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Control of Excitatory and Inhibitory Synapse Formation by Neuroligins
Abstract
The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between pre- and postsynaptic cells. We demonstrate that members of the Neuroligin family promote postsynaptic differentiation in cultured rat hippocampal neurons. Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses. Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons.
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Metadata
- Authors
- Chih, B., Engelman, H., & Scheiffele, P.
- Venue
- Science
- Published
- 2005-02-25
- Volume
- 307
- Issue
- 5713
- Pages
- 1324-1328
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2134236497
- Cited by
- 715
- References
- 6
- FWCI
- 18.68
- Type
- journal article
- Language
- en
- Open access
- closed
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