages
381-386
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
OpenAlex
W2141162872
Cited by
323
References
36
Citations by year
2026: 5 · 2025: 14 · 2024: 8 · 2023: 14 · 2022: 15 · 2021: 15 · 2020: 10 · 2019: 16 · 2018: 22 · 2017: 14 · 2016: 18 · 2015: 14 · 2014: 14 · 2013: 16 · 2012: 17
FWCI
3.23
Type
journal article
Language
en
Open access
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
  • VU Research Portal (publishedVersion, other-oa)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
Keywords
skeletal muscle mass, muscle strength, grip strength, lower extremity performance, physical function, older adults, leg muscle mass, sex differences, body mass index, aging
MeSH terms
Aged, Aging, Cross-Sectional Studies, Female, Humans, Leg, Longitudinal Studies, Male, Netherlands, Obesity, Regression Analysis, Sex Factors, Absorptiometry, Photon, Geriatric Assessment, Confounding Factors, Epidemiologic, Body Mass Index, Prevalence, Walking, Muscle, Skeletal, Hand Strength

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review