Cited by 1,659Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesNeurological Disease Mechanisms and Treatments

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Rate of progression of mild cognitive impairment to dementia – meta‐analysis of 41 robust inception cohort studies

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Mitchell, A. J., Shiri‐Feshki, M.·2009·Acta Psychiatrica Scandinavica

DOI 10.1111/j.1600-0447.2008.01326.x

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Abstract

Objective: To quantify the risk of developing dementia in those with mild cognitive impairment (MCI). Method: Meta‐analysis of inception cohort studies. Results: Forty‐one robust cohort studies were identified. To avoid heterogeneity clinical studies, population studies and clinical trials were analysed separately. Using Mayo defined MCI at baseline and adjusting for sample size, the cumulative proportion who progressed to dementia, to Alzheimer’s disease (AD) and to vascular dementia (VaD) was 39.2%, 33.6% and 6.2%, respectively in specialist settings and 21.9%, 28.9% and 5.2%, respectively in population studies. The adjusted annual conversion rate (ACR) from Mayo defined MCI to dementia, AD and VaD was 9.6%, 8.1% and 1.9%, respectively in specialist clinical settings and 4.9%, 6.8% and 1.6% in community studies. Figures from non‐Mayo defined MCI and clinical trials are also reported. Conclusion: The ACR is approximately 5–10% and most people with MCI will not progress to dementia even after 10 years of follow‐up.

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Reduced cortical cholinergic innervation measured using [18F]-FEOBV PET imaging correlates with cognitive decline in mild cognitive impairment
Xia, Y., Eeles, E. M., Fripp, J., Pinsker, D. M., Thomas, P. A., Latter, M. J., Doré, V., Fazlollahi, A., Bourgeat, P., Villemagne, V. L., et al. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.102992 · Cited by 44
Estimation of the risk of conversion of mild cognitive impairment of Alzheimer type to Alzheimer's disease in a south Brazilian population-based elderly cohort: the PALA study
Godinho, C., Camozzato, A. L., Onyszko, D., & Chaves, M. L. F. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211002043 · Cited by 44
“49 (Bruscoli and Lovestone, 2004; Ishikawa et al., 2006; Dickerson et al., 2007; Palmer et al.2008; Matthews et al., 2008; Mitchell and Shiri-Feshki, 2009; Ganguli et al., 2011) and therefore the observed risk can be considered high.”
BackgroundInfluential
Does Vascular Burden Contribute to the Progression of Mild Cognitive Impairment to Dementia?
Clerici, F., Caracciolo, B., Cova, I., Imperatori, S. F., Maggiore, L., Galimberti, D., Scarpini, E. A., Mariani, C. B., & Fratiglioni, L. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000343776 · Cited by 45
Patterns of Cognitive Decline, Conversion Rates, and Predictive Validity for 3 Models of MCI
Ritchie, L. J., & Tuokko, H. A. (2010) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317510382286 · Cited by 49
“9 depending on the operationalization of MCI in a meta-analytic review of MCI cohort studies.(22) Additionally, the removal of a single criterion causes marked differences in prevalence rates.”
Background
The Effect of Age Correction on Multivariate Classification in Alzheimer’s Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects
Falahati, F., Ferreira, D., Soininen, H. S., Mecocci, P., Vellas, B. J., Tsolaki, M., Kłoszewska, I., Lovestone, S., Eriksdotter, M., Wahlund, L., et al. (2015) · Brain Topography · doi:10.1007/s10548-015-0455-1 · Cited by 48
“Some MCI subjects progress to AD or even other neurological disorders, some remain stable over time, with a smaller number reverting to a cognitively normal status (Mitchell and Shiri-Feshki 2009).”
Background
Framingham Risk Score and the Risk of Progression from Mild Cognitive Impairment to Dementia
Viticchi, G., Falsetti, L., Buratti, L., Sajeva, G., Luzzi, S., Bartolini, M., Provinciali, L., & Silvestrini, M. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170160 · Cited by 45
“We only collected amnestic MCI (aMCI) because, according to literature, this subtype has the highest risk of conversion to AD [15, 16].”
Method
MicroRNAs and mild cognitive impairment: A systematic review
Piscopo, P., Lacorte, E., Feligioni, M., Mayer, F., Crestini, A., Piccolo, L., Bacigalupo, I., Filareti, M., Ficulle, E., Confaloni, A., et al. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.11.005 · Cited by 45
Classification and Graphical Analysis of Alzheimer’s Disease and Its Prodromal Stage Using Multimodal Features From Structural, Diffusion, and Functional Neuroimaging Data and the APOE Genotype
Gupta, Y., Kim, J., Kim, B. C., & Kwon, G. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00238 · Cited by 45
Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population
Angevaare, M. J., Vonk, J. M. J., Bertola, L., Zahodne, L. B., Watson, C. W., Boehme, A., Schupf, N., Mayeux, R. P., Geerlings, M. I., & Manly, J. J. (2021) · Neurology · doi:10.1212/wnl.0000000000013017 · Cited by 45
Detecting MCI and dementia in primary care: efficiency of the MMS, the FAQ and the IQCODE
Cruz, I., Bellón, J. M., Torrero, P., Aparicio, E., Sanz, A., Mula, N., Marzana, G., Begué, C., Cabezon, D., & Olazarán, J. (2011) · Family Practice · doi:10.1093/fampra/cmr114 · Cited by 46
Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study
Hildreth, K. L., Pelt, R. E. V., Moreau, K. L., Grigsby, J., Hoth, K. F., Pelak, V. S., Anderson, C. A., Parnes, B. L., Kittelson, J. M., Wolfe, P., et al. (2015) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000371509 · Cited by 46
Clinical Measures of Prospective Memory in Amnestic Mild Cognitive Impairment
Delprado, J., Kinsella, G., Ong, B., Pike, K. E., Ames, D. J., Storey, E., Saling, M. M., Clare, L., Mullaly, E., & Rand, E. H. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s135561771100172x · Cited by 51
“Although exact figures vary, an annual conversion rate of 5% to 12%, as compared with 1% to 2% of cognitively healthy older adults, has been reported (Mitchell & Shiri-Feshki, 2009).”
Background
White Matter Changes in Patients with Amnestic Mild Cognitive Impairment Detected by Diffusion Tensor Imaging
Liu, J., Yin, C., Xia, S., Jia, L., Guo, Y., Zhao, Z., Li, X., Han, Y., & Jia, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059440 · Cited by 43
“A meta-analysis reported the annual conversion rate from aMCI to AD at 5%–10% [8].”
Background
Body weight status and onset of cognitive impairment among U.S. middle-aged and older adults
Xiang, X., & An, R. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.02.008 · Cited by 44
Occurrence of medical co-morbidity in mild cognitive impairment: implications for generalisation of MCI research
Stephan, B. C. M., Brayne, C., Savva, G. M., & Matthews, F. E. (2011) · Age and Ageing · doi:10.1093/ageing/afr057 · Cited by 46
“Not all individuals with MCI progress to dementia, with some individuals remaining stable or reverting to normal [4, 5].”
Background
Effects of 5 years aerobic exercise on cognition in older adults: the Generation 100 Study: a randomized controlled trial
Zotcheva, E., Håberg, A. K., Wisløff, U., Salvesen, Ø., Selbæk, G., Stensvold, D., & Ernstsen, L. (2022) · Sports Medicine · doi:10.1007/s40279-021-01608-5 · Cited by 43
“Men in the ExComb group had 36% lower odds of MCI, which is a smaller effect than in observational studies of physical activity and cognitive impairment [37, 38], but still can be of significance to public health given that approximately 5–10% of individuals with MCI will progress to dementia annually [41].”
Background
Brain metabolism and cerebrospinal fluid biomarkers profile of non-amnestic mild cognitive impairment in comparison to amnestic mild cognitive impairment and normal older subjects
Coutinho, A. M., Porto, F. H. G., Duran, F., Prando, S., Ono, C. R., Feitosa, E. D. A. A. F., Spíndola, L., de Oliveira, M. O., do Vale, P. H. F., Gomes, H. R., et al. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0143-0 · Cited by 45
“Most studies indicate a preferential conversion of aMCI to AD, but other variables such as the presence of more than one affected domain, type of impairment, intensity of cognitive impairment at baseline, and presence of apolipoprotein E epsilon 4 allele may possibly influence the conversion to dementia [7].”
Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size
Yu, P., Sun, J., Wolz, R., Stephenson, D. T., Brewer, J. B., Fox, N. C., Cole, P. E., Jack, C. R., Hill, D., & Schwarz, A. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.039 · Cited by 45
Progression from mild cognitive impairment to dementia: A 3-year longitudinal study
Brodaty, H., Connors, M. H., Ames, D. J., Woodward, M., & on behalf of the PRIME study group (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414536237 · Cited by 44
“Most research on predictors of progression from MCI has emanated from tertiary referral centres or population studies (Mitchell and Shiri-Feshki, 2009; Petersen et al., 2009), especially from the USA.”
BackgroundResult
Disclosure of amyloid imaging results to research participants: Has the time come?
Lingler, J. H., & Klunk, W. E. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.09.014 · Cited by 44
18F PET with florbetaben for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)
Martínez, G., Vernooij, R. W. M., Padilla, P. F., Zamora, J., Flicker, L. A., & Bonfill, X. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012883 · Cited by 44
Using Base Rate of Low Scores to Identify Progression from Amnestic Mild Cognitive Impairment to Alzheimer's Disease
Oltra‐Cucarella, J., Sánchez‐SanSegundo, M., Lipnicki, D. M., Sachdev, P. S., Crawford, J. D., Pérez-Vicente, J. A., Cabello‐Rodríguez, L., Ferrer‐Cascales, R., & Initiative, A. D. N. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15412 · Cited by 46
Differential Role for Hippocampal Subfields in Alzheimer’s Disease Progression Revealed with Deep Learning
Kwak, K., Niethammer, M., Giovanello, K. S., Styner, M. A., Dayan, E., & Initiative, A. D. N. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab223 · Cited by 43
The impact of hearing impairment and hearing aid use on progression to mild cognitive impairment in cognitively healthy adults: An observational cohort study
Bucholc, M., Bauermeister, S., Kaur, D., McClean, P. L., & Todd, S. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12248 · Cited by 49
“34 As such, the method creates a socalled pseudo-population in which (1) the exposure is independent of the measured covariates and (2) drop-out is not related to the measured exposure and covariates and thus, potential selection bias due to loss to follow-up is accounted for.”
Method
High White Matter Lesion Load Is Associated with Hippocampal Atrophy in Mild Cognitive Impairment
Eckerström, C., Olsson, E., Klasson, N., Bjerke, M., Göthlin, M., Jonsson, M., Rolstad, S., Malmgren, H., Wallin, A., & Edman, Å. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000323014 · Cited by 43
“MCI patients are at risk for further cognitive decline, and it is estimated that roughly 40p of MCI patients will convert to dementia [”
Background
Behavioral Interventions to Prevent or Delay Dementia: Protocol for a Randomized Comparative Effectiveness Study
Smith, G., Chandler, M., Locke, D. E., Fields, J., Phatak, V., Crook, J., Hanna, S., Lunde, A., Morris, M., Graff-Radford, M., et al. (2017) · JMIR Research Protocols · doi:10.2196/resprot.8103 · Cited by 42
“Approximately 15% to 20% of people aged 65 or older have MCI, and it is estimated that 32% to 38% of individuals with MCI develop Alzheimer dementia in 5 years [10].”
Background
Exploring the validity of mild cognitive impairment (MCI) subtypes: Multiple-domain amnestic MCI is the only identifiable subtype at longitudinal follow-up
Klekociuk, S. Z., & Summers, M. J. (2014) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2014.890699 · Cited by 43
“…below age-appropriate normative references: a level of subclinical impairment that is consistent with previous research (Saunders & Summers, 2010, 2011; Summers & Saunders, 2012) and avoids the potential of cutoff scores of 1.5 standard deviations being too severe (Mitchell & Shiri-Feshki, 2009).”
BackgroundResultInfluential
Biomarkers of Exposure to Polycyclic Aromatic Hydrocarbons and Cognitive Function among Elderly in the United States (National Health and Nutrition Examination Survey: 2001-2002)
Best, E. A., Juarez‐Colunga, E., James, K. A., LeBlanc, W. G., & Serdar, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147632 · Cited by 44
“[6, 7, 8], of which 40 percent is expected to progress into the more severe dementia later in life [9].”
Background
Operationalizing the Diagnostic Criteria for Mild Cognitive Impairment: The Salience of Objective Measures in Predicting Incident Dementia
Brodaty, H., Aerts, L., Crawford, J. D., Heffernan, M., Kochan, N. A., Reppermund, S., Kang, K., Maston, K., Draper, B., Trollor, J. N., et al. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.12.012 · Cited by 42
Comparing the Mini-Mental State Examination and the modified Mini-Mental State Examination in the detection of mild cognitive impairment in older adults
Patten, R. V., Britton, K. J., & Tremont, G. N. (2018) · International Psychogeriatrics · doi:10.1017/s1041610218001023 · Cited by 42
Performance on neuropsychological assessment and progression to dementia: A meta-analysis.
Prado, C. E., Watt, S., Treeby, M. S., & Crowe, S. F. (2019) · Psychology and Aging · doi:10.1037/pag0000410 · Cited by 42
Comorbidity‐driven multi‐modal subtype analysis in mild cognitive impairment of Alzheimer's disease
Katabathula, S., Davis, P. B., & Xu, R. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12792 · Cited by 43
“2,3 Some individuals with MCI stay stable after 10-years’ follow-up or even return to normal cognitive status by timely interventions, 4 whereas others progress to AD and die within 3 years after diagnosis.”
Aging and Alzheimer’s Disease
LUPIEN, S. J., Lord, C., Sindi, S., Wilkinson, C. W., & Fiocco, A. J. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00097-8 · Cited by 42
Signature of Alzheimer’s Disease in Intestinal Microbiome: Results From the AlzBiom Study
Laske, C., Müller, S., Preische, O., Ruschil, V., Munk, M. H. J., Honold, I., Peter, S., Schoppmeier, U., & Willmann, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.792996 · Cited by 39
“Both results are conflicting and also surprising, because MCI is a heterogeneous syndrome with varying clinical outcomes: up to 60% of MCI patients develop dementia within a 10year period, however, many people remain cognitively stable or regain normal cognitive function (Manly et al., 2008; Mitchell and Shiri-Feshki,…”
Result
Identifying and Characterizing Trajectories of Cognitive Change in Older Persons with Mild Cognitive Impairment
Xie, H., Mayo, N. E., & Koski, L. M. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000323568 · Cited by 41
Cause of death in mild cognitive impairment: a prospective study (NEDICES)
Contador, I., Bermejo‐Pareja, F., Mitchell, A. J., Trincado, R., Villarejo‐Galende, A., Sánchez‐Ferro, Á., & Benito‐León, J. (2013) · European Journal of Neurology · doi:10.1111/ene.12278 · Cited by 41
“MCI research has become highly relevant during the last decade, especially as people with MCI have a higher risk of developing dementia than age-matched population controls [2].”
BackgroundResultSelf-citation
Age and education adjusted normative data and discriminative validity for Rey’s Auditory Verbal Learning Test in the elderly Greek population
Messinis, L., Nasios, G., Mougias, A. A., Politis, A. M., Zampakis, P. E., Tsiamaki, E., Malefaki, S., Gourzis, P., & Papathanasopoulos, P. (2015) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2015.1085496 · Cited by 43
“Due to a significant increase in elderly patients’ subjective memory complaints (Zygouris & Tsolaki, 2015) and reports (Mitchell & Shiri-Feshki, 2009; Summers & Saunders, 2012) that patients with MCI have elevated rates of conversion to dementia, the objective and accurate assessment of episodic…”
Background
Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers
Handels, R. L. H., Vos, S. J. B., Kramberger, M. G., Jelić, V., Blennow, K., van Buchem, M. A., van der Flier, W. M., Freund‐Levi, Y., Hampel, H. J., Rikkert, M. G. M. O., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.12.015 · Cited by 41
“However, generalizability to old age might be limited as the average age was 69 years, and diagnostic performance has been shown to decrease with age [37], and a 40% a priori risk is higher than other observed proportions [38].”
Background
Quantitative MRI of Perivascular Spaces at 3T for Early Diagnosis of Mild Cognitive Impairment
Niazi, M. Z., Karaman, M., Das, S. R., Zhou, X. J., Yushkevich, P. A., & Cai, K. (2018) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5734 · Cited by 41
“Current research suggests that the MCI population progresses to dementia at a greater rate than those without this condition.(31,32) Anywhere from 32%–38% of individuals with MCI progress to AD in 5 years or longer.”
Background
Mild Cognitive Impairment and Dementia Reported by Former Professional Football Players over 50 yr of Age: An NFL-LONG Study
Walton, S. R., BRETT, B. L., Chandran, A. S., DEFREESE, J. D., Mannix, R., Echemendía, R. J., MEEHAN, W. P., McCrea, M., GUSKIEWICZ, K. M., & KERR, Z. Y. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002802 · Cited by 45
“Copyright © 2022 by the American College of Sports Medicine conditions is estimated around 24%–32% (4).”
Background
Dementia risk prediction in individuals with mild cognitive impairment: a comparison of Cox regression and machine learning models
Wang, M., Greenberg, M., Forkert, N. D., Chekouo, T., Afriyie, G., Ismail, Z., Smith, E. E., & Sajobi, T. T. (2022) · BMC Medical Research Methodology · doi:10.1186/s12874-022-01754-y · Cited by 41
“On average, 5-10% of people with MCI progress to dementia per year [2]; however, not all individuals with MCI progress to dementia [3].”
Background
Impact of supplementation with vitamins B6 , B12 , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review
González, G. O., Inzitari, M., Bellelli, G., Morandi, A., Barcons, N., & Viña, J. (2021) · IUBMB Life · doi:10.1002/iub.2507 · Cited by 40
“As such, early therapeutic interventions are required to prevent degenerative neurological damage.(5,6) Patients suffering from MCI have increased oxidative damage even before the onset of symptoms.”
Background
Mobile Phone Use and Cognitive Impairment among Elderly Chinese: A National Cross-Sectional Survey Study
Qi, S., Sun, Y., Yin, P., Zhang, H., & Wang, Z. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115695 · Cited by 42
“A meta-analysis of 41 robust inception cohort studies summarized that less than half of individuals with MCI tend to progress to dementia in 3–10 years [5], and the annual progression rate is 5–15% [5,6].”
Differential and subtype-specific neuroimaging abnormalities in amnestic and nonamnestic mild cognitive impairment: A systematic review and meta-analysis
Yeung, M. K.-C., Chau, A. K.-Y., Chiu, J. Y.-C., Shek, J. T.-L., Leung, J. P.-Y., & Wong, T. C.-H. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101675 · Cited by 40
Old Worries and New Anxieties: Behavioral Symptoms and Mild Cognitive Impairment in a Population Study
Andreescu, C., Teverovsky, E., Fu, B., Hughes, T. F., Chang, C. H., & Ganguli, M. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.09.010 · Cited by 42
Prognostic Significance of Mild Cognitive Impairment Subtypes for Dementia and Mortality: Data from the NEDICES Cohort
Bermejo‐Pareja, F., Contador, I., Trincado, R., Lora, D., Sánchez‐Ferro, Á., Mitchell, A. J., Boycheva, E., Herrero, A., Hernández‐Gallego, J., Velasco, S. L., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150625 · Cited by 45
Self-citation
Counterpoint. Early intervention for psychosis risk syndromes: Minimizing risk and maximizing benefit
Woods, S. W., Bearden, C. E., Sabb, F. W., Stone, W. S., Torous, J. B., Cornblatt, B. A., Perkins, D. O., Cadenhead, K. S., Addington, J., Powers, A. R., et al. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.04.020 · Cited by 41
Assessment of retinal vascular network in amnestic mild cognitive impairment by optical coherence tomography angiography
Criscuolo, C., Cennamo, G., Montorio, D., Carotenuto, A., Strianese, A., Salvatore, E., Tranfa, F., Cennamo, G., Lanzillo, R., & Morra, V. B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233975 · Cited by 40
“The rate of conversion to AD is 1% to 2% per year in the general population, 5% to 10% in subjects with MCI [3], and up to 50% in 30 months for aMCI [4].”
Background
Planning and optimising a digital intervention to protect older adults’ cognitive health
Essery, R., Pollet, S., Smith, K. A., Mowbray, F., Slodkowska‐Barabasz, J., Denison‐Day, J., Hayter, V., Bradbury, K. J., Grey, E., Western, M. J., et al. (2021) · Pilot and Feasibility Studies · doi:10.1186/s40814-021-00884-2 · Cited by 38

Authors: Mitchell, A. J., & Shiri‐Feshki, M.
Affiliations: University of Leicester (GB)
Nottinghamshire Healthcare NHS Foundation Trust (GB)
Corresponding author: Mitchell, A. J.
ORCID: Mitchell, A. J.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2009-03-03
Volume: 119
Issue: 4
Pages: 252-265
ISSN: 0001-690X (ISSN-L)
1600-0447
DOI: 10.1111/j.1600-0447.2008.01326.x
OpenAlex: W2052226124
Cited by: 1,659
References: 87
Citations by year: 2026: 84 · 2025: 98 · 2024: 135 · 2023: 118 · 2022: 129 · 2021: 176 · 2020: 165 · 2019: 115 · 2018: 96 · 2017: 86 · 2016: 88 · 2015: 85 · 2014: 62 · 2013: 75 · 2012: 55
FWCI: 5.80
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: mild cognitive impairment, dementia progression, Alzheimer's disease, vascular dementia, Mayo criteria
MeSH terms: Aged, Alzheimer Disease, Cognition Disorders, Dementia, Follow-Up Studies, Humans, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Dementia, Vascular, Cohort Studies, Prevalence, Disease Progression

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Rate of progression of mild cognitive impairment to dementia – meta‐analysis of 41 robust inception cohort studies

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