The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index; 1 of the 52 sources its claims cite were checked for support.
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Open accessAbstract
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now‐familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend‐ ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now‐familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
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63 Own result · 16 No full text of the sources · 15 Own method · 6 Not checked yet · 6 Own interpretation · 5 Sources not found · 2 No basis given · 1 Partly supported · accuracy not yet measured
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber)”
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In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1).”
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exception was A/J, a strain that demonstrated a preference for the central chamber.”
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Overall, four of the five inbred and hybrid strains tested spent more time in the side of the social test box containing the unfamiliar stranger, vs. time in the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“DBA/2 mice tended to have lower numbers of entries than the C57BL/6J mice (Fig. 10b; significant main effect of strain, F 1,9 ¼ 16.156, P ¼ 0.003; retest, F 1,9 ¼ 36.215,P ¼ 0.0002; and side, F 1,9 ¼ 8.723, P ¼ 0.0161).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Finally, the adult C57BL/6J and DBA/2 mice had higher numbers of entries into the side of the chamber containing the unfamiliar conspecific in the sociability test.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plainn = 2- Asserted: passes — The authors put it forward as true.
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In the paper
“Adult A/J males failed to show a significant preference for the side containing stranger 1, as compared to the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The low number of entries observed in the A/J mice was significantly different from both of the other inbred strains (post hoc tests following repeated measures ANOVA, F-values above).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 24
- The quote only partly states this claim. 1
- Probably not a substantial claim. 32
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Higher numbers of sniffs were directed toward stranger 1 than towards the empty wire cage, and towards the novel stranger 2 vs. the now-familiar stranger 1, in C57BL/6J, DBA/2J and FVB/NJ male mice (Nadler et al. 2004).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Partly supportedcites Nadler et al. 2004 sourceExperimental — accuracy not yet measured
The “Social behavior tasks in three inbred strains” section reports that males of all three named strains spent more time sniffing the cage containing stranger 1 than the empty cage, and more time sniffing stranger 2 than stranger 1. The “Sociability test” section specifies that sniffing was scored as cumulative duration in seconds, not as a number of sniffs; that measurement in the claim is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“General health, neurological reflexes, activity levels, motor functions and sensory abilities were normal in most regards for the strains tested.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar levels of sociability were clearly evident in a group of young female C57BL/6J mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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The quote only partly states this claim.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A/J was the only strain tested that failed to spend more time with a conspecific, and spent most of its time in the central chamber after the initial 5-minute habituation session.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the inbred strains were able to locate buried food, supporting an interpretation that none were anosmic, which could have severely impacted social behaviors by blocking detection of olfactory cues emitted by the stranger mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For the olfactory test, the majority of the subjects successfully located and retrieved the buried food.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 9, the A/J group did show significant increases in time spent in the side regions (Fig. 9a, significant main effect of retest, F 1,9 ¼ 11.343, P ¼ 0.0083) and in number of entries (Fig. 9b, significant main effect of retest, F 1,9 ¼ 13.302, P ¼ 0.0053) when the openings between chambers were more accessible.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Sociability procedure with modified social test box
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the significantly higher locomotor scores observed in the FVB/NJ strain, in comparison to the other two groups, were not reflected in an overall higher number of entries.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The FVB/NJ mice demonstrated a significantly shorter latency for locating the buried food,”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A significant interaction was found between side of chamber and test condition (F 1,57 ¼ 67.634, P < 0.0001), reflecting the finding that preference was for the stranger 1 side during the first half of the session (the sociability condition), but switched to the stranger 2 side during the last part of the session (the social novelty condition).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Arguing against an artifactual interpretation that hypolocomotion caused the social deficit in the A/J group are the data of Fig. 8. Repeated testing of A/J in the modified apparatus increased the number of entries, but did not yield significant sociability scores.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The A/J mice spent significantly more time in the center chamber, indicating a strong preference for the start box that was not seen in the other strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the second group of juvenile C57BL/6J mice, both males and females made equal numbers of entries into each side of the social test box during the assay for sociability, but showed an increased number of entries into the side of the social box containing the second, 'novel' unfamiliar stranger during the test for social novelty.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences between the strains in body weight or rotarod performance (see Table 1 for mean latency to fall on the second trial).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, for the juvenile male mice, number of entries did not reflect the trends for social preference seen in the duration measures, and only partially correlated with their locomotor activity independently quantitated in the open field.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, low locomotor scores in DBA/2J and high locomotor scores in FVB/NJ appeared to be unrelated to amount of time spent in the chamber with stranger 1 and stranger 2.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant preferences for sociability (Fig. 3a) or preference for social novelty (Fig. 3b) were not observed for number of chamber entries in any of the inbred strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the present study, the juvenile male mice made nests and huddled together while sleeping.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Autistic individuals may further avoid unfamiliar social partners and display diminished interest in novelty (American Psychiatric Association 1994).”
What the sources say
- Not matchedcites American Psychiatric Association 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This modification focuses the task on social approach tendencies, relevant to the social approach deficit in autism, while avoiding potential confounds resulting from aggressive or sexual interactions.”
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Rests on an assumption: Most autistic individuals demonstrate reduced or unusual social approach.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“To ensure that differences in social behaviors were not artifacts of other aspects of mouse behaviors, a series of independent control experiments was conducted to evaluate potential confounding factors.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of times that the mouse exited from the habituated empty central chamber into the novel empty chamber provided a general measure of locomotor function.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Social behaviors have been explored in mice with mutations in candidate genes such as oxytocin (Winslow & Insel 2002;Young et al. 2002), monoamine oxidase-A (Shih & Chen 1999), fragile X (Churchill et al. 2002;Mineur et al. 2002) and dishevelled-1 (Lijam et al. 1997).”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Further controls were designed to detect additional symptoms relevant to autism, such as abnormalities in locomotion or motor coordination (Hallett et al. 1993;Piven et al. 1997), that could directly affect performance of the social task.”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Measures of general health, home cage behavior and neurological reflexes were conducted to rule out gross physical abnormalities (Crawley 2000).”
What the sources say
- Not checked — no full text of the sourcecites Crawley 2000
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Retrieval of food buried in cage bedding was quantitated in a 15-minute olfactory test, to ensure that the subject mice were not grossly impaired in olfaction abilities.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“A large body of evidence from twin and family studies supports the important role of genetic factors in the etiology of autism (Bailey et al. 1995;Ritvo et al. 1989;Szatmari et al. 1998).”
What the sources say
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present mouse tasks were designed to maximize face validity to some of the core symptoms of autism.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the A/J mice were given a second test one week later, with the dividing walls between the chamber sides partially retracted to facilitate exploration.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
plainn = 10- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Given the primacy of social impairment in autism, we considered this symptom to be fundamental to a mouse model of autism (Insel 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Several additional behavioral assays were performed in the initial set of juvenile male mice (C57BL/6J, DBA/2J and FVB/ NJ).These assays were designed as controls for sensory and motor abilities, etc., to ensure that the test mice were physically able to perform the procedures necessary for the social tasks described above.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The chambers of the social apparatus were cleaned and fresh paper chip bedding was added between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The location of stranger 1 in the left vs. right side chamber was systematically alternated between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In our experience to date with the present procedures, human observers attain a high level of proficiency after only one or two practice sessions, with high rates (greater than 95%) of interrater reliability between trained observers.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present protocol used a small wire cage to enclose the stimulus mouse, which allowed visual, auditory and olfactory contact between the mice, but prevented the occurrence of aggressive and other responses.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“From an early age, autistic children show low levels of eye contact and affective responses, less orientation toward others and language deficits, with a concomitant paucity of speech and social communication (for review, see Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites Tager-Flusberg et al. 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The stranger mouse was enclosed in a small, round wire cage (Galaxy Cup, Spectrum Diversified Designs, Inc., Streetsboro, OH), which allowed nose contact between the bars, but prevented fighting.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Previous work in social recognition has shown that mice show both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993;Dluzen & Kreutzberg 1993;Ferguson et al. 2000;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present procedures for the sociability and social novelty tests are designed to be simple, quantitative and easily mastered by investigators.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the present methods were designed to quantitate levels of sociability, i.e. tendency to initiate social contact, and preference for social novelty, i.e. tendency to initiate social contacts with a new individual as compared to someone familiar from past experience, using a simple scoring approach for laboratory mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, some autistic patients demonstrate aberrant motor responses, including repeated hand flapping, jumping and other repetitive and stereotyped behaviors (Bodfish et al. 2000;Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered sensory responses have been reported, including both hypo-and hyper-reactivity to environmental stimuli (Baranek 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Baranek 2002 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Use of the three-chambered apparatus for demonstrating social preference (Insel 2001) was adapted by Brodkin et al. (2004) to investigate social approach and avoidance in female mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Brodkin et al. 2004 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“and the mouse model of fragile X syndrome has been characterized by changes in activity (Bakker et al. 1994;Peier et al. 2000) and reactivity to acoustic stimuli (Chen & Toth 2001;Nielson et al. 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Bakker et al. 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Peier et al. 2000
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Chen & Toth 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Children with fragile X syndrome often show autistic behavior (Hagerman et al. 1986),”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Hagerman et al. 1986 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“As noted by Winslow (2003), the analysis of the full behavioral series that can occur in social tests demands familiarity with the mouse ethogram, extensive training and the ability to discern the sometimes rapid and fleeting responses that mice can emit.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Winslow 2003 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Methods are based on procedures examining pair-bonding in voles (Dean, S.M. & Vandenbergh, J.G. as above), as well as many other elegant tests for social behavior in rodents (Bluthe et al. 1993;Carter et al. 1995;Dluzen & Kreutzberg 1993;Gheusi et al. 1994;Insel and Young 2001;Kogan et al. 2000;Winslow & Camacho 1995;Winslow 2003).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Most autistic individuals demonstrate reduced or unusual social approach.
“We reasoned that most autistic individuals demonstrate reduced or unusual social approach.”
The paper relies on this without support.
Behavioral models of autistic-like responses in mice have received little attention.
“However, to date, behavioral models of autistic-like responses in mice have received little attention.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [530]
In the citing paper
“There is compelling evidence that some strains are more”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
In the citing paper
“However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects 9 ).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
“the social novelty test was not conducted”
Citations
Cites
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Autism as a strongly genetic disorder: evidence from a British twin study
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Epidemiological Surveys of Autism and Other Pervasive Developmental Disorders: An Update
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Varieties of Repetitive Behavior in Autism: Comparisons to Mental Retardation
Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005596502855 · Cited by 1,223
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
A Comparison of the Social Postures of Some Common Laboratory Rodents
Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108
Research works printed but not linked: 1
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Cited by
Sorted by citations
Items 1,001–1,100 of 1,472
Atsumi, T., Ide, M., & Wada, M. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00263 · Cited by 8
“We then developed an experimental set up based on a three-chambered sociability test apparatus for rodents (Moy et al., 2004).”
BackgroundMethodInfluentialCharacterization of an Animal Model of Autism and Social Interaction
Iwata, K. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8994-2_14 · Cited by 9
Mouse models and strain-dependency of Chédiak-Higashi syndrome-associated neurologic dysfunction
Hedberg‐Buenz, A., Dutca, L. M., Larson, D. R., Meyer, K. J., Soukup, D. A., van der Heide, C. J., Mercer, H. E., Wang, K., & Anderson, M. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-42159-0 · Cited by 8
Dugyala, S., Ptacek, T., Simon, J. M., Li, Y., & Frӧhlich, F. (2020) · Animal Microbiome · doi:10.1186/s42523-020-00030-y · Cited by 7
Quezada, N. T., Salas-Ortíz, S. F., Peralta, F. A., Aguayo, F. I., Morgado-Gallardo, K. P., Mac-Rae, C. A., Fiedler, J. L., & Aliaga, E. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.555610 · Cited by 8
Leussis, M. P., Thanos, J. M., Powers, A. E., Peterson, E., Head, J. P., McGovern, N. J., Malarkey, F. J., & Drake, A. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173293 · Cited by 9
Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like statePreprint
Lee, C. R., Matthews, G. A., Lemieux, M., Wasserlein, E. M., Borio, M., Miranda, R. L., Keyes, L. R., Schneider, G. P., Jia, C., Tran, A., et al. (2025) · eLife · doi:10.7554/elife.105955 · Cited by 9
A Systematic Review of the MDMA Model to Address Social Impairment in Autism
Chaliha, D. R., Mamo, J. C. L., Albrecht, M. A., Lam, V., Takechi, R., & Vaccarezza, M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210101130258 · Cited by 7
“These are the ultrasonic-vocalisation test, the social-preference test, the social-novelty-preference test and the social-interaction test [71-73].”
MethodLau, A. R., BAXTER, A. B., He, S., Loyant, L., Ortiz‐Jimenez, C. A., Bauman, M. D., Bales, K. L., & Freeman, S. M. (2024) · Animal Behaviour · doi:10.1016/j.anbehav.2024.08.015 · Cited by 7
“For instance, polygamous mice prefer to spend time near socially novel conspeci fi cs over familiar cagemates within a three-chambered social preference test paradigm (Moy et al., 2004).”
Nicotinamide riboside alleviates sweeteners-induced brain and cognitive impairments in immature mice
Jiang, Y., Zhang, H., Shi, J., Shan, T., Liu, M., Wang, P., Liang, X., & Liang, H. (2025) · Food & Function · doi:10.1039/d4fo05553e · Cited by 7
Xiong, R., Hu, Y., Wang, M., Han, T., Hu, Y., Ma, C., & Li, B. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412995122 · Cited by 7
“The three - chamber social testing (TCS testing) was employed to address the social interaction ability of mice, as described previously (48).”
Szabó, Á., Galla, Z., Spekker, E., Martos, D., Szűcs, M., Fejes-Szabó, A., Fehér, Á., Takeda, K., Ozaki, K., Inoue, H., et al. (2025) · Cells · doi:10.3390/cells14211711 · Cited by 11
Kolodziejczyk, M. H., Faesel, N., Koch, M., & Fendt, M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112782 · Cited by 7
Social Behavior Testing in Mice: Social Interest, Recognition, and Aggression
Clipperton‐Allen, A. E., & Page, D. T. (2022) · Neuromethods · doi:10.1007/978-1-0716-2748-8_14 · Cited by 8
Goral, R. O., Harper, K. M., Bernstein, B. J., Fry, S. A., Lamb, P. W., Moy, S. S., Cushman, J. D., & Yakel, J. L. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1067409 · Cited by 8
Self-citationMort, E. J., Heritage, S., Jones, S., Fowden, A. L., & Camm, E. J. (2023) · Nutrients · doi:10.3390/nu15214594 · Cited by 7
Socha, J., Grochecki, P., Smaga, I., Jastrzębska, J., Wronikowska‐Denysiuk, O., Marszałek‐Grabska, M., Słowik, T., Kotlinski, R., Filip, M., Lübec, G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021041 · Cited by 8
“Specifically, during this task, the test animals spend more time investigating a social stimulus and prefer a novel conspecific over a familiar one [41].”
BackgroundInsulin-like growth factor 2 (IGF-2) rescues social deficits in NLG3–/y mouse model of ASDs
Pizzarelli, R., Pimpinella, D., Jacobs, C., Tartacca, A., Kullolli, U., Monyer, H., Alberini, C. M., & Griguoli, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1332179 · Cited by 8
Dunn, J. T., Guidotti, A., & Grayson, D. R. (2024) · eNeuro · doi:10.1523/eneuro.0186-23.2024 · Cited by 7
“…in C57BL/6J mice, which are commonly used for the generation of genetic mouse models of various disorders, including autism spectrum disorder (ASD); C57BL/6J mice are additionally used as controls for mouse models of idiopathic ASD such as the BTBR mouse (Moy et al., 2004; Amodeo et al., 2012).”
BackgroundPriming of hippocampal microglia by IFN-γ/STAT1 pathway impairs social memory in mice
He, H., Zhang, X., He, H., Xiao, C., Xu, G., Li, L., Li, L., Yang, C., Zhou, T., You, Z., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112191 · Cited by 7
Açıkgöz, B., Ersoy, N., Aksu, İ., Kıray, A., Bağrıyanık, A., & Kıray, M. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102092 · Cited by 7
Shchipanov, N. A., & Demidova, T. B. (2022) · Behavioural Processes · doi:10.1016/j.beproc.2022.104625 · Cited by 7
Interleukin 15 modulates the effects of poly I:C maternal immune activation on offspring behaviour
Haddad, F. L., Patel, S. V., Doornaert, E. E., Oliveira, C. D., Allman, B. L., Baines, K. J., Renaud, S. J., & Schmid, S. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100473 · Cited by 8
“Each rat’s preference for a conspecific over an inanimate object (sociability), as well as its preference for a stranger rat over a familiar rat (social novelty), were assessed using the previously established 3-chamber assay (Crawley, 2007; Moy et al., 2004; Scott et al., 2020).”
MethodCheng, D., Wu, J., Yan, E., Fan, X., Wang, F., Ma, L., & Liu, X. (2022) · Communications Biology · doi:10.1038/s42003-022-04051-y · Cited by 8
Corrone, M., Ratnayake, R., de Oliveira, N., Jaehne, E. J., & van den Buuse, M. (2022) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000708 · Cited by 7
“Sociability and social preference Social behaviour was assessed using three consecutive stages, each lasting 10 min (Moy et al., 2004; Manning and van den Buuse, 2016).”
MethodDemerdash, N. E., Pan, T., Choi, O., Saraswati, M., Koehler, R. C., Robertson, C., & Savonenko, A. V. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2021.0376 · Cited by 8
“Similar deficits in novel object recognition have been demonstrated by our group and others, using the CCI model in immature rats injured at PND 10-21.”
NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation
Diab, A. M., Wigerius, M., Quinn, D. P., Qi, J., Shahin, I., Paffile, J., Krueger, K., Karten, B., Krueger, S., & Fawcett, J. P. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0495-21.2022 · Cited by 9
Béry, A., Etienne, O., Mouton, L., Mokrani, S., Granotier, C., Gauthier, L., Feat-Vetel, J., Kortulewski, T., Pérès, E. A., Lestaevel, P., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2023.112342 · Cited by 7
Prefrontal representation of affective stimuli: importance of stress, sex, and context
Wallace, T., & Myers, B. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad110 · Cited by 7
Circuits underlying social function and dysfunction
Wang, Z., Yueh, H., Chau, M., Veenstra-VanderWeele, J. M., & O’Reilly, K. C. (2023) · Autism Research · doi:10.1002/aur.2978 · Cited by 9
“Sociability is indicated by the test animal’s preference for the social target (Moy et al., 2004).”
BackgroundLoss of GDE2 leads to complex behavioral changes including memory impairment
Daudelin, D., Westerhaus, A., Zhang, N., Leyder, E. C., Savonenko, A. V., & Sockanathan, S. (2024) · Behavioral and Brain Functions · doi:10.1186/s12993-024-00234-1 · Cited by 8
“The social preferences of mice were tested in a three-chamber apparatus using similar protocols and equipment as previously described [26].”
MethodMouse Behavior and Models for Autism Spectrum Disorders
Ricceri, L., Michetti, C., & Scattoni, M. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00017-0 · Cited by 13
Yoshihara, D., Fujiwara, N., Kitanaka, N., Kitanaka, J., Sakiyama, H., Eguchi, H., Takemura, M., & Suzuki, K. (2016) · Free Radical Research · doi:10.1080/10715762.2016.1234048 · Cited by 7
“Social approach behavior monitoring in the three chamber test box was conducted as described previously with minor modifications [25,26].”
MethodIto, W., Huang, H., Brayman, V. L., & Morozov, A. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12513 · Cited by 7
“By contrast, for Eating, there was a significant genotype*familiarity interaction (F(1,60) = 4.”
BackgroundMethodInfluentialZhu, Z., Lu, X., Yuan, D., & Huang, S. (2016) · Genomics · doi:10.1016/j.ygeno.2016.12.001 · Cited by 7
Monaco, S. A., Matamoros, A. J., & Gao, W. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109901 · Cited by 7
Human forebrain endothelial cell therapy for psychiatric disorders
Datta, D., Subburaju, S., Kaye, S., Baruah, J., Choi, Y. K., Nian, Y., Khalili, J. S., Chung, S., Elkhal, A., & Vasudevan, A. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0839-9 · Cited by 7
“Behavioral assays were performed according to established protocols referenced here: nest building with shredded paper [46], selfgrooming [47], light–dark box [48], tail suspension test [49], and three-chamber social interaction test [50].”
MethodWang, X., Gao, C., Zhang, Y., Xu, J., Fang, Q., Gou, L., Yang, Z., Mei, D., Liu, L., Li, L., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00886 · Cited by 7
Goswami, N., Aleem, M., & Manda, K. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113055 · Cited by 7
Zutshi, I., Gupta, S., Zanoletti, O., Sandi, C., & Poirier, G. L. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01659-2 · Cited by 7
“Social investigation Sociability: Social tendencies were evaluated by contrasting free access to a non-threatening juvenile or an inanimate object [24]; adapted from Crawley and collaborators [32], and as previously described [33].”
MethodSalt as a non-caloric behavioral modifier: A review of evidence from pre-clinical studies
Beaver, J. N., & Gilman, T. L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.007 · Cited by 7
Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells
Rivet-Noor, C. R., Merchak, A. R., Li, S., Beiter, R. M., Lee, S., Thomas, J. A., Fernández-Castañeda, A., Shin, J., & Gaultier, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-12464-2 · Cited by 8
Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice
Mehak, S. F., Shivakumar, A. B., Jijimon, F., Gupta, A., Pillai, V. G., & Gangadharan, G. (2025) · Aging Cell · doi:10.1111/acel.70139 · Cited by 6
“The three-chamber test for sociability and social recognition memory was performed as previously described (Figure 1B) (Moy et al. 2004).”
Saghir, K. A., Ashraf, W., Mushtaq, R. M. Z., Alqahtani, F., & Imran, I. (2025) · Behavioural Neurology · doi:10.1155/bn/8037864 · Cited by 6
“The time spent around each cage in the two sessions was noted to calculate the sociability index (SI) and social novelty preference to evaluate social interactions [18].”
Zuo, X., Zhang, S., Bai, H., Yu, Q., Zhao, Q., Sun, M., Zhao, X. J., & Feng, X. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-33148-6 · Cited by 6
“Preference for social novelty is the tendency to spend more time with an unfamiliar mouse than with a familiar one (Moy et al. 2004).”
Roles of AMPA receptors in social behaviors
Xu, Q. W., Larosa, A., & Wong, T. P. (2024) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2024.1405510 · Cited by 6
Lopes, I. S., Souza, A. G., Filho, A. J. M. C., Sampaio, T. L., da Silva, D. M. A., Valentim, J. T., Chaves, R. D. C., Soares, M. V. R., Júnior, D. C. C., Barbosa‐Filho, J. M., et al. (2024) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000788 · Cited by 7
“An unfamiliar mouse (same age, sex, and weight) with the subject mouse was placed in one of two restraining cages while the other was empty (Moy et al. , 2004).”
A social switch: daylength drives meadow vole group dynamics in automatically tracked habitats
Power, K. C., Lee, N. S., Rendon-Torres, K., Soergel, D. A. W., & Beery, A. K. (2025) · Animal Behaviour · doi:10.1016/j.anbehav.2025.123084 · Cited by 6
Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region
Villegas, A., & Siegelbaum, S. A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115992 · Cited by 8
Neocortical excitation/inhibition balance in information processing and social
Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., Stehfest, K., Fudim, R., et al. (2011) · Cited by 6
Kordás, K. S., Kis-Varga, Á., Varga, A., Eldering, H., Bulthuis, R., Lendvai, B., Lévay, G. I., & Román, V. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108841 · Cited by 7
Bhardwaj, S. K., Cui, Q., Moquin, L., Gratton, A. P., Bruno Giros, A., & Srivastava, L. K. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108440 · Cited by 6
Inflammatory Skin Disease Causes Anxiety Symptoms Leading to an Irreversible Course
Iida, S., Shoji, H., Kawakita, F., Nakanishi, T., Matsushima, Y., Kondo, M., Habe, K., Suzuki, H., Miyakawa, T., & Yamanaka, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065942 · Cited by 6
“Three-Chamber Test A three-chamber social approach test was conducted to assess sociability and social novelty preference [30].”
MethodSchulingkamp, R., Wan, H., & Hackenberg, T. D. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1158365 · Cited by 6
“This type of preference for less familiar over more familiar social partners parallels findings from social preference tests in mice (Moy et al., 2004) and rats (Smith et al.”
BackgroundEffects of heterozygous deletion of autism-related gene Cullin-3 in mice
Xia, Q., Walker, A. K., Song, C., Wang, J., Singh, A., Mobley, J. A., Xuan, Z., Singer, J. D., & Powell, C. M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0283299 · Cited by 6
Social isolation leads to mild social recognition impairment and losses in brain cellularity
Guimarães, D. M., Valério‐Gomes, B., Vianna-Barbosa, R. J., Oliveira, W., Neves, G. A., Tovar-Moll, F. F., & Lent, R. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02705-z · Cited by 7
“It is possible to infer a cognitive aspect (memory) from this test since mice are usually social (Kappel et al. 2017) and tend to show interest/curiosity for new stimuli (Moy et al. 2004).”
BackgroundMarkerless Mouse Tracking for Social Experiments
Le, V. A., Sterley, T.-L., Cheng, N., Bains, J. S., & Murari, K. (2024) · eNeuro · doi:10.1523/eneuro.0154-22.2023 · Cited by 8
“It is known that mice and rats typically show a preference for social novelty, spending more time investigating an unfamiliar versus a familiar conspecific (Moy et al., 2004; Oettl et al., 2016).”
BackgroundZhuang, Y., Li, C., Zhao, F., Yan, Y., Pan, H., Zhan, J., & Behnisch, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031543 · Cited by 7
“To achieve this, we conducted the three-chamber social interaction test, which enables the assessment of sociability and social memory in rodents [40].”
MethodCrusio, W. E., Sluyter, F., Gerlai, R. T., & Pietropaolo, S. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139541022.022 · Cited by 5
Yu, D., Xiao, R., Huang, J., Cai, Y., Bao, X., Jing, S., Du, Z., Tian-de, Y., & Fan, X. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5092-4 · Cited by 6
Azogu, I., Cossette, I., Mukunzi, J. N., Ibeke, O., & Plamondon, H. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.04.006 · Cited by 7
Sünnetçi, E., Durankuş, F., Albayrak, Y., Erdoğan, M. A., Atasoy, Ö., & Erbaş, O. (2021) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2021.19.1.84 · Cited by 6
“Sociability test was performed as previously described with minor modifications [22,23].”
MethodLiu, H., Meng, X., Li, Y., Chen, S., Ji, Y., Song, S., Ji, F., & Jin, X. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.01.022 · Cited by 7
Marker-less tracking system for multiple mice using Mask R-CNN
Sakamoto, N., Kakeno, H., Ozaki, N., et al. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1086242 · Cited by 6
“This test quantifies how long a subject mouse is in contact with stranger and familiar mice (Moy et al., 2004).”
BackgroundNeonatal domoic acid alters in vivo binding of [11C]yohimbine to α2-adrenoceptors in adult rat brain
Thomsen, M. B., Lillethorup, T. P., Jakobsen, S., Nielsen, E. N., Simonsen, M., Wegener, G., Landau, A. M., & Tasker, R. A. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4416-5 · Cited by 6
“The same rats were tested on PND75 for social interaction using a modification of Crawley’s sociability and preference for social novelty paradigm (Moy et al. 2004; Ryan et al. 2011).”
MethodAltered GABAergic inhibition in CA1 pyramidal neurons modifies despair-like behavior in micePreprint
Yoon, S. H., Chung, G., Song, W. S., Oh, S. P., Kim, J.-J., Kim, S. J., & Kim, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.18.953786 · Cited by 7
“In the three-chamber test (Moy et al., 2004), the WT and RalBP1–/– mice showed similar sociability and preference for social novelty.”
BackgroundEvidence for the involvement of a fronto-striatal pathway in the processing of social reward
Lin, K., & Coutellier, L. D. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102834 · Cited by 6
Shevchouk, O. T., Edvardsson, C. E., Ericson, M., Sköldheden, S. B., Zhang, Q., Nabinger, D. D., Snoeren, E. M. S., Westberg, L., & Jerlhag, E. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116085 · Cited by 9
Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders
Borges, R. L., González-Blanco, G., Harikumar, A., Huang, Y., Caeiro, L. D., Fattakhov, N. S., Lepore, S., Garcia-Martinez, L., Maurice, M., Mehta, P. D., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.01.023 · Cited by 5
The prefrontal cortex controls memory organization in the hippocampus
de Sousa, A. F., Zeidler, Z., Filho, D. A., Shen, Y., Luchetti, A., Simanian, S., Mardini, M., DeNardo, L. A., & Silva, A. J. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02231-1 · Cited by 10
“Mice with hSyn–hM4Di–mCherry, CamKII–hM4Di–mCherry or hSyn– Cherry in the vmPFC were tested on a classic three-chamber spon-taneous social preference assay 52 .”
Finszter, C. K., Kemecsei, R., Zachár, G., Holtkamp, S., Echevarría, D., Adorján, I., Ádám, Á., & Csillag, A. (2023) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2023.1235047 · Cited by 6
“It is worth to be noted that, as mice approach adulthood, their sociability is often decreased (Moy et al., 2004; Ferri et al., 2020; Fereshetyan et al., 2021), or at least its focus and patterns are changed, probably due to sexual maturation.”
BackgroundTyson, H. R., Harrison, D. J., Higgs, M. J., Isles, A. R., & John, R. M. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1374781 · Cited by 5
Abdelaal, S. M., Rahman, M. M. A., Mahmoud, L. M., Rashed, L. A., El-Galil, T. I. A., & Mahmoud, M. M. (2024) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2024.2392186 · Cited by 5
“All four paws in a single chamber was considered an ingress (Moy et al .”
Kumar, S., Rastogi, S. K., Rastogi, S. K., et al. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107809 · Cited by 5
Central amygdala NPBWR1 neurons facilitate social novelty seeking and new social interactions
Soya, S., Toda, K., Sakurai, K., Chérasse, Y., Saito, Y. C., Abe, M., Sakimura, K., & Sakurai, T. (2025) · Science Advances · doi:10.1126/sciadv.adn1335 · Cited by 6
Establishing a social behavior paradigm for female mice
Xiao, H., Huang, C., Wu, Y. H., Wang, J. J., & Wang, H. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1630491 · Cited by 4
Comprehensive behavioral analysis of mice repeatedly treated with propofol
Fujii, K., Otofuji, H., Nakamura, Y., Koshidaka, Y., Adachi, M., Sasakawa, E., Darwish, M., & Takao, K. (2019) · Translational and Regulatory Sciences · doi:10.33611/trs.1_46 · Cited by 5
Semple, B. D., & Raghupathi, R. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.714253 · Cited by 5
Reiber, M., Stirling, H., Sprengel, R., Gass, P., Palme, R., & Potschka, H. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.877094 · Cited by 5
Edem, E. E., Okhonmina, U., Nebo, K. E., Akinluyi, E. T., Ikuelogbon, D. A., Fafure, A. A., Olabiyi, A. A., & Adedokun, M. A. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00589-1 · Cited by 5
“Rodents are highly social animals, and they establish hierarchies through aggression and defence behaviours (Moy et al. 2004; Panksepp 2010; Martin and Iceberg 2015).”
BackgroundΡυακιωτάκης, Ε., Fousfouka, D., & Stamatakis, A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1201345 · Cited by 6
“Rodents will readily engage in social interactions (Moy et al., 2004) choosing social contact rather than drug consumption (Sampedro-Piquero et al.”
BackgroundEverson, C. A., Szabó, A., Plyer, C., Hammeke, T. A., Stemper, B. D., & Budde, M. D. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114620 · Cited by 5
“…1985; Schmitt and Hiemke, 1998; Shah and Treit, 2003), dyadic sociability (Crawley, 2004; Kaidanovich-Beilin et al., 2011; Loureiro et al., 2015; Moy et al., 2004; Reilly et al., 2015), Porsolt forced swim test (Porsolt et al., 1977), wire hang (Bie-siadecki et al., 1998; Nagakannan et al.,…”
Lopez, K. C., Baker, M. R., & Tóth, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-52200-6 · Cited by 6
“To test the relationship between tube test dominance and social motivation 32 , a different social behavior, we also assessed the behavior of these, cohort 2 males in the 3 chamber social interaction test 33 (Fig.”
MethodChen, T., Meng, H., Ni, F., Shi, P., Chen, M., Liu, Q., Lv, L., & Li, W. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12417 · Cited by 6
Martínez-Drudis, L., Bérard, M., Musiol, D., Rivest, S., & Oueslati, A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39571 · Cited by 6
Lack of Evidence for Neonatal Misoprostol Neurodevelopmental Toxicity in C57BL6/J Mice
Koenig, C. M., Walker, C. K., Qi, L., Pessah, I. N., & Berman, R. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038911 · Cited by 5
“Sociability and preference for social novelty were tested as described previously”
MethodImpaired social memories in 129P2 inbred mice are rescued by reduced Csk expression
Sinai, L., Mathew, R., & Roder, J. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00775.x · Cited by 5
“As previously reported (Moy et al. 2004), the number of entries into each outer side chamber (containing a mouse or empty cage) was the least sensitive index of social approach in the choice tests (Table 1), and is usually used as a control measurement for exploration of the new environment.”
MethodNakazawa, H., Suzuki, Y., Ishikawa, Y., Bandô, Y., Yoshida, S., & Shiosaka, S. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.04.014 · Cited by 5
Chin, E. W. M., & Goh, E. L. K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9554-7_34 · Cited by 5
Use of the Vsoc-maze to Study Sociability and Preference for Social Novelty in Rodents
Martínez‐Torres, S., Gomis‐González, M., Navarro-Romero, A., Maldonado, R. J., & Ozaita, A. (2019) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3393 · Cited by 5
“Instead, preference for social novelty is defined as the propensity to spend more time exploring a new unfamiliar mouse than the now-familiar mouse that was explored in the sociability phase (Moy et al., 2004; Yang et al., 2011).”
BackgroundAn open-source capacitive touch sensing device for three chamber social behavior test
Barbera, G., Liang, B., Zhang, Y., et al. (2020) · MethodsX · doi:10.1016/j.mex.2020.101024 · Cited by 5
A test for studying sociability of the common shrew, Sorex araneus
Shchipanov, N. A., & Demidova, T. B. (2020) · Russian Journal of Theriology · doi:10.15298/rusjtheriol.19.2.01 · Cited by 5
Kim, S., Kim, Y.-E., & Kim, I. H. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101722 · Cited by 6
“For instance, the 3-chamber sociability test (3CST; Figure 1A) (Moy et al., 2004) is difficult to be used for Ca imaging or optogenetics due to the cables tethered to the head of a mouse.”
MethodILF3 prion-like domain regulates gene expression and fear memory under chronic stress
Yamashita, A., Shichino, Y., Fujii, K., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106229 · Cited by 5
Sociability versus empathy in adolescent mice: Different or distinctive?
Panksepp, J. B., & Lahvis, G. P. (2023) · Learning and Motivation · doi:10.1016/j.lmot.2023.101892 · Cited by 6
Multiple behavioral mechanisms shape development in a highly social cichlid fish
Harmon, I. P., McCabe, E. A., Vergun, M. R., Weinstein, J., Graves, H. L., Boldt, C. M., Bradley, D. D., Lee, J., Maurice, J. M., & Solomon‐Lane, T. K. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114520 · Cited by 5
Jhun, M., Panwar, A., Cordner, R., Irvin, D. K., Veiga, L., Yeager, N., Pechnick, R. N., Schubloom, H. E., Black, K. L., & Wheeler, C. J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.557269 · Cited by 5
Inta, D., Vogt, M. A., Lima‐Ojeda, J. M., Pfeiffer, N., Schneider, M., & Gass, P. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.03.020 · Cited by 5
“‘Sociability’ measured in this test represents the propensity to spend time with another mouse, as compared to time spent in an identical but empty chamber (Moy et al., 2004).”
Bauman, M. D., Crawley, J. N., & Berman, R. F. (2010) · Wiley eBooks · doi:10.1002/9780470015902.a0022368 · Cited by 5
Self-citationThe interplay between oxidative stress and inflammation supports autistic-related behaviors in micePreprint
Pangrazzi, L., Cerilli, E., Balasco, L., Tobia, C., Dall‘O’, G. M., Chelini, G., Perini, S., Filosi, M., Ravizza, T., Vezzani, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.11.557109 · Cited by 5
“The three-Chamber social test was used to assess the social behaviors of mice (49).”
Method
Metadata
- Authors
- Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institute of Mental Health (US)
- Corresponding author
- Moy, S. S.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 3
- Issue
- 5
- Pages
- 287-302
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2109091674
- Cited by
- 1,522
- References
- 80
- Citations by year
- 2026: 93 · 2025: 99 · 2024: 99 · 2023: 98 · 2022: 121 · 2021: 110 · 2020: 109 · 2019: 114 · 2018: 98 · 2017: 65 · 2016: 83 · 2015: 72 · 2014: 65 · 2013: 53 · 2012: 57
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- North Carolina State University
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54 MH 66418, MH66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sociability, autism spectrum disorder, mouse models of autism, inbred mouse strains, social interaction deficits, social avoidance, C57BL/6J mice, DBA/2J, A/J, sex differences, age differences
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Female, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Sex Factors, Social Behavior, Species Specificity, Reproducibility of Results, Rotarod Performance Test, Mice
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