The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Abstract
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
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“The scientific interest in resveratrol dates back to 1997 when studies on animal models demonstrated its anticancer properties [7].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [7]
Citations
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The Role of Resveratrol Administration in Human Obesity
Mongioì, L. M., La Vignera, S., Cannarella, R., Cimino, L., Compagnone, M., Condorelli, R. A., & Calogero, A. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094362 · Cited by 71
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Lephart, E. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061193 · Cited by 50
“For resveratrol, the dramatic increase in research interest occurred in early 1997, when its chemoprotective effects were first reported in Science by John Pezzuto’s laboratory [13].”
BackgroundResveratrol, curcumin and gallic acid attenuate glyoxal-induced damage to rat renal cells
Hashemzaei, M., Tabrizian, K., Alizadeh, Z., Pasandideh, S., Rezaee, R., Mamoulakis, C., Tsatsakis, A., Skaperda, Z., Kouretas, D., & Shahraki, J. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.11.008 · Cited by 44
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“Plant- and food-derived antioxidants, such as green-tea polyphenols and resveratrol, have been reported to be beneficial in protecting against these diseases (Ahmad and Mukhtar 1999; Jankun et al. 1997; Jang et al. 1997); hence, antioxidant therapy has become an attractive therapeutic strategy (Rice-Evans et al.”
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Chen, J. L.-Y., Sperry, J., Ip, N. Y., & Brimble, M. A. (2011) · MedChemComm · doi:10.1039/c0md00241k · Cited by 41
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Exploiting the role of resveratrol in rat mitochondrial permeability transition
Zhang, Y., Tian, F., Xiao, Q., Hu, Y., Li, J., Jiang, F., & Liu, Y. (2013) · The Journal of Membrane Biology · doi:10.1007/s00232-013-9540-0 · Cited by 21
Molina-García, M., Malvehy, J., Granger, C., Garre, A., Trullàs, C., & Puig, S. (2022) · Dermatology and Therapy · doi:10.1007/s13555-021-00644-3 · Cited by 15
“Polyphenols, especially resveratrol, have demonstrated antiinflammatory and also anticancer properties, including inhibition of tumorigenesis [95, 96], and they also inhibit UVR damage in human skin cells [97].”
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“Resveratrol began to receive major attention in 1997, after it was discovered to have anti-cancer activity [18].”
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Metadata
- Authors
- Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
- Affiliations
- University of Illinois Chicago (US)
- Universidad Complutense de Madrid (ES)
- M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
- Corresponding author
- Cai, Lining
- Pezzuto, John M.
- Venue
- Science
- Published
- 1997-01-10
- Volume
- 275
- Issue
- 5297
- Pages
- 218-220
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2151089147
- Cited by
- 4,935
- References
- 33
- Citations by year
- 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
- FWCI
- 96.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- Funders
- National Cancer Institute (P01CA048112)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions
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