The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Muscle time under tension during resistance exercise stimulates differential muscle protein sub‐fractional synthetic responses in men
Open accessAbstract
Non‐technical summary A single bout of resistance exercise stimulates the synthesis of new muscle proteins. Chronic performance of resistance exercise (i.e. weight training) is what makes your muscles grow bigger; a process known as hypertrophy. However, it is unknown if increasing the time that muscle is under tension will lead to greater increases in muscle protein synthesis. We report that leg extension exercise at 30% of the best effort (which is a load that is comparatively light), with a slow lifting movement (6 s up and 6 s down) performed to fatigue produces greater increases in rates of muscle protein synthesis than the same movement performed rapidly (1 s up and 1 s down). These results suggest that the time the muscle is under tension during exercise may be important in optimizing muscle growth; this understanding enables us to better prescribe exercise to those wishing to build bigger muscles and/or to prevent muscle loss that occurs with ageing or disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Progression Models in Resistance Training for Healthy Adults
(2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181915670 · Cited by 4,332
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Progression Models in Resistance Training for Healthy Adults
(2002) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200202000-00027 · Cited by 2,979
FUNCTIONAL SIGNIFICANCE OF CELL SIZE IN SPINAL MOTONEURONS
Henneman, E., Somjen, G., & Carpenter, D. O. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.3.560 · Cited by 2,294
Mixed muscle protein synthesis and breakdown after resistance exercise in humans
Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e99 · Cited by 1,132
Self-citationMoore, D. R., Robinson, M. J., Fry, J. L., Tang, J. E., Glover, E. I., Wilkinson, S. B., Prior, T., Tarnopolsky, M. A., & Phillips, S. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26401 · Cited by 973
Self-citationKumar, V., Selby, A., Rankin, D., Patel, R., Atherton, P., Hildebrandt, W., Williams, J., Smith, K., Seynnes, O., Hiscock, N., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164483 · Cited by 740 · cited 3×
“p70S6K, 4EBP-1, and p90RSK) well known to be phosphorylated immediately after resistance exercise (Kumar et al. 2009; Camera et al. 2010; Terzis et al. 2010; Moore et al. 2011) were also phosphorylated at 24 and 30 h post-exercise.”
BackgroundDreyer, H. C., Fujita, S., Cadenas, J. G., Chinkes, D. L., Volpi, E., & Rasmussen, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113175 · Cited by 570 · cited 2×
“…phosphorylation was enhanced at 6 h post-exercise only in the CTL condition, a finding that is consistent with the notion that this signalling protein may be more responsive to feeding (Fujita et al. 2007a; Atherton et al. 2010; Moore et al. 2011) rather than contraction (Dreyer et al. 2006).”
BackgroundBurd, N. A., West, D. W. D., Staples, A. W., Atherton, P. J., Baker, J. M., Moore, D. R., Holwerda, A. M., Parise, G., Rennie, M. J., Baker, S. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012033 · Cited by 531
Self-citation
Cited by
Sex differences in human fatigability: mechanisms and insight to physiological responses
Hunter, S. K. (2014) · Acta Physiologica · doi:10.1111/apha.12234 · Cited by 595
Areta, J. L., Burke, L. M., Ross, M. L., Camera, D. M., West, D. W. D., Broad, E. M., Jeacocke, N. A., Moore, D. R., Stellingwerff, T., Phillips, S. M., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.244897 · Cited by 495
Self-citationSchoenfeld, B. J., Peterson, M. D., Ogborn, D., Contreras, B., & Sonmez, G. T. (2015) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000958 · Cited by 418
Franchi, M. V., Atherton, P. J., Reeves, N. D., Flück, M., Williams, J., Mitchell, W. K., Selby, A., Beltran Valls, R. M., & Narici, M. V. (2014) · Acta Physiologica · doi:10.1111/apha.12225 · Cited by 389
Damas, F., Phillips, S. M., Libardi, C. A., Vechin, F. C., Lixandrão, M. E., Jannig, P. R., Costa, L. A. R., Bacurau, A. V., Snijders, T., Parise, G., et al. (2016) · The Journal of Physiology · doi:10.1113/jp272472 · Cited by 353
Self-citationEgan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278
Nutritional interventions to augment resistance training-induced skeletal muscle hypertrophy
Morton, R. W., McGlory, C., & Phillips, S. M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00245 · Cited by 234
Self-citationDamas, F., Phillips, S., Vechin, F. C., & Ugrinowitsch, C. (2015) · Sports Medicine · doi:10.1007/s40279-015-0320-0 · Cited by 225
Self-citationMacInnis, M. J., Zacharewicz, E., Martin, B. J., Haikalis, M. E., Skelly, L. E., Tarnopolsky, M. A., Murphy, R. M., & Gibala, M. J. (2017) · The Journal of Physiology · doi:10.1113/jp272570 · Cited by 224
Self-citationPasiakos, S. M., McLellan, T. M., & Lieberman, H. R. (2015) · Sports Medicine · doi:10.1007/s40279-014-0242-2 · Cited by 202
Farup, J., de Paoli, F., Bjerg, K., Riis, S., Ringgard, S., & Vissing, K. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12396 · Cited by 195
Energy Metabolism during Repeated Sets of Leg Press Exercise Leading to Failure or Not
Gorostiaga, E. M., Navarro-Amézqueta, I., Calbet, J. A. L., Hellsten, Y., Cusso, R., Guerrero, M., Granados, C., González-Izal, M., Ibañez, J., & Izquierdo, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040621 · Cited by 178
Jessee, M. B., Buckner, S. L., Mouser, J. G., Mattocks, K. T., Dankel, S. J., Abe, T., Bell, Z. W., Bentley, J. P., & Loenneke, J. P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01448 · Cited by 164
Devries, M. C., McGlory, C., Bolster, D. R., Kamil, A., Rahn, M., Harkness, L., Baker, S. K., & Phillips, S. M. (2018) · The Journal of Nutrition · doi:10.1093/jn/nxy091 · Cited by 141
Ogasawara, R., Kobayashi, K., Tsutaki, A., Lee, K., Abe, T., Fujita, S., Nakazato, K., & Ishii, N. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01161.2012 · Cited by 138
Muscle activation during three sets to failure at 80 vs. 30 % 1RM resistance exercise
Jenkins, N. D. M., Housh, T. J., Bergstrom, H. C., Cochrane, K. C., Hill, E. C., Smith, C. M., Johnson, G. O., Schmidt, R. J., & Cramer, J. T. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3214-9 · Cited by 140
Ogasawara, R., Loenneke, J. P., Thiebaud, R. S., & Abe, T. (2013) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2013.42022 · Cited by 139
Reidy, P. T., & Rasmussen, B. B. (2016) · The Journal of Nutrition · doi:10.3945/jn.114.203208 · Cited by 128
Davies, T. B., Kuang, K., Orr, R., Halaki, M., & Hackett, D. (2017) · Sports Medicine · doi:10.1007/s40279-017-0676-4 · Cited by 117
Training to Fatigue: The Answer for Standardization When Assessing Muscle Hypertrophy?
Dankel, S. J., Jessee, M. B., Mattocks, K. T., Mouser, J. G., Counts, B. R., Buckner, S. L., & Loenneke, J. P. (2017) · Sports Medicine · doi:10.1007/s40279-016-0633-7 · Cited by 115
Is repetition failure critical for the development of muscle hypertrophy and strength?
Sampson, J. A., & Groeller, H. (2016) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12445 · Cited by 111
Devries, M. C., McGlory, C., Bolster, D. R., Kamil, A., Rahn, M., Harkness, L., Baker, S. K., & Phillips, S. M. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx028 · Cited by 112
Self-citationWatanabe, Y., Madarame, H., Ogasawara, R., Nakazato, K., & Ishii, N. (2014) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12117 · Cited by 110
Gentil, P., Fisher, J., & Steele, J. (2017) · Sports Medicine · doi:10.1007/s40279-016-0627-5 · Cited by 104
Burd, N. A., Mitchell, C. J., Churchward-Venne, T. A., & Phillips, S. M. (2012) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h2012-022 · Cited by 99
Self-citationJukic, I., Van Hooren, B., Ramos, A. G., Helms, E. R., McGuigan, M. R., & Tufano, J. J. (2021) · Sports Medicine · doi:10.1007/s40279-020-01423-4 · Cited by 85
Skeletal Muscle Molecular Responses to Resistance Training and Dietary Supplementation in COPD
Constantin, D., Menon, M. K., Houchen-Wolloff, L., Morgan, M. D., Singh, S. J., Greenhaff, P., & Steiner, M. C. (2013) · Thorax · doi:10.1136/thoraxjnl-2012-202764 · Cited by 88
Hagstrom, A. D., Marshall, P. W., Halaki, M., & Hackett, D. A. (2020) · Sports Medicine · doi:10.1007/s40279-019-01247-x · Cited by 78
Role of dietary protein and muscular fitness on longevity and aging
Strasser, B., Volaklis, K., Fuchs, D., & Burtscher, M. (2018) · Aging and Disease · doi:10.14336/ad.2017.0202 · Cited by 78
Resistance training variables for optimization of muscle hypertrophy: an umbrella review.
Bernárdez-Vázquez, R., Raya-González, J., Castillo, D., & Beato, M. (2022) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2022.949021 · Cited by 67
Schoenfeld, B. J., Vigotsky, A. D., Grgic, J., Haun, C., Contreras, B., Delcastillo, K., Francis, A., Cote, G., & Alto, A. (2020) · Physiological Reports · doi:10.14814/phy2.14427 · Cited by 56
Valamatos, M. J., Tavares, F., Santos, R. M., Veloso, A. P., & Mil-Homens, P. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3932-x · Cited by 54
Effects of Training Attendance on Muscle Strength of Young Men after 11 Weeks of Resistance Training
Gentil, P., & Bottaro, M. (2013) · Asian Journal of Sports Medicine · doi:10.5812/asjsm.34489 · Cited by 51
Coelho-Júnior, H. J., & Uchida, M. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.702436 · Cited by 47
Blood flow restriction does not augment low force contractions taken to or near task failure
Buckner, S. L., Jessee, M. B., Dankel, S. J., Mattocks, K. T., Mouser, J. G., Bell, Z. W., Abe, T., Bentley, J. P., & Loenneke, J. P. (2020) · European Journal of Sport Science · doi:10.1080/17461391.2019.1664640 · Cited by 41
Is Performing Repetitions to Failure Less Important Than Volume for Muscle Hypertrophy and Strength?
Lacerda, L. T., Marra-Lopes, R. O., Diniz, R. C. R., Lima, F. V., Rodrigues, S. A., Martins-Costa, H. C., Bemben, M. G., & Chagas, M. H. (2020) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003438 · Cited by 39
Impact of blood flow‐restricted bodyweight exercise on skeletal muscle adaptations
Jakobsgaard, J. E., Christiansen, M., Sieljacks, P., Wang, J., Groennebaek, T., de Paoli, F., & Vissing, K. (2018) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12509 · Cited by 33
Effects of Varied Versus Constant Loading Zones on Muscular Adaptations in Trained Men
Schoenfeld, B., Contreras, B., Ogborn, D., Galpin, A., Krieger, J., & Sonmez, G. (2016) · International Journal of Sports Medicine · doi:10.1055/s-0035-1569369 · Cited by 33
Popov, D. V., Lysenko, E. A., Bachinin, A. V., Miller, T. F., Kurochkina, N. S., Kravchenko, I. V., Furalyov, V. A., & Vinogradova, O. L. (2015) · Muscle & Nerve · doi:10.1002/mus.24314 · Cited by 32
Inter-set stretch: A potential time-efficient strategy for enhancing skeletal muscle adaptations
Schoenfeld, B. J., Wackerhage, H., & De Souza, E. (2022) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2022.1035190 · Cited by 21
“In addition to the heightened tension in the stretch, the strategy allows for a greater time-under-tension during a given session, which has been proposed as a driving factor in hypertrophy (56).”
BackgroundFranco, C. M. D. C., Carneiro, M. A. D. S., Alves, L. T. H., Júnior, G. N. D. O., de Sousa, J. D. F. R., & Orsatti, F. L. (2019) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002970 · Cited by 21
Metadata
- Authors
- Burd, N. A., Andrews, R. J., West, D. W. D., Little, J. P., Cochran, A. J. R., Hector, A. J., Cashaback, J. G. A., Gibala, M. J., Potvin, J. R., Baker, S. K., & Phillips, S. M.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2012-01-15
- Volume
- 590
- Issue
- 2
- Pages
- 351-362
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2136662789
- Cited by
- 345
- References
- 22
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.