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Cited by 3,832Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs

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Markram, Henry, Lübke, Joachim, Frotscher, Michael, Sakmann, Bert·1997·Science
DOI 10.1126/science.275.5297.213
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Abstract

Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning. In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs. Their average amplitudes were differentially up- or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs. These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neurons.

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2 of 2 references verified0 citation errors · 0 not checkable

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Show all 2 references

Research works printed but not linked: 16

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Metadata

Authors
Markram, H., Lübke, J., Frotscher, M., & Sakmann, B.
Affiliations
  • Max Planck Institute for Medical Research (DE)
  • University of Freiburg (DE)
Corresponding author
Markram, Henry
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1997-01-10
Volume
275
Issue
5297
Pages
213-215
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.275.5297.213
OpenAlex
W1986246844
Cited by
3,832
References
2
Citations by year
2026: 96 · 2025: 144 · 2024: 144 · 2023: 160 · 2022: 154 · 2021: 147 · 2020: 142 · 2019: 165 · 2018: 169 · 2017: 158 · 2016: 148 · 2015: 155 · 2014: 142 · 2013: 128 · 2012: 135
FWCI
31.71
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
synaptic plasticity, coincidence detection, excitatory postsynaptic potentials, pyramidal neurons, neocortex
MeSH terms
Action Potentials, Animals, Calcium, Cerebral Cortex, Dendrites, Electric Stimulation, Synaptic Transmission, Synapses, Time Factors, Down-Regulation, Up-Regulation, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Rats, In Vitro Techniques

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