The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index; 1 of the 52 sources its claims cite were checked for support.
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Open accessAbstract
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now‐familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend‐ ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now‐familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
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63 Own result · 16 No full text of the sources · 15 Own method · 6 Not checked yet · 6 Own interpretation · 5 Sources not found · 2 No basis given · 1 Partly supported · accuracy not yet measured
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber)”
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In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1).”
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exception was A/J, a strain that demonstrated a preference for the central chamber.”
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Overall, four of the five inbred and hybrid strains tested spent more time in the side of the social test box containing the unfamiliar stranger, vs. time in the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“DBA/2 mice tended to have lower numbers of entries than the C57BL/6J mice (Fig. 10b; significant main effect of strain, F 1,9 ¼ 16.156, P ¼ 0.003; retest, F 1,9 ¼ 36.215,P ¼ 0.0002; and side, F 1,9 ¼ 8.723, P ¼ 0.0161).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Finally, the adult C57BL/6J and DBA/2 mice had higher numbers of entries into the side of the chamber containing the unfamiliar conspecific in the sociability test.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plainn = 2- Asserted: passes — The authors put it forward as true.
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In the paper
“Adult A/J males failed to show a significant preference for the side containing stranger 1, as compared to the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The low number of entries observed in the A/J mice was significantly different from both of the other inbred strains (post hoc tests following repeated measures ANOVA, F-values above).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 24
- The quote only partly states this claim. 1
- Probably not a substantial claim. 32
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Higher numbers of sniffs were directed toward stranger 1 than towards the empty wire cage, and towards the novel stranger 2 vs. the now-familiar stranger 1, in C57BL/6J, DBA/2J and FVB/NJ male mice (Nadler et al. 2004).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Partly supportedcites Nadler et al. 2004 sourceExperimental — accuracy not yet measured
The “Social behavior tasks in three inbred strains” section reports that males of all three named strains spent more time sniffing the cage containing stranger 1 than the empty cage, and more time sniffing stranger 2 than stranger 1. The “Sociability test” section specifies that sniffing was scored as cumulative duration in seconds, not as a number of sniffs; that measurement in the claim is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“General health, neurological reflexes, activity levels, motor functions and sensory abilities were normal in most regards for the strains tested.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar levels of sociability were clearly evident in a group of young female C57BL/6J mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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The quote only partly states this claim.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A/J was the only strain tested that failed to spend more time with a conspecific, and spent most of its time in the central chamber after the initial 5-minute habituation session.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the inbred strains were able to locate buried food, supporting an interpretation that none were anosmic, which could have severely impacted social behaviors by blocking detection of olfactory cues emitted by the stranger mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For the olfactory test, the majority of the subjects successfully located and retrieved the buried food.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 9, the A/J group did show significant increases in time spent in the side regions (Fig. 9a, significant main effect of retest, F 1,9 ¼ 11.343, P ¼ 0.0083) and in number of entries (Fig. 9b, significant main effect of retest, F 1,9 ¼ 13.302, P ¼ 0.0053) when the openings between chambers were more accessible.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Sociability procedure with modified social test box
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the significantly higher locomotor scores observed in the FVB/NJ strain, in comparison to the other two groups, were not reflected in an overall higher number of entries.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The FVB/NJ mice demonstrated a significantly shorter latency for locating the buried food,”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A significant interaction was found between side of chamber and test condition (F 1,57 ¼ 67.634, P < 0.0001), reflecting the finding that preference was for the stranger 1 side during the first half of the session (the sociability condition), but switched to the stranger 2 side during the last part of the session (the social novelty condition).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Arguing against an artifactual interpretation that hypolocomotion caused the social deficit in the A/J group are the data of Fig. 8. Repeated testing of A/J in the modified apparatus increased the number of entries, but did not yield significant sociability scores.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The A/J mice spent significantly more time in the center chamber, indicating a strong preference for the start box that was not seen in the other strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the second group of juvenile C57BL/6J mice, both males and females made equal numbers of entries into each side of the social test box during the assay for sociability, but showed an increased number of entries into the side of the social box containing the second, 'novel' unfamiliar stranger during the test for social novelty.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences between the strains in body weight or rotarod performance (see Table 1 for mean latency to fall on the second trial).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, for the juvenile male mice, number of entries did not reflect the trends for social preference seen in the duration measures, and only partially correlated with their locomotor activity independently quantitated in the open field.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, low locomotor scores in DBA/2J and high locomotor scores in FVB/NJ appeared to be unrelated to amount of time spent in the chamber with stranger 1 and stranger 2.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant preferences for sociability (Fig. 3a) or preference for social novelty (Fig. 3b) were not observed for number of chamber entries in any of the inbred strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the present study, the juvenile male mice made nests and huddled together while sleeping.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Autistic individuals may further avoid unfamiliar social partners and display diminished interest in novelty (American Psychiatric Association 1994).”
What the sources say
- Not matchedcites American Psychiatric Association 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This modification focuses the task on social approach tendencies, relevant to the social approach deficit in autism, while avoiding potential confounds resulting from aggressive or sexual interactions.”
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Rests on an assumption: Most autistic individuals demonstrate reduced or unusual social approach.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“To ensure that differences in social behaviors were not artifacts of other aspects of mouse behaviors, a series of independent control experiments was conducted to evaluate potential confounding factors.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of times that the mouse exited from the habituated empty central chamber into the novel empty chamber provided a general measure of locomotor function.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Social behaviors have been explored in mice with mutations in candidate genes such as oxytocin (Winslow & Insel 2002;Young et al. 2002), monoamine oxidase-A (Shih & Chen 1999), fragile X (Churchill et al. 2002;Mineur et al. 2002) and dishevelled-1 (Lijam et al. 1997).”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Further controls were designed to detect additional symptoms relevant to autism, such as abnormalities in locomotion or motor coordination (Hallett et al. 1993;Piven et al. 1997), that could directly affect performance of the social task.”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Measures of general health, home cage behavior and neurological reflexes were conducted to rule out gross physical abnormalities (Crawley 2000).”
What the sources say
- Not checked — no full text of the sourcecites Crawley 2000
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Retrieval of food buried in cage bedding was quantitated in a 15-minute olfactory test, to ensure that the subject mice were not grossly impaired in olfaction abilities.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“A large body of evidence from twin and family studies supports the important role of genetic factors in the etiology of autism (Bailey et al. 1995;Ritvo et al. 1989;Szatmari et al. 1998).”
What the sources say
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present mouse tasks were designed to maximize face validity to some of the core symptoms of autism.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the A/J mice were given a second test one week later, with the dividing walls between the chamber sides partially retracted to facilitate exploration.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
plainn = 10- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Given the primacy of social impairment in autism, we considered this symptom to be fundamental to a mouse model of autism (Insel 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Several additional behavioral assays were performed in the initial set of juvenile male mice (C57BL/6J, DBA/2J and FVB/ NJ).These assays were designed as controls for sensory and motor abilities, etc., to ensure that the test mice were physically able to perform the procedures necessary for the social tasks described above.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The chambers of the social apparatus were cleaned and fresh paper chip bedding was added between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The location of stranger 1 in the left vs. right side chamber was systematically alternated between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In our experience to date with the present procedures, human observers attain a high level of proficiency after only one or two practice sessions, with high rates (greater than 95%) of interrater reliability between trained observers.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present protocol used a small wire cage to enclose the stimulus mouse, which allowed visual, auditory and olfactory contact between the mice, but prevented the occurrence of aggressive and other responses.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“From an early age, autistic children show low levels of eye contact and affective responses, less orientation toward others and language deficits, with a concomitant paucity of speech and social communication (for review, see Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites Tager-Flusberg et al. 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The stranger mouse was enclosed in a small, round wire cage (Galaxy Cup, Spectrum Diversified Designs, Inc., Streetsboro, OH), which allowed nose contact between the bars, but prevented fighting.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Previous work in social recognition has shown that mice show both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993;Dluzen & Kreutzberg 1993;Ferguson et al. 2000;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present procedures for the sociability and social novelty tests are designed to be simple, quantitative and easily mastered by investigators.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the present methods were designed to quantitate levels of sociability, i.e. tendency to initiate social contact, and preference for social novelty, i.e. tendency to initiate social contacts with a new individual as compared to someone familiar from past experience, using a simple scoring approach for laboratory mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, some autistic patients demonstrate aberrant motor responses, including repeated hand flapping, jumping and other repetitive and stereotyped behaviors (Bodfish et al. 2000;Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered sensory responses have been reported, including both hypo-and hyper-reactivity to environmental stimuli (Baranek 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Baranek 2002 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Use of the three-chambered apparatus for demonstrating social preference (Insel 2001) was adapted by Brodkin et al. (2004) to investigate social approach and avoidance in female mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Brodkin et al. 2004 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“and the mouse model of fragile X syndrome has been characterized by changes in activity (Bakker et al. 1994;Peier et al. 2000) and reactivity to acoustic stimuli (Chen & Toth 2001;Nielson et al. 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Bakker et al. 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Peier et al. 2000
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Chen & Toth 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Children with fragile X syndrome often show autistic behavior (Hagerman et al. 1986),”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Hagerman et al. 1986 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“As noted by Winslow (2003), the analysis of the full behavioral series that can occur in social tests demands familiarity with the mouse ethogram, extensive training and the ability to discern the sometimes rapid and fleeting responses that mice can emit.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Winslow 2003 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Methods are based on procedures examining pair-bonding in voles (Dean, S.M. & Vandenbergh, J.G. as above), as well as many other elegant tests for social behavior in rodents (Bluthe et al. 1993;Carter et al. 1995;Dluzen & Kreutzberg 1993;Gheusi et al. 1994;Insel and Young 2001;Kogan et al. 2000;Winslow & Camacho 1995;Winslow 2003).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Most autistic individuals demonstrate reduced or unusual social approach.
“We reasoned that most autistic individuals demonstrate reduced or unusual social approach.”
The paper relies on this without support.
Behavioral models of autistic-like responses in mice have received little attention.
“However, to date, behavioral models of autistic-like responses in mice have received little attention.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [530]
In the citing paper
“There is compelling evidence that some strains are more”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
In the citing paper
“However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects 9 ).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
“the social novelty test was not conducted”
Citations
Cites
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The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
A Comparison of the Social Postures of Some Common Laboratory Rodents
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Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108
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Cited by
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Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
Peça, J., Feliciano, C., Ting, J. T., Wang, W., Wells, M. F., Venkatraman, T. N., Lascola, C. D., Fu, Z., & Feng, G. (2011) · Nature · doi:10.1038/nature09965 · Cited by 1,570
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
“We developed an automated three-chambered social approach task, which scores time spent in a side chamber with a novel mouse versus time spent in a side chamber with a non-social novel object, an inverted wire pencil cu”
MethodSelf-citationNatural neural projection dynamics underlying social behavior
Gunaydin, L. A., Grosenick, L., Finkelstein, J. C., Kauvar, I. V., Fenno, L. E., Adhikari, A., Lammel, S., Mirzabekov, J. J., Airan, R. D., Zalocusky, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.017 · Cited by 1,389
Pten Regulates Neuronal Arborization and Social Interaction in Mice
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970
“Social preference for novelty was performed as described (Moy et al., 2004), except room and door dimensions were different (15 3 90 3 18.5 cm divided into three rooms of 15 3 29 cm separated by dividers with a central 3.8 3 3.8 cm door), and video tracking software from Noldus (Ethovision 2.3.19)…”
InfluentialBurokas, A., Arboleya, S., Moloney, R. D., Peterson, V. L., Murphy, K., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.031 · Cited by 952
“Sociability was assessed by the three-chambered social approach task (28,29) and the resident-intruder test (30) with minor modifications (see Supplement).”
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813
“Our group examined the behaviour of germ-free mice in the three-chamber test, a well-validated assay to assess social behaviour (Moy et al. 2004), where a germ-free mouse was placed in the centre chamber with a familiar mouse in one chamber and a novel mouse in the other chamber (Desbonnet et al.”
MethodAutism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812
“Although previous experiments found similar social approach by subjects when the strangers were of the same or different strains, and of the same or different sex (Moy et al. 2004; Nadler et al. 2004), the present experiments used strangers of the same strain and sex for internal consistency.”
BackgroundResultInfluentialSelf-citationMouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains
MOY, S., NADLER, J., YOUNG, N., PEREZ, A., HOLLOWAY, L., BARBARO, R., BARBARO, J., WILSON, L., THREADGILL, D., & LAUDER, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.030 · Cited by 776
“Data from the DBA and FVB strains were taken from a previously published dataset using identical methods [86], and included for comparison to the other inbred mouse strains.”
InfluentialSelf-citationAutomated apparatus for quantitation of social approach behaviors in mice
Nadler, J. J., Moy, S. S., Dold, G., Trang, D., Simmons, N., Perez, A., Young, N. B., Barbaro, R. P., Piven, J., Magnuson, T. R., et al. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00071.x · Cited by 775
“Test subjects for the subsequent inbred strain analysis were six-month-old males previously run through a battery of behavioral assays, including the sociability and social novelty preference assays previously conducted at six weeks of age ( Moy et al. 2004 ).”
BackgroundMethodInfluentialSelf-citationUnexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., et al. (2016) · Nature · doi:10.1038/nature18626 · Cited by 697
Automated Three‐Chambered Social Approach Task for Mice
Yang, M., Silverman, J. L., & Crawley, J. N. (2011) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0826s56 · Cited by 598
“We have obtained similar results in mice bred in-house and tested between 8 weeks and 6 months of age (Moy et al., 2004).”
BackgroundResultSelf-citationThe valproic acid-induced rodent model of autism
Nicolini, C., & Fahnestock, M. L. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.017 · Cited by 622
Neural circuit mechanisms of social behavior
Chen, P., & Hong, W. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.026 · Cited by 527
“In mammals, individuals prefer to interact with a conspecific over a nonsocial object (Moy et al., 2004).”
Mouse Behavioral Assays Relevant to the Symptoms of Autism*
Crawley, J. N. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00096.x · Cited by 541
“These high levels of social interaction were seen in both male and female subjects, when this sociability test was conducted at juvenile and adult ages, and when the sociability test was conducted during the light or the dark phase of the circadian cycle (124, 134, 138, 200).”
BackgroundMethodResultInfluentialSelf-citationAssessment of Social Interaction Behaviors
Kaidanovich‐Beilin, O., Lipina, T. V., Vukobradovic, I., Roder, J., & Woodgett, J. R. (2011) · Journal of Visualized Experiments · doi:10.3791/2473 · Cited by 585
Behavioral phenotypes of Disc1 missense mutations in mice
Clapcote, S. J., Lipina, T. V., Millar, J. K., Mackie, S., Christie, S., Ogawa, F., Lerch, J. P., Trimble, K., Uchiyama, M., Sakuraba, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.015 · Cited by 526
“Next, we investigated whether the depressive-like behavior of 31L/31L mice in the FST was also exhibited in the less-aversive social interaction (Moy et al., 2004) and reward responsiveness (Pothion et al.”
BackgroundMethodInfluentialDesigning mouse behavioral tasks relevant to autistic‐like behaviors
Crawley, J. N. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20039 · Cited by 544
Self-citationPrefrontal Cortex and Social Cognition in Mouse and Man
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Etherton, M. R., Blaiss, C. A., Powell, C. M., & Südhof, T. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910297106 · Cited by 447
Neuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior
Blundell, J., Blaiss, C. A., Etherton, M. R., Espinosa, F., Tabuchi, K., Walz, C., Bolliger, M. F., Südhof, T. C., & Powell, C. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4517-09.2010 · Cited by 450
“Social versus inanimate preference and preference for social novelty analyses were modified from previous descriptions (Moy et al., 2004; Nadler et al., 2004) as described in detail previously (Kwon et al., 2006; Tabuchi et al., 2007).”
MethodGreen, M. F. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi049 · Cited by 476
Silverman, J. L., Tolu, S. S., Barkan, C. L., & Crawley, J. N. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.201 · Cited by 438
“…the symptoms of a human disease (Bolivar et al , 2007; Brodkin, 2007; McFarlane et al , 2008; Moy et al , 2004; Moy et al , 2008; Moy et al , 2007; Nadler et al , 2004), conducting biological assays to understand the mechanisms responsible for the phenotypes, and evaluating pharmacological…”
Self-citationThe developmental neurobiology of autism spectrum disorder
DiCicco-Bloom, E., Lord, C., Zwaigenbaum, L., Courchesne, E., Dager, S. R., Schmitz, C., Schultz, R. T., Crawley, J., & Young, L. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1712-06.2006 · Cited by 434
Self-citationIn utero exposure to valproic acid and autism — A current review of clinical and animal studies
Roullet, F., Lai, J., & Foster, J. A. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.01.004 · Cited by 444
“a Three chamber social behavior apparatus is an established tool for testing sociability and social novelty (Moy et al., 2004); for sociability test, chamber 1 contains a stranger mouse or rat in an inverted cup, the center chamber is empty, and chamber 2 contains an empty inverted cup; for social novelty, chamber 1 c…”
MethodDorsal raphe dopamine neurons represent the experience of social isolation
Matthews, G. A., Nieh, E. H., Vander Weele, C. M., Halbert, S. A., Pradhan, R. V., Yosafat, A. S., Glober, G. F., Izadmehr, E. M., Thomas, R. E., Lacy, G. D., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.040 · Cited by 402
“We assessed social preference utilizing the three-chamber sociability task, in which time spent on the ‘‘social’’ side of the chamber (containing a juvenile mouse under a wire cup) is used as a measure of sociability (Moy et al., 2004; Silverman et al., 2010).”
MethodSala, M., Braida, D., Lentini, D., Busnelli, M., Bulgheroni, E., Capurro, V., Finardi, A., Donzelli, A., Pattini, L., Rubino, T., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.022 · Cited by 375
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
Santini, E., Huynh, T. N., MacAskill, A. F., Carter, A. G., Pierre, P., Ruggero, D., Kaphzan, H., & Klann, E. (2012) · Nature · doi:10.1038/nature11782 · Cited by 383
Schizophrenia-Relevant Behavioral Testing in Rodent Models: A Uniquely Human Disorder?
Powell, C. M., & Miyakawa, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.008 · Cited by 381
“For example, the “stranger” rodent can be freely moving (Miyakawa et al 2003) or trapped in a small wire-cage (Moy et al 2004; Nadler et al 2004).”
BackgroundNeuroligin‐3‐deficient mice: model of a monogenic heritable form of autism with an olfactory deficit
Radyushkin, K., Hammerschmidt, K., Boretius, S., Varoqueaux, F., El-Kordi, A., Ronnenberg, A., Winter, D., Frahm, J., Fischer, J., Brose, N., et al. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00487.x · Cited by 362
“…as the percentage of the startle response using the following formula: %prepulse inhibition ¼ 100 ½ðstartle amplitude after prepulse and pulseÞ= ðstartle amplitude after pulse onlyÞ 100 : Sociability and social memory test Sociability and social memory were tested as described (Moy et al. 2004).”
MethodEtherton, M. R., Földy, C., Sharma, M., Tabuchi, K., Liu, X., Shamloo, M., Malenka, R. C., & Südhof, T. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111093108 · Cited by 354
Veenstra-VanderWeele, J., Muller, C. L., Iwamoto, H., Sauer, J. E., Owens, W. A., Shah, C. R., Cohen, J., Mannangatti, P., Jessen, T., Thompson, B. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112345109 · Cited by 333
Self-citationIndividual differences in behavioural plasticities
Stamps, J. A. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12186 · Cited by 329
Epigenetic transgenerational inheritance of altered stress responses
Crews, D. P., Gillette, R., Scarpino, S. V., Manikkam, M., Savenkova, M. I., & Skinner, M. K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118514109 · Cited by 323
Wolstenholme, J. T., Edwards, M., Shetty, S. R. J., Gatewood, J. D., Taylor, J. A., Rissman, E. F., & Connelly, J. J. (2012) · Endocrinology · doi:10.1210/en.2012-1195 · Cited by 319
“The social score, calculated as the time spent in the chamber with the mouse minus the time spent in the empty chamber, also revealed a significant interaction between diet and sex [F(1,47) 9.”
BackgroundDichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299
“Preclinical models Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
BackgroundMucosal fungi promote gut barrier function and social behavior via Type 17 immunity
Leonardi, I., Gao, I. H., Lin, W.-Y., Allen, M., Li, X. V., Fiers, W. D., De Celie, M. B., Putzel, G. G., Yantiss, R. K., Johncilla, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.017 · Cited by 307
Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice
Chadman, K. K., Gong, S., Scattoni, M. L., Boltuck, S. E., Gandhy, S. U., Heintz, N., & Crawley, J. N. (2008) · Autism Research · doi:10.1002/aur.22 · Cited by 292
Self-citationCohen, S., Gabel, H. W., Hemberg, M., Hutchinson, A. N., Sadacca, L. A., Ebert, D. H., Harmin, D. A., Greenberg, R. S., Verdine, V. K., Zhou, Z., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.022 · Cited by 298
“Behavioral Analysis The assay of sociability and preference for social novelty were based on awellcharacterized assay from the Crawley lab (Moy et al., 2004).”
InfluentialC9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD
O’Rourke, J. G., Bogdanik, L., Muhammad, A. K. M. G., Gendron, T. F., Kim, K. J., Austin, A., Cady, J., Liu, E. Y., Zarrow, J., Grant, S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.027 · Cited by 298
Young, J. W., Powell, S. B., Risbrough, V. B., Marston, H. M., & Geyer, M. A. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.004 · Cited by 312
Kouser, M., Speed, H. E., Dewey, C. M., Reimers, J. M., Widman, A. J., Gupta, N., Liu, S., Jaramillo, T. C., Bangash, M. A., Xiao, B., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3017-13.2013 · Cited by 297
“, 2009) and based to a large extent on the original descriptions (Moy et al., 2004; Nadler et al., 2004).”
BackgroundMethodWhat's wrong with my mouse model?
Kalueff, A. V., Wheaton, M., & Murphy, D. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.023 · Cited by 285
“[249] Moy SS, Nadler JJ, Perez A, Barbaro RP, Johns JM, Magnuson TR, et al.”
BackgroundNakajima, M., Görlich, A., & Heintz, N. (2014) · Cell · doi:10.1016/j.cell.2014.09.020 · Cited by 262
“To do so, we chose the viral-mediated tethered toxin (t-toxin) strategy for chronic inhibition of neurotransmission (Auer et al., 2010; Warner-Schmidt et al., 2012) in mPFC OxtrCre interneurons and the three chamber mouse social interaction test (Moy et al., 2004).”
BackgroundMethodPrenatal stress: Role in psychotic and depressive diseases
Markham, J. A., & Koenig, J. I. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2035-0 · Cited by 282
“Rodents are highly social and recent work has devised a procedure to study social interactions in experimental animals under non-anxiogenic conditions (Lee et al. 2005; Moy et al. 2004).”
Chronic Social Instability Induces Anxiety and Defective Social Interactions Across Generations
Saavedra-Rodríguez, L., & Feig, L. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.035 · Cited by 274
“In a related assay, sociability was assessed by measuring time spent with a novel adult mouse in a three-chambered social box (21).”
Grauer, S. M., Pulito, V. L., Navarra, R. L., Kelly, M. P., Kelley, C., Graf, R., Langen, B., Logue, S. F., Brennan, J. A., Jiang, L., et al. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.155994 · Cited by 273
Assessing autism-like behavior in mice: Variations in social interactions among inbred strains
BOLIVAR, V, WALTERS, S., & PHOENIX, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.09.007 · Cited by 264
“This conclusion is in agreement with findings of previous studies [41,50].”
BackgroundResultInfluentialChd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits
Platt, R. J., Zhou, Y., Slaymaker, I. M., Shetty, A. S., Weisbach, N. R., Kim, J.-A., Sharma, J., Desai, M., Sood, S., Kempton, H. R., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.052 · Cited by 240
“As previously described, the three-chambered assay involves habituation, a sociability test, and a social novelty (Chadman et al., 2008; Chao et al., 2010; McFarlane et al., 2008; Moy et al., 2004; Silverman et al., 2010; Yang et al., 2009).”
MethodSocial reward among juvenile mice
Panksepp, J. B., & Lahvis, G. P. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00295.x · Cited by 248
“…Deed, Attribution 2.5, which does not permit commercial exploitation. doi: 10.1111/j.1601-183X.2006.00295.x 661 conspecifics (Brodkin et al. 2004; Moy et al. 2004, 2006; Terranova et al. 1993), but their social interactions are rarely sexual or aggressive in nature, and rough-and-tumble play is…”
BackgroundResultInfluentialTakeuchi, H., Iba, M., Inoue, H., Higuchi, M., Takao, K., Tsukita, K., Karatsu, Y., Iwamoto, Y., Miyakawa, T., Suhara, T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021050 · Cited by 247
“Crawley's three-chamber social approach test consists of a sociability test and a social novelty preference test. These tests assess social interaction that is relatively independent of locomotor activity compared to other social interaction tests, because the preference of the mice can be quantified based on the time…”
BackgroundSocial approach in genetically engineered mouse lines relevant to autism
Moy, S. S., Nadler, J. J., Young, N. B., Nonneman, R. J., Grossman, A. W., Murphy, D. L., D’Ercole, A. J., Crawley, J. N., Magnuson, T. R., & Lauder, J. M. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2008.00452.x · Cited by 246
“Fmr1 mice were tested in a nonautomated three-chambered box, with measures taken by a human observer blind to mouse genotype (Duncan et al. 2004; Moy et al. 2004).”
MethodSelf-citationMárquez, C., Poirier, G. L., Cordero, M. I., Larsen, M. H., Groner, A., Marquis, J., Magistretti, P. J., Trono, D., & Sandi, C. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.144 · Cited by 245
“The sociability test was adapted from the protocol described by Crawley to investigate the sociability of male mice.(29) Briefly, the test was conducted in a rectangular, three-chambered box (a center chamber of 20 35 35 cm”
MethodChd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling
Durak, O., Gao, F., Kaeser-Woo, Y. J., Rueda, R., Martorell, A. J., Nott, A., Liu, C. Y., Watson, L. A., & Tsai, L.-H. (2016) · Nature Neuroscience · doi:10.1038/nn.4400 · Cited by 243
Social approach and repetitive behavior in eleven inbred mouse strains
Moy, S. S., Nadler, J. J., Young, N. B., Nonneman, R. J., Segall, S. K., Andrade, G. M., Crawley, J. N., & Magnuson, T. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.015 · Cited by 240
“These deficits in social approach can be modeled in mice by using social choice tasks, in which mice are presented with a choice between spending time in the proximity of another mouse, or remaining alone [7,30,31,33,42].”
BackgroundMethodResultInfluentialSelf-citationScent marking behavior as an odorant communication in mice
Arakawa, H., Blanchard, D. C., Arakawa, K., Dunlap, C., & Blanchard, R. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.012 · Cited by 229
“…physiology and pathology of communication in this species, complementary to mouse social recognition paradigms (Crawley et al., 1999; Crawley, 2004; Moy et al., 2004, 2007) that have been used for a variety of models associated with neurocognitive disorders including autism (Qiu et al., 2006;…”
BackgroundSchwartzer, J. J., Careaga, M., Onore, C. E., Rushakoff, J. A., Berman, R. F., & Ashwood, P. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.16 · Cited by 230
“For example, systematic phenotyping of ASD-like behaviors across mouse strains has revealed a spectrum of behavioral responses dependent on genetic background.(12,13,36) These studies identified the BTBR strain as a model organism that exhibits behavioral deficits modeling all three core domains of 0 100 200 300 400”
BackgroundLópez‐Erauskin, J., Tadokoro, T., Baughn, M. W., Myers, B., McAlonis‐Downes, M., Chillón-Marinas, C., Asiaban, J. N., Artates, J. W., Bui, A. T., Vetto, A. P., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.044 · Cited by 233
Crawley, J. N., Chen, T., Puri, A., Washburn, R., Sullivan, T. L., Hill, J. M., Young, N. B., Nadler, J. J., Moy, S. S., Young, L. J., et al. (2007) · Neuropeptides · doi:10.1016/j.npep.2007.02.002 · Cited by 232
Self-citationSankoorikal, G. M. V., Kaercher, K. A., Boon, C. J., Lee, J. K., & Brodkin, E. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.026 · Cited by 231
O’Tuathaigh, C. M. P., Babovic, D., O’Sullivan, G. J., Clifford, J. J., Tighe, O., Croke, D. T., Harvey, R. P., & Waddington, J. L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.03.051 · Cited by 238
“Sociability and preference for social novelty 13 Social approach/avoidance behaviour was assessed using a recently developed procedure which provides a simple and easily quantifiable measure of affiliative behaviour in mice (Brodkin et al., 2004; Moy et al., 2004; Sankoorikal et al., 2006).”
MethodThe schizophrenia risk gene product miR-137 alters presynaptic plasticity
Siegert, S., Seo, J., Kwon, E. J., Rudenko, A., Cho, S., Wang, W., Flood, Z., Martorell, A. J., Ericsson, M., Mungenast, A. E., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4023 · Cited by 221
“Social interaction paradigm: Three-chamber social interaction test 57 was performed as in 58 with minor modifications.”
MethodDeLorey, T. M., Sahbaie, P., Hashemi, E., Homanics, G. E., & Clark, J. D. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.09.009 · Cited by 225
“The experimental design of both the social interaction and social novelty tests were adapted from Nadler et al, [53,54].”
MethodBALB/c mice: Low sociability and other phenotypes that may be relevant to autism
Brodkin, E. S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.025 · Cited by 223
C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo
Choi, S. Y., Lopez-Gonzalez, R., Krishnan, G., Phillips, H. L., Nana, A. L., Seeley, W. W., Yao, W., Almeida, S., & Gao, F. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0397-0 · Cited by 230
Garner, J. P. (2014) · ILAR Journal · doi:10.1093/ilar/ilu047 · Cited by 234
Spencer, C. M., Alekseyenko, O. V., Hamilton, S. M., Thomas, A. M., Serysheva, E., Yuva‐Paylor, L. A., & Paylor, R. E. (2011) · Autism Research · doi:10.1002/aur.168 · Cited by 225
Prenatal infection leads to ASD-like behavior and altered synaptic pruning in the mouse offspring
de Cossío, L. F., Guzman, A. S., van der Veldt, S., & Luheshi, G. N. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.028 · Cited by 227
Li, W., Zhou, Y., Jentsch, J. D., Brown, R. A. M., Tian, X., Ehninger, D., Hennah, W., Peltonen, L., Lönnqvist, J. K., HUTTUNEN, M. O., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706900104 · Cited by 205
Strain and Sex Differences in Anxiety-Like and Social Behaviors in C57BL/6J and BALB/cJ Mice
An, X., Jun-Xian, Z. O. U., Wu, R., Yang, Y., Tai, F., Zeng, S., Jia, R., Zhang, X., Liu, E., & Broders, H. G. (2011) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.60.111 · Cited by 203
Blundell, J. J., Tabuchi, K., Bolliger, M. F., Blaiss, C. A., Brose, N., Liu, X., Südhof, T. C., & Powell, C. M. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00455.x · Cited by 210
Ferguson, B. R., & Gao, W.-J. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.033 · Cited by 186
“To measure sociability and social novelty, animals were tested in a threechamber paradigm (27).”
Shoji, H., & Miyakawa, T. (2019) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12052 · Cited by 211
“The three‐chamber social approach test was conducted to assess sociability and social novelty preference.(32) The testing apparatus consisted of a rectangular three‐chambered box and a lid with an video camera (O'Hara & Co.”
MethodRoullet, F., Wollaston, L., deCatanzaro, D., & Foster, J. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.069 · Cited by 213
Advances in behavioral genetics: mouse models of autism
Moy, S. S., & Nadler, J. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002082 · Cited by 204
Self-citationHow and why do T cells and their derived cytokines affect the injured and healthy brain?
Filiano, A. J., Gadani, S. P., & Kipnis, J. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.39 · Cited by 199
Development of a mouse test for repetitive, restricted behaviors: Relevance to autism
Moy, S. S., Nadler, J. J., Poe, M. D., Nonneman, R. J., Young, N. B., Koller, B. H., Crawley, J. N., Duncan, G. E., & Bodfish, J. W. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.10.029 · Cited by 195
Self-citationReith, R. M., McKenna, J., Wu, H. C., Hashmi, S. S., Cho, S., Dash, P. K., & Gambello, M. J. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.10.014 · Cited by 193
“One widely used assay is the three chambered apparatus which has detected social deficits in multiple mouse models of autism (Moy et al., 2004; Kwon et al., 2006; Peca et al., 2011).”
Zhang, J., Buller, B., Zhang, Z. G., Zhang, Y., Lü, M., Rosene, D. L., Medalla, M., Moore, T. L., & Chopp, M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113895 · Cited by 196
To group or not to group? Good practice for housing male laboratory mice
Kappel, S., Hawkins, P., & Mendl, M. (2017) · Animals · doi:10.3390/ani7120088 · Cited by 190
“via scent marking [21,52] - Social company as reward; evidenced by motivation to gain access to a social partner [61,76–78] - Preference for social stimulation over social isolation [61,76,82,83,89] - Strain-dependent sociability and social novelty [79,80] - Rewarding effects of aggression (e.”
BackgroundKalueff, A. V., Fox, M. A., Gallagher, P. S., & Murphy, D. L. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00270.x · Cited by 187
“Because reduced mouse sociability has been recently suggested to represent a model of autistic-like behavior (Crawley 2004; Moy et al. 2004, 2006), this also needs to be considered for SERT / mice.”
BackgroundOxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat
Harony-Nicolas, H., Kay, M., Hoffmann, J. D., Klein, M. E., Bozdagi-Gunal, O., Riad, M., Daskalakis, N. P., Sonar, S., Castillo, P. E., Hof, P. R., et al. (2017) · eLife · doi:10.7554/elife.18904 · Cited by 168
“We used a modified version of the widely used social preference paradigm by Moy et al., (Moy et al., 2004).”
MethodWöhr, M., & Scattoni, M. L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.047 · Cited by 189
Samaco, R. C., McGraw, C. M., Ward, C. S., Sun, Y., Neul, J. L., & Zoghbi, H. Y. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds406 · Cited by 183
Responses and functions of dopamine in nucleus accumbens core during social behaviors
Dai, B., Sun, F., Tong, X., Ding, Y., Kuang, A., Osakada, T., Li, Y., & Lin, D. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111246 · Cited by 187
A Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex
Xu, H., Liu, L., Tian, Y., Wang, J., Li, J., Zheng, J., Zhao, H., He, M., Xu, T.-L., Duan, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.026 · Cited by 181
Talos, D. M., Sun, H., Zhou, X., Fitzgerald, E. C., Jackson, M. C., Klein, P., Lan, V. J., Joseph, A., & Jensen, F. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035885 · Cited by 182
Behavioral phenotypes of genetic mouse models of autism
Kazdoba, T. M., Leach, P. T., & Crawley, J. N. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12256 · Cited by 187
“…of social approach abnormalities and inappropriate social behaviors that are common in ASD, we developed a mouse 3-chambered social approach assay (Moy et al. 2004; Nadler et al. 2004), refined methods for scoring reciprocal social interactions in juvenile and adult mice (McFarlane et al. 2008),…”
BackgroundMethodSelf-citationHines, R. M., Wu, L., Hines, D. J., Steenland, H. W., Mansour, S., Dahlhaus, R., Singaraja, R. R., Cao, X., Sammler, E. M., Hormuzdi, S. G., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0032-08.2008 · Cited by 185
“7E) (Moy et al., 2004; Nadler et al., 2004).”
MethodGenetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice
Pietropaolo, S., Guilleminot, A., Martin, B., D'Amato, F. R., & Crusio, W. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017073 · Cited by 178
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice
Kaidanovich‐Beilin, O., Lipina, T. V., Takao, K., van Eede, M., Hattori, S., Laliberté, C. L., Khan, M., Okamoto, K., Chambers, J. W., Fletcher, P. J., et al. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-35 · Cited by 179
“Aggression was assessed using the resident-intruder test in isolated male mice, essentially as previously described [67].”
MethodWhat Can We Learn about Autism from Studying Fragile X Syndrome?
Budimirovic, D. B., & Kaufmann, W. E. (2011) · Developmental Neuroscience · doi:10.1159/000330213 · Cited by 187
A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism
Chaliha, D. R., Albrecht, M. A., Vaccarezza, M., Takechi, R., Lam, V., Al‐Salami, H., & Mamo, J. C. L. (2020) · Developmental Neuroscience · doi:10.1159/000509109 · Cited by 177
Cheng, D., Low, J. K., Logge, W., Garner, B., & Karl, T. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3478-5 · Cited by 181
“Social preference test (SPT) The SPT was used to assess sociability and social recognition memory (Moy et al. 2004) and performed as described in an earlier study assessing baseline behaviours of APPxPS1 males (Cheng et al. 2013).”
Dhamne, S. C., Silverman, J. L., Super, C. E., Lammers, S. H. T., Hameed, M. Q., Modi, M. E., Copping, N. A., Pride, M. C., Smith, D. G., Rotenberg, A., et al. (2017) · Molecular Autism · doi:10.1186/s13229-017-0142-z · Cited by 168
“Three-chambered social approach, an assay developed by our group in 2004 [36, 37], revealed normal sociability in Shank3B KO males in cohort 1 and in Shank3B KO females in cohorts 1 and 2, but absence of sociability in Shank3B KO males in cohort 2.”
MethodSelf-citationBariselli, S., Hörnberg, H., Prévost-Solié, C., Musardo, S., Hatstatt-Burklé, L., Scheiffele, P., & Bellone, C. (2018) · Nature Communications · doi:10.1038/s41467-018-05382-3 · Cited by 171
Filiano, A. J., Martens, L. H., Young, A. H., Warmus, B. A., Zhou, P., Diaz‐Ramirez, G., Jiao, J., Zhang, Z., Huang, E. J., Gao, F., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.6103-11.2013 · Cited by 175
“To test social withdrawal in progranulin-deficient mice, we used the threechamber sociability test (Moy et al., 2004).”
MethodAssessment of Social Interaction Behaviors
Kaidanovich‐Beilin, O., Lipina, T. V., Vukobradovic, I., Roder, J., & Woodgett, J. R. (2011) · Journal of Visualized Experiments · doi:10.3791/2473-v · Cited by 175
Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice
Wolstenholme, J. T., Taylor, J. A., Shetty, S. R. J., Edwards, M., Connelly, J. J., & Rissman, E. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025448 · Cited by 169
“On PN24, mice were habituated to a testing room for one hour then placed into the center section of a three-chambered Plexiglas box (76.2 cm × 26.67 cm × 17.78 cm), divided by black Plexiglas walls and backed by black Plexiglas so that the center section was darkened on 3 sides with 2 openings leading to the outer cha…”
MethodInfluentialSHANK3 controls maturation of social reward circuits in the VTA
Bariselli, S., Tzanoulinou, S., Glangetas, C., Prévost-Solié, C., Pucci, L., Viguié, J., Bezzi, P., O'Connor, E. C., Georges, F., Lüscher, C., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4319 · Cited by 168
Metadata
- Authors
- Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institute of Mental Health (US)
- Corresponding author
- Moy, S. S.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 3
- Issue
- 5
- Pages
- 287-302
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2109091674
- Cited by
- 1,522
- References
- 80
- Citations by year
- 2026: 93 · 2025: 99 · 2024: 99 · 2023: 98 · 2022: 121 · 2021: 110 · 2020: 109 · 2019: 114 · 2018: 98 · 2017: 65 · 2016: 83 · 2015: 72 · 2014: 65 · 2013: 53 · 2012: 57
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- North Carolina State University
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54 MH 66418, MH66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sociability, autism spectrum disorder, mouse models of autism, inbred mouse strains, social interaction deficits, social avoidance, C57BL/6J mice, DBA/2J, A/J, sex differences, age differences
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Female, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Sex Factors, Social Behavior, Species Specificity, Reproducibility of Results, Rotarod Performance Test, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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