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Cited by 495

The DOI matches its Crossref record.

Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22–65 years

Larsson, Lars, Sjödin, Bertil, Karlsson, Jan·1978·Acta Physiologica Scandinavica
DOI 10.1111/j.1748-1716.1978.tb06187.x
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Abstract

Biopsies for histochemical and biochemical analyses were taken from the vastus lateralis muscle of 55 untrained, healthy male subjects from 22 to 65 years of age. Fibre type distribution changed towards a decrease in the percentage of type II fibres, both in type IIA and type IIB fibres, whereas type IIB/IIA fibre ratio and type IIC percentage did not change with increasing age. It was found that the type IIB/flA fibre ratio was inversely related to type I fibres, i.e. subjects rich in type I fibres had a relatively smaller proportion of type IIB fibres. Fibre area determinations revealed a selective decrease in type II fibre area. Consequently, the type II/I fibre area ratio and relative type II fibre area decreased. No changes in the specific activities of Mg 2+ stimulated ATPase and myokinase were observed, while the activity of lactate dehydrogenase (LDH) was higher in the youngest groups than in the oldest. LDH isozyme pattern shifted towards a decrease in percentage distribution of the muscle specific isozymes and a corresponding decrease in muscle specific activity while the activity of the heart specific isozymes did not change.

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Metadata

Authors
Larsson, L., Sjödin, B., & Karlsson, J.
Venue
Acta Physiologica Scandinavica
Publisher
Wiley
Published
1978-05
Volume
103
Issue
1
Pages
31-39
ISSN
  • 0001-6772 (ISSN-L)
  • 1365-201X
DOI
10.1111/j.1748-1716.1978.tb06187.x
OpenAlex
W2119150168
Cited by
495
References
0
FWCI
2.15
Type
journal article
Language
en
Open access
closed

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