The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index; 1 of the 52 sources its claims cite were checked for support.
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Open accessAbstract
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now‐familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend‐ ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now‐familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
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63 Own result · 16 No full text of the sources · 15 Own method · 6 Not checked yet · 6 Own interpretation · 5 Sources not found · 2 No basis given · 1 Partly supported · accuracy not yet measured
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber)”
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In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1).”
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exception was A/J, a strain that demonstrated a preference for the central chamber.”
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Overall, four of the five inbred and hybrid strains tested spent more time in the side of the social test box containing the unfamiliar stranger, vs. time in the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“DBA/2 mice tended to have lower numbers of entries than the C57BL/6J mice (Fig. 10b; significant main effect of strain, F 1,9 ¼ 16.156, P ¼ 0.003; retest, F 1,9 ¼ 36.215,P ¼ 0.0002; and side, F 1,9 ¼ 8.723, P ¼ 0.0161).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Finally, the adult C57BL/6J and DBA/2 mice had higher numbers of entries into the side of the chamber containing the unfamiliar conspecific in the sociability test.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plainn = 2- Asserted: passes — The authors put it forward as true.
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In the paper
“Adult A/J males failed to show a significant preference for the side containing stranger 1, as compared to the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The low number of entries observed in the A/J mice was significantly different from both of the other inbred strains (post hoc tests following repeated measures ANOVA, F-values above).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 24
- The quote only partly states this claim. 1
- Probably not a substantial claim. 32
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Higher numbers of sniffs were directed toward stranger 1 than towards the empty wire cage, and towards the novel stranger 2 vs. the now-familiar stranger 1, in C57BL/6J, DBA/2J and FVB/NJ male mice (Nadler et al. 2004).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Partly supportedcites Nadler et al. 2004 sourceExperimental — accuracy not yet measured
The “Social behavior tasks in three inbred strains” section reports that males of all three named strains spent more time sniffing the cage containing stranger 1 than the empty cage, and more time sniffing stranger 2 than stranger 1. The “Sociability test” section specifies that sniffing was scored as cumulative duration in seconds, not as a number of sniffs; that measurement in the claim is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“General health, neurological reflexes, activity levels, motor functions and sensory abilities were normal in most regards for the strains tested.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar levels of sociability were clearly evident in a group of young female C57BL/6J mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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The quote only partly states this claim.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A/J was the only strain tested that failed to spend more time with a conspecific, and spent most of its time in the central chamber after the initial 5-minute habituation session.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the inbred strains were able to locate buried food, supporting an interpretation that none were anosmic, which could have severely impacted social behaviors by blocking detection of olfactory cues emitted by the stranger mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For the olfactory test, the majority of the subjects successfully located and retrieved the buried food.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 9, the A/J group did show significant increases in time spent in the side regions (Fig. 9a, significant main effect of retest, F 1,9 ¼ 11.343, P ¼ 0.0083) and in number of entries (Fig. 9b, significant main effect of retest, F 1,9 ¼ 13.302, P ¼ 0.0053) when the openings between chambers were more accessible.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Sociability procedure with modified social test box
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the significantly higher locomotor scores observed in the FVB/NJ strain, in comparison to the other two groups, were not reflected in an overall higher number of entries.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The FVB/NJ mice demonstrated a significantly shorter latency for locating the buried food,”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A significant interaction was found between side of chamber and test condition (F 1,57 ¼ 67.634, P < 0.0001), reflecting the finding that preference was for the stranger 1 side during the first half of the session (the sociability condition), but switched to the stranger 2 side during the last part of the session (the social novelty condition).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Arguing against an artifactual interpretation that hypolocomotion caused the social deficit in the A/J group are the data of Fig. 8. Repeated testing of A/J in the modified apparatus increased the number of entries, but did not yield significant sociability scores.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The A/J mice spent significantly more time in the center chamber, indicating a strong preference for the start box that was not seen in the other strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the second group of juvenile C57BL/6J mice, both males and females made equal numbers of entries into each side of the social test box during the assay for sociability, but showed an increased number of entries into the side of the social box containing the second, 'novel' unfamiliar stranger during the test for social novelty.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences between the strains in body weight or rotarod performance (see Table 1 for mean latency to fall on the second trial).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, for the juvenile male mice, number of entries did not reflect the trends for social preference seen in the duration measures, and only partially correlated with their locomotor activity independently quantitated in the open field.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, low locomotor scores in DBA/2J and high locomotor scores in FVB/NJ appeared to be unrelated to amount of time spent in the chamber with stranger 1 and stranger 2.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant preferences for sociability (Fig. 3a) or preference for social novelty (Fig. 3b) were not observed for number of chamber entries in any of the inbred strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the present study, the juvenile male mice made nests and huddled together while sleeping.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Autistic individuals may further avoid unfamiliar social partners and display diminished interest in novelty (American Psychiatric Association 1994).”
What the sources say
- Not matchedcites American Psychiatric Association 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This modification focuses the task on social approach tendencies, relevant to the social approach deficit in autism, while avoiding potential confounds resulting from aggressive or sexual interactions.”
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Rests on an assumption: Most autistic individuals demonstrate reduced or unusual social approach.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“To ensure that differences in social behaviors were not artifacts of other aspects of mouse behaviors, a series of independent control experiments was conducted to evaluate potential confounding factors.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of times that the mouse exited from the habituated empty central chamber into the novel empty chamber provided a general measure of locomotor function.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Social behaviors have been explored in mice with mutations in candidate genes such as oxytocin (Winslow & Insel 2002;Young et al. 2002), monoamine oxidase-A (Shih & Chen 1999), fragile X (Churchill et al. 2002;Mineur et al. 2002) and dishevelled-1 (Lijam et al. 1997).”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Further controls were designed to detect additional symptoms relevant to autism, such as abnormalities in locomotion or motor coordination (Hallett et al. 1993;Piven et al. 1997), that could directly affect performance of the social task.”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Measures of general health, home cage behavior and neurological reflexes were conducted to rule out gross physical abnormalities (Crawley 2000).”
What the sources say
- Not checked — no full text of the sourcecites Crawley 2000
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Retrieval of food buried in cage bedding was quantitated in a 15-minute olfactory test, to ensure that the subject mice were not grossly impaired in olfaction abilities.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“A large body of evidence from twin and family studies supports the important role of genetic factors in the etiology of autism (Bailey et al. 1995;Ritvo et al. 1989;Szatmari et al. 1998).”
What the sources say
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present mouse tasks were designed to maximize face validity to some of the core symptoms of autism.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the A/J mice were given a second test one week later, with the dividing walls between the chamber sides partially retracted to facilitate exploration.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
plainn = 10- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Given the primacy of social impairment in autism, we considered this symptom to be fundamental to a mouse model of autism (Insel 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Several additional behavioral assays were performed in the initial set of juvenile male mice (C57BL/6J, DBA/2J and FVB/ NJ).These assays were designed as controls for sensory and motor abilities, etc., to ensure that the test mice were physically able to perform the procedures necessary for the social tasks described above.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The chambers of the social apparatus were cleaned and fresh paper chip bedding was added between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The location of stranger 1 in the left vs. right side chamber was systematically alternated between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In our experience to date with the present procedures, human observers attain a high level of proficiency after only one or two practice sessions, with high rates (greater than 95%) of interrater reliability between trained observers.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present protocol used a small wire cage to enclose the stimulus mouse, which allowed visual, auditory and olfactory contact between the mice, but prevented the occurrence of aggressive and other responses.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“From an early age, autistic children show low levels of eye contact and affective responses, less orientation toward others and language deficits, with a concomitant paucity of speech and social communication (for review, see Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites Tager-Flusberg et al. 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The stranger mouse was enclosed in a small, round wire cage (Galaxy Cup, Spectrum Diversified Designs, Inc., Streetsboro, OH), which allowed nose contact between the bars, but prevented fighting.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Previous work in social recognition has shown that mice show both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993;Dluzen & Kreutzberg 1993;Ferguson et al. 2000;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present procedures for the sociability and social novelty tests are designed to be simple, quantitative and easily mastered by investigators.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the present methods were designed to quantitate levels of sociability, i.e. tendency to initiate social contact, and preference for social novelty, i.e. tendency to initiate social contacts with a new individual as compared to someone familiar from past experience, using a simple scoring approach for laboratory mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, some autistic patients demonstrate aberrant motor responses, including repeated hand flapping, jumping and other repetitive and stereotyped behaviors (Bodfish et al. 2000;Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered sensory responses have been reported, including both hypo-and hyper-reactivity to environmental stimuli (Baranek 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Baranek 2002 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Use of the three-chambered apparatus for demonstrating social preference (Insel 2001) was adapted by Brodkin et al. (2004) to investigate social approach and avoidance in female mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Brodkin et al. 2004 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“and the mouse model of fragile X syndrome has been characterized by changes in activity (Bakker et al. 1994;Peier et al. 2000) and reactivity to acoustic stimuli (Chen & Toth 2001;Nielson et al. 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Bakker et al. 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Peier et al. 2000
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Chen & Toth 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Children with fragile X syndrome often show autistic behavior (Hagerman et al. 1986),”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Hagerman et al. 1986 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“As noted by Winslow (2003), the analysis of the full behavioral series that can occur in social tests demands familiarity with the mouse ethogram, extensive training and the ability to discern the sometimes rapid and fleeting responses that mice can emit.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Winslow 2003 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Methods are based on procedures examining pair-bonding in voles (Dean, S.M. & Vandenbergh, J.G. as above), as well as many other elegant tests for social behavior in rodents (Bluthe et al. 1993;Carter et al. 1995;Dluzen & Kreutzberg 1993;Gheusi et al. 1994;Insel and Young 2001;Kogan et al. 2000;Winslow & Camacho 1995;Winslow 2003).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Most autistic individuals demonstrate reduced or unusual social approach.
“We reasoned that most autistic individuals demonstrate reduced or unusual social approach.”
The paper relies on this without support.
Behavioral models of autistic-like responses in mice have received little attention.
“However, to date, behavioral models of autistic-like responses in mice have received little attention.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [530]
In the citing paper
“There is compelling evidence that some strains are more”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
In the citing paper
“However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects 9 ).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
“the social novelty test was not conducted”
Citations
Cites
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Social amnesia in mice lacking the oxytocin gene
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Fmr1 knockout mice: A model to study fragile X mental retardation
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Research works printed but not linked: 1
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Cited by
Sorted by citations
Items 501–600 of 1,472
Leem, Y., Yoon, S. S., Kim, Y.-H., & Jo, S. A. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.08.001 · Cited by 37
A Methionine-Induced Animal Model of Schizophrenia: Face and Predictive Validity
Wang, L., Alachkar, A., Sanathara, N. M., Belluzzi, J. D., Wang, Z., & Civelli, O. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv054 · Cited by 39
Bicker, F., Vasić, V., Horta, G., Ortega, F., Nolte, H., Kavyanifar, A., Keller, S., Stanković, N. D., Harter, P. N., Benedito, R., et al. (2017) · Nature Communications · doi:10.1038/ncomms15922 · Cited by 36
Jaramillo, T. C., Escamilla, C. O., Liu, S., Peca, L., Birnbaum, S. G., & Powell, C. M. (2017) · Autism Research · doi:10.1002/aur.1857 · Cited by 38
“The 3-chamber sociability/preference test and caged conspecific social approach test were conducted as previously described [Moy et al., 2004; Nadler et al., 2004; Blundell et al., 2009; Kouser et al., 2013].”
MethodSmith, B. M., Yao, X., Chen, K. S., & Kirby, E. D. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00142 · Cited by 40
“To determine whether group housing affected social preference or social memory, mice were tested in a 3-chamber sociability task (Moy et al., 2004).”
BackgroundMethodMontani, C., Gritti, L., Beretta, S., Verpelli, C., & Sala, C. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22657 · Cited by 40
“ASDs are characterized by impairments in appropriate reciprocal social interactions, impairments in verbal social communication and high levels of ritualistic repetitive behaviors (Moy et al., 2004).”
BackgroundRogers, E. J., Jada, R., Rozales, K., Sah, M., Cortés, M., Florence, M. A., Levy, N. S., Moss, R. E., Walikonis, R. S., Palty, R., et al. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00043 · Cited by 36
Kaur, S., Sarma, S. J., Marshall, B. L., Liu, Y., Kinkade, J. A., Bellamy, M. M., Mao, J., Helferich, W. G., Schenk, A. K., Bivens, N. J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67709-9 · Cited by 39
Chronic pain impact on rodents’ behavioral repertoire
Cunha, A. M., Pereira-Mendes, J., Almeida, A., Guimarães, M. R., & Leite‐Almeida, H. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.022 · Cited by 38
Yang, E.-J., Ahn, S., Lee, K., Mahmood, U., & Kim, H.-S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157202 · Cited by 37
Suraev, A. S., Bowen, M. T., Ali, S. O., Hicks, C., Ramos, L., & McGregor, I. S. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.002 · Cited by 35
Kopachev, N., Netser, S., & Wagner, S. (2022) · iScience · doi:10.1016/j.isci.2022.103735 · Cited by 36
“Of these, the most famous is the three-chamber test (Moy et al., 2004), which employs two types of social discrimination tasks: social preference (SP) and social novelty preference (SNP).”
BackgroundMethodResultInfluentialPowell, S. B., & Swerdlow, N. R. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad098 · Cited by 43
Fast Cerebellar Reflex Circuitry Requires Synaptic Vesicle Priming by Munc13-3
Netrakanti, P. R., Cooper, B. H., Dere, E., Poggi, G., Winkler, D., Brose, N., & Ehrenreich, H. (2015) · The Cerebellum · doi:10.1007/s12311-015-0645-0 · Cited by 36
“After cognition tests, social behavior (in male mice) was assessed using a modified version of the social interaction in the tripartite chamber test [27], as well as tests of social interaction in pairs, and nest building.”
MethodInfluentialZain, M. A., Pandy, V., Majeed, A. B. A., Wong, W. F., & Mohamed, Z. (2018) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.18-0078 · Cited by 38
“It was suggested that the social novelty preference test is more relevant to the symptoms observed in autism spectrum disorder [21].”
InfluentialSolomon‐Lane, T. K., & Hofmann, H. A. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.06.016 · Cited by 37
Joo, Y., Xue, Y., Wang, Y., McDevitt, R. A., Sah, N., Bossi, S., Su, S., Lee, S. K., Peng, W., Xie, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16884-4 · Cited by 34
Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons
Wang, J., Li, J., Yang, Q., Xie, Y., Wen, Y., Xu, Z., Li, Y., Xu, T., Wu, Z., Duan, S., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019295118 · Cited by 36
Lord, J. S., Gay, S. M., Harper, K. M., Nikolova, V. D., Smith, K. M., Moy, S. S., & Diering, G. H. (2022) · Molecular Autism · doi:10.1186/s13229-022-00514-5 · Cited by 41
“Here we tested the effects of Shank3WT/ΔC heterozygous mutation and the effects of our sleep disruption treatments on sociability and social novelty preference using the 3-chamber choice task previously described [26, 42, 43].”
MethodSelf-citationNakao, A., Miki, T., Shoji, H., Nishi, M., Takeshima, H., Miyakawa, T., & Mori, Y. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00141 · Cited by 39
“Frontiers in Behavioral Neuroscience | www.frontiersin.org 3 June 2015 | Volume 9 | Article 141”
BackgroundVerma, M., Beaulieu‐Abdelahad, D., Ait‐Ghezala, G., Li, R., Crawford, F., MULLAN, M. J., & Paris, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128224 · Cited by 36
“Profound alterations of social behavior have been described in transgenic mouse models of AD [31]; we therefore explored whether anatabine could affect social interaction and social memory in Tg PS1/APPswe mice using the 3-chamber test known as the Crawley's sociability and preference for social novelty protocol [25,3…”
Lu, J. N., Fan, X., Lu, L., Yu, Y., Markiewicz, E. J., Little, J., Sidebottom, A. M., & Claud, E. C. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2178800 · Cited by 35
“There has also been no sociability and novelty difference between the female and male C57BL/6 J mice in the three-chamber test.(72) Our previous publication(23) also agrees with most of the studies in C57BL/6 J mice where we did not find significant differences between the sexes in open field, elevated plus maze, fear…”
ResultBrennaman, L. H., Kochlamazashvili, G., Stoenica, L., Nonneman, R. J., Moy, S. S., Schachner, M., Dityatev, A. E., & Maness, P. F. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.008 · Cited by 35
Self-citationAgo, Y., Hasebe, S., Nishiyama, S., Oka, S., Onaka, Y., Hashimoto, H., Takuma, K., & Matsuda, T. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv062 · Cited by 34
“Keywords: Depression model, dopamine, encounter test, nucleus accumbens, sexual motivation”
Psychiatric Disorders - Trends and Developments
Uehara, T. (2011) · InTech eBooks · doi:10.5772/2330 · Cited by 36
Courchet, V., Roberts, A. J., Meyer-Dilhet, G., del Carmine, P., Lewis, T. L., Polleux, F., & Courchet, J. (2018) · Nature Communications · doi:10.1038/s41467-018-06584-5 · Cited by 39
Yoo, T., Kim, S.-G., Yang, S. H., Kim, H., Kim, E., & Kim, S. Y. (2020) · Molecular Autism · doi:10.1186/s13229-020-00324-7 · Cited by 37
“It should be noted that the level of sociability substantially varies with mouse strain [28, 65], and the strain of a stranger mouse can influence social behaviors of a subject mouse [66].”
BackgroundMethodA Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum
Farini, D., Cesari, E., Weatheritt, R. J., Sala, G. L., Naro, C., Pagliarini, V., Bonvissuto, D., Medici, V., Guerra, M., Pietro, C. D., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107703 · Cited by 33
Inoue, N., Nishizumi, H., Ooyama, R., Mogi, K., Nishimori, K., Kikusui, T., & Sakano, H. (2021) · eLife · doi:10.7554/elife.65078 · Cited by 37
“The Pcdh21-Cre mouse (Nagai et al., 2005) Inoue et al. eLife 2021;10:e65078.”
BackgroundAgeta‐Ishihara, N., Yamakado, H., Morita, T., Hattori, S., Takao, K., Miyakawa, T., Takahashi, R., & Kinoshita, M. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-35 · Cited by 35
“The test was conducted as described [17,18].”
Backgroundter Horst, J. P., van der Mark, M. H., Kentrop, J., Arp, M., van der Veen, R., de Kloet, E. R., & Oitzl, M. S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00026 · Cited by 35
Behavioral characterization of female zinc transporter 3 (ZnT3) knockout mice
Thackray, S. E., McAllister, B. B., & Dyck, R. H. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.12.028 · Cited by 35
Shoji, H., Ikeda, K., & Miyakawa, T. (2023) · Molecular Brain · doi:10.1186/s13041-023-01020-2 · Cited by 38
“The three-chamber test was conducted as previously described [68].”
MethodQuantifying Social Motivation in Mice Using Operant Conditioning
Martin, L. A., & Iceberg, E. (2015) · Journal of Visualized Experiments · doi:10.3791/53009 · Cited by 37
Kirby, B. P., Waddington, J. L., & O’Tuathaigh, C. M. P. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.09.010 · Cited by 36
Subramaniam, S., Magen, I., Bove, N., Zhu, C., Lemesre, V., Dutta, G., Elias, C. J., Lester, H. A., & Chesselet, M. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.05.018 · Cited by 33
Wang, S., Tan, N., Zhu, X., Yao, M., Wang, Y., Zhang, X., & Xu, Z. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.044 · Cited by 36
“action and the ability to discriminate social novelty (Moy et al., 2004; Won et al., 2012).”
BackgroundKiffer, F. C., Alexander, T. C., Anderson, J. E., Groves, T. R., Wang, J., Sridharan, V., Boerma, M., & Allen, A. R. (2019) · Radiation Research · doi:10.1667/rr15092.1 · Cited by 35
“quantify autistic-like behavior in mouse models of autism spectrum disorders (ASD) (50).”
InfluentialEndothelin neurotransmitter signalling controls zebrafish social behaviour
Gutiérrez, H. C., Colanesi, S., Cooper, B., Reichmann, F., Young, A. M. J., Kelsh, R. N., & Norton, W. (2019) · Scientific Reports · doi:10.1038/s41598-019-39907-7 · Cited by 36
Wolstenholme, J. T., Drobná, Z., Henriksen, A. D. P., Goldsby, J. A., Stevenson, R. J., Irvin, J. W., Flaws, J. A., & Rissman, E. F. (2019) · Endocrinology · doi:10.1210/en.2019-00196 · Cited by 34
Serotonin transporter deficiency alters socioemotional ultrasonic communication in rats
Gołębiowska, J., Hołuj, M., Potasiewicz, A., Piotrowska, D., Kuziak, A., Popik, P., Homberg, J. R., & Nikiforuk, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-56629-y · Cited by 34
Deconstructing the contribution of sensory cues in social approach
Contestabile, A., Casarotto, G., Girard, B. J. T., Tzanoulinou, S., & Bellone, C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15179 · Cited by 36
NrCAM ‐regulating neural systems and addiction‐related behaviors
Ishiguro, H., Hall, F. S., Horiuchi, Y., Sakurai, T., Hishimoto, A., Grumet, M., Uhl, G. R., Onaivi, E. S., & Arinami, T. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00469.x · Cited by 34
“Experimental protocols and the test cage were slightly modified from a protocol described in the literature (Moy et al. 2004) to measure preference for a social object.”
MethodPeleh, T., Ike, K. G. O., Wams, E. J., Lebois, E. P., & Hengerer, B. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.018 · Cited by 39
“three-chamber test is the most commonly applied social behavior test for assessment of sociability and social approach (Crawley, 2007a; Moy et al., 2004; Nadler et al., 2004).”
Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment
Ntagwabira, F., Trujillo, M., McElroy, T., Brown, T., Simmons, P., Sykes, D., & Allen, A. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042008 · Cited by 33
“The glutamate cysteine ligase enzyme catalytic subunit (GCLC) was differentially expressed between tr atment groups (Figure 7C; O e-way ANOVA, F [3,23] = 19.”
BackgroundInfluentialFerguson, B. R., Glick, C., & Huguenard, J. R. (2023) · eLife · doi:10.7554/elife.78349 · Cited by 33
Vagal blockade of the brain-liver axis deters cancer-associated cachexia
Garrett, A., Darzi, N., Deshmukh, A., Rosenfeld, N., Goldman, O., Adler, L. N., Bab-Dinitz, E., Singer, O., Najafabadi, A. H., Wong, C. W., et al. (2025) · Cell · doi:10.1016/j.cell.2025.07.016 · Cited by 42
Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice
Kusakari, S., Saitow, F., Ago, Y., Shibasaki, K., Sato‐Hashimoto, M., Matsuzaki, Y., Kotani, T., Murata, Y., Hirai, H., Matsuda, T., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01339-14 · Cited by 33
“In addition, Shp2 cKO mice exhibited a slight reduction in the interaction with a novel stranger mouse in the Crawley-type social interaction test (35) (Fig.”
BackgroundOxytocin is implicated in social memory deficits induced by early sensory deprivation in mice
Zhang, J., Chen, L., Lv, Z.-M., Niu, X.-Y., Shao, C.-C., Zhang, C., Pruski, M., Huang, Y., Qi, C., Song, N., et al. (2016) · Molecular Brain · doi:10.1186/s13041-016-0278-3 · Cited by 33
“The test was designed in accordance with previous studies [39, 40].”
Is exposure to aluminium adjuvants associated with social impairments in mice? A pilot study
Sheth, S. K. S., Li, Y., & Shaw, C. A. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.11.012 · Cited by 33
Wang, S.-C., Lin, C.-C., Tzeng, N., Tung, C., & Liu, Y. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0514-0 · Cited by 35
Heterozygous loss of epilepsy geneKCNQ2alters social, repetitive and exploratory behaviors
Kim, E. C., Patel, J., Zhang, J., Soh, H., Rhodes, J. S., Tzingounis, A. V., & Chung, H. J. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12599 · Cited by 33
“To examine social behaviors, we first used the three-chamber social interaction test which measures social motivation and approach (Figure 6A).(64) After habituation in the empty three-chamber apparatus for 10 minutes, the subject mouse (KCNQ2 or KCNQ2) was reintroduced to the center chamber of the apparatus that cont…”
MethodIshola, I. O., Balogun, A. O., & Adeyemi, O. O. (2020) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12567 · Cited by 34
Palumbo, S., Paterson, C., Yang, F., Hood, V. L., & Law, A. J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00964-4 · Cited by 35
Zhang, X., Xun, Y., Wang, L., Zhang, J., Hou, W., Ma, H., Cai, W., Li, L., Guo, Q., Li, Y., et al. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147497 · Cited by 33
Krüttner, S., Falasconi, A., Valbuena, S., Galimberti, I., Bouwmeester, T., Arber, S., & Caroni, P. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.001 · Cited by 31
“Furthermore, and notably, the original report to which most of the studies refer to (Moy et al., 2004) included a small amount of bedding material in the chamber.”
BackgroundTwenty years of discoveries emerging from mouse models of autism
Crawley, J. N. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105053 · Cited by 33
“, 2008), age and sex of the subject mice (Moy et al., 2004); strain of the target mouse inside the wire cup (Nadler et al.”
Self-citationKnoll, A. T., Jiang, K., & Levitt, P. R. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12431 · Cited by 27
“Social approach (a measure of affiliation) and social novelty preference (a measure of social recognition) were assessed using a modified 3-chamber social interaction task.(51,75) In this task, mice are assessed 2 of 17 KNOLL ET AL.”
MethodResultYook, C., Kim, K., Kim, D., Kang, H., Kim, S.-G., Kim, E., & Kim, S. Y. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00241 · Cited by 33
“Three-Chamber Test Social approach and social novelty recognition were assessed by performing three-chamber test (Moy et al., 2004; Silverman et al., 2010) as described previously (Jung et al.”
MethodTakaba, R., Ibi, D., Yoshida, K., Hosomi, E., Kawase, R., Kitagawa, H., Goto, H., Achiwa, M., Mizutani, K., Maeda, K., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02778-x · Cited by 35
“This test was carried out as described previously, with some modifications (Moy et al. 2004; De Gregorio et al. 2021).”
Yao, I., Takao, K., Miyakawa, T., Ito, S., & Setou, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017317 · Cited by 31
“a familiar mouse in the social novelty preference test [29].”
Francis, K., Dougali, A., Sideri, K., Κroupis, C., Vasdekis, V., Dima, K., & Douzenis, A. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12872 · Cited by 33
“Furthermore, BDNF alterations were reported in ASD animal models influencing social (22) and anxious behaviours (23).”
BackgroundAmbra1 Shapes Hippocampal Inhibition/Excitation Balance: Role in Neurodevelopmental Disorders
Nobili, A., Krashia, P., Cordella, A., Barbera, L. L., Dell’Acqua, M. C., Caruso, A., Pignataro, A., Marino, R., Sciarra, F., Biamonte, F., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0911-5 · Cited by 32
“Social approach was tested using a three-chambered apparatus [33], consists of a rectangular box (60 cm length × 40 cm width × 40 cm height) of clear Plexiglas, divided into a central chamber and two side chambers.”
Capibaribe, V. C. C., Mallmann, A. S. V., Lopes, I. S., Oliveira, I. C. M., de Oliveira, N. F., Chaves, R. D. C., Fernandes, M. L., de Araújo, M. A., da Silva, D. M. A., Valentim, J. T., et al. (2019) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13162 · Cited by 32
“For 5 min, the mouse placed in the central chamber was analysed and the time spent in the three chambers was recorded.([32,33])”
MethodNeurobiological Mechanisms of Autism Spectrum Disorder and Epilepsy, Insights from Animal Models
Sierra-Arregui, T., Llorente, J., Mínguez, P., Tønnesen, J., & Peñagarikano, O. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.02.043 · Cited by 34
Chen, X., Wang, F., Gan, J., Zhang, Z., Liang, X., Li, T., Huang, N., Zhao, X., Mei, F., & Xiao, L. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-019-00449-7 · Cited by 33
“The social interaction test is widely used to analyze sociability in mice [38].”
Habif, M., Carmo, S. D., Báez, M. V., Colettis, N. C., Cercato, M. C., Salas, D. A., Acutain, M. F., Sister, C. L., Berkowicz, V. L., Canal, M. P., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.585873 · Cited by 32
“A slightly modified version of the three chambered task for social approaching was used to assess social interaction and related memory (Moy et al., 2004; Yang et al., 2011) in naïve 4-monthold Tg (NTg+/− = 12, NTg+/+ = 6) and wt (Nwt = 10) male rats.”
BackgroundMethodXu, J., Marshall, J. J., Kraniotis, S., Nomura, T., Zhu, Y., & Contractor, A. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113378 · Cited by 34
“original studies [85,86] to 6 min in our study.”
BackgroundAhadullah, Yau, S., Lu, H., Lee, T. M. C., Guo, H., & Chan, C. C. H. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.043 · Cited by 33
Kozlova, E. V., Valdez, M. C., Denys, M. E., Bishay, A. E., Krum, J. M., Rabbani, K. M., Carrillo, V., Gonzalez, G. M., Lampel, G., Tran, J. D., et al. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03163-4 · Cited by 31
Dickerson, M. R., Murphy, S. F., Urban, M. J., White, Z., & VandeVord, P. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.787475 · Cited by 33
Kim, E. C., Zhang, J., Tang, A. Y., Bolton, E. C., Rhodes, J. S., Christian, C. A., & Chung, H. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021265118 · Cited by 35
Serra, D., Henriques, J. F., Sousa, F. J., Laranjo, M., Resende, R., Ferreira‐Marques, M., de Freitas, V. A. P., Silva, G., Peça, J., Dinis, T. C. P., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169259 · Cited by 34
“In general, rodents tend to spend time with other rodents (Stranger 1) and investigate the novel stranger (Stranger 2) rather than the familiar one (Stranger 1) [20].”
BackgroundNeuroligin1 Drives Synaptic and Behavioral Maturation through Intracellular Interactions
Hoy, J. L., Haeger, P. A., Constable, J. R. L., Arias, R. J., McCallum, R., Kyweriga, M., Davis, L., Schnell, E., Wehr, M., Castillo, P. E., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4660-12.2013 · Cited by 30
“We also screened for the presence of normal acoustic startle reflexes, average weight, and incidence of mortality before testing in more complicated behavioral assays (Moy et al., 2004, 2006).”
BackgroundMethodInfluentialLópez‐Cruz, L., Miguel, N. S., Bayarri, P., Baqi, Y., Müller, C. E., Salamone, J. D., & Correa, M. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00206 · Cited by 32
“A decrease in exploring a familiar conspecific when a new one is also present has been interpreted as an index of social recognition (Thor and Holloway, 1982; Crawley, 2004; Moy et al., 2004), which some authors consider to be also an index of preference for novelty seeking (Costa et al., 2014).”
BackgroundMethodA systematic review and meta-analysis of how social memory is studied
Cum, M., Pérez, J., Wangia, E., Lopez, N., Wright, E. S., Iwata, R. L., Li, A., Chambers, A. R., & Padilla-Coreano, N. (2024) · Scientific Reports · doi:10.1038/s41598-024-52277-z · Cited by 35
“Rats and mice have been shown to have both sociability preferences (preferring social interaction to no social interaction) and social novelty preferences (preferring interaction with a novel vs. familiar animal) 17,18 .”
BackgroundO’Tuathaigh, C. M. P., & Waddington, J. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.016 · Cited by 31
Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior
Chou, A., Morganti, J. M., & Rosi, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151418 · Cited by 34
“At 29 d after surgery, a group of animals(n = 16-17/group) were tested for sociability and social recognition behavior on the three-chamber social approach task as previously described [22].”
BackgroundMethodGuan, Z., Tao, Y., Zhang, X., Guo, Q., Liu, Y., Zhang, Y., Wang, Y., Ji, G., Wu, G., Wang, N., et al. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12691 · Cited by 30
Azogu, I., & Plamondon, H. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.008 · Cited by 31
Thomas, A. M., Schwartz, M. D., Saxe, M., & Kilduff, T. S. (2017) · SLEEP · doi:10.1093/sleep/zsx138 · Cited by 36
“Sociability Preference for a live social stimulus was ascertained with a sociability test.(30) The apparatus used was a clear acrylic box (90 × 40 × 30 cm) with three equally sized chambers (30 × 40 × 30 cm), each connected by a vertical opening (9 cm wide).”
MethodEffects of chronic fentanyl administration on behavioral characteristics of mice
Fujii, K., Koshidaka, Y., Adachi, M., et al. (2018) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12040 · Cited by 31
“5 | Three‐chamber social approach test The three‐chamber social approach test is a well‐designed method to investigate sociability and preference for social novelty in mice.(20) The apparatus comprised a rectangular, three‐chambered box and a lid with a video camera (O'Hara & Co.”
MethodGabriel, P., Mastracchio, T.-A., Bordner, K. A., & Jeffrey, R. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113133 · Cited by 37
“Behavior Sociability: Three-Chamber Social Approach – Crawley paradigm (Crawley, 2004)”
BackgroundShin, S., Santi, A., & Huang, S. (2021) · Molecular Brain · doi:10.1186/s13041-021-00731-8 · Cited by 35
Ferrara, N. C., Trask, S., & Rosenkranz, J. A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.021 · Cited by 33
“action) is high during adolescence and this progressively declines into adulthood (Douglas et al., 2004; Li et al., 2019; Moy et al., 2004).”
Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy
Jeong, Y. Y., Han, S., Jia, N., Zhang, M., Sheshadri, P., Tammineni, P., Cheung, J., Nissenbaum, M., Baskar, S. S., Kwan, K. Y., et al. (2022) · UCL Discovery (University College London) · Cited by 32
Cannabidiol (CBD) treatment improves spatial memory in 14-month-old female TAU58/2 transgenic mice
Kreilaus, F., Przybyla, M., Ittner, L. M., & Karl, T. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113812 · Cited by 33
Encoding of social novelty by sparse GABAergic neural ensembles in the prelimbic cortex
Zhao, Z., Zeng, F., Wang, H., Wu, R., Chen, L., Wu, Y., Li, S., Shao, J., Wang, Y., Wu, J., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo4884 · Cited by 31
“Normal mice can discriminate between new and familiar mice (36), while MECP2-TG autism model mice cannot (23, 25, 37, 38).”
BackgroundMethodThe basolateral amygdala to lateral septum circuit is critical for regulating social novelty in mice
Rodriguez, L. A., Kim, S.-H., Page, S. C., Nguyen, C. V., Pattie, E. A., Hallock, H. L., Valerino, J., Maynard, K. R., Jaffe, A. E., & Martinowich, K. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01487-y · Cited by 31
“Mice are a highly social species that display robust responses to novel conspecifics, such as attention to, and investigation of, novel individuals [6, 7].”
BackgroundDutra, M. L., Dias, P., Freiberger, V., Ventura, L., Comim, C. M., Martins, D. F., & Bobinski, F. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136974 · Cited by 33
Impaired Social Behavior in 5-HT3A Receptor Knockout Mice
Smit‐Rigter, L. A., Wadman, W. J., & van Hooft, J. A. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00169 · Cited by 31
“This test focuses on the preference for social novelty while reciprocal social interactions are intentionally avoided by allowing the test mice to explore all chambers while target mice are caged within a plastic cup (Brodkin et al., 2004; Moy et al., 2004; Sankoorikal et al., 2006).”
Computerized assessment of social approach behavior in mouse
Page, D. T. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.048.2009 · Cited by 32
“…using three-chambered apparatuses of varying dimensions (Crawley et al., 2007; Labrie et al., 2008; McFarlane et al., 2008), there was no substantial difference in chamber preference, even in cases where the mice tested were 5–6 weeks of age (Moy et al., 2004), or female (Brodkin et al., 2004).”
Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing
Tian, R., Li, Y., Zhao, H., Lyu, W., Zhao, J., Wang, X., Lu, H., Xu, H., Ren, W., Tan, Q.-Q., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02276-9 · Cited by 31
“The test of social interaction between home-caged dog and human included two steps: (1) step 1, the experimenter who were familiar to the test dogs walked back and forth twice in front of the home cage for 30 s; (2) step 2, the experimenter placed hands on the cage and moved fi ngers for 30 s.”
Genetic, hormonal, and metabolomic influences on social behavior and sex preference of XXY mice
Liu, P. Y., Erkkilä, K., Lue, Y., Jentsch, J. D., Schwarcz, M., Abuyounes, D., Hikim, A. P. S., Wang, C., Lee, P. W.-N., & Swerdloff, R. S. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00085.2010 · Cited by 29
“We assessed sociability by comparing the relative amount of time XY and XXY mice cohabited a chamber containing a newly introduced mouse, using two-sample Student’s t-test as previously described (28, 31).”
MethodInfluentialThe SocioBox: A Novel Paradigm to Assess Complex Social Recognition in Male Mice
Krueger‐Burg, D., Winkler, D., Mitkovski, M., Daher, F., Ronnenberg, A., Schlüter, O. M., Dere, E., & Ehrenreich, H. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00151 · Cited by 29
“…are capable of a rich set of social behaviors (Singleton and Krebs, 2007), but virtually all current tests assess only simple two-way discriminations between a mouse and an inanimate object or between a familiar and an unfamiliar mouse (Moy et al., 2004; Silverman et al., 2010; Kas et al., 2014).”
Chu, D., Li, L., Jiang, Y., Jianxin, T., Ji, J., Zhang, Y., Jin, N., & Liu, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00313 · Cited by 32
Xiang, D., Lu, J., Wei, C., Cai, X., Wang, Y., Liang, Y., Xu, M., Wang, Z., Liu, M., Wang, M., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00087 · Cited by 31
Pagliusi, M., Franco, D., Cole, S. L., Morais‐Silva, G., Chandra, R., Fox, M. E., Iñiguez, S. D., Sartori, C. R., & Lobo, M. K. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.854494 · Cited by 32
“This test was performed as previously described (27).”
MethodReevaluating hippocampus-dependent learning in FVB/N mice.
Farley, S. J., McKay, B. M., Disterhoft, J. F., & Weiss, C. (2011) · Behavioral Neuroscience · doi:10.1037/a0026033 · Cited by 30
Umemori, J., Takao, K., Koshimizu, H., Hattori, S., Furuse, T., Wakana, S., & Miyakawa, T. (2013) · BMC Research Notes · doi:10.1186/1756-0500-6-203 · Cited by 32
“The test for sociability and preference for social novelty is a well-designed method to investigate the complex genetics of social behaviors [83].”
Method
Metadata
- Authors
- Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institute of Mental Health (US)
- Corresponding author
- Moy, S. S.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 3
- Issue
- 5
- Pages
- 287-302
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2109091674
- Cited by
- 1,522
- References
- 80
- Citations by year
- 2026: 93 · 2025: 99 · 2024: 99 · 2023: 98 · 2022: 121 · 2021: 110 · 2020: 109 · 2019: 114 · 2018: 98 · 2017: 65 · 2016: 83 · 2015: 72 · 2014: 65 · 2013: 53 · 2012: 57
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- North Carolina State University
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54 MH 66418, MH66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sociability, autism spectrum disorder, mouse models of autism, inbred mouse strains, social interaction deficits, social avoidance, C57BL/6J mice, DBA/2J, A/J, sex differences, age differences
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Female, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Sex Factors, Social Behavior, Species Specificity, Reproducibility of Results, Rotarod Performance Test, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-12, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-12 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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