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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Abstract
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
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“Resveratrol possesses important anti-inflammatory effects in vitro, similar to those observed for indomethacin and phenylbutazone, and it has even been found to inhibit carcinogenesis in animal models (69).”
BackgroundResveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo
Garvin, S., Öllinger, K. M., & Dabrosin, C. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.01.031 · Cited by 351
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“Jang et al. (1997) reported the ability of resveratrol to inhibit carcinogenesis at multiple stages (initiation, promotion and progression).”
BackgroundResveratrol: One molecule, many targets
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“Also, both tumour number and incidence in a mouse skin model of tumorigenesis were effectively decreased by topic application of 25 lM resveratrol twice a week (5).”
InfluentialChemoprevention by resveratrol: molecular mechanisms and therapeutic potential
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“In other studies a inhibition effect of resveratrol on carcinogenesis at multiple stages particularly on skin has been reported (11).”
BackgroundThe red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury
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Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines
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Clavicipitaceous endophytes: Their ability to enhance resistance of grasses to multiple stresses
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“Resveratrol is a polyketide-derived stilbene and has considerable chemopreventive activity in humans as it is a selective inhibitor of cyclooxygenase and peroxidases activities of COX-1 and it also has antioxidant properties (Jang et al., 1997).”
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Microwave-assisted extraction of phenolic antioxidant compounds from peanut skins
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Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway
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“It was shown to have an anti-carcinogenic effect in a two-stage mouse skin cancer model ( 21 ).”
BackgroundIns and outs of dietary phytochemicals in cancer chemoprevention
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Mechanism-based in vitro screening of potential cancer chemopreventive agents
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An LC-MS Method for Analyzing Total Resveratrol in Grape Juice, Cranberry Juice, and in Wine
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Bråkenhielm, E., Cao, R., & Cao, Y. (2001) · The FASEB Journal · doi:10.1096/fj.01-0028fje · Cited by 334
“Its antitumor activity was observed in several tumor models and appears to be independent of cell type (2, 8).”
BackgroundMethodResultInfluentialMurakami, A., Nakamura, Y., Torikai, K., Tanaka, T., Koshiba, T., Koshimizu, K., Kuwahara, S., Takahashi, Y., Ogawa, K., Yano, M., et al. (2000) · PubMed · Cited by 333
Kim, S., Jin, Y., Choi, Y., & Park, T. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.03.012 · Cited by 341
Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.
Bhat, K., Lantvit, D. D., Christov, K. T., Mehta, R. G., Moon, R. C., & Pezzuto, J. M. (2001) · PubMed · Cited by 330
Self-citationThe effects of nuts on coronary heart disease risk
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Oxyresveratrol and Hydroxystilbene Compounds
Kim, Y. M., Yun, J., Lee, C., Lee, H., Min, K. R., & Kim, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200678200 · Cited by 330
Resveratrol and Its Effects on the Vascular System
Breuss, J. M., Atanasov, A. G., & Uhrín, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071523 · Cited by 344
“Anti-inflammatory effects of resveratrol include the inhibition of the pro-inflammatory enzyme cyclooxygenase-1 (COX-1), leading to the suppression of synthesis of proinflammatory eicosanoids [56,57].”
BackgroundMetabolic constituents of grapevine and grape-derived products
Ali, K., Maltese, F., Choi, Y. H., & Verpoorte, R. (2009) · Phytochemistry Reviews · doi:10.1007/s11101-009-9158-0 · Cited by 325
“Another anti-carcinogenic study showed that resveratrol was capable to inhibit tumor initiation, promotion and progression and also explaining how it intervened in each stage (Jang et al. 1997).”
Background
Metadata
- Authors
- Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
- Affiliations
- University of Illinois Chicago (US)
- Universidad Complutense de Madrid (ES)
- M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
- Corresponding author
- Cai, Lining
- Pezzuto, John M.
- Venue
- Science
- Published
- 1997-01-10
- Volume
- 275
- Issue
- 5297
- Pages
- 218-220
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2151089147
- Cited by
- 4,935
- References
- 33
- Citations by year
- 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
- FWCI
- 96.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- Funders
- National Cancer Institute (P01CA048112)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions
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