The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Abstract
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The scientific interest in resveratrol dates back to 1997 when studies on animal models demonstrated its anticancer properties [7].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [7]
Citations
Cites
Aspirin Use and Reduced Risk of Fatal Colon Cancer
Thun, M. J., Namboodiri, M. M., & Heath, C. W. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112053252301 · Cited by 1,685
Prospective study of alcohol consumption and risk of coronary disease in men.
Rimm, E. B., Giovannucci, E. L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B., & Stampfer, M. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)90542-w · Cited by 1,239
Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G. J., & Goldberg, D. M. (1995) · Clinica Chimica Acta · doi:10.1016/0009-8981(95)06045-1 · Cited by 877
Zhang, Y., Kensler, T. W., Cho, C., Posner, G. H., & Talalay, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3147 · Cited by 746
Klatsky, A. L., Armstrong, M. A., & FRIEDMAN, G. D. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-8-646 · Cited by 541
Prochaska, H. J., & Santamaria, A. B. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90292-8 · Cited by 495
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
Gierse, J. K., Hauser, S. D., Creely, D., Koboldt, C. M., Rangwala, S. H., Isakson, P. C., & Seibert, K. (1995) · Biochemical Journal · doi:10.1042/bj3050479 · Cited by 412
Sulindac for polyposis of the colon
Waddell, W. R., Ganser, G. F., Cerise, E. J., & Loughry, R. W. (1989) · The American Journal of Surgery · doi:10.1016/0002-9610(89)90442-x · Cited by 409
Jeandet, P., Bessis, R., & Gautheron, B. (1991) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1991.42.1.41 · Cited by 401
Chemoprevention of cancer with retinoids
Peck, G. L. (1981) · Gynecologic Oncology · doi:10.1016/0090-8258(81)90086-x · Cited by 366
Research works printed but not linked: 11
- Sporn M. B., Newton D. L., Fed. Proc. 38, 2528 (1979).
- Kudo T., Narisawa T., Abo S., Gann 71 260 (1980);
- Zenser T. V., et al., J. Pharmacol. Exp. Ther. 227 545 (1983);
- Wattenberg L. W., Cancer Res. 53, 5890 (1993).
- Sharma S., Stutzman J. D., Kelloff G. J., Steele V. E., Cancer Res. 54 5848 (1994);
- Shamon L. A., et al., Anticancer Res. 14 1775 (1995).
- Suh N., Luyengi L., Fong H. H. S., Kinghorn A. D., Pezzuto J. M., Anticancer Res. 15, 233 (1995).
- Moon R. C., Mehta R. G., in Chemistry and Biology of Retinoids, , Dawson M. I., Okamura W. H., Eds. (CRC Press, Boca Raton, FL, 1990), pp. 501-518.
- Dercks W., Creasy L. L., Physiol. Mol. Plant Pathol. 34, 289 (1989).
- Siemann E. H. and , Creasy L. L., ibid. 43, 49 (1992);
- Goldberg D. M., et al., ibid. 46, 159 (1995).
Cited by
Sorted by citations
Items 701–800 of 1,018
Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis
Ulrich, S., Wolter, F., & Stein, J. M. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200400081 · Cited by 138
Progress in COX-2 Inhibitors: A Journey So Far
Chakraborti, A. K., Garg, S., Kumar, R., Motiwala, H. F., & Jadhavar, P. S. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790979980 · Cited by 141
“1,2-Diarylethenes and 1,1,2-Triarylethenes Based on naturally occurring trans-stilbene, the antiinflammatory resveratrol (75) [98] and acyclic triaryl olefin, tamoxifen (76)[99] (Fig.”
BackgroundDhar, S., Kumar, A., Li, K., Tzivion, G., & Levenson, A. S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.11.004 · Cited by 137
Ballard, T. S., Mallikarjunan, P., Zhou, K., & O’Keefe, S. F. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8030925 · Cited by 137
Kosuru, R., Rai, U., Prakash, S., Singh, A., & Singh, S. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.07.046 · Cited by 139
“They demonstrated that, similar to the well-known polyphenol anticancer agent resveratrol (ED50 = 3.2 µM), PS (ED50 = 4.8 µM) significantly reduced the 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in vitro using mouse mammary culture cells (Jang et al., 1997).”
BackgroundInfluentialCai, Y.-J., Fang, J.-G., Ma, L.-P., Li, Y., & Liu, Z.-L. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00174-6 · Cited by 137
Preharvest Chitosan and Postharvest UV Irradiation Treatments Suppress Gray Mold of Table Grapes
Romanazzi, G., Gabler, F. M., & Smilanick, J. L. (2006) · Plant Disease · doi:10.1094/pd-90-0445 · Cited by 137
Välimaa, A., Honkalampi-Hämäläinen, U., Pietarinen, S. P., Willför, S. M., Holmbom, B. R., & VONWRIGHT, A. (2006) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2006.10.031 · Cited by 137
Resveratrol and its antioxidant and antimicrobial effectiveness
Filip, V., Plocková, M., Šmidrkal, J., Špičková, Z., Melzoch, K., & Schmidt, Š. (2003) · Food Chemistry · doi:10.1016/s0308-8146(03)00157-2 · Cited by 137
Cardiovascular and antiobesity effects of resveratrol mediated through the gut microbiota
Bird, J. K., Raederstorff, D., Weber, P., & Steinert, R. E. (2017) · Advances in Nutrition · doi:10.3945/an.117.016568 · Cited by 136
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
Boily, G., He, X. H., Pearce, B., Jardine, K. E., & McBurney, M. W. (2009) · Oncogene · doi:10.1038/onc.2009.147 · Cited by 137
Efficiency of resveratrol-loaded sericin nanoparticles: Promising bionanocarriers for drug delivery
Suktham, K., Koobkokkruad, T., Wutikhun, T., & Surassmo, S. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.12.015 · Cited by 139
“The toxicity of encapsulated RES is expecting, given that RSV is active against colon cancer cells (Jang et al., 1997).”
BackgroundPiver, B., Fer, M., Vitrac, X., Mérillon, J., Dréano, Y., Berthou, F., & Lucas, D. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.008 · Cited by 136
Paul, B., Masih, I. E., Deopujari, J. Y., & Charpentier, C. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(99)00044-6 · Cited by 142
Vian, M. A., Tomao, V., Gallet, S., Coulomb, P. O., & Lacombe, J. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.05.083 · Cited by 136
Cellular and molecular effects of sirtuins in health and disease
Horio, Y., Hayashi, T., Kuno, A., & Kunimoto, R. (2011) · Clinical Science · doi:10.1042/cs20100587 · Cited by 138
Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats.
Whitsett, T. G., Carpenter, M., & Lamartiniere, C. A. (2006) · Journal of Carcinogenesis · doi:10.1186/1477-3163-5-15 · Cited by 135
Murugan, S., Viswanathan, P., & Nalini, N. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi286 · Cited by 135
Khan, M. A., Chen, H., Wan, X.-X., Tania, M., Xu, A.-H., Chen, F., & Zhang, D. (2013) · Molecules and Cells · doi:10.1007/s10059-013-2259-z · Cited by 134
“RSV has been considered as an effective chemo-preventive agent against different cancers by hindering cancer initiation, promotion, and progression (Huang and Zhu, 2011; Jang et al., 1997).”
BackgroundResveratrol-induced apoptotic death in human U251 glioma cells
Jiang, H., Zhang, L., Kuo, J., Kuo, K., Gautam, S. C., Groc, L., Rodríguez, A. I., Koubi, D., Hunter, T. J., Corcoran, G. B., et al. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0056 · Cited by 134
“Most recently, it has been shown that resveratrol can act as a cancer-chemopreventive agent (10).”
BackgroundCurrent Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy
Montané, X., Kowalczyk, O., Reig-Vano, B., Bajek, A., Roszkowski, K., Tomczyk, R., Pawliszak, W., Giamberini, M., Mocek-Płóciniak, A., & Tylkowski, B. (2020) · Molecules · doi:10.3390/molecules25153342 · Cited by 134
“were the first researchers that reported the inhibition of skin cancer development in mice by using resveratrol [19].”
BackgroundDave, M. N., Attur, M. G., Palmer, G. D., Al-Mussawir, H., Kennish, L., Patel, J., & Abramson, S. B. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23799 · Cited by 135
Wine and resveratrol: mechanisms of cancer prevention?
Bianchini, F., & Vainio, H. (2003) · European Journal of Cancer Prevention · doi:10.1097/00008469-200310000-00011 · Cited by 134
“Several mechanistic pathways that could account for the cancer-preventive activity of resveratrol have been explored, suggesting that resveratrol may affect either initiation or promotion and progression of the cancer process (Jang et al., 1997).”
BackgroundInfluentialAlcohol consumption and risk of non-Hodgkin lymphoma: a pooled analysis
Morton, L. M., Zheng, T., Holford, T. R., Holly, E. A., Chiu, B. C. ‐., Costantini, A. S., Stagnaro, E., Willett, E. V., Maso, L. D., Serraino, D., et al. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70214-x · Cited by 134
Concise Synthesis of Pauciflorol F Using a Larock Annulation
Jeffrey, J. L., & Sarpong, R. (2009) · Organic Letters · doi:10.1021/ol902141z · Cited by 134
Resveratrol, in its natural combination in whole grape, for health promotion and disease management
Singh, C. K., Liu, X., & Ahmad, N. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12798 · Cited by 133
Quincozes-Santos, A., Bobermin, L., Latini, A., Wajner, M., Souza, D., Gonçalves, C., & Gottfried, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064372 · Cited by 135
“Many studies have shown that resveratrol can prevent or slow the progression of a wide variety of illnesses, including cancer [8] and cardiovascular diseases [9,10] and improves health and survival of mice on a high-calorie diet [11].”
BackgroundUsing Liposomes as Carriers for Polyphenolic Compounds: The Case of Trans-Resveratrol
Bonechi, C., Martini, S., Ciani, L., Lamponi, S., Rebmann, H., Rossi, C., & Ristori, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041438 · Cited by 141
“ability, as well as beneficial cardiovascular effects [1,2,3].”
BackgroundEffects of Quercetin on Liver Damage in Rats with Carbon Tetrachloride-Induced Cirrhosis
Pavanato, A., Tuñón, M. J., Sánchez‐Campos, S., Marroni, C. A., Llesuy, S., González‐Gallego, J., & Marroni, N. P. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1022869716643 · Cited by 133
“They contain a number of phenolic hydroxyl groups conferring strong antioxidative activity and therapeutic potential in some diseases, including cancer, ischemic heart disease, and atherosclerosis (2, 3).”
BackgroundAntimutagenic Activity of Phenylpropanoids from Clove (Syzygium aromaticum)
Miyazawa, M., & Hisama, M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030247q · Cited by 133
Resveratrol enhances insulin secretion by blocking KATP and KV channels of beta cells
Chen, W., Chi, T.-C., Chuang, L., & Su, M. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.04.062 · Cited by 134
Billard, C., Izard, J., Roman, V., Kern, C., Mathiot, C., Mentz, F., & Kolb, J. (2002) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/1042819021000015952 · Cited by 133
“In addition to its anti-inflamatory properties, resveratrol exhibits cancer chemopreventive activity in assays representing different stages of carcinogenesis [6].”
BackgroundKumazaki, M., Noguchi, S., Yasui, Y., Iwasaki, J., Shinohara, H., Yamada, N. O., & Akao, Y. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.04.006 · Cited by 132
“It was reported over a decade ago that RES inhibits tumorigenesis in a mouse skin cancer model [10] and that it also interacts with the mitochondria of cancer cells to induce an imbalance in cellular antioxidant activities that leads to a significant increase in the levels of both intracellular reactive oxygen species…”
BackgroundAnticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress
Farooqı, A. A., Li, K.-T., Fayyaz, S., Chang, Y., Ismail, M., Liaw, C., Yuan, S. F., Tang, J., & Chang, H. (2015) · Tumor Biology · doi:10.1007/s13277-015-3797-0 · Cited by 132
El‐Mowafy, A. M., & White, R. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00541-4 · Cited by 132
Szende, B., Tyihák, E., & Király-Véghely, Z. (2000) · Experimental & Molecular Medicine · doi:10.1038/emm.2000.16 · Cited by 131
Chen, J., Lazarenko, O. P., Wu, X., Kang, J., Blackburn, M. L., Shankar, K., Badger, T. M., & Ronis, M. J. J. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.137 · Cited by 133
“Prompted by the discovery of resveratrol, a natural product derived from grapes, and its cancer chemopreventive activity,((35))”
BackgroundCrawford, S. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00068 · Cited by 108
“Additional natural products with demonstrated anti-cancer activity that also block inflammation via NF-kB pathway inhibition include curcumin, resveratrol, ursolic acid, and others (Huang et al., 1994; Jang et al., 1997).”
BackgroundStilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity
Hagiwara, K., Kosaka, N., Yoshioka, Y., Takahashi, R., Takeshita, F., & Ochiya, T. (2012) · Scientific Reports · doi:10.1038/srep00314 · Cited by 131
“Experimental studies have shown that resveratrol inhibits the growth of various cancer cells and induces apoptotic cell deat”
BackgroundZang, N., Xie, X., Deng, Y., Wu, S., Wang, L., Peng, C., Li, S., Ni, K., Luo, Y., & Liu, E. (2011) · Journal of Virology · doi:10.1128/jvi.05869-11 · Cited by 129
“Previous studies demonstrated that resveratrol exhibited a wide range of biological and pharmacological activities, including anticarcinogenic and anti-inflammatory properties in addition to being beneficial to the maintenance of cardiovascular integrity (8, 28).”
BackgroundNF‐κB targeting for overcoming tumor resistance and normal tissues toxicity
Mortezaee, K., Najafi, M., Farhood, B., Ahmadi, A., Shabeeb, D., & Musa, A. E. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28504 · Cited by 130
“Thus, it has been selected as an antitumor agent (Jang et al., 1997).”
BackgroundWhyte, L., Huang, Y.-Y., Torres, K. E. O., & Mehta, R. G. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2464 · Cited by 133
“(11) reported that resveratrol exerts antitumor properties at all three stages of skin carcinogenesis, including initiation, promotion, and progression.”
BackgroundSelf-citationWaffo‐Téguo, P., Hawthorne, M., Cuendet, M., Mérillon, J., Kinghorn, A. D., Pezzuto, J. M., & Mehta, R. G. (2001) · Nutrition and Cancer · doi:10.1207/s15327914nc402_14 · Cited by 131
“In addition, trans-resveratrol inhibited carcinogenesis in a mouse mammary organ culture model and tumorigenesis in a mouse skin cancer model (24).”
BackgroundSelf-citationResveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells
Sexton, É., Themsche, C. V., Leblanc, K., Parent, S., Lemoine, P., & Asselin, É. (2006) · Molecular Cancer · doi:10.1186/1476-4598-5-45 · Cited by 131
Yuan, Y., Xue, X., Guo, R., Sun, X., & Hu, G. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00319.x · Cited by 130
Singleton, R. H., Yan, H. Q., Fellows-Mayle, W. K., & Dixon, C. E. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1291 · Cited by 130
“…2 (Buryanovskyy et al., 2004), and cytochrome P450 (Chun et al., 1999; Ciolino et al., 1998; Piver et al., 2001; Yu et al., 2003), and activation of catalase (Floreani et al., 2003), heme oxygenase (Kaga et al., 2005), and phase 2 enzymes in the drug metabolism pathway (Jang et al., 1997).”
Modulatory Effects of Polyphenols on Apoptosis Induction: Relevance for Cancer Prevention
D’Archivio, M., Santangelo, C., Scazzocchio, B., Varı́, R., Filesi, C., Masella, R., & Giovannini, C. (2008) · International Journal of Molecular Sciences · doi:10.3390/ijms9030213 · Cited by 130
“Among the food-derived polyphenols screened for the chemopreventive effectiveness, resveratrol, a stilbene present in high amounts in grapes [49], is particularly interesting because of its ability to affect a broad range of intracellular mediators involved in the initiation, promotion and progression of cancer [50-52…”
BackgroundResveratrol and prostate cancer: Promising role for microRNAs
Dhar, S., Hicks, C., & Levenson, A. S. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100141 · Cited by 130
“Res (3, 5, 4’trihydroxy-trans-stilbene), a natural phytoalexin, is known for its cardioprotective, anti-inflammatory and anticancer activities [3].”
BackgroundFlavonoid Effects Relevant to Cancer
Brownson, D. M., Azios, N. G., Fuqua, B. K., Dharmawardhane, S., & Mabry, T. J. (2002) · Journal of Nutrition · doi:10.1093/jn/132.11.3482s · Cited by 130
“Our data on the effects of resveratrol in ER( ) and ER ( ) breast cancer cells support the well-established properties of resveratrol as an ER-dependent antagonist of estrogenic effects that inhibit cellular events associated with tumor initiation, promotion and progression (9,59,120).”
BackgroundPostharvest Stilbene-Enrichment of Red and White Table Grape Varieties Using UV-C Irradiation Pulses
Cantos‐Villar, E., Espı́n, J. C., & Tomás-Barberán, F. A. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020562x · Cited by 130
Yen, G., Duh, P., & Lin, C.-W. (2003) · Free Radical Research · doi:10.1080/1071576031000083099 · Cited by 130
“These properties may contribute to its cancer chemopreventive activity.([6]) In the present study, the GST activity induced by resveratrol at a higher concentration (100mM) might be another mechanism against genotoxicity in cells.”
BackgroundLohmann, C. H., Schwartz, Z., Liu, Y., Li, Z., Simon, B. J., Sylvia, V. L., Dean, D. D., Bonewald, L. F., Donahue, H. J., & Boyan, B. D. (2003) · Journal of Orthopaedic Research® · doi:10.1016/s0736-0266(02)00137-7 · Cited by 130
Park, J.-W. (2001) · Carcinogenesis · doi:10.1093/carcin/22.10.1633 · Cited by 129
“Recently, Jang et al. ( 18 ) demonstrated that resveratrol is a potent chemopreventive agent in assays representing the three major stages (e.g.”
BackgroundDistribution of [3H]trans-resveratrol in rat tissues following oral administration
El-Mohsen, M. A., Bayele, H. K., Kuhnle, G., Gibson, G., Debnam, E. S., Srai, S. K., Rice-Evans, C. A., & Spencer, J. P. E. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061810 · Cited by 128
“It has been reported to possess anti-inflammatory (Kimura et al. 1985), vasorelaxing (Jager & Nguyen-Duong, 1999) and anti-tumour (Jang et al. 1997; Lu & Serrero, 1999) properties, and it has been demonstrated to inhibit platelet aggregation (Kimura et al. 1985) and lipid peroxidation (Fauconneau…”
BackgroundSignal transduction pathways: targets for chemoprevention of skin cancer
Bode, A. M., & Dong, Z. (2000) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00029-2 · Cited by 130
Arakaki, N., Nagao, T., 仁木理恵, Toyofuku, A., Tanaka, H., Kuramoto, Y., Emoto, Y., Shibata, H., Magota, K., & Higuti, T. (2003) · PubMed · Cited by 130
Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections
Jøraholmen, M. W., Škalko‐Basnet, N., Acharya, G., & Basnet, P. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.09.007 · Cited by 129
Wang, Y., Xu, H., Fu, Q., Ma, R., & Xiang, J. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.02.025 · Cited by 133
Liu, P., Liang, H.-L., Xia, Q., Li, P., Kong, H., Lei, P., Wang, S., & Tu, Z. (2013) · Clinical & Translational Oncology · doi:10.1007/s12094-012-0999-4 · Cited by 129
Antioxidant and Anti-Inflammatory Effects of Resveratrol in Airway Disease
Wood, L. G., Wark, P. A. B., & Garg, M. L. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3064 · Cited by 130
“The anti-inflammatory effects of resveratrol also occur through inhibition of the cyclooxygenase (COX) enzymes (78), as resveratrol inhibits both COX-2 transcription (95) and COX-1 activity (69).”
Wang, L., Heredia, A., Song, H., Zhang, Z., Yu, B., Davis, C. E. L. B., & Redfield, R. (2004) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20156 · Cited by 129
Giovinazzo, G., D’Amico, L., Paradiso, A., Bollini, R., Sparvoli, F., & Gara, L. D. (2004) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2004.00099.x · Cited by 129
Soy isoflavone genistein in prevention and treatment of prostate cancer
Perabo, F., Löw, E. C. V., Ellinger, J., von Rücker, A., Müller, S. C., & Bastian, P. J. (2007) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4501000 · Cited by 128
Wang, Z., Niu, J., Zhao, C., Wang, X., Ren, J., & Qu, X. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202016442 · Cited by 128
Idiotypic protein-pulsed dendritic cell vaccination in multiple myeloma
Lim, S. H., & Bailey-Wood, R. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19991008)83:2 · Cited by 162
Insulin Secretion and Cyclooxygenase Enzyme Inhibition by Cabernet Sauvignon Grape Skin Compounds
Zhang, Y., Bolleddula, J., Seeram, N. P., Olson, L. K., DeWitt, D. L., & Nair, M. G. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034616u · Cited by 128
Pedersen, A. B., Johansen, C., & Grønbæk, M. (2003) · Gut · doi:10.1136/gut.52.6.861 · Cited by 128
“46 With regard to colorectal cancer,resveratrol has been shown to depress the growth of colorectal aberrant crypt foci in rats 47 and to inhibit growth of human colon cancer cells.”
BackgroundLin, H., Tang, H., Keating, T., Wu, Y.-H., Shih, A., Hammond, D., Sun, M., Hercbergs, A. A., Davis, F. B., & Davis, P. J. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm239 · Cited by 128
“apoptosis in a number of different cancer cell lines (6, 7 ), and to suppress cancer growth in vivo”
BackgroundSynthesis of Curcumin Analogues as Potential Antioxidant, Cancer Chemopreventive Agents
Youssef, K. M., El‐Sherbeny, M. A., El‐Shafie, F. S., Farag, H. A., Al‐Deeb, O. A., & Awadalla, S. A. A. (2004) · Archiv der Pharmazie · doi:10.1002/ardp.200300763 · Cited by 128
Saponins and Phenolics of Yucca schidigera Roezl: Chemistry and Bioactivity
Piacente, S., Pìzza, C., & Oleszek, W. A. (2005) · Phytochemistry Reviews · doi:10.1007/s11101-005-1234-5 · Cited by 127
“In the last 15 years this compound has received a lot of attention because of its biological activities, as antimutagenic (Uenobe et al., 1997), antiviral (Docherty et al., 1999), antiinflammatory (Tsai et al., 1999) and cancer preventing (Jang et al., 1997; Surh et al., 1999).”
BackgroundMitjavila, M. T., & Moreno, J. J. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.07.017 · Cited by 126
Pancreatic cancer: Pathogenesis, prevention and treatment
Sarkar, F. H., BANERJEE, S., & LI, Y. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.11.007 · Cited by 127
“Resveratrol was first noted to be a cancer chemopreventive agent having antioxidant and anti-tumorigenic properties (Jang et al., 1997).”
BackgroundChen, Y., Tseng, S., Lai, H., & Chen, W. (2004) · Surgery · doi:10.1016/j.surg.2004.01.017 · Cited by 127
Resveratrol Inhibits Proliferation and Induces Apoptosis in Human Pancreatic Cancer Cells
Ding, X., & Adrian, T. E. (2002) · Pancreas · doi:10.1097/00006676-200211000-00024 · Cited by 127
“The incidence of tumors among transgenic mice developing spontaneous breast cancer was reduced with its administration, and resveratrol also decreased the number of preneoplastic lesions in a murine model of chemically induced breast cancer (5).”
BackgroundInfluentialModulation of signal transduction by tea catechins and related phytochemicals
Shimizu, M., & Weinstein, I. B. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.04.010 · Cited by 127
Resveratrol‐based combinatorial strategies for cancer management
Singh, C. K., George, J., & Ahmad, N. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12160 · Cited by 132
Resveratrol, human health and winemaking perspectives
Pastor, R. F., Restani, P., Di Lorenzo, C., Orgiu, F., Teissedre, P.-L., Stockley, C., Ruf, J. C., Quini, C. I., Garcìa Tejedor, N., Gargantini, R., et al. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1400517 · Cited by 123
“Potential cancer preventive effects have also been proposed for resveratrol (Jang et al. 1997; Carter et al. 2014; Xue et al. 2014).”
BackgroundChu, X., Sun, A., & Liu, R. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.08.008 · Cited by 126
Antioxidant activity of extract from Polygonum cuspidatum
HSU, C.-Y., Chan, Y.-P., & CHANG, J. (2007) · Biological Research · doi:10.4067/s0716-97602007000100002 · Cited by 126
“The higher content of total phenolics and flavonoids in Polygonum cuspidatum have been correlated with hepatitis B virus inhibition (13), bacterial DNA primase inhibition (15), acyl-coenzyme A acyltransferase activity (16), inhibition of copper catalyzed oxidation for low-density lipoprotein (32), inhibition of platel…”
BackgroundKu, K.-L., Chang, P.-S., Cheng, Y.-C., & Lien, C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050242o · Cited by 126
Gao, X.-H., Xu, Y. X., Divine, G., Janakiraman, N., Chapman, R., & Gautam, S. (2002) · Journal of NutriLife · doi:10.1093/jn/132.7.2076 · Cited by 132
Phytoestrogens Act as Estrogen Agonists in an Estrogen-Responsive Pituitary Cell Line
Stahl, S., Chun, T.-Y., & Gray, W. (1998) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8500 · Cited by 126
Resveratrol preserves cerebrovascular density and cognitive function in aging mice
Oomen, C. A. (2009) · Frontiers in Aging Neuroscience · doi:10.3389/neuro.24.004.2009 · Cited by 128
“…antioxidant (Frankel et al., 1993; Fremont et al., 1999; Mizutani et al., 2001; Jang and Surh, 2003), phytoestrogenic (Gehm et al., 1997), vasorelaxing (Fitzpatrick et al., 1993; Jager and Nguyen-Duong, 1999; Das et al., 2005), anti-infl ammatory and anti-carcinogenic activity (Jang et al., 1997).”
Cyclodextrins and Antioxidants
López-Nicolás, M., Rodríguez-Bonilla, P., & García‐Carmona, F. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.582544 · Cited by 125
“3B) is a phytoalexin found in at least 72 species of plant distributed among 31 genera and 12 families (Jang et al., 1997).”
BackgroundFormulation of resveratrol entrapped niosomes for topical use
Pando, D., Matos, M., Gutiérrez, G., & Pazos, C. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.02.037 · Cited by 125
Preparation and characterization of niosomes containing resveratrol
Pando, D., Gutiérrez, G., Coca, J., & Pazos, C. (2013) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2013.02.020 · Cited by 125
Theilmann, M. C., Goh, Y. J., Nielsen, K. F., Klaenhammer, T. R., Barrangou, R., & Hachem, M. A. (2017) · mBio · doi:10.1128/mbio.01421-17 · Cited by 130
Resveratrol and Resveratrol Analogues—Structure—Activity Relationship
Szekeres, T., Fritzer‐Szekeres, M., Saiko, P., & Jäger, W. R. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0090-1 · Cited by 128
“Resveratrol proved to be effective in preventing the development of cancer in a skin cancer animal model ( 12 ).”
BackgroundTargeting signal transduction pathways by chemopreventive agents
Bode, A. M., & Dong, Z. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.05.018 · Cited by 127
Trincheri, N. F., Nicotra, G., Follo, C., Castino, R., & Isidoro, C. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl223 · Cited by 122
New Enzymatic Method for the Determination of Total Phenolic Content in Tea and Wine
Stevanato, R., Fabris, S., & Momo, F. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049898s · Cited by 124
LIU, Y.-Z., Wu, K., Huang, J., Liu, Y., WANG, X., Meng, Z., YUAN, S.-X., Wang, D., Luo, J., Zuo, G., et al. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2392 · Cited by 125
“The PI3K/Akt signaling pathway is one of the essential pathways for cell survival and proliferation, which is over-activated in many human cancers, such as breast, colon and prostate cancers (10,14).”
BackgroundInfluentialJung, K., Lee, J. H., Quach, C. H. T., Paik, J.-Y., Oh, H., Park, J. W., Lee, E. J., Moon, S. H., & Lee, K.-H. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.115436 · Cited by 125
“Resveratrol has antioxidant properties through modulation of antioxidant enzyme activity or intrinsic ROS scavenging capacity, which are thought to contribute to its anticancer effects (2,3).”
BackgroundThe antimicrobial effects of wood-associated polyphenols on food pathogens and spoilage organisms
Plumed‐Ferrer, C., Väkeväinen, K., Komulainen, H., Rautiainen, M., Smeds, A. I., Raitanen, J., Eklund, P., Willför, S. M., Alakomi, H., Saarela, M., et al. (2013) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2013.04.001 · Cited by 124
“In bioassays with cancer cell lines and in animal studies, resveratrol appears to interfere with the major steps of the carcinogenesis (Boissy et al., 2005; Boocock et al., 2007; Jang et al., 1997; Tolomeo et al., 2005).”
BackgroundSirerol, J. A., Feddi, F., Mena, S., Rodríguez, M. L., Sirera, P. S., Aupí, M., Pérez, S., Asensi, M. A., Ortega, Á., & Estrela, J. M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.027 · Cited by 124
Roles of AMP-Activated Protein Kinase in Diabetes-Induced Retinal Inflammation
Kubota, S., Ozawa, Y., Kurihara, T., Sasaki, M., Yuki, K., Miyake, S., Noda, K., Ishida, S., & Tsubota, K. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8041 · Cited by 126
Kubota, S., Kurihara, T., Ebinuma, M., Kubota, M., Yuki, K., Sasaki, M., Noda, K., Ozawa, Y., Oike, Y., Ishida, S., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100098 · Cited by 127
Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update
Cui, J., & Jia, J. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327999200917150939 · Cited by 131
Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells
Hou, R. C., Huang, H., Tzen, J. T. C., & Jeng, K.-C. G. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10749 · Cited by 124
“Resveratrol has an ROS-reducing effect to protect PC12 cells from oxidative stress-induced cell death (Chanvitayapongs et al., 1997; Jang et al., 1997; Jang et al., 1999).”
BackgroundEffect of resveratrol on the development of spontaneous mammary tumors in HER‐2/neu transgenic mice
Provinciali, M., Re, F., Donnini, A., Orlando, F., Bartozzi, B., Stasio, G. D., & Smorlesi, A. (2005) · International Journal of Cancer · doi:10.1002/ijc.20874 · Cited by 124
“1,8–12 Jang et al.(1) reported FIGURE 3 – Effect of Res supplementation on HER-2/neu mRNA expression in tumoral mammary glands.”
BackgroundInfluential
Metadata
- Authors
- Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
- Affiliations
- University of Illinois Chicago (US)
- Universidad Complutense de Madrid (ES)
- M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
- Corresponding author
- Cai, Lining
- Pezzuto, John M.
- Venue
- Science
- Published
- 1997-01-10
- Volume
- 275
- Issue
- 5297
- Pages
- 218-220
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2151089147
- Cited by
- 4,935
- References
- 33
- Citations by year
- 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
- FWCI
- 96.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- Funders
- National Cancer Institute (P01CA048112)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
