The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index; 1 of the 52 sources its claims cite were checked for support.
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Open accessAbstract
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now‐familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend‐ ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now‐familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
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63 Own result · 16 No full text of the sources · 15 Own method · 6 Not checked yet · 6 Own interpretation · 5 Sources not found · 2 No basis given · 1 Partly supported · accuracy not yet measured
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber)”
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In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1).”
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exception was A/J, a strain that demonstrated a preference for the central chamber.”
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Overall, four of the five inbred and hybrid strains tested spent more time in the side of the social test box containing the unfamiliar stranger, vs. time in the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“DBA/2 mice tended to have lower numbers of entries than the C57BL/6J mice (Fig. 10b; significant main effect of strain, F 1,9 ¼ 16.156, P ¼ 0.003; retest, F 1,9 ¼ 36.215,P ¼ 0.0002; and side, F 1,9 ¼ 8.723, P ¼ 0.0161).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Finally, the adult C57BL/6J and DBA/2 mice had higher numbers of entries into the side of the chamber containing the unfamiliar conspecific in the sociability test.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plainn = 2- Asserted: passes — The authors put it forward as true.
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In the paper
“Adult A/J males failed to show a significant preference for the side containing stranger 1, as compared to the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The low number of entries observed in the A/J mice was significantly different from both of the other inbred strains (post hoc tests following repeated measures ANOVA, F-values above).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 24
- The quote only partly states this claim. 1
- Probably not a substantial claim. 32
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Higher numbers of sniffs were directed toward stranger 1 than towards the empty wire cage, and towards the novel stranger 2 vs. the now-familiar stranger 1, in C57BL/6J, DBA/2J and FVB/NJ male mice (Nadler et al. 2004).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Partly supportedcites Nadler et al. 2004 sourceExperimental — accuracy not yet measured
The “Social behavior tasks in three inbred strains” section reports that males of all three named strains spent more time sniffing the cage containing stranger 1 than the empty cage, and more time sniffing stranger 2 than stranger 1. The “Sociability test” section specifies that sniffing was scored as cumulative duration in seconds, not as a number of sniffs; that measurement in the claim is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“General health, neurological reflexes, activity levels, motor functions and sensory abilities were normal in most regards for the strains tested.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar levels of sociability were clearly evident in a group of young female C57BL/6J mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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The quote only partly states this claim.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A/J was the only strain tested that failed to spend more time with a conspecific, and spent most of its time in the central chamber after the initial 5-minute habituation session.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the inbred strains were able to locate buried food, supporting an interpretation that none were anosmic, which could have severely impacted social behaviors by blocking detection of olfactory cues emitted by the stranger mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For the olfactory test, the majority of the subjects successfully located and retrieved the buried food.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 9, the A/J group did show significant increases in time spent in the side regions (Fig. 9a, significant main effect of retest, F 1,9 ¼ 11.343, P ¼ 0.0083) and in number of entries (Fig. 9b, significant main effect of retest, F 1,9 ¼ 13.302, P ¼ 0.0053) when the openings between chambers were more accessible.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Sociability procedure with modified social test box
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the significantly higher locomotor scores observed in the FVB/NJ strain, in comparison to the other two groups, were not reflected in an overall higher number of entries.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The FVB/NJ mice demonstrated a significantly shorter latency for locating the buried food,”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A significant interaction was found between side of chamber and test condition (F 1,57 ¼ 67.634, P < 0.0001), reflecting the finding that preference was for the stranger 1 side during the first half of the session (the sociability condition), but switched to the stranger 2 side during the last part of the session (the social novelty condition).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Arguing against an artifactual interpretation that hypolocomotion caused the social deficit in the A/J group are the data of Fig. 8. Repeated testing of A/J in the modified apparatus increased the number of entries, but did not yield significant sociability scores.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The A/J mice spent significantly more time in the center chamber, indicating a strong preference for the start box that was not seen in the other strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the second group of juvenile C57BL/6J mice, both males and females made equal numbers of entries into each side of the social test box during the assay for sociability, but showed an increased number of entries into the side of the social box containing the second, 'novel' unfamiliar stranger during the test for social novelty.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences between the strains in body weight or rotarod performance (see Table 1 for mean latency to fall on the second trial).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, for the juvenile male mice, number of entries did not reflect the trends for social preference seen in the duration measures, and only partially correlated with their locomotor activity independently quantitated in the open field.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, low locomotor scores in DBA/2J and high locomotor scores in FVB/NJ appeared to be unrelated to amount of time spent in the chamber with stranger 1 and stranger 2.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant preferences for sociability (Fig. 3a) or preference for social novelty (Fig. 3b) were not observed for number of chamber entries in any of the inbred strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the present study, the juvenile male mice made nests and huddled together while sleeping.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Autistic individuals may further avoid unfamiliar social partners and display diminished interest in novelty (American Psychiatric Association 1994).”
What the sources say
- Not matchedcites American Psychiatric Association 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This modification focuses the task on social approach tendencies, relevant to the social approach deficit in autism, while avoiding potential confounds resulting from aggressive or sexual interactions.”
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Rests on an assumption: Most autistic individuals demonstrate reduced or unusual social approach.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“To ensure that differences in social behaviors were not artifacts of other aspects of mouse behaviors, a series of independent control experiments was conducted to evaluate potential confounding factors.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of times that the mouse exited from the habituated empty central chamber into the novel empty chamber provided a general measure of locomotor function.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Social behaviors have been explored in mice with mutations in candidate genes such as oxytocin (Winslow & Insel 2002;Young et al. 2002), monoamine oxidase-A (Shih & Chen 1999), fragile X (Churchill et al. 2002;Mineur et al. 2002) and dishevelled-1 (Lijam et al. 1997).”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Further controls were designed to detect additional symptoms relevant to autism, such as abnormalities in locomotion or motor coordination (Hallett et al. 1993;Piven et al. 1997), that could directly affect performance of the social task.”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Measures of general health, home cage behavior and neurological reflexes were conducted to rule out gross physical abnormalities (Crawley 2000).”
What the sources say
- Not checked — no full text of the sourcecites Crawley 2000
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Retrieval of food buried in cage bedding was quantitated in a 15-minute olfactory test, to ensure that the subject mice were not grossly impaired in olfaction abilities.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“A large body of evidence from twin and family studies supports the important role of genetic factors in the etiology of autism (Bailey et al. 1995;Ritvo et al. 1989;Szatmari et al. 1998).”
What the sources say
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present mouse tasks were designed to maximize face validity to some of the core symptoms of autism.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the A/J mice were given a second test one week later, with the dividing walls between the chamber sides partially retracted to facilitate exploration.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
plainn = 10- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Given the primacy of social impairment in autism, we considered this symptom to be fundamental to a mouse model of autism (Insel 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Several additional behavioral assays were performed in the initial set of juvenile male mice (C57BL/6J, DBA/2J and FVB/ NJ).These assays were designed as controls for sensory and motor abilities, etc., to ensure that the test mice were physically able to perform the procedures necessary for the social tasks described above.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The chambers of the social apparatus were cleaned and fresh paper chip bedding was added between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The location of stranger 1 in the left vs. right side chamber was systematically alternated between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In our experience to date with the present procedures, human observers attain a high level of proficiency after only one or two practice sessions, with high rates (greater than 95%) of interrater reliability between trained observers.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present protocol used a small wire cage to enclose the stimulus mouse, which allowed visual, auditory and olfactory contact between the mice, but prevented the occurrence of aggressive and other responses.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“From an early age, autistic children show low levels of eye contact and affective responses, less orientation toward others and language deficits, with a concomitant paucity of speech and social communication (for review, see Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites Tager-Flusberg et al. 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The stranger mouse was enclosed in a small, round wire cage (Galaxy Cup, Spectrum Diversified Designs, Inc., Streetsboro, OH), which allowed nose contact between the bars, but prevented fighting.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Previous work in social recognition has shown that mice show both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993;Dluzen & Kreutzberg 1993;Ferguson et al. 2000;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present procedures for the sociability and social novelty tests are designed to be simple, quantitative and easily mastered by investigators.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the present methods were designed to quantitate levels of sociability, i.e. tendency to initiate social contact, and preference for social novelty, i.e. tendency to initiate social contacts with a new individual as compared to someone familiar from past experience, using a simple scoring approach for laboratory mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, some autistic patients demonstrate aberrant motor responses, including repeated hand flapping, jumping and other repetitive and stereotyped behaviors (Bodfish et al. 2000;Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered sensory responses have been reported, including both hypo-and hyper-reactivity to environmental stimuli (Baranek 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Baranek 2002 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Use of the three-chambered apparatus for demonstrating social preference (Insel 2001) was adapted by Brodkin et al. (2004) to investigate social approach and avoidance in female mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Brodkin et al. 2004 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“and the mouse model of fragile X syndrome has been characterized by changes in activity (Bakker et al. 1994;Peier et al. 2000) and reactivity to acoustic stimuli (Chen & Toth 2001;Nielson et al. 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Bakker et al. 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Peier et al. 2000
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Chen & Toth 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Children with fragile X syndrome often show autistic behavior (Hagerman et al. 1986),”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Hagerman et al. 1986 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“As noted by Winslow (2003), the analysis of the full behavioral series that can occur in social tests demands familiarity with the mouse ethogram, extensive training and the ability to discern the sometimes rapid and fleeting responses that mice can emit.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Winslow 2003 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Methods are based on procedures examining pair-bonding in voles (Dean, S.M. & Vandenbergh, J.G. as above), as well as many other elegant tests for social behavior in rodents (Bluthe et al. 1993;Carter et al. 1995;Dluzen & Kreutzberg 1993;Gheusi et al. 1994;Insel and Young 2001;Kogan et al. 2000;Winslow & Camacho 1995;Winslow 2003).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Most autistic individuals demonstrate reduced or unusual social approach.
“We reasoned that most autistic individuals demonstrate reduced or unusual social approach.”
The paper relies on this without support.
Behavioral models of autistic-like responses in mice have received little attention.
“However, to date, behavioral models of autistic-like responses in mice have received little attention.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [530]
In the citing paper
“There is compelling evidence that some strains are more”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
In the citing paper
“However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects 9 ).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
“the social novelty test was not conducted”
Citations
Cites
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Varieties of Repetitive Behavior in Autism: Comparisons to Mental Retardation
Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005596502855 · Cited by 1,223
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
A Comparison of the Social Postures of Some Common Laboratory Rodents
Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Fmr1 knockout mice: A model to study fragile X mental retardation
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Research works printed but not linked: 1
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Cited by
Sorted by citations
Items 801–900 of 1,472
Zhang, Y., Zhang, X., Niu, W.-P., Sun, M., Zhang, Y., Li, J., Si, T., & Su, Y. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.110995 · Cited by 18
Lack of Tryptophan Hydroxylase-1 in Mice Results in Gait Abnormalities
Suidan, G. L., Duerschmied, D., Dillon, G. M., VanderHorst, V., Hampton, T., Wong, S. L., Voorhees, J. R., & Wagner, D. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059032 · Cited by 19
“A three-chambered rectangular box was used to evaluate sociability and preference for social novelty as previously described [25,26].”
MethodLetting a Typical Mouse Judge Whether Mouse Social Interactions Are Atypical
Shah, C. R., Forsberg, C. G., Kang, J., & Veenstra-VanderWeele, J. M. (2013) · Autism Research · doi:10.1002/aur.1280 · Cited by 18
“…to evaluate the social behavior of mouse models of autism susceptibility [Bolivar, Walters, & Phoenix, 2007; Crawley, 2007; Moy & Nadler, 2008; Moy et al., 2004; Panksepp & Lahvis, 2007; Pobbe et al., 2010; Roullet, Wohr, & Crawley, 2010; Silverman et al., From the Department of Psychiatry,…”
BackgroundMethodChallenges of Analysing Gene-Environment Interactions in Mouse Models of Schizophrenia
Oliver, P. L. (2011) · The Scientific World JOURNAL · doi:10.1100/tsw.2011.128 · Cited by 18
“Social activity was also analysed using the three-compartment social testing apparatus[46]; time spent interacting with a stranger mouse confined to a small cage compared to an identical, but empty, cage (sociability) is analysed, followed by the time spent with a novel, confined, intruder mouse compared to the origin…”
MethodOverexpression of Telomerase Reverse Transcriptase Induces Autism-like Excitatory Phenotypes in Mice
Kim, K. C., Rhee, J., Park, J., Lee, D.-K., Choi, C. S., Kim, J., Lee, H., Song, M.-R., Yoo, H. J., Chung, C., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9630-3 · Cited by 18
“The sociability test was adapted from Crawley [20, 21] and performed with minor modifications [22].”
BackgroundMethodPhenotypic abnormalities in a chorea-acanthocytosis mouse model are modulated by strain background
Sakimoto, H., Nakamura, M., Nagata, O., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.02.077 · Cited by 18
Sociability and Social Novelty Preference Tests Using a U-shaped Two-choice Field
Lee, E.-H., Park, J., Lee, Y., & Han, P. (2018) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2853 · Cited by 18
“…of sociability tests have been developed to measure specific aspects of social behaviors of experimental animals, such as social interactions (Moy et al., 2004; Berton et al., 2006; McFarlane et al., 2008; Silverman et al., 2010), social communication using olfactory and visual cues or…”
Stetzik, L. A., Ganshevsky, D., Lende, M. N., Roache, L. E., Musatov, S. A., & Cushing, B. S. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.05.035 · Cited by 19
“In prairie voles, this shift was attributed to a rat- or mouse-like response where novel females are preferred over familiar females [50,51], as they represent a greater potential mating opportunity.”
Kim, Y., Noh, Y. W., Kim, K., Yang, E., Kim, H., & Kim, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00023 · Cited by 18
Zheng, J., Zou, R., Huang, S., Song, T.-J., & Yu, X. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.004 · Cited by 17
Tantillo, E., Colistra, A., Baroncelli, L., Costa, M., Caleo, M., & Vannini, E. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17165667 · Cited by 18
“We further investigated the mood state and the sociability of the animals using the three-chamber test [37] and we did not find any differences between the two experimental groups in the three parameters considered (time spent exploring the object, t-test, p = 0.”
MethodBagnall-Moreau, C., Huerta, P. T., Comoletti, D., Bella, A. L., Berlin, R., Zhao, C., Volpe, B. T., Diamond, B., & Brimberg, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-71201-9 · Cited by 18
Chen, Q., Chu, W., Sheng, R., Song, S., Yang, J., Ji, F., & Jin, X. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.03.063 · Cited by 19
Blumkin, E., Levav-Rabkin, T., Melamed, O. C., Galron, D., & Golan, H. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.52 · Cited by 19
Morris, S. L., & Vollmer, T. R. (2020) · Journal of Applied Behavior Analysis · doi:10.1002/jaba.750 · Cited by 18
Reddy, D., Li, Y.-F., Qamari, T., & Ramakrishnan, S. (2024) · Current Protocols · doi:10.1002/cpz1.70019 · Cited by 16
A ventral hippocampal-lateral septum pathway regulates social novelty preference
Rashid, M., Thomas, S., Isaac, J., Karkare, S. C., Klein, H., & Murugan, M. (2024) · eLife · doi:10.7554/elife.97259.2 · Cited by 24
“For instance, mice readily discriminate between novel and familiar conspecifics, preferentially spending more time investigating a novel individual relative to a familiar individual ( Moy et al., 2004 ).”
Lin, R., Learman, L. N., Bangash, M. A., Melnikova, T., Leyder, E. C., Reddy, S. C., Naidoo, N. N., Park, J. M., Savonenko, A. V., & Worley, P. F. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110014 · Cited by 18
“To test for sociability, preferences to social and non-social stimuli were assayed as described in Lin et al. (2021) and Moy et al. (2004) with minor modifications.”
Corley, C. L., McElroy, T., Sridharan, B., Trujillo, M., Simmons, P., Kandel, S., Sykes, D. J., Robeson, M. S., & Allen, A. R. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1212791 · Cited by 17
Brain Serotonin Signaling Does Not Determine Sexual Preference in Male Mice
Angoa‐Pérez, M., Herrera‐Mundo, N., Kane, M. J., Sykes, C. E., Anneken, J. H., Francescutti, D. M., & Kuhn, D. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118603 · Cited by 17
“, intruder mice interacting with each other as well as with the resident mouse), we modified the test to restrict access of the resident mouse with the intruder mice by placing the intruders in wire cups as used in the three chamber social approach test in the study of autism-like behaviors in rodents [40,44,45].”
MethodAbnormal glutamate release in aged BTBR mouse model of autism.
Wei, H., Ding, C., Jin, G., Yin, H., Liu, J., & Hu, F. (2015) · PubMed Central · Cited by 17
Disruption of visual circuit formation and refinement in a mouse model of autism
Cheng, N., Khanbabaei, M., Murari, K., & Rho, J. M. (2016) · Autism Research · doi:10.1002/aur.1687 · Cited by 17
Functional brain connectivity in a rodent seizure model of autistic-like behavior
Mouchati, P. R., Barry, J. M., & Holmes, G. L. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.03.046 · Cited by 16
Vaes, J. E. G., Kosmeijer, C. M., Kaal, M., van Vliet, R., Brandt, M. J. V., Benders, M. J. N. L., & Nijboer, C. H. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010211 · Cited by 18
Social behavior in 16p11.2 and 22q11.2 copy number variations: Insights from mice and humans
Benedetti, A., Molent, C., Barcik, W., & Papaleo, F. (2021) · Genes Brain & Behavior · doi:10.1111/gbb.12787 · Cited by 18
“automated), even in the classical three-chamber task.(110) Moreover, each mouse line of the”
BackgroundBrief Report: Altered Social Behavior in Isolation-Reared Fmr1 Knockout Mice
Heitzer, A. M., Roth, A. K., Nawrocki, L., Wrenn, C. C., & Valdovinos, M. G. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1670-1 · Cited by 17
“This simple control experiment has not been routinely performed in the three-chamber paradigm (e.g., Moy et al. 2004, 2009; Nadler et al. 2004), but it seems to be a necessary aspect of future studies using this relatively new rodent behavioral paradigm.”
MethodZhao, G., Gao, J., Liang, S., Wang, X., Sun, C., Xia, W. T., Hao, Y., Li, X., Cao, Y., & Wu, L. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.04.350 · Cited by 19
“The sociability test evaluated the social interaction of the rats on PND31 (Moy et al., 2004).”
MethodBehavioral and Neuroanatomical Abnormalities in Pleiotrophin Knockout Mice
Krellman, J. W., Ruiz, H. H., Marciano, V. A., Mondrow, B., & Croll, S. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100597 · Cited by 18
Upregulation of cystathione β‐synthase and p70S6K/S6 in neonatal hypoxic ischemic brain injury
Lechpammer, M., Tran, Y. P., Wintermark, P., Martínez‐Cerdeño, V., Krishnan, V. V., Ahmed, W., Berman, R. F., Jensen, F. E., Nudler, E., & Zagzag, D. (2016) · Brain Pathology · doi:10.1111/bpa.12421 · Cited by 17
“Untreated rats typically spend more time in the chamber with the new unfamiliar rat compared to the familiar rat, and this difference is used as a measure of preference for social novelty (5, 20).”
InfluentialChen, X., Liu, H., Gan, J., Wang, X., Yu, G., Li, T., Liang, X., Yu, B., & Xiao, L. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00984 · Cited by 17
Ji, C., Tang, Y., Zhang, Y., Huang, X., Li, C., Yang, Y., Wu, Q., Xia, X., Cai, Q., Qi, X.-R., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112712 · Cited by 16
Age-associated deficits in social behaviour are microbiota-dependent
Cruz-Pereira, J. S., Moloney, G. M., Bastiaanssen, T. F. S., Boscaini, S., Fitzgerald, P., Clarke, G. A., & Cryan, J. F. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.02.008 · Cited by 17
“It is based on the premise that mice are attracted to novelty, hence would prefer a novel conspecific to a familiar one (Moy et al., 2004).”
Yashima, J., Uekita, T., & Sakamoto, T. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284666 · Cited by 17
“Social investigation can be assessed by measuring the duration of approach, exploratory, and interaction behavior toward a social stimulus in the social interaction test and three-chamber test [1, 15, 34, 35].”
BackgroundFanizzi, C., Sauerbeck, A. D., Gangolli, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07701-y · Cited by 16
Object, spatial and social recognition testing in a single test paradigm
Lian, B., Gao, J., Sui, N., Feng, T., & Li, M. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.05.006 · Cited by 16
“stimulus over an object one and has become a standard paradigm used to evaluate sociability and social novelty preference in rodents (Moy et al., 2004).”
Contribution of GABAA receptor subunits to attention and social behavior
Paine, T. A., Chang, S., & Poyle, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112261 · Cited by 16
Ferreira, F. R., Moura, N., Hassib, L., & Pombo, T. R. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135100 · Cited by 16
Pain‐induced aggression and changes in social behavior in mice
Khosravi, H., Khalilzadeh, E., & Saiah, G. V. (2020) · Aggressive Behavior · doi:10.1002/ab.21912 · Cited by 16
Ryu, Y., Park, H., Go, J., Choi, D., Choi, Y., Rhee, M., Lee, C., & Kim, K. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05812-z · Cited by 16
On the novel mechanisms for social memory and the emerging role of neurogenesis
Lunardi, P. S., Mansk, L. M. Z., Jaimes, L. F., & Pereira, G. S. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.03.006 · Cited by 20
Yang, X., Sun, W., Wu, Q., Lin, H., Lu, Z., Shen, X., Chen, Y., Zhou, Y., Huang, L., Wu, F., et al. (2021) · Nutrients · doi:10.3390/nu14010066 · Cited by 16
“Sociability and social novelty of the mice were evaluated in a three-chambered box [27] (Ugo Basile, Gemonio, Italy), with each chamber being 20 cm W × 40 cm L × 22 cm H.”
MethodJiang, S., He, M., Xiao, L., Sun, Y., Ding, J., Li, W., Guo, B., Wang, L., Wang, Y., Gao, C., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.835993 · Cited by 19
Looking for prosocial genes: ITRAQ analysis of proteins involved in MDMA-induced sociability in mice
Kuteykin‐Teplyakov, K. B., & Maldonado, R. J. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.08.007 · Cited by 16
“Sociability has been investigated using Crawley’s three-chamber test as previously described (Moy et al., 2004) with minor modifications.”
Sadigurschi, N., & Golan, H. M. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12547 · Cited by 16
“Mouse strains vary widely in their basal social behavior.(40,44) Strains commonly used in ASD research include C57BL/6J with significant sociability and SV129 with low social approach.”
BackgroundMethodRyan, K., Thompson, L., Mendoza, P. A., & Chadman, K. K. (2019) · Autism Research · doi:10.1002/aur.2158 · Cited by 16
“The most commonly used test for sociability in mice is the three-chambered social approach test, where a mouse has a choice between spending time exploring a novel object or a novel (stranger) mouse [Moy et al., 2004].”
MethodLyon, K. A., Rood, B. D., Wu, L., Senft, R. A., Goodrich, L. V., & Dymecki, S. M. (2020) · eNeuro · doi:10.1523/eneuro.0202-20.2020 · Cited by 16
“Gad2 expression in Drd2-Pet1 neurons is in line with prior reports showingGad2 expression more generally in the serotonergic DR (Nanopoulos et al., 1982; Calizo et al., 2011; Shikanai et al., 2012).”
ResultHeterozygous L1-deficient mice express an autism-like phenotype
Sauce, B., Wass, C., Netrakanti, M., Saylor, J., Schachner, M., & Matzel, L. D. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.040 · Cited by 17
Early-life gut microbiome maturity regulates blood–brain barrier and cognitive development
Zemmel, Z. M., Fan, X., Yu, Y., Markiewicz, E. J., Tsai, H., Lu, L., Little, J., Ramaswamy, R., Andrews, B., Claud, E. C., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2551879 · Cited by 19
Rabow, Z., Morningstar, T., Showalter, M. R., Heil, H., Thongphanh, K., Fan, S., Chan, J., Martínez‐Cerdeño, V., Berman, R. F., Zagzag, D., et al. (2021) · Brain and Behavior · doi:10.1002/brb3.2146 · Cited by 16
“Rat social behaviors were observed using “Social Approach” and “Social Novelty” tests adapted from Moy et al. (2004) as described previously by Lechpammer et al. (2017) (Lechpammer et al., 2017; Moy et al., 2004).”
MethodXiao, L., Wang, M., Zhang, W., Song, Y., Zeng, J., Li, H., Yu, H. Y., Li, L., Gao, P., & Yao, P. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00693-0 · Cited by 16
Potrebić, M., Pavković, Ž., Puškaš, N., & Pešić, V. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.872628 · Cited by 15
Erdoğan, M. A., Bozkurt, M. F., & Erbaş, O. (2022) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10248 · Cited by 15
“2.3.1 | Three-chamber sociability and social novelty test The sociability test was carried out as previously reported (Ellegood & Crawley, 2015; Erbas et al., 2018; Moy et al., 2004) with a few minor adjustments.”
MethodInfluentialWalker, S. L., Sud, N., Beyene, R., Palin, N., & Glasper, E. R. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06354-2 · Cited by 15
“A preference for social novelty is typical in uniparental rodents (Moy et al. 2004), but may not always be observed in biparental rodents.”
BackgroundWang, J., Gao, Y., Xiao, L., Lin, Y., Huang, L., Chen, J., Liang, G., Li, W., Yi, W., Lao, J., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107476 · Cited by 15
Visual identification of conspecifics shapes social behavior in mice
Greer, D., Lei, T., Kryshtal, A., Jessen, Z. F., & Schwartz, G. W. (2024) · Current Biology · doi:10.1016/j.cub.2024.11.041 · Cited by 15
Klarić, T., Jaehne, E. J., Koblar, S. A., Baune, B. T., & Lewis, M. D. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.050 · Cited by 15
Sociability development in mice with cell-specific deletion of the NMDA receptor NR1 subunit gene
Ferri, S. L., Pallathra, A. A., Kim, H., Dow, H. C., Raje, P., McMullen, M., Bilker, W. B., Siegel, S. J., Abel, T., & Brodkin, E. S. (2020) · Genes, Brain and Behavior · doi:10.1111/gbb.12624 · Cited by 15
“Specifically, single housing has been shown to have negative effects on sociability.(76,77,114-116) Other groups have also found excitatory neurons to be important in social behavior.”
BackgroundMethodSex‐linked roles of the CRF 1 and the CRF 2 receptor in social behavior
Piccin, A., & Contarino, A. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24629 · Cited by 22
“For this purpose, CRF2 receptor-deficient mice (CRF2−/−) were tested in the three-chamber task, a behavioral paradigm thought to reliably measure sociability independently of emotional-like states or locomotor activity (Moy et al., 2004, 2013; Silverman, Yang, Lord, & Crawley, 2010).”
MethodNguyen, P. A. H., Kim, K., Kim, A., Kang, S., Osabutey, A. F., Jin, H., Guo, Y.-R., Park, H.-W., Suh, J., & Koh, Y. H. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114520 · Cited by 15
Autistic-like social deficits in hippocampal MeCP2 knockdown rat models are rescued by ketamine
Choi, M., Ko, S. Y., Seo, J. Y., Kim, D. G., Lee, H., Chung, H., & Son, H. (2022) · BMB Reports · doi:10.5483/bmbrep.2022.55.5.038 · Cited by 15
“Three-chamber test The tests for sociability and social preference were performed in a three-chamber apparatus as previously described (31).”
MethodWassink, T. H., Hazlett, H. C., Davis, L. K., Reiss, A. L., & Piven, J. (2014) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-6-6 · Cited by 15
“Mice of different genetic backgrounds display markedly different patterns of social behavior, with some strains exhibiting social deficits resembling those seen in autism [59,60].”
BackgroundSelf-citationPeleh, T., Ike, K. G. O., Frentz, I., Buwalda, B., de Boer, S. F., Hengerer, B., & Kas, M. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.04.045 · Cited by 15
Varinthra, P., Ganesan, K., Huang, S., Chompoopong, S., Eurtivong, C., Suresh, P., Wen, Z., & Liu, I. Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.615079 · Cited by 15
“Our results are consistent with previous studies (Moy et al., 2004; Nakatani et al., 2009; Pearson et al., 2010), in which the “social recognition” of C57BL/6 remained intact with alterations to the “social novelty” behavior.”
ResultPsychiatric disease: All in the mind of a mouse
Dennis, C. (2005) · Nature · doi:10.1038/438151a · Cited by 15
The role of MeCP2 in learning and memoryPreprint
Robinson, H., & Pozzo‐Miller, L. D. (2019) · Learning & Memory · doi:10.1101/lm.048876.118 · Cited by 16
“Therefore, social memory can be measured as the preference for interaction with a novel mouse over a familiar mouse using a 3-chamber assay with one chamber containing anovelmouse and a second chamber containing a familiar mouse (Moy et al. 2004).”
BackgroundO’Tuathaigh, C. M. P., Desbonnet, L., & Waddington, J. L. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.08.009 · Cited by 16
“Affiliative behaviour is typically measured in a three-chambered apparatus, where dividers containing small centrally located doors allow the mouse access to each of the three chambers (Moy et al., 2004; Nadler et al., 2004).”
BackgroundImpact of Coffee Intake on Measures of Wellbeing in Mice
Machado, N. J., Ardais, A. P., Nunes, A., Szabó, E. C., Silveirinha, V., Silva, H. B. L., Kaster, M. P., & Cunha, R. A. (2024) · Nutrients · doi:10.3390/nu16172920 · Cited by 16
“After 10 min, the tested mouse was allowed to explore the entire social test box during 10 min to record the time spent interacting with the encaged unfamiliar mouse, as previously described [40].”
MethodGoto, T., Okayama, T., & Toyoda, A. (2015) · Behavioural Processes · doi:10.1016/j.beproc.2015.07.007 · Cited by 14
Phospholipase C-β1 Hypofunction in the Pathogenesis of Schizophrenia
Kim, S.-W., Cho, T., & Lee, S. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00159 · Cited by 14
Arakawa, H. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.10.045 · Cited by 15
Adrenergic receptor β3 is involved in the memory consolidation process in mice
Souza-Braga, P., Lorena, F. B., do Nascimento, B. P. P., Marcelino, C. P., Ravache, T. T., Ricci, E., Bernardi, M. M., & Ribeiro, M. O. (2018) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20187564 · Cited by 15
TLR2 deficiency attenuated chronic intermittent hypoxia-induced neurocognitive deficits
Li, W., Yu, Y., Li, D., Xu, N., Fang, J., Sun, Y., Xu, M., Wang, X., Han, X., Zhang, X., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106284 · Cited by 14
N-acetylcysteine reduces brain injury after delayed hypoxemia following traumatic brain injury
Celorrio, M., Rhodes, J., Vadivelu, S., Davies, M., & Friess, S. H. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113507 · Cited by 13
Zhou, X., Wu, B., Liu, W., Xiao, Q., He, W., Zhou, Y., Wei, P., Zhang, X., Liu, Y., Wang, J., et al. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00731-7 · Cited by 14
Nass, S. R., Lark, A. R. S., Hahn, Y. K., McLane, V. D., Ihrig, T. M., Contois, L. W., Napier, T. C., Knapp, P. E., & Hauser, K. F. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.105008 · Cited by 14
Yau, S., Yip, Y. S. L., Formolo, D. A., He, S., Lee, T. H.-Y., Wen, C., & Hryciw, D. H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113538 · Cited by 14
Sheardown, E., Mech, A. M., Petrazzini, M. E. M., Leggieri, A., Gidziela, A., Hosseinian, S., Sealy, I. M., Torres-Pérez, J. V., Busch‐Nentwich, E. M., Malanchini, M., et al. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104559 · Cited by 13
Corticosterone may interact with peripubertal development to shape adult resistance to social defeat
Latsko, M. S., Farnbauch, L. A., Gilman, T. L., Lynch, J. F., & Jasnow, A. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.04.009 · Cited by 13
“A Galaxy cup with metal bars (Spectrum, Streetsboro, OH; Moy et al., 2004; Nadler et al., 2004) was placed upside-down against one of the four corners.”
BackgroundJackson, M. R., Lee, K., Mattiske, T., Jaehne, E. J., Öztürk, E., Baune, B. T., O'Brien, T. J., Jones, N. C., & Shoubridge, C. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.05.012 · Cited by 14
“Sociability (PA1 n=12, PA2 n=6, WT n=23) was determined using a threechambered enclosure, with three stages of social interactions, as previously described by (Moy et al., 2004; Nadler et al., 2004).”
MethodSchizophrenia: What’s Arc Got to Do with It?
Managò, F., & Papaleo, F. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00181 · Cited by 14
Can Male Mice Develop Preference Towards Gentle Stroking by an Experimenter?
Cho, C., Chan, C., & Martin, L. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.12.017 · Cited by 13
Jagadeeswaran, I., Pruitt, A., Gautier, N. M., Crane, K., & Glasscock, E. (2021) · Brain and Behavior · doi:10.1002/brb3.2041 · Cited by 12
“…plexiglass three-chamber box (66-cm length × 45-cm width × 22-cm height), composed of a middle chamber separated by dividing walls with retractable doorways from two flanking and equalsized side chambers (20-cm length × 45-cm width), as previously described (Crawley, 2007; Moy et al., 2004).”
MethodSiena, A., Yuzawa, J. M. C., Ramos, A. C., Henrique, E., Brito, M. D., Calvazara, M. B., & Rosenstock, T. R. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02317-w · Cited by 17
Aspen shaving versus chip bedding: effects on breeding and behavior
Jackson, E., Demarest, K., Eckert, W. J., Cates‐Gatto, C., Nadav, T., Cates, L., Howard, H., & Roberts, A. J. (2014) · Laboratory Animals · doi:10.1177/0023677214553320 · Cited by 15
Lichtman, D., Bergmann, E., Kavushansky, A., Cohen, N., Levy, N. S., Levy, A. P., & Kahn, I. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01289-8 · Cited by 14
Zárate-López, D., Garzón‐Partida, A. P., González-Pérez, Ó., & Gálvez‐Contreras, A. Y. (2024) · Developmental Psychobiology · doi:10.1002/dev.22469 · Cited by 12
Developmental exposure to the Fox River PCB mixture modulates behavior in juvenile mice
Wilson, R. J., Suh, Y. P., Dursun, İ., Li, X., Souza, F. D. C., Grodzki, A. C., Cui, J. Y., Lehmler, H., & Lein, P. J. (2024) · NeuroToxicology · doi:10.1016/j.neuro.2024.06.008 · Cited by 13
“The three-chambered social approach task (Crawley, 2012; Nadler et al., 2004) was used to measure levels of sociability in FRM-exposed pups at P35.”
BackgroundMethodInfluentialPrefrontal cortical circuits in social behaviors: an overview
Cao, W., Li, H., & Luo, J. (2024) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2300743 · Cited by 14
“These behaviors encompass sociability, social memory/ recognition, and dominance, offering conceptual par ‐ allelism with human social categories (Moy et al., 2004; Bariselli et al., 2018; Zhou et al., 2018).”
Klauck, S. M., & Poustka, A. (2006) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2006.11.005 · Cited by 13
Sabatos‐DeVito, M., Murias, M., Dawson, G., Howell, T., Yuan, A., Marsan, S., Bernier, R., Brandt, C., Chawarska, K., Dzuira, J. D., et al. (2019) · Biological Psychology · doi:10.1016/j.biopsycho.2019.05.012 · Cited by 14
Yang, Y.-C., Lu, L., Jeng, S., Tsao, P., Cheong, P., Li, Y., Wang, S.-Y., Huang, H., & Wu, Y. (2019) · Physical Therapy · doi:10.1093/ptj/pzz114 · Cited by 13
Nieraad, H., de Bruin, N. M. W. J., Arne, O., Hofmann, M. C. J., Schmidt, M., Saito, T., Saido, T. C., Gurke, R., Schmidt, D., Till, U., et al. (2020) · Nutrients · doi:10.3390/nu12113248 · Cited by 13
Blum, K., Modestino, E. J., Baron, D. A., Brewer, R., Thanos, P. K., Elman, I., Badgaiyan, R. D., Downs, B. W., Bagchi, D., McLaughlin, T., et al. (2021) · Current Psychopharmacologye · doi:10.2174/2211556009999210104221215 · Cited by 15
The clock gene Period1 regulates innate routine behaviour in mice
Bechstein, P., Rehbach, N.-J., Yuhasingham, G., Schürmann, C., Göpfert, M., Kössl, M., & Maronde, E. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.0034 · Cited by 14
Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice
Li, Q., Chan, S. Y., Wong, K.-K., Wei, R., Leung, Y. O., Ding, A. Y., Hui, T. C. K., Cheung, C., Chua, S. E., Sham, P. C., et al. (2016) · Behavior Genetics · doi:10.1007/s10519-015-9777-8 · Cited by 14
“The generation of KO mice on a pure 129 Sv/Ev genetic background has been fully described previously, with the loss of Tspyl2 transcripts (Tao et al. 2011) and protein (Tsang et al. 2014).”
BackgroundPark, S. M., Plachez, C., & Huang, S. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00261 · Cited by 13
“A slightly modified three-chamber social test was conducted as previously described (Moy et al., 2004; Mei et al., 2016; Park et al., 2016).”
MethodGiorla, E., Nordmann, S., Vielle, C., Pelloux, Y., Roux, P., Protopopescu, C., Manrique, C., Davranche, K., Montanari, C., Giorgi, L., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-021-06033-0 · Cited by 13
“Reinforcing properties of social presence Social preference To examine if the STN is involved in social preference and could modulate a rat’s social preference for a social stimulus (a peer) versus an object, we subjected rats to a social preference test (Jacobs and Tsien 2017; Moy et al. 2004).”
MethodPérez-Martín, E., Muñoz-Castañeda, R., Moutin, M., Ávila-Zarza, C. A., Munõz-Castañeda, J. M., del Pilar, C., Alonso, J. R., Andrieux, A., Díaz, D., & Weruaga, E. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01044-3 · Cited by 12
“The three-chambered social preference test was performed to assess sociability in a white Plexiglas box (50 × 29 cm) divided into three connected chambers [14, 44].”
MethodDrzewiecki, C. M., Brinks, A. S., Sellinger, E. P., Doshi, A., Koh, J. Y., & Juraska, J. M. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.11.011 · Cited by 12
Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice
Kin, K., de Oliveira, J. F., Kano, S., & Niwa, M. (2023) · Nature Communications · doi:10.1038/s41467-023-38799-6 · Cited by 12
Metadata
- Authors
- Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institute of Mental Health (US)
- Corresponding author
- Moy, S. S.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 3
- Issue
- 5
- Pages
- 287-302
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2109091674
- Cited by
- 1,522
- References
- 80
- Citations by year
- 2026: 93 · 2025: 99 · 2024: 99 · 2023: 98 · 2022: 121 · 2021: 110 · 2020: 109 · 2019: 114 · 2018: 98 · 2017: 65 · 2016: 83 · 2015: 72 · 2014: 65 · 2013: 53 · 2012: 57
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- North Carolina State University
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54 MH 66418, MH66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sociability, autism spectrum disorder, mouse models of autism, inbred mouse strains, social interaction deficits, social avoidance, C57BL/6J mice, DBA/2J, A/J, sex differences, age differences
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Female, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Sex Factors, Social Behavior, Species Specificity, Reproducibility of Results, Rotarod Performance Test, Mice
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