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The emerging role of retromer in neuroprotection

McMillan, Kirsty J, Korswagen, Hendrick C, Cullen, Peter J·2017·Current Opinion in Cell Biology
DOI 10.1016/j.ceb.2017.02.004PMC PMC5677836
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  • Perturbed endosomal transport is a contributing factor and, in some cases, a causative factor in human diseases, including neurodegenerative and neurological, and metabolic syndromes and cardiovascular disease.

    “An increasing body of evidence points to perturbed endosomal transport being a contributing factor and, in some cases, a causative factor in human diseases, including neurodegenerative and neurological2–4, and metabolic syndromes and cardiovascular disease5.”

    From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [2]

  • Sub-domain dysfunction is associated with human disease.

    “Sub-domain dysfunction is associated with human disease, but our mechanistic understanding of its function remains poorly described.”

    From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [2]

  • Functional retrieval sub-domains are essential for development and homeostasis, and disease-associated sub-domain dysregulation is associated with human disease.

    “Analysis in cells and organisms have established the essential importance of functional retrieval sub-domains for development and homeostasis, and disease-associated sub-domain dysregulation is associated with human disease2–5.”

    From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [2]

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Research works printed but not linked: 82

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Metadata

Authors
McMillan, K. J., Korswagen, H. C., & Cullen, P. J.
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2017-08
Volume
47
Pages
72-82
ISSN
0955-0674
DOI
10.1016/j.ceb.2017.02.004
PMC
PMC5677836
Cited by
66
References
5
Language
en
Licence
Funders
  • Medical Research Council (MR/K018299/1)
  • Wellcome Trust (104568, 089928)

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