The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index; 1 of the 52 sources its claims cite were checked for support.
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Open accessAbstract
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now‐familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend‐ ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now‐familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
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63 Own result · 16 No full text of the sources · 15 Own method · 6 Not checked yet · 6 Own interpretation · 5 Sources not found · 2 No basis given · 1 Partly supported · accuracy not yet measured
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber)”
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In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1).”
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exception was A/J, a strain that demonstrated a preference for the central chamber.”
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Overall, four of the five inbred and hybrid strains tested spent more time in the side of the social test box containing the unfamiliar stranger, vs. time in the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“DBA/2 mice tended to have lower numbers of entries than the C57BL/6J mice (Fig. 10b; significant main effect of strain, F 1,9 ¼ 16.156, P ¼ 0.003; retest, F 1,9 ¼ 36.215,P ¼ 0.0002; and side, F 1,9 ¼ 8.723, P ¼ 0.0161).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Finally, the adult C57BL/6J and DBA/2 mice had higher numbers of entries into the side of the chamber containing the unfamiliar conspecific in the sociability test.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plainn = 2- Asserted: passes — The authors put it forward as true.
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In the paper
“Adult A/J males failed to show a significant preference for the side containing stranger 1, as compared to the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The low number of entries observed in the A/J mice was significantly different from both of the other inbred strains (post hoc tests following repeated measures ANOVA, F-values above).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 24
- The quote only partly states this claim. 1
- Probably not a substantial claim. 32
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Higher numbers of sniffs were directed toward stranger 1 than towards the empty wire cage, and towards the novel stranger 2 vs. the now-familiar stranger 1, in C57BL/6J, DBA/2J and FVB/NJ male mice (Nadler et al. 2004).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Partly supportedcites Nadler et al. 2004 sourceExperimental — accuracy not yet measured
The “Social behavior tasks in three inbred strains” section reports that males of all three named strains spent more time sniffing the cage containing stranger 1 than the empty cage, and more time sniffing stranger 2 than stranger 1. The “Sociability test” section specifies that sniffing was scored as cumulative duration in seconds, not as a number of sniffs; that measurement in the claim is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“General health, neurological reflexes, activity levels, motor functions and sensory abilities were normal in most regards for the strains tested.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar levels of sociability were clearly evident in a group of young female C57BL/6J mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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The quote only partly states this claim.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A/J was the only strain tested that failed to spend more time with a conspecific, and spent most of its time in the central chamber after the initial 5-minute habituation session.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the inbred strains were able to locate buried food, supporting an interpretation that none were anosmic, which could have severely impacted social behaviors by blocking detection of olfactory cues emitted by the stranger mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For the olfactory test, the majority of the subjects successfully located and retrieved the buried food.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 9, the A/J group did show significant increases in time spent in the side regions (Fig. 9a, significant main effect of retest, F 1,9 ¼ 11.343, P ¼ 0.0083) and in number of entries (Fig. 9b, significant main effect of retest, F 1,9 ¼ 13.302, P ¼ 0.0053) when the openings between chambers were more accessible.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Sociability procedure with modified social test box
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the significantly higher locomotor scores observed in the FVB/NJ strain, in comparison to the other two groups, were not reflected in an overall higher number of entries.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The FVB/NJ mice demonstrated a significantly shorter latency for locating the buried food,”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A significant interaction was found between side of chamber and test condition (F 1,57 ¼ 67.634, P < 0.0001), reflecting the finding that preference was for the stranger 1 side during the first half of the session (the sociability condition), but switched to the stranger 2 side during the last part of the session (the social novelty condition).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Arguing against an artifactual interpretation that hypolocomotion caused the social deficit in the A/J group are the data of Fig. 8. Repeated testing of A/J in the modified apparatus increased the number of entries, but did not yield significant sociability scores.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The A/J mice spent significantly more time in the center chamber, indicating a strong preference for the start box that was not seen in the other strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the second group of juvenile C57BL/6J mice, both males and females made equal numbers of entries into each side of the social test box during the assay for sociability, but showed an increased number of entries into the side of the social box containing the second, 'novel' unfamiliar stranger during the test for social novelty.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences between the strains in body weight or rotarod performance (see Table 1 for mean latency to fall on the second trial).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, for the juvenile male mice, number of entries did not reflect the trends for social preference seen in the duration measures, and only partially correlated with their locomotor activity independently quantitated in the open field.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, low locomotor scores in DBA/2J and high locomotor scores in FVB/NJ appeared to be unrelated to amount of time spent in the chamber with stranger 1 and stranger 2.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant preferences for sociability (Fig. 3a) or preference for social novelty (Fig. 3b) were not observed for number of chamber entries in any of the inbred strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the present study, the juvenile male mice made nests and huddled together while sleeping.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Autistic individuals may further avoid unfamiliar social partners and display diminished interest in novelty (American Psychiatric Association 1994).”
What the sources say
- Not matchedcites American Psychiatric Association 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This modification focuses the task on social approach tendencies, relevant to the social approach deficit in autism, while avoiding potential confounds resulting from aggressive or sexual interactions.”
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Rests on an assumption: Most autistic individuals demonstrate reduced or unusual social approach.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“To ensure that differences in social behaviors were not artifacts of other aspects of mouse behaviors, a series of independent control experiments was conducted to evaluate potential confounding factors.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of times that the mouse exited from the habituated empty central chamber into the novel empty chamber provided a general measure of locomotor function.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Social behaviors have been explored in mice with mutations in candidate genes such as oxytocin (Winslow & Insel 2002;Young et al. 2002), monoamine oxidase-A (Shih & Chen 1999), fragile X (Churchill et al. 2002;Mineur et al. 2002) and dishevelled-1 (Lijam et al. 1997).”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Further controls were designed to detect additional symptoms relevant to autism, such as abnormalities in locomotion or motor coordination (Hallett et al. 1993;Piven et al. 1997), that could directly affect performance of the social task.”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Measures of general health, home cage behavior and neurological reflexes were conducted to rule out gross physical abnormalities (Crawley 2000).”
What the sources say
- Not checked — no full text of the sourcecites Crawley 2000
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Retrieval of food buried in cage bedding was quantitated in a 15-minute olfactory test, to ensure that the subject mice were not grossly impaired in olfaction abilities.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“A large body of evidence from twin and family studies supports the important role of genetic factors in the etiology of autism (Bailey et al. 1995;Ritvo et al. 1989;Szatmari et al. 1998).”
What the sources say
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present mouse tasks were designed to maximize face validity to some of the core symptoms of autism.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the A/J mice were given a second test one week later, with the dividing walls between the chamber sides partially retracted to facilitate exploration.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
plainn = 10- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Given the primacy of social impairment in autism, we considered this symptom to be fundamental to a mouse model of autism (Insel 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Several additional behavioral assays were performed in the initial set of juvenile male mice (C57BL/6J, DBA/2J and FVB/ NJ).These assays were designed as controls for sensory and motor abilities, etc., to ensure that the test mice were physically able to perform the procedures necessary for the social tasks described above.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The chambers of the social apparatus were cleaned and fresh paper chip bedding was added between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The location of stranger 1 in the left vs. right side chamber was systematically alternated between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In our experience to date with the present procedures, human observers attain a high level of proficiency after only one or two practice sessions, with high rates (greater than 95%) of interrater reliability between trained observers.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present protocol used a small wire cage to enclose the stimulus mouse, which allowed visual, auditory and olfactory contact between the mice, but prevented the occurrence of aggressive and other responses.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“From an early age, autistic children show low levels of eye contact and affective responses, less orientation toward others and language deficits, with a concomitant paucity of speech and social communication (for review, see Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites Tager-Flusberg et al. 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The stranger mouse was enclosed in a small, round wire cage (Galaxy Cup, Spectrum Diversified Designs, Inc., Streetsboro, OH), which allowed nose contact between the bars, but prevented fighting.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Previous work in social recognition has shown that mice show both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993;Dluzen & Kreutzberg 1993;Ferguson et al. 2000;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present procedures for the sociability and social novelty tests are designed to be simple, quantitative and easily mastered by investigators.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the present methods were designed to quantitate levels of sociability, i.e. tendency to initiate social contact, and preference for social novelty, i.e. tendency to initiate social contacts with a new individual as compared to someone familiar from past experience, using a simple scoring approach for laboratory mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, some autistic patients demonstrate aberrant motor responses, including repeated hand flapping, jumping and other repetitive and stereotyped behaviors (Bodfish et al. 2000;Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered sensory responses have been reported, including both hypo-and hyper-reactivity to environmental stimuli (Baranek 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Baranek 2002 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Use of the three-chambered apparatus for demonstrating social preference (Insel 2001) was adapted by Brodkin et al. (2004) to investigate social approach and avoidance in female mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Brodkin et al. 2004 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“and the mouse model of fragile X syndrome has been characterized by changes in activity (Bakker et al. 1994;Peier et al. 2000) and reactivity to acoustic stimuli (Chen & Toth 2001;Nielson et al. 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Bakker et al. 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Peier et al. 2000
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Chen & Toth 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Children with fragile X syndrome often show autistic behavior (Hagerman et al. 1986),”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Hagerman et al. 1986 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“As noted by Winslow (2003), the analysis of the full behavioral series that can occur in social tests demands familiarity with the mouse ethogram, extensive training and the ability to discern the sometimes rapid and fleeting responses that mice can emit.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Winslow 2003 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Methods are based on procedures examining pair-bonding in voles (Dean, S.M. & Vandenbergh, J.G. as above), as well as many other elegant tests for social behavior in rodents (Bluthe et al. 1993;Carter et al. 1995;Dluzen & Kreutzberg 1993;Gheusi et al. 1994;Insel and Young 2001;Kogan et al. 2000;Winslow & Camacho 1995;Winslow 2003).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Most autistic individuals demonstrate reduced or unusual social approach.
“We reasoned that most autistic individuals demonstrate reduced or unusual social approach.”
The paper relies on this without support.
Behavioral models of autistic-like responses in mice have received little attention.
“However, to date, behavioral models of autistic-like responses in mice have received little attention.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [530]
In the citing paper
“There is compelling evidence that some strains are more”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
In the citing paper
“However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects 9 ).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
“the social novelty test was not conducted”
Citations
Cites
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Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,168
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Epidemiological Surveys of Autism and Other Pervasive Developmental Disorders: An Update
Fombonne, E. (2003) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1025054610557 · Cited by 1,505
Varieties of Repetitive Behavior in Autism: Comparisons to Mental Retardation
Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005596502855 · Cited by 1,223
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
A Comparison of the Social Postures of Some Common Laboratory Rodents
Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108
Research works printed but not linked: 1
- Bachevalier J., 1991, Advances in Neuropsychiatry and Psychopharmacology, 129
Cited by
Sorted by citations
Items 901–1,000 of 1,472
Metaorganismal choline metabolism shapes olfactory perception
Massey, W. J., Kay, K. E., Jaramillo, T. C., Horak, A. J., Cao, S., Osborn, L. J., Banerjee, R., Mrdjen, M., Hamoudi, M. K., Silver, D. J., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105299 · Cited by 13
“Mouse pairs were placed at separate ends in an open fi eld arena (44 × 44 × 44 cm) and allowed to interact for 5 min 3-chamber social interaction test was performed using a three-chambered box as described previously (71, 72) and based to a large extent on the original descriptions (75, 76).”
MethodSantos‐Silva, T., Ülgen, D. H., Lopes, C. F. B., Guimarães, F. S., Alberici, L. C., Sandi, C., & Gomes, F. V. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02648-3 · Cited by 13
Cannabidiol is a behavioral modulator in BTBR mouse model of idiopathic autism
Shrader, S. H., Mellen, N. M., Cai, J., Barnes, G. N., & Song, Z.-H. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1359810 · Cited by 17
“Recordings were carried out in a sound-proofed enclosure built using modular aluminum elements (McMaster-Carr, Aurora OH) that support experimental enclosures made of Plexiglas, to standard dimensions (Crawley, 2004; Moy et al., 2004; Yang et al., 2008).”
MethodCortés, B. I., Meza, R. C., Ancatén-González, C., Ardiles, N. M., Aránguiz, M.-I., Tomita, H., Kaplan, D. R., Cornejo, F., Nunez-Parra, A., Moya, P. R., et al. (2024) · Biological Research · doi:10.1186/s40659-024-00522-0 · Cited by 14
“To address this, we evaluated social behavior using the three-chamber test for social interaction and novelty [44].”
MethodA molecularly defined mPFC-BLA circuit specifically regulates social novelty preference
Liu, Y., Wang, Y., Xie, G., Yang, Q., Bhattacherjee, A., Zhang, C., & Zhang, Y. (2025) · Science Advances · doi:10.1126/sciadv.adt9008 · Cited by 13
“Besides innate factors such as interacting with skin or opposite sex, social preference could be influenced by attention, perception, social memory, and hierarchy ( 7 – 9 ).”
Neurotrophins in Neurodevelopmental Disorders: A Narrative Review of the Literature
Panvino, F., Paparella, R., Tarani, F., Lombardi, C., Ferraguti, G., Pisani, F., Fiore, M., Pancheva, R., Ardizzone, I., & Tarani, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178335 · Cited by 13
“Moreover, BDNF dysregulation in experimental animal models has been shown to influence social interaction and anxiety [127,128].”
Cheli, V. T., González, D. A. S., Spreuer, V., Handley, V., Campagnoni, A. T., & Paez, P. M. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9499-1 · Cited by 13
“Finally, social interaction was tested using Crawley’s three-chamber social approach test in which the social preference of mice can be quantified by comparing the time spent around a wire cage containing a stranger mouse versus the time spent around an empty cage [33].”
MethodAssessing Sociability, Social Memory, and Pup Retrieval in Mice
Zimprich, A., Niessing, J., Cohen, L., Garrett, L., Einicke, J., Sperling, B., Schmidt, M. V., & Hölter, S. M. (2017) · Current Protocols in Mouse Biology · doi:10.1002/cpmo.36 · Cited by 12
“A widely used test paradigm to quantitatively measure this behavior is the three-chamber sociability test (Moy et al., 2004; Nadler et al., 2004), but simpler versions of the test also exist where the focus of investigation lies on social avoidance behavior after social defeat stress (Berton et…”
BackgroundMethodResultChoi, Y., Park, H., Kang, S., Jung, H., Kweon, H., Kim, S., Choi, I., Lee, S. Y., Choi, Y., Lee, S., et al. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00250 · Cited by 12
Maternal Programming of Social Dominance via Milk Cytokines
Taki, F., Lopez, K. C., Zupan, B., Bergin, P., Docampo, M. D., Alves‐Bezerra, M., Toth, J. G., Chen, Q., Argyropoulos, K. V., Barboza, L., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101357 · Cited by 12
Martinez, M. E., Stohn, J. P., Mutina, E. M., Whitten, R. J., & Hernández, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1055116 · Cited by 12
“Sociability and social novelty were assessed using the threechambered social box previously described (Moy et al., 2004; Stohn et al., 2018).”
MethodMilman, N., Tinsley, C. E., Raju, R. M., & Lim, M. M. (2022) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2022.100085 · Cited by 12
Ferrer-Ferrer, M., Jia, S., Kaushik, R., Schneeberg, J., Figiel, I., Aleshin, S. E., Mironov, A. A., Safari, M., Frischknecht, R., Włodarczyk, J., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04720-z · Cited by 10
Gandhi, T., Liu, C., Adeyelu, T. T., Canepa, C. R., & Lee, C. C. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1114789 · Cited by 13
Acute cannabidiol treatment enhances social interaction in adult male mice
Ferreira, L. F., Pathapati, N., Schultz, S. T., Nunn, M. C., Pierce, B. L., Sanchez, Y. R., Murrell, M. D., Ginsburg, B. C., Onaivi, E. S., & Gould, G. G. (2023) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2023.11163 · Cited by 12
Behavioral Assays in the Study of Olfaction: A Practical Guide
Papes, F., Nakahara, T. S., & Camargo, A. P. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8609-5_21 · Cited by 13
Sex-Dependent Behavioral Functions of the Purkinje Cell-Specific Gαi/o Binding Protein, Pcp2(L7)
Walton, J. C., Schilling, K., Nelson, R. J., & Oberdick, J. (2012) · The Cerebellum · doi:10.1007/s12311-012-0368-4 · Cited by 12
“Social testing consisted of three phases—habituation, sociability, and preference for social novelty—as previously described in [31, 32].”
Programming social behavior by the maternal fragile X protein
Zupan, B., Sharma, A., Frazier, A., Klein, S. L., & Tóth, M. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12298 · Cited by 14
“Adult male offspring of Fmr1+/− and Fmr1+/+ dams were exposed to a conspecific stranger in a three-chamber sociability test, following 5-min habituation (Moy et al. 2004).”
MethodMi, Z., Yang, J., He, Q., Zhang, X., Xiao, Y., & Shu, Y. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00554 · Cited by 12
“The sociability and social novelty preference test protocols were adapted from previous study with slight modifications (Moy et al., 2004).”
MethodAuts2 regulated autism-like behavior, glucose metabolism and oxidative stress in mice
Liu, M., Chen, Y., Sun, M., Du, Y., Bai, Y., Lei, G., Zhang, C., Zhang, M., Zhang, Y., Xi, C., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114298 · Cited by 12
Narvaiz, D. A., Nolan, S. O., Smith, G. D., Holley, A. J., Reynolds, C. D., Blandin, K. J., Nguyen, P. H., Tran, D. L. K., & Lugo, J. N. (2023) · Genes Brain & Behavior · doi:10.1111/gbb.12854 · Cited by 9
“Mice were measured for their preference for social interaction using the three-chambered social preference task modified to include a novel object.(15,32) The testing apparatus was a clear acrylic box (24.”
MethodSex-specific prefrontal-hypothalamic control of behavior and stress responding
Schaeuble, D., Wallace, T., Pace, S. A., Hentges, S. T., & Myers, B. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106413 · Cited by 12
Ventral hippocampal cholecystokinin interneurons gate contextual reward memory
Nguyen, R., Sivakumaran, S., Lambe, E. K., & Kim, J. C. (2024) · iScience · doi:10.1016/j.isci.2024.108824 · Cited by 13
Mice Recognise Mice in Neighbouring Rearing Cages and Change Their Social Behaviour
Ueno, H., Takahashi, Y., Mori, S., Murakami, S., Wani, K., Matsumoto, Y., Okamoto, M., & Ishihara, T. (2024) · Behavioural Neurology · doi:10.1155/2024/9215607 · Cited by 11
“Mice spend more time exploring social stimuli than inanimate objects and show a preference for new conspe-ci fi cs over familiar ones [39].”
BackgroundMedeiros, D., Ayala-Baylon, K., Egido‐Betancourt, H. X., Miller, E. C., Chapleau, C. A., Robinson, H., Phillips, M. L., Yang, T., Longo, F. M., Li, W., et al. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050612 · Cited by 13
“5A), but LM22A-4 did not affect these durations ( P >0.9999, ANOVA-Bonferroni ’ s; LM22A-4 Mecp2 HET versus control Mecp2 HET; Fig.”
InfluentialO’Tuathaigh, C. M. P., Moran, P. M., & Waddington, J. L. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1652-4 · Cited by 11
Peters, S. M., Tuffnell, J. A., Pintér, I. J., van der Harst, J. E., & Spruijt, B. M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.027 · Cited by 11
Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety
Hamieh, A. M., Mallaret, G., Méleine, M., Lashermes, A., Roumeau, S., Boudieu, L., Barbier, J., Aissouni, Y., Ardid, D., Gewirtz, A. T., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.020 · Cited by 11
Age and an obesogenic diet affect mouse behaviour in a sex‐dependent manner
Mort, E. J., Fordington, S., Heritage, S., Fowden, A. L., Jones, S., & Camm, E. J. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16070 · Cited by 11
“The SP task (Moy et al., 2004) comprises a threechambered box, with containers placed in the two outer chambers that can house mice.”
BackgroundEffects of FGF receptor peptide agonists on animal behavior under normal and pathological conditions
Rudenko, O., Tkach, V., Berezin, V., & Bock, E. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.05.002 · Cited by 11
Reduced sulfate plasma concentrations in the BTBR T+tf/J mouse model of autism
Corley, M. J., Meyza, K. Z., Blanchard, D. C., & Blanchard, R. J. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.04.010 · Cited by 11
“BTBR mice show decreased social interaction [6, 12], impaired communication [13, 14], and restricted stereotypical behavioral patterns [15, 16].”
BackgroundTarland, E., & Brosda, J. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.023 · Cited by 11
“Social interaction deficits and social withdrawal are crucial early indicators for autism [3], core behavioural symptoms of schizophrenia and important readouts in animal models of negative symptoms of schizophrenia [4,5].”
BackgroundMethodTakeuchi, E., Yamada, D., Suzuki, S., Saitoh, A., Itoh, M., Hayashi, T., Yamada, M., Wada, K., & Sekiguchi, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230647 · Cited by 11
“Male mice fed a KO diet for 6 weeks showed less immobility time than male mice fed a control diet (t [32] = 11.”
BackgroundDing, Q., Zhang, F., Feng, Y., & Wang, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239327 · Cited by 12
“For social interaction test, we used a 3-chamber paradigm [44] that has been sufficient to detect social deficits in FXS mouse model [45,46].”
MethodSocial deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test
Winiarski, M., Kondrakiewicz, L., Kondrakiewicz, K., Jędrzejewska‐Szmek, J., Turzyński, K., Knapska, E., & Meyza, K. Z. (2022) · Genes Brain & Behavior · doi:10.1111/gbb.12814 · Cited by 9
Mice age — Does the age of the mother predict offspring behaviour?
Lerch, S., Brandwein, C., Dormann, C., Gass, P., & Chourbaji, S. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.04.041 · Cited by 11
“Social recognition The social recognition test apparatus to assess socially induced motivation [20] consists of three compartments (measuring 50 × 16.”
Comprehensive behavioral analysis of indoleamine 2,3‐dioxygenase knockout mice
Hirata, N., Hattori, S., Shoji, H., Funakoshi, H., & Miyakawa, T. (2018) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12019 · Cited by 10
“In the sociability test, social behavior can be assessed based on the time spent around a wire cage with an unfamiliar mouse (stranger-side) vs the time spent around an empty cage (empty side).(22) In the sociability test, both the Ido1 KO and WT mice spent more time around the stranger-side cage than empty side cage…”
MethodDetection of social approach in inbred mice
Pratte, M., & Jamon, M. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.011 · Cited by 11
Quantifying social roles in multi-animal videos using subject-aware deep-learningPreprint
Goss, K., Bueno-Júnior, L. S., Stangis, K. A., Ardoin, T., Carmon, H., Zhou, J. N., Satapathy, R., Baker, I., Jones, C. E., Lim, M. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.07.602350 · Cited by 11
“In the social recognition assay 28,29 , a freely moving “test mouse” interacts with the two objects ( Fig.”
BackgroundNygaard, K. R., Maloney, S. E., Swift, R. G., McCullough, K. B., Wagner, R. E., Fass, S. B., Garbett, K. A., Mirnics, K., Veenstra-VanderWeele, J. M., & Dougherty, J. D. (2023) · Genes Brain & Behavior · doi:10.1111/gbb.12853 · Cited by 10
“Specifically, the authors reported deficits in motor performance in a rotarod task and a decreased habituation to social stimuli in an open field social interaction test of sociability, or the tendency to initiate social contact.(21,29) However, the previous measures on a mostly C57BL/6J background ( F5) showing incre…”
BackgroundTurpin, V., Schaffhauser, M., Thabault, M., Aubert, A., Joffre, C., Balado, É., Longueville, J.-E., Francheteau, M., Burucoa, C., Pichon, M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-38423-z · Cited by 11
“Social interaction was assessed between P50 and P60 using the three-chamber test (3-CT) as previously described 3,73 .”
From rodents to humans: Rodent behavioral paradigms for social behavioral disorders
Guo, M., & Sun, L. (2023) · Brain Circulation · doi:10.4103/bc.bc_48_23 · Cited by 11
“[34] [34‑38] As the name implies, the three‑chamber social test contains three connected chambers.”
BackgroundNavarrete, J. S., Schneider, K. N., Smith, B. M., Goodwin, N. L., Zhang, Y. Y., Salazar, A. S., Gonzalez, Y. E., Anumolu, P., Gross, E., Tsai, V. S., et al. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.01.007 · Cited by 12
Chen, S., Xu, Q., Zhao, L., Zhang, M.-L., & Xu, H. (2024) · Birth Defects Research · doi:10.1002/bdr2.2336 · Cited by 10
“The three-chamber social interaction test is a useful tool for assessing sociability impairments in autistic mouse models (Moy et al., 2004).”
BackgroundMethodZahran, M. A., Mañas-Ojeda, A., Navarro-Sánchez, M., Castillo-Gómez, E., & Olucha-Bordonau, F. E. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36352 · Cited by 11
“Since the three-chamber test was developed in 2004 [1,30,31], many automatic scoring methods have been introduced.”
MethodSocial Interactions in the Clinic and the Cage: Toward a More Valid Mouse Model of Autism
Lahvis, G. P., & Black, L. M. (2010) · Neuromethods · doi:10.1007/978-1-60761-883-6_7 · Cited by 11
Shoji, H., Irino, Y., Yoshida, M., & Miyakawa, T. (2018) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12002 · Cited by 8
“The three-chamber social approach test is a well-designed method to investigate sociability and preference for social novelty in mice.(34) The apparatus consisted of a rectangular, three-chambered box and a lid with a video camera (O’Hara & Co.”
MethodGiacomo, V. D., Ruehle, S., Lutz, B., Häring, M., & Remmers, F. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15069 · Cited by 10
Zhang, F., Icyuz, M., Tollefsbol, T. O., Cox, P. A., Banack, S. A., & Sun, L. Y. (2022) · Biomedicines · doi:10.3390/biomedicines11010104 · Cited by 9
“Sociability is an important early marker for autism and related neurodevelopmental disorders [40].”
BackgroundInfluentialMoffat, J. J., Sakhai, S. A., Hoisington, Z. W., Ehinger, Y., & Dorit Ron, A. (2023) · Psychopharmacology · doi:10.1007/s00213-022-06305-3 · Cited by 9
“Thus, to determine if the mouse BDNFVal68Met polymorphism increases susceptibility for social anxiety in female and male mice, we first measured sociability and social novelty behaviors using a three-chamber social interaction paradigm (Moy et al. 2004; Kaidanovich-Beilin et al. 2011).”
MethodEffects of fingolimod administration in a genetic model of cognitive deficits
Becker‐Krail, D. D., Farrand, A. Q., Boger, H. A., et al. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23799 · Cited by 10
“Social interaction was measured across 49 mice (12 WT 1 saline, 12 WT 1 fingolimod, 12 MUT 1 saline, 13 MUT 1 fingolimod) with a social choice/approach task similar to that described elsewhere (Moy et al., 2004; O’Tuathaig and Waddington, 2010; Wilson and Koenig, 2014).”
Effects of a social stimulus on gene expression in a mouse model of fragile X syndrome
Rogers, T. D., Anacker, A. M. J., Kerr, T. M., Forsberg, C. G., Wang, J., Zhang, B., & Veenstra-VanderWeele, J. M. (2017) · Molecular Autism · doi:10.1186/s13229-017-0148-6 · Cited by 11
“We first tested the classic 3-chamber sociability apparatus, as implemented by the Crawley lab [58], for social exposures in wildtype C57BL/6J mice.”
MethodStrain and sex-based glucocentric & behavioral differences between KK/HlJ and C57BL/6J mice
Inglis, A. L., Shibin, S., Ubungen, R., Farooq, S., Mata, P., Thiam, J., Al-Mohanna, F. A., & Collison, K. S. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112646 · Cited by 10
Xiong, G.-J., Cheng, X., Sun, T., Xie, Y., Huang, N., Li, S., Lin, M.-Y., & Sheng, Z. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0713-9 · Cited by 11
Cranial irradiation impairs juvenile social memory and modulates hippocampal physiology
Newton, J., Brown, T., Corley, C. L., Alexander, T. C., Trujillo, M., McElroy, T., Ntagwabira, F., Wang, J., Byrum, S. D., & Allen, A. R. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147095 · Cited by 10
Gao, Y., Duque‐Wilckens, N., Aljazi, M. B., Moeser, A. J., Mias, G. I., Robison, A. J., Zhang, Y., & He, J. (2022) · iScience · doi:10.1016/j.isci.2022.103742 · Cited by 11
Wu, R., Jiang, X., Wu, X., Pang, J., Tang, Y., Ren, Z., Yang, F., Yang, S., & Wei, W. (2022) · Behavioural Processes · doi:10.1016/j.beproc.2022.104624 · Cited by 10
Zhao, Y.-H., Fu, H., Cheng, H., Zheng, R.-J., Wang, G., Li, S., Li, E.-Y., & Li, L.-G. (2022) · Gene · doi:10.1016/j.gene.2022.146440 · Cited by 10
Göpferich, M., George, N. O., Domingo-Muelas, A., Bizyn, A., Pascual, R., Fijałkowska, D., Kalamakis, G., Müller, U., Krijgsveld, J., Méndez, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.12.247627 · Cited by 13
“Sociability and social novelty for Aplp1-/- vs. WTr6 mice were tested in young mice (Post natal day 40) as described previously 33,34,40 .”
MethodZhang, J., Eaton, M., Chen, X., Zhao, Y., Kant, S., Deming, B. A., Harish, K., Nguyen, H. P., Shu, Y. L., Lai, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.04.641498 · Cited by 10
Behavioral phenotyping of young Scn1a haploinsufficient mice
Reiber, M., Miljanovic, N., Schönhoff, K., Palme, R., & Potschka, H. (2022) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2022.108903 · Cited by 9
“Moy and colleagues [53] have already described relevant nest building activity in mice of different strains aged three to four weeks.”
BackgroundShchipanov, N. A., & Касаткин, М. В. (2023) · Biology Bulletin · doi:10.1134/s1062359022700169 · Cited by 9
“The propensity of the animals for social contact (sociability) (Moy et al., 2004) was assessed in a modified preference test (Crawley, 2000).”
MethodKif15 deficiency contributes to depression-like behavior in mice
Wang, J., Tu, Q., Zhang, S., He, X., Ma, C., Qian, X., Wu, R., Shi, X., Yang, Z., Liu, Y., et al. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01238-y · Cited by 9
Albrechet‐Souza, L., Kasten, C. R., Bertagna, N. B., & Wills, T. A. (2024) · Addiction Biology · doi:10.1111/adb.13366 · Cited by 8
“These cycles were separated by 3 days of no exposure, starting from postnatal day (PND) 27, and ending on PND 38.”
BackgroundInfluentialLenoël, I., Ribon, M., Lorenc, F., Diebold, A., Philibert, C. E., Robaldo, D., Badsi, M., Perronnet, J., Lameth, J., Berriat, F., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63211-w · Cited by 11
Acquarone, M., Poleto, A. L. O., Perozzo, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-93504-1 · Cited by 9
Targeted Tshz3 deletion in corticostriatal circuit components segregates core autistic behaviors
Caubit, X., Gubellini, P., Roubertoux, P. L., Carlier, M., Molitor, J., Chabbert, D., Metwaly, M., Salin, P., Fatmi, A., Belaïdouni, Y., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01865-6 · Cited by 10
Yao, Y., Uddin, M. N., MANLEY, K. M., & Lawrence, D. A. (2022) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2022.577893 · Cited by 9
Salari, Z., Moslemizadeh, A., Tezerji, S. S., Sabet, N., parizi, A. S., Khaksari, M., Sheibani, V., Jafari, E., Shafieipour, S., & Bashiri, H. (2024) · Birth Defects Research · doi:10.1002/bdr2.2310 · Cited by 10
“The trial lasted for 20 min overall after a 5-min habituation period (Meymandi et al., 2020; Moy et al., 2004).”
BackgroundA tracking system for laboratory mice to support medical researchers in behavioral analysis
Macrı̀, S., Mainetti, L., Patrono, L., et al. (2015) · doi:10.1109/embc.2015.7319501 · Cited by 9
“The first test was performed by comparing the positional data acquired by the RFID system with the data coming from video analysis performed by an operator in the sociability and social novelty preference test [18].”
MethodMoore, M. E., Koenig, A. E., Hillgartner, M. A., Otap, C. C., Barnby, E., & MacGregor, G. G. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0071-8 · Cited by 9
“The three-chambered Crawley sociability apparatus The three-chambered sociability apparatus design was created by Moy et al. (2004), based on the earlier work of Brodkin et al. (2004).”
BackgroundMethodTsoupri, E., Kostavasili, I., Kloukina, I., Tsikitis, M., Miliou, D., Vasilaki, E., Varela, A., Nakos‐Bimpos, M., Davos, C. H., Mavroidis, M., et al. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03447-2 · Cited by 9
“sociability test (propensity to interact with a conspecific) but not in the social novelty test (propensity to prefer an interaction with a novel mouse) (Moy et al. 2004), suggesting that social motivation is disrupted but not social memory and novelty.”
BackgroundZhang, Y.-X., Xing, B., Li, Y., Yan, C., & Gao, W. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108895 · Cited by 10
Muhia, M., Yuanxiang, P., Sedlacik, J., Schwarz, J. R., Heisler, F. F., Gromova, K. V., Thies, E., Breiden, P., Pechmann, Y., Kreutz, M. R., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03446-1 · Cited by 9
“that Mkln1 deletion significantly increases dendritic branching in dissociated hippocampal neurons (Genotype: F(1,19)= 8.”
BackgroundHarshaw, C., & Warner, A. G. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173463 · Cited by 12
Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
Adongo, D. W., Mante, P. K., Kukuia, K. K. E., Ameyaw, E. O., Woode, E., & Azi, I. H. (2016) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2015-0067 · Cited by 9
Comparative Behavioral Correlation of High and Low-Performing Mice in the Forced Swim Test
Valencia, S. T., Gonzales, E. L., Adil, K. J., Jeon, S. J., Kwon, K. J., Cho, K. S., & Shin, C. Y. (2019) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.210 · Cited by 9
Mahdi, S., Almosawi, S., Baksh, H., Qareeballa, A. A., Alsaleh, B., Falamarzi, F., Alrabaani, M., Alkalbani, A., & Kamal, A. (2019) · Europe PMC (PubMed Central) · Cited by 9
Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse
Burns, P. L., Bowditch, J., McFadyen, J. D., Loiacono, R. E., Albiston, A. L., Pham, V., & Chai, S. Y. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112150 · Cited by 9
Barabas, A. J., Soini, H. A., Novotný, M. V., Williams, D. R., Desmond, J. A., Lucas, J. R., Erasmus, M. A., Cheng, H. W., & Gaskill, B. N. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251416 · Cited by 9
“However, AJ have previously demonstrated low sociability to stranger mice [44, 45], so these data extend this pattern to behavior towards familiar cage mates.”
BackgroundInactivation of the Catalytic Phosphatase Domain of PTPRT/RPTPρ Increases Social Interaction in Mice
Rajamani, K. T., O’Neill, B., Han, D. D., Frostholm, A., Rotter, A., & Gu, H. H. (2014) · Autism Research · doi:10.1002/aur.1390 · Cited by 9
Correction: Lack of Tryptophan Hydroxylase-1 in Mice Results in Gait Abnormalities
Suidan, G. L., Duerschmied, D., Dillon, G. M., VanderHorst, V., Hampton, T., Wong, S. L., Voorhees, J. R., & Wagner, D. D. (2013) · PLoS ONE · doi:10.1371/annotation/49097405-57c1-4923-875a-9216de91d230 · Cited by 9
Noshadian, M., Kashani, I. R., Asadi-Golshan, R., Zarini, D., Ghafari, N., Zahedi, E., & Pasbakhsh, P. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09292-0 · Cited by 9
Pangrazzi, L., Cerilli, E., Balasco, L., Dall‘O’, G. M., Chelini, G., Pastore, A., Weinberger, B., & Bozzi, Y. (2024) · Antioxidants · doi:10.3390/antiox13111390 · Cited by 8
Emotions in multi-brain dynamics: A promising research frontier
Antonelli, F., Bernardi, F., Koul, A., Novembre, G., & Papaleo, F. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105965 · Cited by 9
“…behaviors, including basic sociability (Moy et al., 2004; Thor and Holloway, 1982) and social personality (Forkosh et al., 2019), familiarity (Moy et al., 2004; Thor and Holloway, 1982), social motivation (Martin and Iceberg, 2015; Solie, Contestabile, et al., 2022; Solie, Girard, et al.,…”
Kawamura, A., Fujii, K., Tamada, K., Abe, Y., Nitahara, K., Iwasaki, T., Yagishita, S., Tanaka, K. F., Takumi, T., Takao, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59853-5 · Cited by 10
Marcantonio, W., Simonti, M., Léna, I., & Mantegazza, M. (2025) · Genes Brain & Behavior · doi:10.1111/gbb.70034 · Cited by 8
“This test consists of 3 phases of 10 min: Habituation, Sociability, and Social Novelty [35, 36].”
Varga, T. G., Simões, J. G. D. T., Siena, A., Henrique, E., da Silva, R. C. B., Bioni, V. S., Ramos, A. C., & Rosenstock, T. R. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05880-1 · Cited by 9
Social and maternal behavior in mesoderm specific transcript (Mest)-deficient mice
Anunciado‐Koza, R. P., Stohn, J. P., Hernández, A., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271913 · Cited by 8
“Sociability and social novelty were assessed using a three-chambered box similar to that previously described [11].”
MethodFarokhi-Sisakht, F., Farhoudi, M., Mahmoudi, J., Kahfi‐Ghaneh, F., & Sadigh‐Eteghad, S. (2022) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2022-028 · Cited by 8
“Social memory was defined as a propensity to spend more time with a new mouse than a familiar mouse (Moy et al., 2004).”
BackgroundPeng, J., He, Y., He, J., et al. (2023) · Brain and Behavior · doi:10.1002/brb3.3204 · Cited by 8
“Normalratswould spend more time in the S chamber (Moy et al., 2004).”
Smith, D. M., Aggarwal, G., Niehoff, M. L., Jones, S. A., Banerjee, S., Farr, S. A., & Nguyen, A. D. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04190-9 · Cited by 10
“The three-chamber test [42] was used to assess the sociability of a mouse when given the choice between interacting with another mouse versus an inanimate object.”
Effects of Embryo Transfer on Emotional Behaviors in C57BL/6 Mice.
Lerch, S., Tolksdorf, G., Schütz, P., Brandwein, C., Dormann, C., Gass, P., & Chourbaji, S. (2016) · Europe PMC (PubMed Central) · Cited by 8
Gómez, Y. G., Sánchez-Aparicio, P., Mejía-Chávez, S., García‐García, F., Pascual-Mathey, L. I., Aguilera-Reyes, U., Galicia-Castillo, O., & Venebra-Muñoz, A. (2019) · Neuroreport · doi:10.1097/wnr.0000000000001236 · Cited by 8
Huang, S., Zeng, J., Sun, R., Yu, H. Y., Zhang, H., Su, X., & Yao, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.840398 · Cited by 8
Zhao, L., Li, Y., Kou, X., Chen, B., Cao, J., Li, J., Zhang, J., Wang, H., Zhao, J., & Shi, S. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szac028 · Cited by 9
Toor, I., Maynard, R., Peng, X., Beery, A. K., & Holmes, M. M. (2022) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2022.860885 · Cited by 8
“Gregarious species such as rats, mice, and spiny mice show a lack of familiarity preferences and sometimes even show novelty preferences (Moy et al., 2004; Smith et al., 2015; Beery and Shambaugh, 2021; Fricker et al., 2022).”
BackgroundNagai, M., Iemura, K., Kikkawa, T., Naher, S., Hattori, S., Hagihara, H., Nagata, K., Anzawa, H., Kugisaki, R., Wanibuchi, H., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac220 · Cited by 9
“This test is a method to investigate the effect of complex genetics on sociability and preference for social novelty.(39) The testing apparatus consisted of a rectangular, threechambered box and a lid with a video camera (O’HARA & Co.”
Sugawara, A., Pearson, B. L., Blanchard, D. C., & Ward, M. A. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.009 · Cited by 7
“Prior to the aforementioned fecundity testing, mice were tested for social approach behavior in a three chamber apparatus, constructed and performed according to published studies (Moy et al., 2004).”
Graham, D. L., Meyer, J. S., & Stanwood, G. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809405-1.00025-0 · Cited by 9
Metadata
- Authors
- Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institute of Mental Health (US)
- Corresponding author
- Moy, S. S.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 3
- Issue
- 5
- Pages
- 287-302
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2109091674
- Cited by
- 1,522
- References
- 80
- Citations by year
- 2026: 93 · 2025: 99 · 2024: 99 · 2023: 98 · 2022: 121 · 2021: 110 · 2020: 109 · 2019: 114 · 2018: 98 · 2017: 65 · 2016: 83 · 2015: 72 · 2014: 65 · 2013: 53 · 2012: 57
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- North Carolina State University
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54 MH 66418, MH66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sociability, autism spectrum disorder, mouse models of autism, inbred mouse strains, social interaction deficits, social avoidance, C57BL/6J mice, DBA/2J, A/J, sex differences, age differences
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Female, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Sex Factors, Social Behavior, Species Specificity, Reproducibility of Results, Rotarod Performance Test, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-12, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-12 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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