The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index; 1 of the 52 sources its claims cite were checked for support.
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Open accessAbstract
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now‐familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend‐ ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now‐familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
63 Own result · 16 No full text of the sources · 15 Own method · 6 Not checked yet · 6 Own interpretation · 5 Sources not found · 2 No basis given · 1 Partly supported · accuracy not yet measured
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber)”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1).”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exception was A/J, a strain that demonstrated a preference for the central chamber.”
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Overall, four of the five inbred and hybrid strains tested spent more time in the side of the social test box containing the unfamiliar stranger, vs. time in the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“DBA/2 mice tended to have lower numbers of entries than the C57BL/6J mice (Fig. 10b; significant main effect of strain, F 1,9 ¼ 16.156, P ¼ 0.003; retest, F 1,9 ¼ 36.215,P ¼ 0.0002; and side, F 1,9 ¼ 8.723, P ¼ 0.0161).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Finally, the adult C57BL/6J and DBA/2 mice had higher numbers of entries into the side of the chamber containing the unfamiliar conspecific in the sociability test.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plainn = 2- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Adult A/J males failed to show a significant preference for the side containing stranger 1, as compared to the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The low number of entries observed in the A/J mice was significantly different from both of the other inbred strains (post hoc tests following repeated measures ANOVA, F-values above).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- It may state two separate claims as one. 24
- The quote only partly states this claim. 1
- Probably not a substantial claim. 32
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Higher numbers of sniffs were directed toward stranger 1 than towards the empty wire cage, and towards the novel stranger 2 vs. the now-familiar stranger 1, in C57BL/6J, DBA/2J and FVB/NJ male mice (Nadler et al. 2004).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Partly supportedcites Nadler et al. 2004 sourceExperimental — accuracy not yet measured
The “Social behavior tasks in three inbred strains” section reports that males of all three named strains spent more time sniffing the cage containing stranger 1 than the empty cage, and more time sniffing stranger 2 than stranger 1. The “Sociability test” section specifies that sniffing was scored as cumulative duration in seconds, not as a number of sniffs; that measurement in the claim is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“General health, neurological reflexes, activity levels, motor functions and sensory abilities were normal in most regards for the strains tested.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar levels of sociability were clearly evident in a group of young female C57BL/6J mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The quote only partly states this claim.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A/J was the only strain tested that failed to spend more time with a conspecific, and spent most of its time in the central chamber after the initial 5-minute habituation session.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the inbred strains were able to locate buried food, supporting an interpretation that none were anosmic, which could have severely impacted social behaviors by blocking detection of olfactory cues emitted by the stranger mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For the olfactory test, the majority of the subjects successfully located and retrieved the buried food.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 9, the A/J group did show significant increases in time spent in the side regions (Fig. 9a, significant main effect of retest, F 1,9 ¼ 11.343, P ¼ 0.0083) and in number of entries (Fig. 9b, significant main effect of retest, F 1,9 ¼ 13.302, P ¼ 0.0053) when the openings between chambers were more accessible.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Sociability procedure with modified social test box
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the significantly higher locomotor scores observed in the FVB/NJ strain, in comparison to the other two groups, were not reflected in an overall higher number of entries.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The FVB/NJ mice demonstrated a significantly shorter latency for locating the buried food,”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A significant interaction was found between side of chamber and test condition (F 1,57 ¼ 67.634, P < 0.0001), reflecting the finding that preference was for the stranger 1 side during the first half of the session (the sociability condition), but switched to the stranger 2 side during the last part of the session (the social novelty condition).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Arguing against an artifactual interpretation that hypolocomotion caused the social deficit in the A/J group are the data of Fig. 8. Repeated testing of A/J in the modified apparatus increased the number of entries, but did not yield significant sociability scores.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The A/J mice spent significantly more time in the center chamber, indicating a strong preference for the start box that was not seen in the other strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the second group of juvenile C57BL/6J mice, both males and females made equal numbers of entries into each side of the social test box during the assay for sociability, but showed an increased number of entries into the side of the social box containing the second, 'novel' unfamiliar stranger during the test for social novelty.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences between the strains in body weight or rotarod performance (see Table 1 for mean latency to fall on the second trial).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, for the juvenile male mice, number of entries did not reflect the trends for social preference seen in the duration measures, and only partially correlated with their locomotor activity independently quantitated in the open field.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, low locomotor scores in DBA/2J and high locomotor scores in FVB/NJ appeared to be unrelated to amount of time spent in the chamber with stranger 1 and stranger 2.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant preferences for sociability (Fig. 3a) or preference for social novelty (Fig. 3b) were not observed for number of chamber entries in any of the inbred strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the present study, the juvenile male mice made nests and huddled together while sleeping.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Autistic individuals may further avoid unfamiliar social partners and display diminished interest in novelty (American Psychiatric Association 1994).”
What the sources say
- Not matchedcites American Psychiatric Association 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This modification focuses the task on social approach tendencies, relevant to the social approach deficit in autism, while avoiding potential confounds resulting from aggressive or sexual interactions.”
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Most autistic individuals demonstrate reduced or unusual social approach.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“To ensure that differences in social behaviors were not artifacts of other aspects of mouse behaviors, a series of independent control experiments was conducted to evaluate potential confounding factors.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of times that the mouse exited from the habituated empty central chamber into the novel empty chamber provided a general measure of locomotor function.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Social behaviors have been explored in mice with mutations in candidate genes such as oxytocin (Winslow & Insel 2002;Young et al. 2002), monoamine oxidase-A (Shih & Chen 1999), fragile X (Churchill et al. 2002;Mineur et al. 2002) and dishevelled-1 (Lijam et al. 1997).”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Further controls were designed to detect additional symptoms relevant to autism, such as abnormalities in locomotion or motor coordination (Hallett et al. 1993;Piven et al. 1997), that could directly affect performance of the social task.”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Measures of general health, home cage behavior and neurological reflexes were conducted to rule out gross physical abnormalities (Crawley 2000).”
What the sources say
- Not checked — no full text of the sourcecites Crawley 2000
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Retrieval of food buried in cage bedding was quantitated in a 15-minute olfactory test, to ensure that the subject mice were not grossly impaired in olfaction abilities.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“A large body of evidence from twin and family studies supports the important role of genetic factors in the etiology of autism (Bailey et al. 1995;Ritvo et al. 1989;Szatmari et al. 1998).”
What the sources say
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present mouse tasks were designed to maximize face validity to some of the core symptoms of autism.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the A/J mice were given a second test one week later, with the dividing walls between the chamber sides partially retracted to facilitate exploration.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
plainn = 10- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Given the primacy of social impairment in autism, we considered this symptom to be fundamental to a mouse model of autism (Insel 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Several additional behavioral assays were performed in the initial set of juvenile male mice (C57BL/6J, DBA/2J and FVB/ NJ).These assays were designed as controls for sensory and motor abilities, etc., to ensure that the test mice were physically able to perform the procedures necessary for the social tasks described above.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The chambers of the social apparatus were cleaned and fresh paper chip bedding was added between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The location of stranger 1 in the left vs. right side chamber was systematically alternated between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In our experience to date with the present procedures, human observers attain a high level of proficiency after only one or two practice sessions, with high rates (greater than 95%) of interrater reliability between trained observers.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present protocol used a small wire cage to enclose the stimulus mouse, which allowed visual, auditory and olfactory contact between the mice, but prevented the occurrence of aggressive and other responses.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“From an early age, autistic children show low levels of eye contact and affective responses, less orientation toward others and language deficits, with a concomitant paucity of speech and social communication (for review, see Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites Tager-Flusberg et al. 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The stranger mouse was enclosed in a small, round wire cage (Galaxy Cup, Spectrum Diversified Designs, Inc., Streetsboro, OH), which allowed nose contact between the bars, but prevented fighting.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Previous work in social recognition has shown that mice show both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993;Dluzen & Kreutzberg 1993;Ferguson et al. 2000;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present procedures for the sociability and social novelty tests are designed to be simple, quantitative and easily mastered by investigators.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the present methods were designed to quantitate levels of sociability, i.e. tendency to initiate social contact, and preference for social novelty, i.e. tendency to initiate social contacts with a new individual as compared to someone familiar from past experience, using a simple scoring approach for laboratory mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, some autistic patients demonstrate aberrant motor responses, including repeated hand flapping, jumping and other repetitive and stereotyped behaviors (Bodfish et al. 2000;Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered sensory responses have been reported, including both hypo-and hyper-reactivity to environmental stimuli (Baranek 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Baranek 2002 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Use of the three-chambered apparatus for demonstrating social preference (Insel 2001) was adapted by Brodkin et al. (2004) to investigate social approach and avoidance in female mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Brodkin et al. 2004 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“and the mouse model of fragile X syndrome has been characterized by changes in activity (Bakker et al. 1994;Peier et al. 2000) and reactivity to acoustic stimuli (Chen & Toth 2001;Nielson et al. 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Bakker et al. 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Peier et al. 2000
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Chen & Toth 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Children with fragile X syndrome often show autistic behavior (Hagerman et al. 1986),”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Hagerman et al. 1986 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“As noted by Winslow (2003), the analysis of the full behavioral series that can occur in social tests demands familiarity with the mouse ethogram, extensive training and the ability to discern the sometimes rapid and fleeting responses that mice can emit.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Winslow 2003 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Methods are based on procedures examining pair-bonding in voles (Dean, S.M. & Vandenbergh, J.G. as above), as well as many other elegant tests for social behavior in rodents (Bluthe et al. 1993;Carter et al. 1995;Dluzen & Kreutzberg 1993;Gheusi et al. 1994;Insel and Young 2001;Kogan et al. 2000;Winslow & Camacho 1995;Winslow 2003).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Most autistic individuals demonstrate reduced or unusual social approach.
“We reasoned that most autistic individuals demonstrate reduced or unusual social approach.”
The paper relies on this without support.
Behavioral models of autistic-like responses in mice have received little attention.
“However, to date, behavioral models of autistic-like responses in mice have received little attention.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [530]
In the citing paper
“There is compelling evidence that some strains are more”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
In the citing paper
“However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects 9 ).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
“the social novelty test was not conducted”
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,168
(1943) · The Nervous child · Cited by 8,870
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Autism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461
Epidemiological Surveys of Autism and Other Pervasive Developmental Disorders: An Update
Fombonne, E. (2003) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1025054610557 · Cited by 1,505
Varieties of Repetitive Behavior in Autism: Comparisons to Mental Retardation
Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005596502855 · Cited by 1,223
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
A Comparison of the Social Postures of Some Common Laboratory Rodents
Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108
Research works printed but not linked: 1
- Bachevalier J., 1991, Advances in Neuropsychiatry and Psychopharmacology, 129
Cited by
Sorted by citations
Items 1,301–1,400 of 1,472
Behavioral Phenotyping in Genetic Mouse Models of Autism Spectrum Disorders: A Translational Outlook
Scattoni, M. L., Michetti, C., Caruso, A., & Ricceri, L. (2017) · Wiley eBooks · doi:10.1002/9781118540770.ch11
Wang, D. Y. (2016) · TSpace (University of Toronto)
Haque, F. N. (2010) · TSpace (University of Toronto)
Pitta, F. D. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.59.2018.tde-19122017-230524
Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice
Cox, K. H., Quinnies, K. M., Eschendroeder, A., Didrick, P., Eugster, E. A., & Rissman, E. F. (2015) · PMC
Cellular And Molecular Insight Into Autonomic Function And Dysfunction
Wu, Y. (2022) · Digital Archive @ GSU · doi:10.57709/12426547
Molecular and Synaptic Alterations in the Striatum of GluN1-Deficient Mice
Chen, Y. (2018) · TSpace (University of Toronto)
Donzelli, A. (2013) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/donzelli-andrea_phd2013-01-16
“Olfactory test was carried out as described (Moy et al., 2004).”
MethodAssessing the role of PTEN in cholinergic neurons in glucose and energy homeostasis
Rapps, J. A. (2018) · TSpace (University of Toronto)
Correa, M., López‐Cruz, L., Porru, S., & Salamone, J. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813125-1.00056-8
Sassano, M. F. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/wwr3-7m34
The Role of PAK Signaling in Synaptic Transmission and Plasticity and Social Memory in Mice
Leung, C. (2019) · TSpace (University of Toronto)
Chromatin Dynamics and Genetic Variation Combine to Regulate Innate Immune Memory.
Kim, J. S., & Ciernia, A. V. (2020) · PubMed
Adolescent alcohol binge-drinking induces delayed appearance of behavioral defects in micePreprint
Hees, L. V., Didone, V., Charlet‐Briart, M., Ingelgom, T. V., Alexandre, A., Quertemont, É., Nguyen, L., & Laguesse, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.11.245878
“The three chamber test was employed to characterize sociability and preference for social novelty, as described in Moy et al (81).”
MethodNew insights into creatine transporter deficiency
Molinaro, A. (2020) · Premio Tesi dottorato/Premio Tesi di dottorato · doi:10.36253/978-88-5518-082-5
Kuprash, L., Panteleymonova, T., Sharabura, L., Labunets, І. F., Sykalo, N. V., & Olar, V. (2020) · Ageing & Longevity · doi:10.47855/jal9020-2020-1-2
“The test is widely used, in particular, both in the modeling of psycho-emotional disorders and in the study of neural mechanisms that influence social behavior [16, 17].”
Notaras, M. J., Allen, M., Longo, F., Volk, N. L., Tóth, M., Jeon, N. L., Klann, E., & Colak, D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/389585
Pimpinella, D., Mastrorilli, V., Giorgi, C., Coemans, S., Lecca, S., Lalive, A. L., Ostermann, H., Fuchs, E. C., Monyer, H., Mele, A., et al. (2021) · eLife · doi:10.7554/elife.65580.sa2
De la aldea de Potemkim a la democracia virtual en Rusia
Cardona, P. B. (2004) · Claves de razón práctica
Neuronale Grundlagen bewusstseinsassoziierter Prozesse
Volkmer, H. (2021) · Vandenhoeck & Ruprecht eBooks · doi:10.13109/9783666573279.63
Stress-Induced Despair Behavior Develops Independently of the AHR-RORgt Axis in CD4+ cellsPreprint
Rivet-Noor, C. R., Merchak, A. R., Li, S., Beiter, R. M., Lee, S., Thomas, J. A., Fernández-Castañeda, A., Shin, J., & Gaultier, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1181536/v1
Hu, H. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737407081.793578753
Schizophrenia risk factor Tcf4 and gene-environment interaction in mice
Badowska, D. M. (2015) · doi:10.53846/goediss-4943
“Déjà vu” in an autism gene mouse model modifies social mores
Xia, Q.-Q., Sekar, P., & Powell, C. M. (2022) · Neuron · doi:10.1016/j.neuron.2022.04.007
Excessive Cap-dependent Translation as a Molecular Mechanism Underlying ASD
Klann, E. (2014) · Defense Technical Information Center (DTIC) · doi:10.21236/ada612864
“…in eIF4E transgenic mice with two well-established behavioral paradigms, the three-chamber arena and the reciprocal social interaction task (Moy et al., 2004). eIF4E transgenic mice exhibited reduced preference for a nonspecific stranger as indicated by an equal amount of time spent…”
MethodSullivan, R. M., & Raineki, C. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733419583.793550327
Gore, A. C., & Walker, D. M. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718013220.793477281
An Immune Rat Model of Autism: Does Environmental Enrichment Alter Higher Social Functioning?
Wilkin-Krug, L. C. M. (2021) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.14635356.v1
Scherer, S. W., & Wintle, R. F. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.9869956.13296054
Crawley, J. N., & Brielmaier, J. M. (2021) · Springer eBooks · doi:10.1007/978-3-319-91280-6_546
Self-citationCarandini, M., & Benucci, A. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13296985.15429076
Muellerleile, J. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.68693
Jaber, M., Turpin, V., Schaffhauser, M., Thabault, M., Aubert, A., Joffre, C., Balado, É., Longueville, J.-E., Francheteau, M., Burucoa, C., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2063811/v1
Navarrete, J. S., Schneider, K. N., Smith, B. M., Goodwin, N. L., Zhang, Y. Y., Gross, E., Tsai, V. S., Heshmati, M., & Golden, S. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.08.515718
T-cell deficiency induces deficits in social behavior and dyslipidemia in mice
Asami, S., Tsutsui, Y., Yamamoto, S., & Miyajima, M. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.01.059
Differential effects of an obesogenic post-weaning diet on male and female behaviour in micePreprint
Mort, E. J., Fordington, S., Heritage, S., Fowden, A. L., Jones, S., & Camm, E. J. (2023) · doi:10.22541/au.167661732.22370393/v1
Bi, Y., Gao, H., & Bi, Y. (2023) · Research Square · doi:10.21203/rs.3.rs-2597380/v1
Multiple Behavioural Mechanisms Shape Development in a Highly Social Cichlid FishPreprint
Harmon, I. P., McCabe, E. A., Vergun, M. R., Weinstein, J., Graves, H. L., Bradley, D. D., Boldt, C. M., Lee, J., Maurice, J. M., & Solomon‐Lane, T. K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.14.536957
Febrile seizure in infants underlies endophenotypes of autism spectrum disorder in ratsPreprint
Yu, Y. H., Kim, S.-W., Im, H., Lee, Y. R., Kim, G. W., Ryu, S., Park, D., & Kim, D. (2023) · Research Square · doi:10.21203/rs.3.rs-3158638/v1
Pharmacotherapeutic effects of cannabidiol in autism spectrum disorders
Parkhill, M. (2023) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2023-15479
Pérez-Revuelta, L. (2023) · Gredos (University of Salamanca) · doi:10.14201/gredos.153257
Santos‐Silva, T. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2023.tde-10112023-160657
Microbiota influence behavior—Work in animal models
Foster, J. A., & Clarke, G. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-814800-6.00002-9
Differences in physiology and behavior between male winner and loser mice in the tube test
Wang, L., Huang, N., Cai, Q., Guo, S., & Ai, H. (2024) · Behavioural Processes · doi:10.1016/j.beproc.2024.105013
Yoo, T., Kim, S.-G., Yang, S. H., Kim, H., Kim, E., & Kim, S. Y. (2020) · Figshare · doi:10.6084/m9.figshare.11978484
Shchipanov, N. A., & Касаткин, М. В. (2023) · Известия Российской академии наук Серия биологическая · doi:10.31857/s1026347022700123
Disease Models for Rare Genetic Disorders
Kanakarajan, S., Selvaraj, R., & Kaleena, P. K. (2024) · Springer eBooks · doi:10.1007/978-981-99-9323-9_4
Neurobiological mechanisms of social recognition memory
Park, G., & Lee, Y. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00027-4
In vivo and in vitro assays, and safety profiles of cannabinoids
Gwedela, M. N. V., Jana, C. E., Mwambyale, T., Chikowe, I., Chimphepo, L., & Chirambo, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95927-8.00009-8
Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in micePreprint
Matoba, K., Dohi, E., Garcia, P. A., de Oliveira, J. F., Mirramezanializamini, M., Berkiks, I., Anguiano, F., Badrani, J. H., Fatoba, O., Choi, E. Y., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.12.605506
Piccin, A., Allain, A., Baufreton, J., Bertrand, S. S., & Contarino, A. (2024) · eLife · doi:10.7554/elife.100849
Piccin, A., Allain, A., Baufreton, J., Bertrand, S. S., & Contarino, A. (2024) · eLife · doi:10.7554/elife.100849.1
Low-Intensity Blast Exposure Induces Multifaceted Long-Lasting Anxiety-Related Behaviors in Mice
Siedhoff, H. R., Chen, S., Balderrama, A., Jackson, D., Li, R., Sun, G. Y., DePalma, R. G., Cui, J., & Gu, Z. (2024) · Neurotrauma Reports · doi:10.1089/neur.2024.0134
Shaping behaviors through social experience and their proposed sensitivity to stressPreprint
Rosenkranz, J. A. (2024) · Learning & Memory · doi:10.1101/lm.053926.124 · Cited by 2
“…and itch are greater between familiar conspeci fi cs, despite higher attention toward an unfamiliar conspeci fi c (Thor et al. 1982; Dant-zer et al. 1987; Engelmann et al. 1995; Cirulli et al. 1996; Popik and van Ree 1998; Winslow 2003; Moy et al. 2004; Markham and Juraska 2007; Shayan et al. 2024).”
Asis, J. L. B., Carampel, A. C., Bacar, J. N. B., Munar, J. C., Gregorio, C. G. C., Medina, P. M. B., Dalmacio, L. M. M., Sevilleja, J. E., Quirk, G. J., & Cena-Navarro, R. B. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06731-5 · Cited by 1
“This task was based on a prior study that modeled social deficits in a mouse model of autism spectrum disorder (Moy et al. 2004).”
Piccin, A., Allain, A., Baufreton, J., Bertrand, S. S., & Contarino, A. (2025) · eLife · doi:10.7554/elife.100849.2
Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state
Lee, C. R., Matthews, G. A., Lemieux, M., Wasserlein, E. M., Borio, M., Miranda, R. L., Keyes, L. R., Schneider, G. P., Jia, C., Tran, A., et al. (2025) · eLife · doi:10.1101/2025.02.03.636224 · Cited by 4
“To assess how projection-specific photostimulation of DRN DAT terminals affected social preference, we used the three-chamber sociability task ( Moy et al., 2004 ), where group-housed mice freely explored CeA injections (left panels), BNST and BLP (center panels), and CeA and BLP (right panels).”
Jury, N., Sánchez-Rubio, M., Nardocci, G., Mercado, C., Peña-Baeza, N., Ruiz-Rudolph, P., Montecino, M. A., Varela‐Nallar, L., & van Zundert, B. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5141000
Wise, T. B., Templer, V. L., & Burwell, R. D. (2025) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2025.110414
“…used to evaluate spontaneous social behavior in Experiments 1 A, 1B, and 1 C. Test procedures were adapted from the 3-Chamber sociability and social novelty task (Crawley, 2004; Moy et al., 2004) with the exception that demonstrators were presented below the subject in the vertical columns (Fig.”
InfluentialSeparable Dorsal Raphe Dopamine Projections mediate the Facets of Loneliness-like statePreprint
Lee, C. R., Matthews, G. A., Lemieux, M., Wasserlein, E. M., Borio, M., Miranda, R. L., Keyes, L. R., Schneider, G. P., Jia, C., Tran, A., et al. (2025) · eLife · doi:10.7554/elife.105955.1 · Cited by 1
Behavioral Assays in the Study of Olfaction
Papes, F., Nakahara, T. S., & Camargo, A. P. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4466-9_15
Pancaro, C., Carter, I. C., Watson, C. J., Norat, M. A., Cassidy, R. B., Segal, S., Marchand, J. E., & Palanisamy, A. (2025) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2025.104374
Friesen, C. N., Hartswick, D., Selke, A., Vries, G. J. D., & Petrulis, A. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5265287
Sociability genetically separable from social hierarchy in amniotes
Lin, X., Dai, G., Zhou, S., Li, Y., Zhou, B., Pan, Y.-H., & Li, H. (2025) · iScience · doi:10.1016/j.isci.2025.112930
The Laxmann’s shrew Sorex caecutiens. Step towards "sociality"Preprint
Shchipanov, N. A., Kalinin, A. A., & Demidova, T. B. (2025) · Research Square · doi:10.21203/rs.3.rs-6810348/v1
Meyer, N., Gottschalk, R., Jakobi, L., Schönhoff, A.-M., & Touma, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-07384-w
“…was not significantly affected by handling method, tail-handled B6 mice showed a greater preference for a novel conspecific in the Social Novelty Phase than their tunnel-handled counterparts, indicating a stronger interest in social novelty, which is expected for a socially living species 25 .”
Conrad, C. D., Peay, D. N., Sladkova, S., Kim, J. L., Donnay, M. E., Acuña, A. M., & Whittaker, K. E. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1553501
The mouse gut microbiota responds to predator odor and predicts host behavior
Real, M. V. F., Vitousek, M. N., Sheehan, M. J., & Moeller, A. H. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-026-01028-1
Hidema, S., Nishimori, K., Otsuka, A., Horiai, M., Mizuno, K., Ono, T., Maejima, Y., & Shimomura, K. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120263 · Cited by 1
Analysis of social interaction and proximity preferences in mice exposed to valproic acid prenatally
Sugiyama, R., & Komada, M. (2025) · Neuroscience Letters · doi:10.1016/j.neulet.2025.138319
Jury, N., Sánchez-Rubio, M., Nardocci, G., Mercado, C., Peña-Baeza, N., Ruiz-Rudolph, P., Montecino, M. A., Varela‐Nallar, L., & van Zundert, B. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.180145
Jones, M. J., Uzuneser, T. C., O’Sullivan, S. E., Pérez-Valenzuela, E., Sarikahya, M. H., Yates, A., Hardy, D. B., Rushlow, W. J., & Laviolette, S. R. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111478
Transient Early Postnatal Neuronal Hyperexcitation Results in Lasting Social Preference DeficitsPreprint
Bach, H., Nakamura-Vernet, M., Lançon, K., Drapeau, P., Mhenni, H. B., Oram, C., Martin, S., Séguéla, P., & Poulin, J.-F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.04.674307
“Previous studies analyzing sociability in the three-chamber test have found that social preference is strongest during the initial minutes of the phase (Nadler et al., 2004; Page et al., 2009).”
InfluentialWeidner, M. T., Zöller, J. E. M., Hamann, C. S., Schraut, K., Ali, M., Lardenoije, R., Eijssen, L., Foerstner, K. U., Gorbunov, N., Strekalova, T. V., et al. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1633386
van den Buuse, M., Wilson, K.-E., Payet, J. M., & Hale, M. W. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.09.032
Identity-stable multi-animal tracking using bidirectional segmentation with object-level memoryPreprint
Wang, S., Quine, K., Jordan, A., Dasari, S., Manoli, D. S., & Kirst, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.22.677949
Shadani, S., Greaves, E., Andrews, Z. B., & Foldi, C. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.14.682467
“Mice remained in their home cage for 4-5h post-administration before being subjected to the 3-chamber social preference and novelty test (Moy et al., 2004).”
Neves, C. N., Rymer, T. L., Hartman, K.-J., & Pillay, N. (2025) · Behavioural Processes · doi:10.1016/j.beproc.2025.105284
The Intermediate CA1 and CA3 Subfields of the Hippocampus Differentially Encode Social RecognitionPreprint
Dykstra, B., Lin, A., Kim, P., Sevinc, C., Berman, G. J., & Murugan, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.27.684580
“In mice, the ability to discriminate between novel and familiar conspecifics is well established 1 , and depends on hippocampal circuitry 2,3 .”
Fujii, K., Koshidaka, Y., Yanagibashi, Y., Adachi, M., Matsuo, M., Kimura, K., Saito, T., Saido, T. C., & Takao, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-20006-9 · Cited by 2
“The three ‐ chamber social approach test is used to investigate sociability and preference for social novelty in mice 84 .”
Takemoto, T., Kawano, S., Endo, R., Kitagawa, K., Ago, Y., Kikusui, T., Hashimoto, H., & Nakazawa, T. (2025) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2025.11.001
The Impacts of Binge Drinking and Hangover on the Social Brain: An Integrative Narrative Review
Bagosi, Z., Karasz, G., Thury, A. Á., Simon, B., Földesi, I., & Csabafi, K. (2025) · Biomedicines · doi:10.3390/biomedicines13112802
“A modified version of the three-chamber social interaction test is the two-chamber social interaction test developed by Moy et al. [83].”
Lyle, T. T., Elbeh, K. M., Chambers, D., Vieira, H., & Verpeut, J. L. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03404-3 · Cited by 1
Михайлович, Ч. С., Gerasimenko, M., Yuhi, T., Furuhara, K., Tsuji, C., Yokoyama, S., Nakayama, K. I., Nishiyama, M., & Higashida, H. (2021) · Figshare · doi:10.6084/m9.figshare.14525969
Lopuch, A. J., Swinehart, B. D., Widener, E. L., Holley, Z. L., Bland, K. M., Handwerk, C. J., Brett, C. A., Cook, H. N., Kalinowski, A. R., Rodriguez, H. V., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19313363
Dugyala, S., Ptacek, T., Simon, J. M., Li, Y., & Frӧhlich, F. (2020) · Figshare · doi:10.6084/m9.figshare.12258065
Cherepanov, S. M., Gerasimenko, M., Yuhi, T., Furuhara, K., Tsuji, C., Yokoyama, S., Nakayama, K. I., Nishiyama, M., & Higashida, H. (2021) · Figshare · doi:10.6084/m9.figshare.14525966
Shin, S., Santi, A., & Huang, S. (2021) · Figshare · doi:10.6084/m9.figshare.13655281
Lord, J. S., Gay, S. M., Harper, K. M., Nikolova, V. D., Smith, K. M., Moy, S. S., & Diering, G. H. (2022) · Figshare · doi:10.6084/m9.figshare.20727811
Self-citationLord, J. S., Gay, S. M., Harper, K. M., Nikolova, V. D., Smith, K. M., Moy, S. S., & Diering, G. H. (2022) · Figshare · doi:10.6084/m9.figshare.20727817
Self-citationYoo, T., Kim, S.-G., Yang, S. H., Kim, H., Kim, E., & Kim, S. Y. (2020) · Figshare · doi:10.6084/m9.figshare.11978490
Михайлович, Ч. С., Gerasimenko, M., Yuhi, T., Furuhara, K., Tsuji, C., Yokoyama, S., Nakayama, K. I., Nishiyama, M., & Higashida, H. (2021) · Figshare · doi:10.6084/m9.figshare.14525963
Lord, J. S., Gay, S. M., Harper, K. M., Nikolova, V. D., Smith, K. M., Moy, S. S., & Diering, G. H. (2022) · Figshare · doi:10.6084/m9.figshare.20727814
Self-citationLord, J. S., Gay, S. M., Harper, K. M., Nikolova, V. D., Smith, K. M., Moy, S. S., & Diering, G. H. (2022) · Figshare · doi:10.6084/m9.figshare.20727808
Self-citationAdditional file 1 of Loss of GDE2 leads to complex behavioral changes including memory impairment
Daudelin, D., Westerhaus, A., Zhang, N., Leyder, E. C., Savonenko, A. V., & Sockanathan, S. (2024) · Figshare · doi:10.6084/m9.figshare.26702176
Metadata
- Authors
- Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institute of Mental Health (US)
- Corresponding author
- Moy, S. S.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 3
- Issue
- 5
- Pages
- 287-302
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2109091674
- Cited by
- 1,522
- References
- 80
- Citations by year
- 2026: 93 · 2025: 99 · 2024: 99 · 2023: 98 · 2022: 121 · 2021: 110 · 2020: 109 · 2019: 114 · 2018: 98 · 2017: 65 · 2016: 83 · 2015: 72 · 2014: 65 · 2013: 53 · 2012: 57
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- North Carolina State University
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54 MH 66418, MH66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sociability, autism spectrum disorder, mouse models of autism, inbred mouse strains, social interaction deficits, social avoidance, C57BL/6J mice, DBA/2J, A/J, sex differences, age differences
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Female, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Sex Factors, Social Behavior, Species Specificity, Reproducibility of Results, Rotarod Performance Test, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-12, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-12 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
