Cited by 4,935Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

Jang, Meishiang, Cai, Lining, Udeani, George O., Slowing, Karla V., Thomas, Cathy F., Beecher, Christopher W. W., Fong, Harry H. S., Farnsworth, Norman R., Kinghorn, A. Douglas, Mehta, Rajendra G., Moon, Richard C., Pezzuto, John M.·1997·Science

DOI 10.1126/science.275.5297.218

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Abstract

Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

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Functional foods: An overview
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High-Yield Resveratrol Production in Engineered Escherichia coli
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“Yet, resveratrol may have additional health benefits, as numerous studies have found that its biological activities include antioxidative, antiinflammatory, anticancer, and chemopreventive abilities (6, 10, 14).”
Background
The Role of Phenolic Compounds in the Fight against Cancer – A Review
Carocho, M., & Ferreira, I. C. F. R. (2013) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113139990301 · Cited by 267
“The first record of its chemopreventive activity dates back to 1997 [123].”
Background
Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
Brookins-Danz, E. D., Skramsted, J., Henry, N., Bennett, J. A., & Keller, R. S. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.03.011 · Cited by 273
“RV may be a preferable cardioprotective agent used in combination with DOX owing to its ability to limit DOX-induced cardiotoxicity as well as act as an anticancer agent itself [31,48].”
Background
Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry
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“Antitumor activities of stilbenes have also been reported [9, 10].”
Background
Resveratrol and cancer: Challenges for clinical translation
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Stilbene Content of Mature Vitis vinifera Berries in Response to UV-C Elicitation
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Dose-Dependency of Resveratrol in Providing Health Benefits
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“Resveratrol has been shown to possess potential anticancer activity in various cancer cells at the initiation, promotion, and progression stages (Jang et al. 1997).”
Nanotechnology for angiogenesis: opportunities and challenges
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Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice☆☆Part of this work was conducted at the Department of Dermatology, Case Western Reserve University and the Research Institute of University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106.
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Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms
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Cancer Epigenetics: An Introduction
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Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2.
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Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4′-tetramethoxystilbene
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“Resveratrol has been reported to possess a variety of anti-inflammatory, antiplatelet and both pro- and antioestrogenic effects (Bertelli et al, 1996; Gehm et al, 1997; Jang et al, 1997; Uenobe et al, 1997).”
Background
Total Synthesis of Diverse Carbogenic Complexity within the Resveratrol Class from a Common Building Block
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Estimates for World Population and Global Food Availability for Global Health
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Neuroinflammation, Neurodegeneration, and Depression
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“Resveratrol has been shown to impedes cancer progression at various stages (Jang et al. 1997), reduce cardiovascular disease (Bradamante et al.”
Background
Peroxidases
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Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats
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Resveratrol in Cardioprotection: A Therapeutic Promise of Alternative Medicine
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Resveratrol, a Natural Product Present in Wine, Decreases Tumour Growth in a Rat Tumour Model
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Herbal bioactivation: The good, the bad and the ugly
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“Inhibition of Phase I enzymes and induction of Phase II enzymes will contribute to the chemopreventive activity of resveratrol (Dubuisson et al., 2002; Jang et al., 1997).”
Background
Resveratrol: review on therapeutic potential and recent advances in drug delivery
Pangeni, R., Sahni, J. K., Ali, J., Sharma, S., & Baboota, S. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.919253 · Cited by 255
“Tumorigenesis was also studied in two-stage mouse skin cancer model for 18 weeks with the application of different concentrations (1, 5, 10 and 25 μmol) of resveratrol together with 12-O-tetradecanoylphorbol-13-acetate twice a week; a reduction in the number of skin tumors per mouse by 68, 81, 76 or 98%, respectively,…”
Method
Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation
Dai, Z., Li, Y., Quarles, L. D., Song, T., Pan, W., Zhou, H., & Xiao, Z. (2007) · Phytomedicine · doi:10.1016/j.phymed.2007.04.003 · Cited by 255
“Resveratrol (3,40,5-trihydroxystilbene, RSVL), a known phytoestrogen, is a phenolic compound that occurs naturally in mulberries, peanuts and the berry skins of most grape cultivars (Jang et al., 1997) and”
Isolation and Identification of Stilbenes in Two Varieties of Polygonum c uspidatum
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Inhibition of Influenza A Virus Replication by Resveratrol
Palamara, A. T., Nencioni, L., Aquilano, K., Chiara, G. D., Hernandez, L., Cozzolino, F., Ciriolo, M. R., & Garaci, E. (2005) · The Journal of Infectious Diseases · doi:10.1086/429694 · Cited by 254
“activity [8–11].”
Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin
Yang, J., Della‐Fera, M. A., Rayalam, S., Ambati, S., Hartzell, D. L., Park, H. J., & Baile, C. A. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.03.003 · Cited by 253
Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production.
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Medicinal Plant Analysis: A Historical and Regional Discussion of Emergent Complex Techniques
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A comparison of the anticarcinogenic properties of four red wine polyphenols
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“In 1997, it was reported that trans-resveratrol (1–25 M) inhibited the initiation and promotion of hydrocarbon-induced skin cancer in mice, as well as the progression of breast cancer in this species [17].”
Background
Effects of Resveratrol in Inflammatory Arthritis
Elmali, N., Baysal, Ö., Harma, A., Esenkaya, İ., & Mızrak, B. (2006) · Inflammation · doi:10.1007/s10753-006-9012-0 · Cited by 251
“The anti-inflammatory properties of resveratrol have been demonstrated by suppression of carrageenaninduced paw edema, an effect attributed to suppression of PG synthesis [12].”
Background
Design and Synthesis of Potent and Multifunctional Aldose Reductase Inhibitors Based on Quinoxalinones
Qin, X., Hao, X., Han, H., Zhu, S., Yang, Y., Wu, B., Hussain, S., Parveen, S., Jing, C., Ma, B., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501484b · Cited by 251
The Possible Implication of trans-Resveratrol in the Cardioprotective Effects of Long-Term Moderate Wine Consumption
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“On the other hand, it is also interesting to note that 1) NO has been described to have important vasodilator, platelet antiaggregatory, and inhibitory effects on low-density lipoprotein oxidation (Radomski and Moncada, 1993; Kuriyama et al., 1995; Moncada et al., 1997).”
Influential
Anticancer and Cancer Chemopreventive Potential of Grape Seed Extract and Other Grape-Based Products
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Authors: Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
Affiliations: University of Illinois Chicago (US)
Universidad Complutense de Madrid (ES)
M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Corresponding author: Cai, Lining
Pezzuto, John M.
ORCID: Udeani, George O.
Slowing, Karla V.
Kinghorn, A. Douglas
Mehta, Rajendra G.
Pezzuto, John M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-01-10
Volume: 275
Issue: 5297
Pages: 218-220
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.275.5297.218
OpenAlex: W2151089147
Cited by: 4,935
References: 33
Citations by year: 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
FWCI: 96.50
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
Funders: National Cancer Institute (P01CA048112)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions

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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

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