Wireless smart contact lens for diabetic diagnosis and therapy
Open accessAbstract
A smart contact lens can be used as an excellent interface between the human body and an electronic device for wearable healthcare applications. Despite wide investigations of smart contact lenses for diagnostic applications, there has been no report on electrically controlled drug delivery in combination with real-time biometric analysis. Here, we developed smart contact lenses for both continuous glucose monitoring and treatment of diabetic retinopathy. The smart contact lens device, built on a biocompatible polymer, contains ultrathin, flexible electrical circuits and a microcontroller chip for real-time electrochemical biosensing, on-demand controlled drug delivery, wireless power management, and data communication. In diabetic rabbit models, we could measure tear glucose levels to be validated by the conventional invasive blood glucose tests and trigger drugs to be released from reservoirs for treating diabetic retinopathy. Together, we successfully demonstrated the feasibility of smart contact lenses for noninvasive and continuous diabetic diagnosis and diabetic retinopathy therapy.
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Keum et al. used a smart contact lens with an electrochemical biosensor to continuously monitor glucose levels in tears and perform diabetic diagnosis and diabetic retinopathy therapy.
“In this regard, Keum et al. [219] used a smart contact lens with an electrochemical biosensor to continuously monitor glucose levels in tears and, thus, perform diabetic diagnosis and diabetic retinopathy therapy.”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [219]
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- Authors
- Keum, D. H., Kim, S.-K., Koo, J., Lee, G.-H., Jeon, C., Mok, J. W., Mun, B. H., Lee, K. J., Kamrani, E., Joo, C.-K., Shin, S., Sim, J.-Y., Myung, D., Yun, S. H., Bao, Z., & Hahn, S. K.
- Affiliations
- Pohang University of Science and Technology (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Harvard University (US)
- PHI BIOMED Co., #613, 12 Gangnam-daero 65-gil, Seocho-gu, Seoul 06612, Korea.
- Stanford Medicine (US)
- Stanford University (US)
- Corresponding author
- Hahn, Sei Kwang
- ORCID
- Venue
- Science Advances
- Published
- 2020-04-24
- Volume
- 6
- Issue
- 17
- Pages
- eaba3252-eaba3252
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC7182412
- OpenAlex
- W3006183395
- Cited by
- 483
- References
- 34
- Citations by year
- 2026: 51 · 2025: 94 · 2024: 81 · 2023: 89 · 2022: 73 · 2021: 78 · 2020: 17
- FWCI
- 20.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Funders
- the National Research Foundation (2017R1E1A1A03070458, CASE-2015M3A6A5072945)
- Samsung Science & Technology Foundation (SRFC-IT1401-03)
- the Small and Medium Business Administration (S2482887)
- the National Eye Institute (K08EY028176, P30-EY026877)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- smart contact lens, continuous glucose monitoring, diabetic retinopathy, on-demand drug delivery, electrochemical biosensing, tear glucose, wearable healthcare, flexible electronics, biocompatible polymers, microcontroller
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