Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women
Open accessAbstract
OBJECTIVE: Low muscle strength is associated with poorer physical function, but limited empirical evidence is available to prove the relationship between muscle mass and physical function. We tested the hypothesis that persons with lower muscle mass or muscle strength have poorer lower-extremity performance (LEP). DESIGN: A cross-sectional, population-based study. PARTICIPANTS: A cohort of 449 men and women aged 65 years and older living in Amsterdam and its surroundings participating in the second examination (1995-1996) of the Longitudinal Aging Study Amsterdam. MEASUREMENTS: Leg skeletal muscle mass was measured using dual-energy X-ray absorptiometry (DXA). Grip strength was used as an indicator of muscle strength. Timed functional performance tests, including walking and repeated chair stands, were used to assess LEP. RESULTS: After adjustment for body height and age, leg muscle mass was positively associated with LEP in men (regression coefficient 0.178 [95% confidence interval 0.013-0.343], P = .035). In women an inverse association was observed, which became positive after additional adjustment for body mass index (BMI) (0.202 [-0.001-0.405], P = .052). Grip strength was positively associated with LEP in men and women. After additional adjustment for behavioral, physiological, and psychological variables, the associations between leg muscle mass and LEP disappeared, whereas grip strength remained to be independently associated with LEP in men (0.079 [0.042-0.116], P = .0001), with a tendency in women (0.046 [-0.009-0.101], P = .11). Results were similar when quartiles of leg muscle mass or grip strength were used. CONCLUSIONS: These results suggest that low muscle strength, but not low muscle mass, is associated with poor physical function in older men and women. However, prospective studies are needed to investigate the association between loss of muscle mass and physical function.
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- Authors
- Visser, M., Deeg, D. J. H., Lips, P., Harris, T. B., & Bouter, L. M.
- Affiliations
- National Institutes of Health (US)
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Visser, Marjolein
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2000-04
- Volume
- 48
- Issue
- 4
- Pages
- 381-386
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2141162872
- Cited by
- 323
- References
- 36
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 8 · 2023: 14 · 2022: 15 · 2021: 15 · 2020: 10 · 2019: 16 · 2018: 22 · 2017: 14 · 2016: 18 · 2015: 14 · 2014: 14 · 2013: 16 · 2012: 17
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- green
- research.vu.nl
- Licence
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Keywords
- skeletal muscle mass, muscle strength, grip strength, lower extremity performance, physical function, older adults, leg muscle mass, sex differences, body mass index, aging
- MeSH terms
- Aged, Aging, Cross-Sectional Studies, Female, Humans, Leg, Longitudinal Studies, Male, Netherlands, Obesity, Regression Analysis, Sex Factors, Absorptiometry, Photon, Geriatric Assessment, Confounding Factors, Epidemiologic, Body Mass Index, Prevalence, Walking, Muscle, Skeletal, Hand Strength
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