The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index; 1 of the 52 sources its claims cite were checked for support.
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Open accessAbstract
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now‐familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend‐ ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now‐familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
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63 Own result · 16 No full text of the sources · 15 Own method · 6 Not checked yet · 6 Own interpretation · 5 Sources not found · 2 No basis given · 1 Partly supported · accuracy not yet measured
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber)”
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In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1).”
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exception was A/J, a strain that demonstrated a preference for the central chamber.”
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Overall, four of the five inbred and hybrid strains tested spent more time in the side of the social test box containing the unfamiliar stranger, vs. time in the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“DBA/2 mice tended to have lower numbers of entries than the C57BL/6J mice (Fig. 10b; significant main effect of strain, F 1,9 ¼ 16.156, P ¼ 0.003; retest, F 1,9 ¼ 36.215,P ¼ 0.0002; and side, F 1,9 ¼ 8.723, P ¼ 0.0161).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Finally, the adult C57BL/6J and DBA/2 mice had higher numbers of entries into the side of the chamber containing the unfamiliar conspecific in the sociability test.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plainn = 2- Asserted: passes — The authors put it forward as true.
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In the paper
“Adult A/J males failed to show a significant preference for the side containing stranger 1, as compared to the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The low number of entries observed in the A/J mice was significantly different from both of the other inbred strains (post hoc tests following repeated measures ANOVA, F-values above).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 24
- The quote only partly states this claim. 1
- Probably not a substantial claim. 32
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Higher numbers of sniffs were directed toward stranger 1 than towards the empty wire cage, and towards the novel stranger 2 vs. the now-familiar stranger 1, in C57BL/6J, DBA/2J and FVB/NJ male mice (Nadler et al. 2004).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Partly supportedcites Nadler et al. 2004 sourceExperimental — accuracy not yet measured
The “Social behavior tasks in three inbred strains” section reports that males of all three named strains spent more time sniffing the cage containing stranger 1 than the empty cage, and more time sniffing stranger 2 than stranger 1. The “Sociability test” section specifies that sniffing was scored as cumulative duration in seconds, not as a number of sniffs; that measurement in the claim is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“General health, neurological reflexes, activity levels, motor functions and sensory abilities were normal in most regards for the strains tested.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar levels of sociability were clearly evident in a group of young female C57BL/6J mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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The quote only partly states this claim.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A/J was the only strain tested that failed to spend more time with a conspecific, and spent most of its time in the central chamber after the initial 5-minute habituation session.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the inbred strains were able to locate buried food, supporting an interpretation that none were anosmic, which could have severely impacted social behaviors by blocking detection of olfactory cues emitted by the stranger mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For the olfactory test, the majority of the subjects successfully located and retrieved the buried food.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 9, the A/J group did show significant increases in time spent in the side regions (Fig. 9a, significant main effect of retest, F 1,9 ¼ 11.343, P ¼ 0.0083) and in number of entries (Fig. 9b, significant main effect of retest, F 1,9 ¼ 13.302, P ¼ 0.0053) when the openings between chambers were more accessible.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Sociability procedure with modified social test box
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the significantly higher locomotor scores observed in the FVB/NJ strain, in comparison to the other two groups, were not reflected in an overall higher number of entries.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The FVB/NJ mice demonstrated a significantly shorter latency for locating the buried food,”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A significant interaction was found between side of chamber and test condition (F 1,57 ¼ 67.634, P < 0.0001), reflecting the finding that preference was for the stranger 1 side during the first half of the session (the sociability condition), but switched to the stranger 2 side during the last part of the session (the social novelty condition).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Arguing against an artifactual interpretation that hypolocomotion caused the social deficit in the A/J group are the data of Fig. 8. Repeated testing of A/J in the modified apparatus increased the number of entries, but did not yield significant sociability scores.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The A/J mice spent significantly more time in the center chamber, indicating a strong preference for the start box that was not seen in the other strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the second group of juvenile C57BL/6J mice, both males and females made equal numbers of entries into each side of the social test box during the assay for sociability, but showed an increased number of entries into the side of the social box containing the second, 'novel' unfamiliar stranger during the test for social novelty.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences between the strains in body weight or rotarod performance (see Table 1 for mean latency to fall on the second trial).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, for the juvenile male mice, number of entries did not reflect the trends for social preference seen in the duration measures, and only partially correlated with their locomotor activity independently quantitated in the open field.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, low locomotor scores in DBA/2J and high locomotor scores in FVB/NJ appeared to be unrelated to amount of time spent in the chamber with stranger 1 and stranger 2.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant preferences for sociability (Fig. 3a) or preference for social novelty (Fig. 3b) were not observed for number of chamber entries in any of the inbred strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the present study, the juvenile male mice made nests and huddled together while sleeping.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Autistic individuals may further avoid unfamiliar social partners and display diminished interest in novelty (American Psychiatric Association 1994).”
What the sources say
- Not matchedcites American Psychiatric Association 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This modification focuses the task on social approach tendencies, relevant to the social approach deficit in autism, while avoiding potential confounds resulting from aggressive or sexual interactions.”
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Rests on an assumption: Most autistic individuals demonstrate reduced or unusual social approach.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“To ensure that differences in social behaviors were not artifacts of other aspects of mouse behaviors, a series of independent control experiments was conducted to evaluate potential confounding factors.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of times that the mouse exited from the habituated empty central chamber into the novel empty chamber provided a general measure of locomotor function.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Social behaviors have been explored in mice with mutations in candidate genes such as oxytocin (Winslow & Insel 2002;Young et al. 2002), monoamine oxidase-A (Shih & Chen 1999), fragile X (Churchill et al. 2002;Mineur et al. 2002) and dishevelled-1 (Lijam et al. 1997).”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Further controls were designed to detect additional symptoms relevant to autism, such as abnormalities in locomotion or motor coordination (Hallett et al. 1993;Piven et al. 1997), that could directly affect performance of the social task.”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Measures of general health, home cage behavior and neurological reflexes were conducted to rule out gross physical abnormalities (Crawley 2000).”
What the sources say
- Not checked — no full text of the sourcecites Crawley 2000
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Retrieval of food buried in cage bedding was quantitated in a 15-minute olfactory test, to ensure that the subject mice were not grossly impaired in olfaction abilities.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“A large body of evidence from twin and family studies supports the important role of genetic factors in the etiology of autism (Bailey et al. 1995;Ritvo et al. 1989;Szatmari et al. 1998).”
What the sources say
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present mouse tasks were designed to maximize face validity to some of the core symptoms of autism.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the A/J mice were given a second test one week later, with the dividing walls between the chamber sides partially retracted to facilitate exploration.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
plainn = 10- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Given the primacy of social impairment in autism, we considered this symptom to be fundamental to a mouse model of autism (Insel 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Several additional behavioral assays were performed in the initial set of juvenile male mice (C57BL/6J, DBA/2J and FVB/ NJ).These assays were designed as controls for sensory and motor abilities, etc., to ensure that the test mice were physically able to perform the procedures necessary for the social tasks described above.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The chambers of the social apparatus were cleaned and fresh paper chip bedding was added between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The location of stranger 1 in the left vs. right side chamber was systematically alternated between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In our experience to date with the present procedures, human observers attain a high level of proficiency after only one or two practice sessions, with high rates (greater than 95%) of interrater reliability between trained observers.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present protocol used a small wire cage to enclose the stimulus mouse, which allowed visual, auditory and olfactory contact between the mice, but prevented the occurrence of aggressive and other responses.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“From an early age, autistic children show low levels of eye contact and affective responses, less orientation toward others and language deficits, with a concomitant paucity of speech and social communication (for review, see Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites Tager-Flusberg et al. 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The stranger mouse was enclosed in a small, round wire cage (Galaxy Cup, Spectrum Diversified Designs, Inc., Streetsboro, OH), which allowed nose contact between the bars, but prevented fighting.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Previous work in social recognition has shown that mice show both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993;Dluzen & Kreutzberg 1993;Ferguson et al. 2000;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present procedures for the sociability and social novelty tests are designed to be simple, quantitative and easily mastered by investigators.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the present methods were designed to quantitate levels of sociability, i.e. tendency to initiate social contact, and preference for social novelty, i.e. tendency to initiate social contacts with a new individual as compared to someone familiar from past experience, using a simple scoring approach for laboratory mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, some autistic patients demonstrate aberrant motor responses, including repeated hand flapping, jumping and other repetitive and stereotyped behaviors (Bodfish et al. 2000;Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered sensory responses have been reported, including both hypo-and hyper-reactivity to environmental stimuli (Baranek 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Baranek 2002 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Use of the three-chambered apparatus for demonstrating social preference (Insel 2001) was adapted by Brodkin et al. (2004) to investigate social approach and avoidance in female mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Brodkin et al. 2004 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“and the mouse model of fragile X syndrome has been characterized by changes in activity (Bakker et al. 1994;Peier et al. 2000) and reactivity to acoustic stimuli (Chen & Toth 2001;Nielson et al. 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Bakker et al. 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Peier et al. 2000
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Chen & Toth 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Children with fragile X syndrome often show autistic behavior (Hagerman et al. 1986),”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Hagerman et al. 1986 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“As noted by Winslow (2003), the analysis of the full behavioral series that can occur in social tests demands familiarity with the mouse ethogram, extensive training and the ability to discern the sometimes rapid and fleeting responses that mice can emit.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Winslow 2003 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Methods are based on procedures examining pair-bonding in voles (Dean, S.M. & Vandenbergh, J.G. as above), as well as many other elegant tests for social behavior in rodents (Bluthe et al. 1993;Carter et al. 1995;Dluzen & Kreutzberg 1993;Gheusi et al. 1994;Insel and Young 2001;Kogan et al. 2000;Winslow & Camacho 1995;Winslow 2003).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Most autistic individuals demonstrate reduced or unusual social approach.
“We reasoned that most autistic individuals demonstrate reduced or unusual social approach.”
The paper relies on this without support.
Behavioral models of autistic-like responses in mice have received little attention.
“However, to date, behavioral models of autistic-like responses in mice have received little attention.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [530]
In the citing paper
“There is compelling evidence that some strains are more”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
In the citing paper
“However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects 9 ).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
“the social novelty test was not conducted”
Citations
Cites
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Varieties of Repetitive Behavior in Autism: Comparisons to Mental Retardation
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The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
A Comparison of the Social Postures of Some Common Laboratory Rodents
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Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Fmr1 knockout mice: A model to study fragile X mental retardation
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Research works printed but not linked: 1
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Cited by
Sorted by citations
Items 601–700 of 1,472
Thanos, P. K., Clavin, B. H., Hamilton, J., O’Rourke, J. R., Maher, T., Koumas, C., Miao, E., Lankop, J., Elhage, A., Haj‐Dahmane, S., et al. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00054 · Cited by 30
Peripheral T Cells as a Biomarker for Oxygen-Ion-Radiation-Induced Social Impairments
Krukowski, K., Jones, T., Campbell-Beachler, M., Nelson, G. A., & Rosi, S. (2018) · Radiation Research · doi:10.1667/rr15046.1 · Cited by 29
Neurobiology and treatment of social cognition in schizophrenia: Bridging the bed-bench gap
Kimoto, S., Makinodan, M., & Kishimoto, T. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.10.022 · Cited by 33
Nygaard, K. R., Maloney, S. E., & Dougherty, J. D. (2019) · Autism Research · doi:10.1002/aur.2154 · Cited by 31
“The typical version of this task comprises two test trials: the sociability trial and the preference for social novelty trial [Moy et al., 2004; Nadler et al., 2004], along with two preceding habituation trials.”
BackgroundMethodInfluentialDawson, M., Terstege, D. J., Jamani, N. F., Tsutsui, M., Pavlov, D., Bugescu, R., Epp, J. R., Leinninger, G. M., & Sargin, D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112815 · Cited by 34
A prefrontal-thalamic circuit encodes social information for social recognition
Chen, Z., Han, Y., Ma, Z., Wang, X., Xu, S., Tang, Y. Y., Vyssotski, A. L., Si, B., & Zhan, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-45376-y · Cited by 35
Ornoy, A., Echefu, B. E., & Becker, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910469 · Cited by 36
“The objective of test initially to test for social interaction between a subject and conspecific can now be expanded to concomitantly test also for social preference [16–21].”
BackgroundComprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice
Umemura, M., Ogura, T., Matsuzaki, A., Nakano, H., Takao, K., Miyakawa, T., & Takahashi, Y. K. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00125 · Cited by 29
“The correlation between values from the Accuscan system and the video tracking system for distance traveled was greater than 0.9 (Nakajima et al., 2008).”
MethodInfluentialLong-lasting pseudo-social aggressive behavior in opiate-withdrawn mice
Piccin, A., & Contarino, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109780 · Cited by 31
Carter, M. E., & Shieh, J. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800511-8.00002-2 · Cited by 37
Magno, L., Asgarian, Z., Pendolino, V., Velona, T., Mackintosh, A. I., Lee, F., Stryjewska, A., Zimmer, C., Guillemot, F., Farrant, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109249 · Cited by 29
“Social behavior was assessed in the threechambered Crawley’s sociability paradigm (Moy et al., 2004).”
MethodLoss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
Gao, Y., Duque‐Wilckens, N., Aljazi, M. B., Wu, Y., Moeser, A. J., Mias, G. I., Robison, A. J., & He, J. (2021) · Communications Biology · doi:10.1038/s42003-021-02282-z · Cited by 31
Tsai, T.-C., Fang, Y.-S., Hung, Y.-C., Hung, L.-C., & Hsu, K. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00834-x · Cited by 34
Kietzman, H. W., & Gourley, S. L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105075 · Cited by 34
Zhu, J., Chen, C., Li, Z., Liu, X., He, J., Zhao, Z., He, M., Nie, B., Liu, Z., Chen, Y., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.371370 · Cited by 28
Beard, D. C., Zhang, X., Wu, D. Y., Martin, J. R., Erickson, A., Boua, J.-V. K., Hamagami, N., Swift, R. G., McCullough, K. B., Ge, X., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113411 · Cited by 33
“31,32 In a three-chamber social approach assay, 33 the P900L mutants and WT littermates showed similar preferences for exploring a conspecific over an object and for exploring a novel conspecific over a familiar mouse, with no change in overall distance traveled (Figure 3K; Figure S3J), suggesting…”
Hill, J. M., Cuasay, K., & Abebe, D. T. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.04.004 · Cited by 29
Harrison, E. L., Jaehne, E. J., Jawahar, M. C., Corrigan, F., & Baune, B. T. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.036 · Cited by 29
Chabout, J., Cressant, A., Hu, M. X., Edeline, J., & Granon, S. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00468 · Cited by 34
Seo, J., Jung, S., Lee, S., Yang, H. J., Kim, B. S., Choi, J., Bang, M., Shin, H., & Jeon, D. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.11.024 · Cited by 29
“Sociability/social novelty preference task: This experiment was performed in a three-room chamber as described previously (Moy et al., 2004; Nadler et al., 2004) (illustration in Fig.”
MethodSupplementation of Korean Red Ginseng improves behavior deviations in animal models of autism
Gonzales, E. L., Jang, J., Mabunga, D. F. N., Kim, J., Ko, M. J., Cho, K. S., Bahn, G. H., Hong, M., Ryu, J. H., Kim, H. J., et al. (2016) · Food & Nutrition Research · doi:10.3402/fnr.v60.29245 · Cited by 29
Van Hees, L., Didone, V., Charlet‐Briart, M., Van Ingelgom, T., Alexandre, A., Quertemont, E., Nguyen, L., & Laguesse, S. (2022) · Addiction Biology · doi:10.1111/adb.13102 · Cited by 27
Yang, M., Lewis, F., Foley, G., & Crawley, J. N. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.04.023 · Cited by 28
Self-citationDopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit
Molas, S., Freels, T. G., Zhao-Shea, R., Lee, T., Giménez‐Gómez, P., Barbini, M., Martin, G. E., & Tapper, A. R. (2024) · Nature Communications · doi:10.1038/s41467-024-47255-y · Cited by 31
Shoji, H., Maeda, Y., & Miyakawa, T. (2024) · Molecular Brain · doi:10.1186/s13041-024-01146-x · Cited by 38
“The three-chamber test was conducted as previously described [51].”
MethodMissense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice
Lazar, N. L., Singh, S. M., Paton, T., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.020 · Cited by 28
Examining the Reversibility of Long-Term Behavioral Disruptions in Progeny of Maternal SSRI Exposure
Maloney, S. E., Akula, S. K., Rieger, M. A., McCullough, K. B., Chandler, K., Corbett, A. M., McGowin, A. E., & Dougherty, J. D. (2018) · eNeuro · doi:10.1523/eneuro.0120-18.2018 · Cited by 27
“The social approach task was used to quantify sociability and preference for social novelty, and as previously described (Moy et al., 2004; Dougherty et al., 2013).”
MethodOuardi, F. Z., Anarghou, H., Malqui, H., Ouasmi, N., Chigr, M., Najimi, M., & Chigr, F. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1252-6 · Cited by 28
Early genistein exposure of California mice and effects on the gut microbiota–brain axis
Marshall, B. L., Liu, Y., Farrington, M. J., Mao, J., Helferich, W. G., Schenk, A. K., Bivens, N. J., Sarma, S. J., Lei, Z., Sumner, L. W., et al. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0214 · Cited by 29
Butler, M. C., Long, C. N., Kinkade, J. A., Green, M. T., Martin, R. E., Marshall, B. L., Willemse, T. E., Schenk, A. K., Mao, J., & Rosenfeld, C. S. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12847 · Cited by 27
Comprehensive Behavioral Phenotyping of a 16p11.2 Del Mouse Model for Neurodevelopmental Disorders
Lynch, J. F., Ferri, S. L., Angelakos, C. C., Schoch, H., Nickl‐Jockschat, T., Gonzalez, A., O'Brien, W. T., & Abel, T. G. (2020) · Autism Research · doi:10.1002/aur.2357 · Cited by 28
Thornton, A. M., Humphrey, R. M., Kerr, D. M., Finn, D. P., & Roche, M. (2021) · Molecules · doi:10.3390/molecules26123720 · Cited by 29
“The three-chamber test is one of the most widely used tests for assessing sociability and social novelty preference in rodents [43].”
BackgroundSex differences in addiction-relevant behavioral outcomes in rodents following early life stress
Rincón‐Cortés, M. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100067 · Cited by 26
Comprehensive Behavioral Analysis of Cluster of Differentiation 47 Knockout Mice
Koshimizu, H., Takao, K., Matozaki, T., Ohnishi, H., & Miyakawa, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089584 · Cited by 28
Gunn, R. K., Huentelman, M. J., & Brown, R. E. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.008 · Cited by 31
“While it is difficult to model a multifaceted disease such as autism in mice, there are certain behaviors in mice that are analogous to those found in the autism spectrum disorders, and these have been used to determine the validity of various genetic and inbred mouse models of autism [16–26].”
BackgroundMethodThe role of mutagenesis in defining genes in behaviour
Godinho, S. I. H., & Nolan, P. M. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201545 · Cited by 29
Cohen, I. L., Gardner, J. M., Karmel, B. Z., & Kim, S.-Y. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-15 · Cited by 28
“One such task involves measuring the percentage of time spent with an unfamiliar mouse relative to a conspecific as a measure of social preference [5,6].”
BackgroundEffects of Bax gene deletion on social behaviors and neural response to olfactory cues in mice
Holmes, M. M., Niel, L., Anyan, J. J., Griffith, A. T., Monks, D. A., & Forger, N. G. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07881.x · Cited by 28
“At 12.5 weeks of age, all animals were tested for sociability in a test similar to that described by Moy et al. (2004).”
MethodInfluentialSeillier, A., & Giuffrida, A. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.009 · Cited by 28
“The three-chamber social interaction task, which was originally designed to assess autistic-like behavior in mice, allows to focus on a defined set of behavioral parameters such as reduced social approach and diminished interest in novelty (Moy et al., 2004).”
BackgroundMethodInfluentialImpairment of social behaviors in Arhgef10 knockout mice
Lu, D., Liao, H., Chen, C., Tu, H., Liou, H., Gau, S. S., & Fu, W. (2018) · Molecular Autism · doi:10.1186/s13229-018-0197-5 · Cited by 28
“The tests for sociability and social novelty preference were performed in a three-chamber apparatus as previously described with minor modification [18, 19].”
MethodChabbert, D., Caubit, X., Roubertoux, P. L., Carlier, M., Habermann, B. H., Jacq, B., Salin, P., Metwaly, M., Frahm, C., Fatmi, A., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.974 · Cited by 27
“Sociability and interest in social novelty were measured in a two-chamber task (20,38) adapted from the three-chamber task (39).”
MethodBiamonte, F., Latini, L., Giorgi, F. S., Zingariello, M., Marino, R., Luca, R. D., D’Ilio, S., Majorani, C., Petrucci, F., Violante, N., et al. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.09.006 · Cited by 27
“…alterations, we considered two different cial tasks, i.e. ‘‘sociability’’ and ‘‘preference for social novelty’’, hich have been recently proposed to assess ‘‘autistic’’ phenotypes mice (Moy et al., 2004, 2009) and for which we analyzed two ecific parameters: ‘‘duration’’ and ‘‘number of entries’’.”
MethodAriyasiri, K., Choi, T., Kim, O.-H., Hong, T. I., Gerlai, R. T., & Kim, C. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.06.009 · Cited by 28
Oxytocin Ameliorates Impaired Behaviors of High Fat Diet-Induced Obese Mice
Hayashi, R., Kasahara, Y., Hidema, S., Fukumitsu, S., Nakagawa, K., & Nishimori, K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00379 · Cited by 31
Reppucci, C. J., Brown, L. A., Chambers, A. Q., & Veenema, A. H. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113162 · Cited by 28
Wang, H., Bavley, C. C., Li, A., Jones, R., Hackett, J., Bayleyen, Y., Lee, F. S., Rajadhyaksha, A. M., & Pitt, G. S. (2021) · JCI Insight · doi:10.1172/jci.insight.150698 · Cited by 31
“To further explore this effect, we utilized a modified 3-chamber social interaction protocol to monitor sociability and habituation to a novel mouse, typically seen in WT mice across repeated testing sessions (23, 24).”
Pochakom, A., Mu, C., Rho, J. M., Tompkins, T. A., Mayengbam, S., & Shearer, J. (2022) · Brain Sciences · doi:10.3390/brainsci12060781 · Cited by 30
“Social novelty preference is determined by the time spent interacting with a familiar versus a novel conspecific, measuring social memory and novelty [28].”
BackgroundSánchez‐Castillo, C., Cuartero, M. I., Fernández‐Rodrigo, A., Briz, V., López-García, S., Jiménez-Sánchez, R., López, J. A., Graupera, M., & Esteban, J. A. (2022) · Science Advances · doi:10.1126/sciadv.abq8109 · Cited by 30
Lotan, A., Lifschytz, T., Slonimsky, A., Broner, E. C., Greenbaum, L., Abedat, S., Fellig, Y., Cohen, H. R., Lory, O., Goelman, G., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.123 · Cited by 30
Preweaning Sensorimotor Deficits and Adolescent Hypersociability in Grin1 Knockdown Mice
Moy, S. S., Nikolova, V. D., Riddick, N. V., Baker, L. K., & Koller, B. H. (2012) · Developmental Neuroscience · doi:10.1159/000337984 · Cited by 28
Self-citationJansen, F., Heiming, R. S., Kloke, V., Kaiser, S., Palme, R., Lesch, K., & Sachser, N. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.029 · Cited by 29
Amos‐Kroohs, R. M., Davenport, L. L., Gutierrez, A., Wendel, J. R. H., Vorhees, C. V., & Williams, M. T. (2016) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2016.06.004 · Cited by 26
“: A three chamber acrylic apparatus was used (Moy et al., 2004).”
MethodMaloney, S. E., Creeley, C. E., Hartman, R. E., Yuede, C. M., Zorumski, C. F., Jevtović‐Todorović, V., Dikranian, K. T., Noguchi, K. K., Farber, N. B., & Wozniak, D. F. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.03.014 · Cited by 27
Fricano-Kugler, C. J., Gordon, A., Shin, G. S., Gao, K., Nguyen, J., Berg, J. M., Starks, M., & Geschwind, D. H. (2019) · Molecular Autism · doi:10.1186/s13229-019-0278-0 · Cited by 27
“Social deficits are one of the defining features of children with ASD; therefore, we utilized the widely used three-chamber test [23, 44, 46] to assess abnormalities in general sociability of CYFIP1 Tg mice.”
MethodHan, L., Picker, J. D., Schaevitz, L. R., Tsai, G. E., Feng, J., Jiang, Z., Chu, H. C., Basu, A. C., Berger-Sweeney, J. E., & Coyle, J. T. (2009) · Synapse · doi:10.1002/syn.20649 · Cited by 27
“The social interaction test (Moy et al., 2004) was designed to assess sociability as well as a preference for social novelty both of which have been shown to be impaired in rodent models of reduced NMDAR function and schizophrenia (Rung et al., 2005).”
MethodKarlsson, S. A., Studer, E., Kettunen, P., & Westberg, L. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00041 · Cited by 26
“The three-chambered social approach test (Moy et al., 2004) was used to assess persistence of social investigation as well as social preference, measured as preference for a novel conspecific vs. an object.”
BackgroundMethodKarkaba, A., Soualeh, N., Soulimani, R., & Bouayed, J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.09.002 · Cited by 26
“The mouse is accepted as a highly social species, and thus, it is novelty-seeking (Moy et al., 2004, 2007; Provenzano et al., 2016).”
BackgroundWatt, G., Chesworth, R., Przybyla, M., Ittner, A., Garner, B., Ittner, L. M., & Karl, T. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172970 · Cited by 26
Solmaz, V., Erdoğan, M. A., Alnak, A., Meral, A., & Erbaş, O. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102073 · Cited by 26
Kaur, S., Kinkade, J. A., Green, M. T., Martin, R. E., Willemse, T. E., Bivens, N. J., Schenk, A. K., Helferich, W. G., Trainor, B. C., Fass, J., et al. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104890 · Cited by 26
“2.5 Social Behavior Testing At PND180, the test individuals underwent Crawley’s sociability and preference for social novelty three-chambered test, as detailed previously by (Marshall et al., 2019; Moy et al., 2004).”
MethodInfluentialShahrbabaki, S. S. V., Jonaidi, H., Sheibani, V., & Bashiri, H. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113739 · Cited by 27
Development of behavioral patterns in young C57BL/6J mice: a home cage-based study
Reiber, M., Koska, I., Pace, C., Schönhoff, K., von Schumann, L., Palme, R., & Potschka, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-06395-1 · Cited by 27
de Arce, K. P., Ribic, A., Chowdhury, D., Watters, K. E., Thompson, G. J., Sanganahalli, B. G., Lippard, E., Rohlmann, A., Strittmatter, S. M., Missler, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36042-w · Cited by 26
Guerra, M., Medici, V., Weatheritt, R. J., Corvino, V., Palacios, D., Geloso, M. C., Farini, D., & Sette, C. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02391-9 · Cited by 27
“The three-chamber social behaviour test was performed as previously described [40], with small modifications [38].”
MethodChen, C., Noble‐Haeusslein, L. J., Ferriero, D. M., & Semple, B. D. (2013) · Developmental Neuroscience · doi:10.1159/000355874 · Cited by 26
Martin, M. M., Liu, Y., & Wang, Z. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.09.015 · Cited by 26
“Studies in rodent species have previously been able to replicate some of the behavioral abnormalities typically seen in autism [103-110].”
BackgroundDachtler, J., Elliott, C., Rodgers, R., Baillie, G. S., & Clapcote, S. (2016) · Scientific Reports · doi:10.1038/srep18748 · Cited by 26
Kim, S.-W., Seo, M., Kim, D., Kang, M., Kim, Y.-S., Koh, H.-Y., & Shin, H. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130285 · Cited by 26
Owona, B. A., Zug, C., Schluesener, H. J., & Zhang, Z. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw043 · Cited by 26
“Previous work in social recognition has shown that C57BL/6J, DBA/2J, and FVB/NJ mice exhibited similar sociability (24).”
BackgroundMethodAdult forebrain NMDA receptors gate social motivation and social memory
Jacobs, S., & Tsien, J. Z. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.019 · Cited by 26
“This task investigates the preference of the subject mouse to explore either an object or a conspecific (Moy et al., 2004).”
BackgroundClark, S. M., Vaughn, C. N., Soroka, J. A., Li, X., & Tonelli, L. H. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13860 · Cited by 27
“Sociability was assessed on PND 36 using a modified social interaction arena based upon the three-chambered design (Moy et al., 2004).”
MethodInfluentialEmpathic behavior according to the state of others in mice
Ueno, H., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Okamoto, M., Matsumoto, Y., Aoki, S., & Ishihara, T. (2018) · Brain and Behavior · doi:10.1002/brb3.986 · Cited by 27
Overview of genetic models of autism spectrum disorders
Patel, J., Lukkes, J. L., & Shekhar, A. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.10.002 · Cited by 29
In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia
Koszła, O., Targowska‐Duda, K. M., Kędzierska, E., & Kaczor, A. A. (2020) · Biomolecules · doi:10.3390/biom10010160 · Cited by 26
Identifying Essential Cell Types and Circuits in Autism Spectrum Disorders
Maloney, S. E., Rieger, M. A., & Dougherty, J. D. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-418700-9.00003-4 · Cited by 26
“…reciprocal social behaviors during full contact between the mice (Pellis & Pasztor, 1999; Scattoni, Martire, Cartocci, Ferrante, & Ricceri, 2012; Scattoni et al., 2008) and the social approach assay, which is designed to measure sociability initiated by the test mouse only (Moy et al., 2004).”
BackgroundHolman, P. J., Ellis, L. A., Morgan, E., & Weinberg, J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.08.004 · Cited by 29
“Our first assessment of adolescent social behavior was accomplished using the social interaction test, which provided a measure of social motivation (Moy et al., 2004).”
García-Valtanen, P., van Diermen, B. A., Lakhan, N., Lousberg, E. L., Robertson, S. A., Hayball, J. D., & Diener, K. R. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13260 · Cited by 26
“Following the protocol by Moy et al 2004,27 sociability and social novelty were tested in an apparatus consisting of a three chamber rectangles.”
MethodOxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism
Михайлович, Ч. С., Gerasimenko, M., Yuhi, T., Furuhara, K., Tsuji, C., Yokoyama, S., Nakayama, K. I., Nishiyama, M., & Higashida, H. (2021) · BMC Neuroscience · doi:10.1186/s12868-021-00631-6 · Cited by 24
“In contrast to our data, previous reports [46, 47] indicated a social preference for novel social stimulus, for C57BL/6 female mouse.”
BackgroundResultInfluentialSafety and efficacy of genetic MECP2 supplementation in the R294X mouse model of Rett syndrome
Collins, B. E., Merritt, J. K., Erickson, K. R., & Neul, J. L. (2021) · Genes Brain & Behavior · doi:10.1111/gbb.12739 · Cited by 24
“Social behavior was assessed using the Crawley 3-chamber assay.(32) The 3-chamber apparatus consists of a clear 60 42 22 cm box divided into three adjacent and equally sized compartments.”
MethodMehta, R., Bhandari, R., & Kuhad, A. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05941-5 · Cited by 26
Nazir, S., Farooq, R. K., Nasir, S., Hanif, R., & Javed, A. (2022) · Psychopharmacology · doi:10.1007/s00213-021-06038-9 · Cited by 26
“Crawley’s sociability and preference for the social novelty test comprised two sessions: social interaction session and social novelty preference session (Moy et al. 2004).”
BackgroundNumber of X-chromosome genes influences social behavior and vasopressin gene expression in mice
Cox, K. H., Quinnies, K. M., Eschendroeder, A., Didrick, P., Eugster, E. A., & Rissman, E. F. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.010 · Cited by 25
NOMA-GAP/ARHGAP33 regulates synapse development and autistic-like behavior in the mouse
Schuster, S., Rivalan, M., Strauß, U., Stoenica, L., Trimbuch, T., Rademacher, N., Parthasarathy, S., Lajkó, D., Rosenmund, C., Shoichet, S. A., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.42 · Cited by 26
der Jeugd, A. V., Vermaercke, B., Halliday, G. M., Staufenbiel, M., & Götz, J. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.01.007 · Cited by 26
“At later stages, FTD patients develop deficits in executive function: they have problems planning, coordinating and executing simple tasks (Harciarek and Cosentino, 2013; Huey et al., 2009; Johns et al., 2009; Moy et al., 2004; Stopford et al., 2012).”
Social Reward and Empathy as Proximal Contributions to Altruism: The Camaraderie Effect
Lahvis, G. P. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_449 · Cited by 28
Martin, C. D., Fricke, D., Vijayashanthar, A., Lowinger, C., Koutsomitis, D., Popoola, D. O., Hadjiargyrou, M., Komatsu, D. E., & Thanos, P. K. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.07.001 · Cited by 25
“Novel object recognition Short term working memory was assessed using the Novel Object Recognition test as previously described (Moy et al., 2004) and by our lab (Robison et al.”
Interconnected neural circuits mediating social reward
Isaac, J., & Murugan, M. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.10.004 · Cited by 26
Ajao, M. Y., & Akindele, A. J. (2012) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2012005000138 · Cited by 24
“The duration and frequency of social interaction decreases with increased anxiety (Moy et al., 2004).”
BackgroundThe other side of the coin: Hypersociability
Tóth, M. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12512 · Cited by 24
Tanaka, K., Osako, Y., Takahashi, K., Hidaka, C., Tomita, K., & Yuri, K. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01646 · Cited by 25
“We first conducted the social preference test, using apparatus designed to assess priority for processing of social versus non-social stimuli [19, 20, 21].”
MethodPérez, M. Á., Morales, C., Santander, O., García, F., Gómez, I., Peñaloza‐Sancho, V., Fuentealba, P., Dagnino‐Subiabre, A., Moya, P. R., & Fuenzalida, M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00372 · Cited by 24
Watt, G., Przybyla, M., Zak, V., van Eersel, J., Ittner, A., Ittner, L. M., & Karl, T. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.01.047 · Cited by 24
Wang, H., Li, J., Wang, H., Sun, Y., Liu, R., Wang, X., Su, Y., & Si, T. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00499-2 · Cited by 22
Xu, H., Wang, J., Jing, H., Ellenbroek, B. A., Shao, F., & Wang, W. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108412 · Cited by 24
Yu, H. Y., Niu, Y., Jia, G., Liang, Y., Chen, B., Sun, R., Wang, M., Huang, S., Zeng, J., Lu, J., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03005-8 · Cited by 24
Kdm6b Haploinsufficiency Causes ASD/ADHD-Like Behavioral Deficits in Mice
Gao, Y., Aljazi, M. B., & He, J. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.905783 · Cited by 26
Borelli, K. G., Blanchard, D. C., Javier, L. K., Defensor, E. B., Brandão, M. L., & Blanchard, R. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.047 · Cited by 24
Effects of oxytocin on serotonin 1B agonist-induced autism-like behavior in mice
Lawson, S. K., Gray, A. C., & Woehrle, N. S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.027 · Cited by 26
Tuttle, A. H., Tansley, S. N., Dossett, K., Tohyama, S., Khoutorsky, A., Maldonado‐Bouchard, S., Stein, L., Gerstein, L., Crawhall-Duk, H., Pearl, R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703477114 · Cited by 26
“) had no effect in sibling dyads, it significantly increased cooccupancy in stranger dyads: main effect of drug, F(1, 33) =12.”
BackgroundMethodInfluentialAssessment of cognitive functions in animal models of schizophrenia
Nikiforuk, A. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.01.009 · Cited by 23
Metadata
- Authors
- Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institute of Mental Health (US)
- Corresponding author
- Moy, S. S.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 3
- Issue
- 5
- Pages
- 287-302
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2109091674
- Cited by
- 1,522
- References
- 80
- Citations by year
- 2026: 93 · 2025: 99 · 2024: 99 · 2023: 98 · 2022: 121 · 2021: 110 · 2020: 109 · 2019: 114 · 2018: 98 · 2017: 65 · 2016: 83 · 2015: 72 · 2014: 65 · 2013: 53 · 2012: 57
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- North Carolina State University
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54 MH 66418, MH66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sociability, autism spectrum disorder, mouse models of autism, inbred mouse strains, social interaction deficits, social avoidance, C57BL/6J mice, DBA/2J, A/J, sex differences, age differences
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Female, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Sex Factors, Social Behavior, Species Specificity, Reproducibility of Results, Rotarod Performance Test, Mice
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