Cited by 4,935Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

Jang, Meishiang, Cai, Lining, Udeani, George O., Slowing, Karla V., Thomas, Cathy F., Beecher, Christopher W. W., Fong, Harry H. S., Farnsworth, Norman R., Kinghorn, A. Douglas, Mehta, Rajendra G., Moon, Richard C., Pezzuto, John M.·1997·Science

DOI 10.1126/science.275.5297.218

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Abstract

Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

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Background
Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells.
Deeb, D., Xu, Y. X., Jiang, H., Gao, X., Janakiraman, N., Chapman, R., & Gautam, S. C. (2003) · PubMed · Cited by 156
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“RES has been shown to inhibit tumor initiation, promotion, and progression in a variety of cell culture systems, including breast cancer cells (Jang et al., 1997; Bhat et al., 2001).”
Background
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“Resveratrol is a potent sirtuin stimulator and it also reduces acute inflammation in vivo and free radicals and mutations in vitro, inhibits tumor generation in response to the DMBA carcinogen, and protects against early death from injected neuroblastoma cells (Jang et al. 1997; Chen et al. 2004).”
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Resveratrol and chemoprevention
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“Interest in resveratrol took a further upsurge when it was reported in 1997 that it also has anti-neoplastic activities [27].”
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Transformation of apple ( Malus domestica Borkh.) with the stilbene synthase gene from grapevine ( Vitis vinifera L.) and a PGIP gene from kiwi ( Actinidia deliciosa )
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The chemodiversity of wines can reveal a metabologeography expression of cooperage oak wood
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“C progress has been made in recent years in the characterization of grape and wine metabolites, which have been shown to be responsible for therapeutic (1, 2) or organoleptic properties (3, 4).”
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Bioactive non-coloured polyphenols content of grapes, wines and vinification by-products: Evaluation of the antioxidant activities of their extracts
Anastasiadi, M., Pratsinis, H., Kletsas, D., Skaltsounis, A., & Haroutounian, S. A. (2009) · Food Research International · doi:10.1016/j.foodres.2009.11.017 · Cited by 153
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Background
Anti-inflammatory Action of Pterostilbene Is Mediated through the p38 Mitogen-Activated Protein Kinase Pathway in Colon Cancer Cells
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“The discovery of resveratrol as a cancer-preventive agent (24) has fostered interest in testing the cancer-preventive activity of other naturally occurring stilbenes inmany laboratories (25–28).”
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Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells
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“As a constituent of root extracts of Polygonum cuspidatum(10,11) resveratrol was used in the Japanese and Chinese folk medicine, and was recently identified as a cyclooxygenase I-inhibiting component of the Peruvian root Cassia quinquangulata.(1) In assays representing three major stages of carcinogenesis, resveratrol…”
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A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol
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Background
Resveratrol Inhibits Paraquat-Induced Oxidative Stress and Fibrogenic Response by Activating the Nuclear Factor Erythroid 2-Related Factor 2 Pathway
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“…exhibits multiple health-promoting properties including antioxidative, anticancer, anti-inflammatory, antiaging, blood sugar-lowing, and beneficial cardiovascular effects (Jang et al., 1997; Duffy and Vita, 2003; Leonard et al., 2003; Su et al., 2006; Valenzano et al., 2006; Elmali et al., 2007).”
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“Stilbenes, namely resveratrol, have shown effects in preventing or treating certain diseases such as breast cancer [187,188] and skin tumors [189].”
BackgroundInfluential
Germination of Peanut Kernels to Enhance Resveratrol Biosynthesis and Prepare Sprouts as a Functional Vegetable
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Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells
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Background
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F'guyer, S., Afaq, F., & Mukhtar, H. (2003) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2003.00019.x · Cited by 205
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“Resveratrol, a stilbene polyphenol found in wine and grapes, has been reported to protect against coronary heart disease and to possess cancer chemopreventive activity (8).”
Background
Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production
Martin, S., Andriambeloson, E., Takeda, K., & Andriantsitohaina, R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704603 · Cited by 150
“Natural dietary polyphenolic compounds that are present in a wide variety of plants are thought to protect against cardiovascular disease and cancer (Renaud & de Lorgeril, 1992; Hertog et al., 1993; Jang et al., 1997; Carbo et al., 1999).”
Background
Effects of resveratrol on 12-O-tetradecanoylphorbol-13-acetate-induced oxidative events and gene expression in mouse skin
Jang, M., & Pezzuto, J. M. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00250-x · Cited by 150
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“In contrast to the few in vivo studies (Jang et al., 1997; Tessitore et al., 2000; Bhat et al., 2001; Bove et al., 2002), several investigations have demonstrated in vitro antiproliferative/proapoptotic effects of resveratrol in cells of a large variety of human cancers (Hsieh and Wu, 1999;…”
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Nutraceuticals, apoptosis, and disease prevention
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Effect of Soil Type on Wines Produced fromVitisviniferaL. Cv. Grenache in Commercial Vineyards
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Comparision of Piceid and Resveratrol in Antioxidation and Antiproliferation Activities In Vitro
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“The antioxidation activity of resveratrol can be traced back to its cancer chemoprevention since free-radical-mediated oxidative damage of DNA is involved with the development of cancer cells [31,32,33,34].”
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Antioxidant polyphenols in cancer treatment: Friend, foe or foil?
Russo, G. L., Tedesco, I., Spagnuolo, C., & Russo, M. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.05.005 · Cited by 148
Cancer Prevention: From 1727 to Milestones of the Past 100 Years
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Neuroprotective Effects of Resveratrol against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress in Rats
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Human Cytochrome P450 Enzymes
Guengerich, F. P. (2015) · Springer eBooks · doi:10.1007/978-3-319-12108-6_9 · Cited by 159
Optimization of extraction of phenolic antioxidants from peanut skins
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“It also has preventive effects on inflammation, cardiovascular disease and cancer (Jang et al., 1997; Wang, et al., 2002; Donnelly et al., 2004).”
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Biological and Potential Therapeutic Roles of Sirtuin Deacetylases
Taylor, D. M., Maxwell, M. M., Luthi‐Carter, R., & Kazantsev, A. G. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8357-y · Cited by 146
Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms.
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“One of the mechanisms by which resveratrol exerts its antitumorigenic effects on cancer cells is inhibition of cyclooxygenases (COX) (24).”
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Biochemical effects of SIRT1 activators
Baur, J. A. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.10.025 · Cited by 150
“For example, some of the cardioprotective and anti-inflammatory effects or resveratrol may be due to direct inhibition of cyclooxygenases [47], and an alternate explanation for many of the effects attributed to direct SIRT1 activation, such as increases in mitochondrial biogenesis and fatty acid oxidation, could be pr…”
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Drug interaction potential of resveratrol
Detampel, P., Beck, M., Krähenbühl, S., & Huwyler, J. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2012.700715 · Cited by 146
“Resveratrol also possesses cancer-preventive activity in the micromolar range (Jang et al., 1997).”
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Overexpression of Human Papillomavirus Type 16 Oncoproteins Enhances Hypoxia-Inducible Factor 1α Protein Accumulation and Vascular Endothelial Growth Factor Expression in Human Cervical Carcinoma Cells
Tang, X., Zhang, Q., Nishitani, J., Brown, J. J., Shi, S., & Le, A. D. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2704 · Cited by 142
Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma
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“Moreover, resveratrol (RSV, 3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in the skin of red grapes and peanuts (124), suppressed cell cycle progression in HT29 advanced human colon cancer cells by downregulating two key enzymes of the PPP, G6PD, and TKT (125).”
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The Potential Use of Resveratrol for Cancer Prevention
Fasseur, D., & Latruffe, N. (2019) · Molecules · doi:10.3390/molecules24244506 · Cited by 146
“Historically, the preventive effect of resveratrol towards cancer, especially skin and mammal cancers in mice, started with the discovery of Pezzutto’s group in 1997 [3].”
Background
Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats
Miura, D., Miura, Y., & Yagasaki, K. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00469-7 · Cited by 145
Differential Inhibition and Inactivation of Human CYP1 Enzymes bytrans-Resveratrol: Evidence for Mechanism-Based Inactivation of CYP1A2
Chang, T. K. H., Chen, J., & Lee, W. B. K. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29205-3 · Cited by 145
“current study came from a published report indicating that resveratrol reduced the number of preneoplastic lesions in mouse mammary gland cultures treated with the procarcinogen 7,12-dimethylbenz[a]anthracene (DMBA) and decreased the incidence of tumor formation in mice treated with DMBA as an initiator and 12-O-tetra…”
Background
Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway
Pan, L., Becker, H., & Gerhäuser, C. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500065 · Cited by 145
Deprotonation Mechanism and Acidity Constants in Aqueous Solution of Flavonols: a Combined Experimental and Theoretical Study
Álvarez-Diduk, R., Ramírez-Silva, M. T., Galano, A., & Merkoçi, A. (2013) · The Journal of Physical Chemistry B · doi:10.1021/jp4049617 · Cited by 149
Resveratrol Improves Vascular Function in Patients With Hypertension and Dyslipidemia by Modulating NO Metabolism
Carrizzo, A., Puca, A. A., Damato, A., Marino, M., Franco, E., Pompeo, F., Traficante, A., Civitillo, F., Santini, L., Trimarco, V., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.01009 · Cited by 143
“In experimental models, this stilbenoid has been reported to exert antioxidant, anticancer, antiproliferative, and antibacterial effects.(6,7) Numerous experimental and clinical studies have suggested that endothelial dysfunction, frequently evaluated as impairment of endothelium-dependent vasodilation, is a phenomeno…”
Background
Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy
Estrela, J. M., Mena, S., Obrador, E., Benlloch, M., Castellano, G., Palmer, R. S., & Dellinger, R. W. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01026 · Cited by 144
Effects of trans-Resveratrol on Copper-Dependent Hydroxyl-Radical Formation and DNA Damage: Evidence for Hydroxyl-Radical Scavenging and a Novel, Glutathione-Sparing Mechanism of Action
Burkitt, M. J., & Duncan, J. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1973 · Cited by 144
Therapeutic approaches of resveratrol on endometriosis via anti-inflammatory and anti-angiogenic pathways
Dull, A.-M., Moga, M. A., Dimienescu, O. G., Sechel, G., Burtea, V., & Anastasiu, C. V. (2019) · Molecules · doi:10.3390/molecules24040667 · Cited by 141
“In demonstrating the anti-inflammatory effect of resveratrol several studies shown that this natural compound suppresses the production of ROS and inhibits COX-2 expression and prostaglandin synthesis [96].”
Background
Small mitochondria-targeting molecules as anti-cancer agents
Wang, F., Ogasawara, M. A., & Huang, P. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.12.003 · Cited by 143
The Anticancer Effects of Resveratrol: Modulation of Transcription Factors
Whitlock, N. C., & Baek, S. J. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.667862 · Cited by 142
“This compound has elicited much attention as a potential anticancer agent since its inhibitory effect on carcinogenic processes (initiation, promotion, and progression) was first reported in 1997 (3).”
Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging
Sarubbo, F., Esteban, S., Miralles, A., & Moranta, D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170703113212 · Cited by 146
“Similar results have been shown in cancer studies, where resveratrol has been shown to exert antitumor actions through NF-κB inhibition [161-163].”
Result
The effects of natural antioxidants on oxidative processes and metmyoglobin reducing activity in beef patties
Bekhit, A. E. A., Geesink, G. H., Ilian, M. A., Morton, J. D., & Bickerstaffe, R. (2003) · Food Chemistry · doi:10.1016/s0308-8146(02)00410-7 · Cited by 143
Resveratrol and quercetin cooperate to induce senescence‐like growth arrest in C6 rat glioma cells
Zamin, L. L., Filippi‐Chiela, E. C., Dillenburg-Pilla, P., Horn, F., Salbego, C. G., & Lenz, G. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01215.x · Cited by 146
“(5–7) The cancer chemopreventive properties of Rsv were first appreciated when Jang et al. (1997)(5) demonstrated that Rsv inhibited cellular events associated with tumor initiation, promotion, and progression.”
Background
Inhibitory mechanisms of resveratrol in platelet activation: pivotal roles of p38 MAPK and NO/cyclic GMP
Shen, M., Hsiao, G., Liu, C. L., Fong, T. H., Lin, K. H., Chou, D., & Sheu, J. R. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06788.x · Cited by 143
“…of the human diet (e.g. peanuts, grapes and mulberries), has been demonstrated to have various biological activities including antiplatelet activity, and anticancer, antimutagenic, antifungal, antiinflammatory, and antioxidant properties (Jang et al, 1997; Olas & Wachowicz, 2005; Stef et al, 2006).”
Background
HPLC Analysis of Grapevine Phytoalexins Coupling Photodiode Array Detection and Fluorometry
Jeandet, P., Breuil, A.-C., Adrian, M., Weston, L. A., Debord, S., Meunier, P., Maume, G., & Bessis, R. (1997) · Analytical Chemistry · doi:10.1021/ac970582b · Cited by 141
Reactive oxygen species in melanoma and its therapeutic implications
Wittgen, H. G. M., & van Kempen, L. C. L. T. (2007) · Melanoma Research · doi:10.1097/cmr.0b013e3282f1d312 · Cited by 145
Currants (Vitis vinifera L.) content of simple phenolics and antioxidant activity
Chiou, A., Karathanos, V. Τ., MYLONA, A., Salta, F. N., Preventi, F., & Andrikopoulos, N. K. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.06.009 · Cited by 143
“Resveratrol has gained considerable interest, since this compound has been found to have anticarcinogenic properties (Ider et al., 2000; Jang et al., 1997).”
Background
The genetics of human longevity
Browner, W. S., Kahn, A., Ziv, E., Reiner, A. P., Oshima, J., Cawthon, R., Hsueh, W.-C., & Cummings, S. R. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.06.033 · Cited by 140
DNA oxidatively damaged by chromium(III) and H2O2 is protected by the antioxidants melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, resveratrol and uric acid
Burkhardt, S. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00052-8 · Cited by 142
Sequestering Ability of Butylated Hydroxytoluene, Propyl Gallate, Resveratrol, and Vitamins C and E against ABTS, DPPH, and Hydroxyl Free Radicals in Chemical and Biological Systems
Soares, D. G., Andreazza, A. C., & Salvador, M. M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020864z · Cited by 140
Pterostilbene, an Active Constituent of Blueberries, Suppresses Aberrant Crypt Foci Formation in the Azoxymethane-Induced Colon Carcinogenesis Model in Rats
Suh, N., Paul, S., Hao, X., Simi, B., Xiao, H., Rimando, A. M., & Reddy, B. S. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1528 · Cited by 142
“org Clin Cancer Res 2007;13(1) January1, 2007 351”
Influential
Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancer
Cavalieri, E. L., & Rogan, E. G. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.03.008 · Cited by 141
Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection
Naidu, S. D., Kostov, R. V., & Dinkova‐Kostova, A. T. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.10.011 · Cited by 142
Resveratrol–Cu(II) induced DNA breakage in human peripheral lymphocytes: Implications for anticancer properties
Azmi, A. S., Bhat, S. H., & Hadi, S. M. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.04.077 · Cited by 141
Quercetin Attenuates Nuclear Factor-κB Activation and Nitric Oxide Production in Interleukin-1β–Activated Rat Hepatocytes
Martínez‐Flórez, S., Gutiérrez-Fernández, B., Sánchez‐Campos, S., González‐Gallego, J., & Tuñón, M. J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1359 · Cited by 143
Antioxidants in cervical cancer: Chemopreventive and chemotherapeutic effects of polyphenols
Domenico, F. D., Foppoli, C., Coccia, R., & Marzia Perluigi, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.005 · Cited by 140
Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation
Lin, J.-N., Lin, V. C.-H., Rau, K., Shieh, P., Kuo, D., Shieh, J., Chen, W. J., Tsai, S., & Way, T. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9035782 · Cited by 142
Validation of anti-aging drugs by treating age-related diseases
Blagosklonny, M. V. (2009) · Aging · doi:10.18632/aging.100034 · Cited by 142
“[89, 90] Resveratrol was shown to prevent cancer, atherosclerosis, neurodegeneration and insulin-resistance (diabetes type II) [10, 91-100].”
Background
Inhibitory effects of resveratrol analogs on unopsonized zymosan-induced oxygen radical production
Jang, D.-S., Kang, B.-S., Ryu, S. Y., Chang, I., Min, K. R., & Kim, Y. S. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00350-5 · Cited by 140
Classic NSAID and selective cyclooxygenase (COX)‐1 and COX‐2 inhibitors in healing of chronic gastric ulcers
Brzozowski, T., Konturek, P. C., Konturek, S. J., Śliwowski, Z., Pajdo, R., Drozdowicz, D., Ptak, A., & Hahn, E. G. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1102 · Cited by 140
“Among COX-inhibitors used, we employed resveratol, which is a phenolic product derived from grapes that was shown to inhibit selectively COX-1 and the major enzyme of COX-1, hydroxyperoxidase (Jang et al., 1997).”
MethodResultInfluential
Resveratrol Inhibits Dioxin-Induced Expression of Human CYP1A1 and CYP1B1 by Inhibiting Recruitment of the Aryl Hydrocarbon Receptor Complex and RNA Polymerase II to the Regulatory Regions of the Corresponding Genes
Beedanagari, S. R., Bebenek, I. G., Bui, P. H., & Hankinson, O. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp079 · Cited by 140
“…a strong antioxidant and a free radical scavenger, much of its mechanism of action are not clearly understood (Aziz et al., 2003; Chen et al., 2004; Jang et al., 1997; Khan et al., 2008; Le Corre et al., 2005; Potter et al., 2002; Signorelli and Ghidoni, 2005; Stewart et al., 2003; Whitsett and…”
Background
Resveratrol Inhibits Phorbol Ester and UV-Induced Activator Protein 1 Activation by Interfering with Mitogen-Activated Protein Kinase Pathways
Yu, R., Hebbar, V., Kim, D. W., Mandlekar, S., Pezzuto, J. M., & Kong, A.-N. T. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.1.217 · Cited by 140
“In search of cancer chemopreventive agents from natural sources, resveratrol was identified as an inhibitor of cyclooxygenases (Jang et al., 1997).”
Self-citation
Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner
Yang, Q., Wang, B., Zang, W., Wang, X., Liu, Z., Li, W., & Jia, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070627 · Cited by 141
“Res was first reported to exert anti-tumor activities in 1997 [8].”
BackgroundResult
Photoprotective characteristics of natural antioxidant polyphenols
Stevanato, R., Bertelle, M., & Fabris, S. (2014) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2014.02.014 · Cited by 139
Preparation and biological activity studies of resveratrol loaded ionically cross-linked chitosan-TPP nanoparticles
Wu, J., Wang, Y., Yang, H., Liu, X., & Lu, Z. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.07.058 · Cited by 141
“Resveratrol (trans-3, 4’, 5-trihydroxystilbene, Res), a natural polyphenol compound presenting in grapes, mulberries, peanuts, chocolate and red wine, is well-known for its antioxidant, anticancer and cardiovascular effects (Jang et al., 1997; Minuti & Pellegrino, 2008; Robards, 2003).”
Background
Resveratrol as a new type of DNA-cleaving agent
Fukuhara, K., & Miyata, N. (1998) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(98)00585-x · Cited by 139
Prevention of Ultraviolet-B Radiation Damage by Resveratrol in Mouse Skin Is Mediated via Modulation in Survivin¶
Aziz, M. H., Afaq, F., & Ahmad, N. (2004) · Photochemistry and Photobiology · doi:10.1562/2004-08-13-ra-274.1 · Cited by 143
“studies from other laboratories (22,32,33), we used resveratrol at a dose of 10 lmol/mouse (topically applied 30 min before each”
Method
Grape cane waste as a source of trans-resveratrol and trans-viniferin: High-value phytochemicals with medicinal and anti-phytopathogenic applications
Rayne, S., Karacabey, E., & Mazza, G. (2008) · Industrial Crops and Products · doi:10.1016/j.indcrop.2007.11.009 · Cited by 138
Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR–Chk1/2–Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells
Tyagi, A., Singh, R. P., Agarwal, C., Siriwardana, S., Sclafani, R. A., & Agarwal, R. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi165 · Cited by 138
Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies
Yousef, M., Vlachogiannis, I. A., & Tsiani, E. (2017) · Nutrients · doi:10.3390/nu9111231 · Cited by 138
“properties and since then numerous in vitro and in vivo studies have been performed [15] and other studies showed that acts as a cancer chemopreventive too [16].”
Background
Resveratrol inhibited the metastatic behaviors of cisplatin‐resistant human oral cancer cells via phosphorylation of ERK/p‐38 and suppression of MMP‐2/9
CHANG, W.-S., Tsai, C., Yang, J., Hsu, Y., Shih, L., Chiu, H., Bau, D., & Tsai, F. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13666 · Cited by 138
Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3
Cadenas, S., & Barja, G. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00019-2 · Cited by 139
Risk factors of myelodysplastic syndromes: a case–control study
Strom, S. S., Gu, Y., Gruschkus, S. K., Pierce, S. A., & Estey, E. H. (2005) · Leukemia · doi:10.1038/sj.leu.2403945 · Cited by 138

Authors: Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
Affiliations: University of Illinois Chicago (US)
Universidad Complutense de Madrid (ES)
M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Corresponding author: Cai, Lining
Pezzuto, John M.
ORCID: Udeani, George O.
Slowing, Karla V.
Kinghorn, A. Douglas
Mehta, Rajendra G.
Pezzuto, John M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-01-10
Volume: 275
Issue: 5297
Pages: 218-220
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.275.5297.218
OpenAlex: W2151089147
Cited by: 4,935
References: 33
Citations by year: 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
FWCI: 96.50
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
Funders: National Cancer Institute (P01CA048112)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions

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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

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